107 results about "Sleep in non-human animals" patented technology

A method, an arrangement and a computer application for conducting measurements of sleep disorders by capturing and analyzing the sounds associated with movements of the subject during a long-term or overnight monitoring session. A small-sized consumer apparatus such as an MP3 recorder may be attached to the subject for capturing the emanating sounds. Specially selected materials can be used to alter the spectral content of the sound so as to optimize the reception at the recording apparatus.

The present apparatus and method for using the same detects REM in a sleeping mammal and awakens the mammal after the cessation of a specific episode of REM. The system comprises an alarm setting means for setting a predetermined wakeup time, a data collection means for collecting physiological data from the mammal over time, a processing means for determining the occurrence and cessation of REM and means of providing a stimulation signal for awakening the mammal within a prescribed window of time before said predetermined wakeup time and after the cessation of REM and after the mammal's nadir in body temperature with respect to time.

Traditional analysis of sleep patterns requires several channels of data. This analysis can be useful for customized analysis including assessing sleep quality, detecting pathological conditions, determining the effect of medication on sleep states and identifying biomarkers, and drug dosages or reactions.

A method of measuring the stress or relaxation level of a mammal and a method of measuring the activity of the sympathetic nervous system of a mammal by measuring quantititative levels of deoxyhemoglobin and oxyhemoglobin are disclosed. Preferably, the levels of deoxyhemoglobin and hemoglobin are measured by a noninvasive technique, such as spectroscopy. A method of changing the activity of the sympathetic nervous system of a mammal is also disclosed, wherein the method includes a step of administering an effective amount of sensory regimen to the mammal. The method is useful for humans who are operating vehicles or machinery, who are suffering from cardiovascular disease or related complications, who are pregnant, or who are preparing for sleep. In addition, a method of improving the complexion of the skin of a mammal is disclosed.

The invention discloses a traditional Chinese medicine composition for assisting to improve sleep, a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition for assisting to improve sleep is prepared from, by weight, 15-65 parts of semen juglandis, 15-65 parts of spina date seed, 5-55 parts of salvia miltiorrhiza, 5-35 parts of acanthopanax, 5-35 parts of tuber fleeceflower stem, 5-15 parts of Astragalus membranaceus, 5-15 parts of lotus seed, 5-35 parts of jujube, 5-35 parts of wolfberry, 5-15 parts of sesame, 5-15 parts of grape skin, 5-15 parts of dark plum, and 5-15 parts of hawthorn. The animal experiment proves that the high and medium dosages of test materials can assist to prolong the sleep time of mice pentobarbital sodium and significantly shorten the sleep latent time of the mice pentobarbital sodium; however, every dosage is not directly acted on promoting animal sleep; therefore, the traditional Chinese medicine composition is promoted to be a health care product for improving human sleep; thus the life quality of the human body is obviously improved. The traditional Chinese medicine composition is applied to both of cold and warm figures, capable of eliminating and supplementing at the same time, compensating without obstructing the evil, giving consideration to Yin and Yang of liver, spleen and kidney, so that the dampness of spleen can be removed; moreover, the composition has the effects of sedative and hypnotic, promoting blood circulation to remove meridian obstruction, nourishing liver and kidney, and replenishing qi to invigorate the spleen.

The invention relates to a non-contact sleep state monitoring method and system based on a biological microwave radar, and the method comprises the following steps: S1, enabling a microwave radar sensor to transmit a microwave signal to a to-be-monitored individual, receiving a radar echo signal, and carrying out the preprocessing of the radar echo signal, and obtaining radar original data; s2, performing radar signal processing on the radar original data to obtain a sleep body movement characteristic data set and a sleep state classification data set including physiological sign data; and S3, based on big data and an artificial intelligence algorithm, combining the sleep body movement characteristic data set and the sleep state classification data set to obtain a sleep state result of the to-be-monitored individual, and completing sleep state monitoring. Compared with the prior art, the non-contact sleep state monitoring method has the advantages of convenience, accuracy and the like.

