3results about How to "Sleep longer" patented technology

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

The invention discloses a strain of Lactobacillus buchneri for improving GABA content and sleep and application thereof, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide a strain of Lactobacillus buchneri capable of regulating and controlling GABA content and improving sleep, and the key point of the technical scheme is to provide a strain of Lactobacillus buchneri with a preservation number of CGMCC No.37544. The Lactobacillus buchneri is a strain of Lactobacillus buchneri with a preservation number of CGMCC No.37544. The Lactobacillus buchneri JZ-QX01 disclosed by the invention has the capabilities of regulating and controlling the content of GABA (gamma-aminobutyric acid) in a host and improving sleep, and has a huge application prospect in the preparation of a product for regulating and controlling the content of the GABA in the host and regulating the sleep.

The invention discloses a sheep colostrum composition capable of improving sleep and application of the sheep colostrum composition, and belongs to the technical field of microbial fermentation and functional food. The core of the invention lies in that a composite leavening agent is compounded by using the casei paracasei GP66 and the streptococcus salivarius subsp. Thermophilus HX-ST36, and then the sheep colostrum of concentrated whey protein, galactooligosaccharide and acerola cherry powder is subjected to synergistic fermentation. According to the fermentation process, IgG in sheep colostrum can be efficiently reserved, and the content of small molecule peptide and gamma-aminobutyric acid in a fermentation system is remarkably increased. Meanwhile, the invention also generates a novel pentapeptide, the pentapeptide has a sleep aiding effect, and the amino acid sequence of the pentapeptide is Arg-Phe-Leu-Trp-Pro (RFLWP). Animal experiments prove that the traditional Chinese medicine composition can play a role in improving sleep by regulating a neurotransmitter system. The invention provides a new way of a product for improving sleep, which is natural, safe and clear in mechanism.