10results about How to "Sleep longer" patented technology

The invention discloses a pharmaceutical composition for insomnia (heart-spleen deficiency type) and hypomnesis and a preparation method of the pharmaceutical composition, and relates to the technical field of medicines.The composition is prepared from acanthopanax, astragalus membranaceus, lucid ganoderma, ginseng leaves, schisandra chinensis and gastrodia elata, the prescription mainly aims at the pathogenesis of insomnia caused by heart-spleen deficiency, the synergistic effect is achieved from multiple aspects, and the curative effect is good. The traditional Chinese medicine composition has the effect of treating insomnia caused by heart and spleen, and is a comprehensive and effective treatment scheme. Meanwhile, the effect of improving memory is also achieved. The prescription provided by the invention can be prepared into granules, oral preparations and the like. The pharmaceutical composition disclosed by the invention has a remarkable insomnia treatment effect which is superior to that of Western medicines such as eszopiclone tablets and estazolam tablets, the sleep inducing time is shortened, the sleep time of a patient with difficulty in falling asleep can be effectively shortened, meanwhile, the sleep time is optimally prolonged, the insomnia treatment effect is remarkable, and the situations of somnolence and non-awakening are avoided; the memory can also be improved. Meanwhile, no dependence is caused, and the insomnia is fundamentally treated.

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

The present application embodiment discloses a soothing and sleep-aiding composition containing agarwood leaves, and its preparation method, use, and health tea. The soothing and sleep-aiding composition includes, by weight: agarwood leaves: 10-18 parts; Alpinia oxyphylla: 5-12 parts; Polygonum multiflorum: 8-16 parts; Platycladus orientalis: 8-16 parts; Theanine: 3-7 parts. In the soothing and sleep-aiding composition of the present application embodiment, the combination of Platycladus orientalis leaves and agarwood leaves has a better sedative effect, and Alpinia oxyphylla can promote brain blood circulation together with theanine, thereby better improving sleep quality; on this basis, Polygonum multiflorum has both the effects of calming and calming the mind and improving sleep quality, thereby not only improving the sedative effect of the soothing and sleep-aiding composition, but also further improving sleep quality.

The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating insomnia. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-25 parts of ligusticum wallichii and 1.5-8 parts of gastrodia elata. The traditional Chinese medicine composition disclosed by the invention has certain sedative and hypnotic effects and can exert a curative effect on insomnia.

The invention relates to a dexmedetomidine microneedle patch as well as a preparation method and application thereof. The dexmedetomidine microneedle patch comprises a substrate and a needle body arranged on the surface of the substrate, wherein the needle body comprises dexmedetomidine hydrochloride, a framework material and a penetration enhancer; the penetration enhancer is prepared from one or more of dodecyl-beta-D-maltoside, ethylenediamine tetraacetic acid and tetrahydropiperine. The dexmedetomidine microneedle patch is higher in medicine cumulative penetration amount, facilitates shortening of sleep-aiding onset time and prolonging of sleep-aiding action time, and has a good insomnia treatment effect.

The invention discloses a strain of Lactobacillus buchneri for improving GABA content and sleep and application thereof, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide a strain of Lactobacillus buchneri capable of regulating and controlling GABA content and improving sleep, and the key point of the technical scheme is to provide a strain of Lactobacillus buchneri with a preservation number of CGMCC No.37544. The Lactobacillus buchneri is a strain of Lactobacillus buchneri with a preservation number of CGMCC No.37544. The Lactobacillus buchneri JZ-QX01 disclosed by the invention has the capabilities of regulating and controlling the content of GABA (gamma-aminobutyric acid) in a host and improving sleep, and has a huge application prospect in the preparation of a product for regulating and controlling the content of the GABA in the host and regulating the sleep.

The invention discloses a sheep colostrum composition capable of improving sleep and application of the sheep colostrum composition, and belongs to the technical field of microbial fermentation and functional food. The core of the invention lies in that a composite leavening agent is compounded by using the casei paracasei GP66 and the streptococcus salivarius subsp. Thermophilus HX-ST36, and then the sheep colostrum of concentrated whey protein, galactooligosaccharide and acerola cherry powder is subjected to synergistic fermentation. According to the fermentation process, IgG in sheep colostrum can be efficiently reserved, and the content of small molecule peptide and gamma-aminobutyric acid in a fermentation system is remarkably increased. Meanwhile, the invention also generates a novel pentapeptide, the pentapeptide has a sleep aiding effect, and the amino acid sequence of the pentapeptide is Arg-Phe-Leu-Trp-Pro (RFLWP). Animal experiments prove that the traditional Chinese medicine composition can play a role in improving sleep by regulating a neurotransmitter system. The invention provides a new way of a product for improving sleep, which is natural, safe and clear in mechanism.

This invention proposes a material for manufacturing polymer air fibers, its preparation method, and its applications, belonging to the field of home furnishing technology. The process involves preparing antibacterial TiO2 / ZnO / ZrO2 doped ceramic powder, depositing magnetic iron oxide (Fe3O4), modifying the surface with tannic acid, adding it to a water-soluble chitosan solution, immersing it in a melt-blown TPEE air fiber membrane, uniformly adding genipin solution, heating and reacting, removing the membrane, washing, and drying to obtain the material for manufacturing polymer air fibers. The TPEE air fiber membrane prepared by this invention has good mechanical properties. The modified ceramic powder is uniformly dispersed in the TPEE air fiber membrane, resulting in excellent antibacterial, environmentally friendly, immune-regulating, magnetic therapy, and far-infrared heating effects. This gives the resulting polymer air fiber material better comprehensive performance, making it a superior mattress support material with broad application prospects.

The present invention belongs to the field of functional polypeptides, and specifically relates to a casein hydrolyzate with sleep-improving effects, and its preparation and application. The casein hydrolyzate uses high-concentration casein as a substrate, and by adding a composite protease, the enzymatic hydrolysis effect is improved without prolonging the enzymatic hydrolysis time, and the degree of hydrolysis reaches 27.67%, and the polypeptide content in the casein hydrolyzate reaches 67.4%. Both low-dose (25 mg / kg) and high-dose (50 mg / kg) casein hydrolyzates can effectively shorten the sleep latency and prolong the sleep time. In addition, the casein hydrolyzate product prepared by the process of the present invention contains two polypeptides with high-efficiency sleep-aiding activity: YAKPAA and TPTLN. The content of YAKPAA in the hydrolyzate reaches 1.58%, and the content of TPTLN reaches 0.5%, which can effectively improve sleep problems.

The invention discloses a probiotic-TCM compound composition with a sleep aiding effect. The probiotic-TCM compound composition comprises a TCM compound and probiotics, wherein the TCM compound comprises a spina date seed extract, a poria cocos extract, a lily bulb extract and a gardenia extract; the probiotics are lactobacillus plantarum. The invention further discloses a preparation method and application of the probiotic-TCM compound composition. According to the probiotic-TCM compound composition provided by the invention, the compound of the probiotics and the TCM can play a synergistic sleep-aiding role, and the probiotic-TCM compound composition is expected to become a safe and effective natural substance sleep-aiding solution, so that a new way is provided for improving the sleep quality.