The invention provides a composition capable of improving sleep, and belongs to the field of medicines or health care foods. The composition contains the following ingredients in parts by weight: 10-30 parts of theanine, 40-60 parts of [gamma]-aminobutyric acid, 10-30 parts of ziziphi spinosae semen extracts, 0.2-0.3 part of astaxanthin and 1-3 parts of magnesium gluconate. The composition also comprises 5-20 parts of fructus lycii, 5-15 parts of rhizoma polygonati, 5-10 parts of Passiflora caerulea L. herba, 5-30 parts of mori fructus, 5-20 parts of Lepidium meyenii Walp. roots, 3-20 parts ofginseng radix, 0.2-0.5 part of sea cucumber peptide, 0.1-0.6 part of oyster peptide, 5-15 parts of black rhizoma zingiberis recens, 1-5 parts of deer heart blood and 5-20 parts of cortex cinnamomi. The invention also provides a medicine preparation or a health care food prepared from the composition, and a preparation method for the health care food. The invention also provides a purpose of the composition, the medicine preparation or the health care food. The composition provided by the invention can obviously eliminate insomnia and improve sleep quality and has the function of invigoratingthe brain and soothing the nerves.

The invention relates to the field of traditional Chinese medicines and in particular discloses a traditional Chinese medicine composition for improving sleep. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of spina date seed, 15-25 parts of lucid ganoderma, 15-20 parts of acanthopanax and 5-15 parts of schisandra chinensis. According to the traditional Chinese medicine composition disclosed by the invention, the sleep time of a pentobarbital sodium hypnosis mouse can be prolonged; the sleep onset latency of the pentobarbital sodium hypnosis mouse is shortened; and the traditional Chinese medicine composition does not have an obvious direct sleeping effect and does not have bad effect on the weight of the mouse. The invention also provides a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention is a pure traditional Chinese medicine preparation, does not have a toxic or side effect and has good application prospects, and the sleep can be effectively improved.

The invention provides a milk beverage for regulating sleep disorder. The milk beverage comprises 1%-6.1% of blueberry juice powder, 0.5%-4.1% of whole milk powder, 1%-6.1% of gamma aminobutyric acid,0.1%-1.21% of spina date seed, 0.1%-1.21% of walnut peptide, 0.04%-0.41% of lily, 0.04%-0.41% of poria cocos, 0.04%-0.41% of double-petal red rose, 0.1%-1.21% of tea leaf theanine, 0.35%-2.62% of a stabilizing agent, 0.15%-0.502% of acidulant, 0.015%-0.151% of sweetening agent, 0.075%-0.251% of essence and the balance of water. According to the milk beverage, gamma-aminobutyric acid and medicinaland edible traditional Chinese medicines are taken as main components, so that in a hypnosis experiment of a pentobarbital sodium valve dosage, the sleep rate of a mouse is as high as 70%, and in anexperiment of prolonging the sleep time of pentobarbital sodium, the sleep time is as long as 42.13 min, so that the milk beverage has very good effects of regulating sleep disorder and helping sleep.

The invention relates to the technical field of health products and in particular relates to a composition for improving sleep and a preparation method thereof. The composition is characterized in that apple stem cell lyophilized powder, spina date seed extract and gamma-aminobutyric acid are compounded, the effect of obviously improving sleep is realized, and no toxic or side effect is produced. Experiments show that the effect for improving sleep of the provided composition is obviously better than the effects of respective components, and mouse acute toxicity test results show that abnormality is not found on a mouse and no poisoning or death phenomenon is caused; and the provided composition can effectively improve incidence that the mouse at subthreshold dose of pentobarbital sodium falls asleep at a dosage of 0.5g / kg.

The invention discloses an application of a composition of bacillus subtilis BS01 and ganoderma lucidum spore powder in improving sleep. According to the invention, with the combination of bacillus subtilis BS01 and ganoderma lucidum spore powder, mice sleep latency time and serum MDA content can be substantially reduced. Mice sleep time, subliminal hypnotic sleep rate, CAT activity, GSH-Px activity and SOD activity are respectively improved by 54.36%, 43.75%, 98.13%, 49.27% ??and 12.61%. With the composition of bacillus subtilis BS01 and ganoderma lucidum spore powder, mice sleep quality is effectively improved. The composition can be used for preparing biological products used for improving sleep.

The invention belongs to the technical field of medicines and discloses novel application of pepper extractives in sedative-hypnotic. The pepper extractives use fruits or seeds of pepper plants as raw materials, and by means of a method of carbon dioxide supercritical fluid extraction or water extraction or ethanol extraction, the pepper extractives are obtained. By means of analysis and experimental verification of righting reflex experiments of mice and sleep time phase of rabbits, the pepper extractives have a good function of sedative-hypnotic, can be used in the development of sedative hypnotic Chinese medicines and natural medicines, and can also be used in the development of the health foods with effects of promoting sleep.

The invention belongs to the technical field of biological medicines, and discloses a beta-sitosterol derivative as well as a preparation method and application thereof. The beta-sitosterol derivativecan be assembled with avidin to form nanoparticles. Animal tests prove that the beta-sitosterol derivative and the nano-drug thereof can obviously reduce the sleep latency time of mice, significantlyimprove the sleep time and the subthreshold hypnotic sleep rate of the mice, can effectively improve the sleep quality of the mice, and can be used for further preparing drugs or health products forimproving the sleep quality.

The invention discloses an application of Bacillussubtilis BS01 fermented ganoderma lucidum spore powder in sleep improvement. The Bacillussubtilis BS01 fermented ganoderma lucidum spore powder has the functions of obviously reducing the sleep latency time of mice and MDA (methane dicarboxylic aldehyde) content of serum. The sleeping time, the subliminal sleeping rate, the T-AOC (total antioxidative capacity) activity, the SOD (superoxide dismutase) activity, the CAT (catalase) activity and the GSH-Px (glutathione peroxidase) activity of mice are respectively enhanced by 41.44%, 66.67%, 24.66%, 19.49%, 55.68% and 31.27%. The Bacillussubtilis BS01 fermentation ganoderma lucidum spore powder effectively improves the sleeping quality of mice, enhances the antioxidant ability of serum, and can be used for preparing microecologics for sleeping improvement.

The invention discloses a tortoise small peptide. The tortoise small peptide has any one of the following amino acid sequences: W-W-Y-W-R-Hex; W-G-P-G-B; W-R-W-X-H-T-H-N-W. The invention further discloses a preparation method and application of the tortoise small peptide. The tortoise small peptide can significantly shorten the sleep latency period of mice and prolong the sleep time, has a good sleep promoting effect, is clear in structural composition, stable in physical and chemical properties, more controllable in quality and easier to guarantee in efficacy compared with existing polypeptides, can be prepared by a synthesis method, and is beneficial to reducing resource waste and lowering the production cost.

The invention discloses the application of ganoderma lucidum spore powder fermented by Bacillus subtilis (Bacillus subtilis) BS01 in improving sleep. The fermentation of Ganoderma lucidum spore powder by Bacillus subtilis BS01 significantly reduced the sleep latency and serum MDA content of mice. The sleep time, subthreshold hypnotic sleep rate, T‑AOC activity, SOD activity, CAT activity and GSH‑Px activity of the mice were increased by 41.44%, 66.67%, 24.66%, 19.49%, 55.68% and 31.27%, respectively. The Ganoderma lucidum spore powder fermented by Bacillus subtilis BS01 can effectively improve the sleep quality of mice, increase the antioxidant capacity of serum, and can be used to prepare microecological preparations for improving sleep.

The present invention relates to the technical field of health products, particularly to a sleep improving composition and a preparation method thereof. According to the present invention, apple stem cell freeze-drying powder, melatonin and vitamin B6 are compounded so as to provide characteristics of significant sleep improvement function and no toxic-side effect; experiment results show that the sleep improving effect of the composition of the present invention is significantly superior to the sleep improving effect of the single use of each component, and mouse acute toxicity test results show that the mouse does not present abnormality and no poisoning or death occur; and the falling-asleep occurrence rate of the mice with the sub-threshold dose of sodium pentobarbital can be effectively improved under the composition dose of 0.5 g / kg.

The invention discloses a sleep recording bin which comprises a protection assembly, a raising assembly and a monitoring assembly. The protection assembly comprises an outer bin body and an inner binbody, and the outer bin body is arranged on the periphery of the inner bin body. The raising assembly is arranged in the inner bin body. The monitoring assembly comprises implanters, a collecting board and a displayer, the implanters are placed on animals to be detected in the raising assembly, the implanters are in wireless connection with the collecting board, and the input end of the collectingboard is connected with the displayer. According to the sleep recording bin, the arranged outer bin body is made from a sound insulation anti-static plate material, the sound of the surroundings canbe effectively shielded, and the accuracy of detection data is guaranteed. Multiple isolating rooms are arranged, mutual interference among the detected animals is avoided effectively, the sleep conditions of the detected animals can be monitored and recorded at the same time, behavior data is recorded in real time through cameras mounted in the isolating rooms, and reference bases are provided for sleep management and scientific research of the detected animals.

The invention establishes a novel method for preparing a product by taking cordyceps militaris as a raw material and extracting and separating anti-insomnia medicinal components from the cordyceps militaris according to a certain formula process. Experimental results of toxicity, medicinal effect and the like show that the product is free of toxicity, and has effects of improving the sleep effectof a human body and improving sleep quality. As effective components and auxiliary materials are both extracted from cordyceps militaris, the product has no toxic or side effect on human bodies and does not casue tolerance. According to the characteristics of the cordyceps militaris, the product can improve functional quality of human bodies while preventing and treating sleep problems, and can besafely used for regulating sleep of a human body and treating insomnia.

The invention discloses a composition capable of calming mind and assisting sleep, a preparation method therefor and application of the composition. The composition capable of calming the mind and assisting the sleep comprises raw oyster shells, wild jujube seeds, lily bulbs, poria cocos, dried red dates, roses, fried malt, fructus crataegi, radix glycyrrhizae, dried tangerine peels, fresh oyster meat, mussels and gamma-aminobutyric acid. The composition capable of calming the mind and assisting the sleep is natural in ingredient, scientific in proportioning ratio and free of toxic or side effects; and confirmed by animal in-vivo experiments, the composition can be used for obviously increasing sleep incidence rate of sodium pentobarbital in a sub-threshold dose and shortening the sleep latency period of sodium barbital, plays a role in improving the sleep, and then, can be applied to preparation of foods or healthcare products for improving the sleep.

The invention relates to a sleep accessory for catching bed bugs, having a closed frame for supporting at least one person, a base being arranged on the frame, which base closes the frame on one side, wherein at least one bed bug trap is arranged on the frame, which bed bug trap continuously encloses the entire frame, a peripheral groove being arranged on upper edges of the frame. According to the invention, all the inner frame sides of the frame and an inner base side of the base and a transition region from the inner base side to the inner frame sides are substantially gap- and / or crack-free, in particular smooth, and the bed bug trap is arranged on a base of the groove.

The invention relates to a composition with a sleep improving function and application. The composition with the sleep improving function is prepared from the following components in parts by weight: 10 to 40 parts of cannabidiol, 20 to 80 parts of rhizoma polygonati extract and 60 to 150 parts of human milk oligosaccharide. The cannabidiol, the rhizoma polygonati extract and the human milk oligosaccharide are taken as main raw materials, the three components are reasonably combined, the cannabidiol can relieve pressure and resist anxiety, the rhizoma polygonati can tonify deficiency and nourish yin, and the human milk oligosaccharide can nourish cranial nerves; the three components are matched and used, supplement each other and synergistically play a role in improving sleep. Animal experiment results prove that after the composition is orally taken to a mouse for 30 days, experiment results of prolonging the pentobarbital sodium sleep time and experiment of pentobarbital sodium subthreshold hypnotic dose are positive, and no obvious direct sleep effect exists, so that the composition has the effect of improving the sleep function, and the composition can be used for preventing and treating the sleep. Meanwhile, side effects on human bodies are avoided, and the product safety is high.

A method for determining whether a substance can increase the expression level of a fatty acid binding protein (FABP) in an animal. The method includes using a cell that includes an expression construct that comprises a FABP promoter operably linked to a polynucleotide sequence encoding a reporter molecule, wherein the cell is contacted with a candidate substance and then cultivating the cell under conditions conducive to expression of the reporter molecule. Increased expression of the construct in the presence of the candidate substance as compared to a control leads to improved sleep and long-term memory in the subject.

The invention provides a casein peptide with a sleep improving effect and a preparation method and application thereof, and belongs to the technical field of functional polypeptides. Casein is used asa raw material and prepared into a casein peptide mixture through a biological enzymolysis technology, and two bioactive peptide sequences with opium properties are obtained through multiple times ofseparation and purification. Zebra fish tests prove that the casein peptide has an ideal effect on improving sleep. Therefore, the casein peptide prepared through the method is applied to preparationof medicine for treating insomnia or preparation of health-care products or health-care food for improving sleep quality.

The invention provides a sleep anti-interference method. The method comprises: receiving an environment image sent by a shooting module; recognizing whether an animal exists in the environment image or not through a pre-trained animal recognition model; if the animal exists in the environment image, outputting an identification target box of the animal in the environment image; inputting the environment image and the identification target frame into a target tracking module, and outputting the position of the identification target frame in the environment image; and guiding the animal to moveto a preset area by controlling a guiding module, so that the animal is far away from the no-disturbing area. The animal is guided to move to the preset area through the guiding module, so that the animal is far away from the rest area of the user, and user sleep quality is prevented from being affected.

The invention discloses a health-care food with function of improving sleep and a preparation method thereof and belongs to the technical field of health-care foods. The health-care food is prepared from the following traditional Chinese medicinal materials in parts by weight: 480-720 parts of schisandra chinensis, 360-540 parts of spina date seed, 2-90 parts of salvia miltiorrhiza 190, 120-180 parts of ginseng and 240-360 parts of Chinese date. The health-care food keeps to guidance of the traditional Chinese medicine theory, accords with the insomnia improvement thinking in modern medicine, obeys the strict code standard according to the requirements of the modern health-care food, is safe, effective, stable, controllable in quality and convenient to take, and is a new generation health-care food with a modern dosage form. The efficacy validation experiment proves that the health-care food has a good calming and hypnotizing function, the autonomic activity frequency of a mouse can be obviously reduced, the incubation period of falling asleep for the mouse can be obviously shortened, and the sleep time of the mouse is prolonged.

The invention discloses a real-time sleep monitoring recording and analyzing method, which is a common method for researching sleep states of people or other animals in the field of biomedicine, and provides a system for performing real-time sleep monitoring by combining hardware and software, the hardware is responsible for acquiring data, and the software is responsible for performing sleep classification on the data and achieving a real-time effect. According to the analysis algorithm, based on the dimension parameters (key frequency band energy, effective values and motion data) and dimensionless parameters (standardized convolution calculation values), Euclidean distance and Mahalanobis distance are used for distance calculation to determine classification of sleep states, so that theaccuracy of the classification algorithm is improved; in addition, the data is grabbed from the equipment in real time to calibrate the sleep state.

Methods and compositions for promoting sleep in an animal are provided. In a general aspect, a sleep promoting amount of astaxanthin and a sleep promoting amount of melatonin are administered in conjunction to an animal. The astaxanthin can be administered in an amount ranging from about 0.1 to about 60 mg / kg / body weight of the animal. The melatonin can be administered in an amount ranging from about U. I to about 40 mg / kg / body weight of the animal. The method can further comprise administering in conjunction a sleep promoting amount of zinc to the animal. The zinc can be administered in an amount ranging from about 10 to about 100 mg / kg / body weight of the animal.

Disclosed are novel compositions, devices, patches, systems and methods that are useful for estimating, determining, modulating and / or improving the sleep / wake and / or circadian phase of a subject (e.g., a human subject) by the dispensing of measured quantities of agents to a subject or into an environment of the subject and the continuous monitoring and / or tracking of the subject's consciousness (e.g., sleep / wake) patterns. In certain aspects, the compositions, devices, patches, systems and methods disclosed herein are capable of delivering one or more agents to a subject in response to measured consciousness patterns estimations and circadian phase estimations, thereby aligning the subject's circadian biology to the external environment and improving the quality and duration of sleep.