33 results about "Anticholinesterase Agents" patented technology

This document provides methods and materials related to regulating inflammatory pathways. For example, compositions and kits containing two or more of an anticholinesterase compound, a choline compound, and a carnitine compound and methods for using the compositions and kits described herein to support acetylcholine function to regulate one or more inflammatory pathways are provided.

The invention discloses a preparation and application of macleyine and other medicine preparation extract from plants, its character lies in: it extracts macleyine with purity of 98% from bloodroot, and part of barberry family and buckthorn plants, and produces solid preparation, injection preparation compound with medicine accessories, the product can be used for curing heart and brain vessel diseases, and AD sufferer, at the same time, the product also has functions of analgesia, anticholinesterase functions and it can advances the bile secretion, and so on.

A method of screening for a genetic predisposition to anticholinesterase exposure. The method includes the steps of obtaining a peripheral blood sample, and then analysing serum from the blood sample for BuChE levels and inhibitor-susceptibilities. The DNA of peripheral white blood cells from the blood sample is also screened for the presence of BuChE alleles thereby identifying patients who have a genetic predisposition to anticholinesterase exposure.

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an alkaloid compound extracted, separated and identified from purslane and an extraction and separation method thereof. The alkaloid compound has a molecular formula of C19H34N2O3 and is named oleraurea. The invention also provides an extraction and separation method of the novel compound, which sequentially adopts 50-percent ethanol reflux extraction, polyamide column chromatography, silica gel column chromatography, an ODS medium pressure column, and Sephadex LH-20 to successfully extract and separate a novel alkaloid compound. The novel compound has anti-cholinesterase and anti-inflammatory effects, and the novel compound and a salt or a derivative thereof can be used as asynthetic precursor for other compounds and a raw material for new drug development and pharmacological activity research, and can be used for preparing anti-cholinesterase and anti-inflammatory drugsor health products.

This invention concerns a dosage form comprising a therapeutically effective amount of A19-144 or A2-73 and a therapeutically effective amount of at least one AED. This invention further encompasses a method of treating a subject in need of such treatment comprising administering a therapeutically effective amount of A19-144 or A2-73 in conjunction with an therapeutically effective amount of an AED.

The invention discloses novel medical application of isopentenyl isoflavone compounds in licorice roots. Through systematic research on the chemical components and activity screening of the licorice roots, it is discovered that the isopentenyl isoflavone compounds including licoricidin, angustone A and glyasperin D of which the structures are similar have the significant activity on inhibition of cancer cell proliferation and inhibition of protein tyrosine phosphatase 1B (PTP1B), licoricidin and glyasperin D have the significant activity on inhibition of acetylcholine esterase (AChE), and glyasperin D also has the significant activity on inhibition of tyrosinase. On the basis of the discovery, the active compounds or salt, ester and solvent compounds, stereoisomers, tautomer and prodrugs which are acceptable in pharmacy of the active compounds and mixtures of the compounds can be used for preparing anti-cancer drugs, PTP1B inhibitors, antidiabetic drugs, tyrosinase inhibitors, freckle removing and whitening products, AChE inhibitors, anticholinesterase drugs and the like.

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to a new compound extracted, separated and identified from a purslane medicinal material aswell as an extraction and separation method and application thereof. The invention provides (7E,9E)-6-oxooctadecyl-7,9-dienoic acid ethyl ester extracted from purslane as well as an extraction and separation method and application thereof. The ester compound is prepared by sequentially adopting alcohol decoction extraction, silica gel column chromatography, polyamide column chromatography, ODS medium-pressure column, Sephadex LH-20 purification, and liquid phase separation. The extraction separation method is simple, convenient, rapid and environment-friendly; the compound separated by the method is relatively high in purity; Pharmacological experiments prove that the obtained compound has anti-tumor and anti-cholinesterase effects, so that the new ester compound extracted from purslane and the salt and derivative thereof can be used as natural products to develop new traditional Chinese medicine, and have broad medical application prospects.

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to a new compound extracted, separated and identified from a purslane medicinal material andan extraction and separation method and application thereof. The invention provides 1-ethyl-7-(4-octyl-5-oxo cyclopentyl-1, 3-diene-1-yl) pimelate extracted from purslane and an extraction and separation method and application thereof. The ester compound is prepared by sequentially adopting alcohol decoction extraction, silica gel column chromatography, polyamide column chromatography, ODS medium-pressure column and Sephadex LH-20 purification and liquid phase separation. The extraction and separation method is simple, convenient, rapid and environment-friendly, the compound separated by themethod is relatively high in purity, and pharmacological experiments prove that the obtained compound has anti-tumor and anti-cholinesterase effects so that the new ester compound extracted from purslane and the salt and derivative thereof can be used as natural products to develop new traditional Chinese medicine, and wide medical application prospects are realized.

A combination of a muscarinic receptor antagonist consisting of a M2-receptor antagonist and of a non-selective, peripheral anticholinergic agent, and optionally an anticholinesterase inhibitor, and use of the same for treatment of hypocholinergic type disorders such as Alzheimer type dementia, schizophrenia, schizophrenia associated dementia, and schizoaffective disorders.

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to three alkaloid compounds extracted, separated and identified from purslane and an extraction and separation method thereof. The molecular formulas of the three alkaloid compounds are respectively C16H15NO5, C13H11NO3 and C14H13NO3, and the three alkaloid compounds are respectively named as 4,9,10-trihydroxy-2-methoxy-6,7-dihydrodibenzo [b,e]azocin-12(5H)-one, 9,10-dihydroxy-5,6-dihydro-11H-benzo[d]pyrrolo[1,2-a]azepin-11-one, and 8,9-dihydroxy-6,11-dihydro-5H-benzo[d] pyrrolo[1,2-a]azepine-3-carbaldehyde. The invention further provides an extraction and separation method of the alkaloid compounds. The extraction and separation method sequentially comprises the steps of ethanol reflux extraction, silica gel column chromatography, ODS medium-pressure column and hydroxypropyl dextran column chromatography purification and HPLC separation and preparation. The structures of the novel alkaloid compounds are determined by adopting methods of 1H-NMR, 13C-NMR and UHPLC-ESI-TOF-MS. The three compounds have potential anti-inflammatory and anti-cholinesterase activities and the like, a preparation method is provided, and a primer and a theoretical basis are provided for developing new drugs and new components.

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a nitrogen-containing organic acid compound extracted, separated and identified from purslane and an extraction and separation method thereof. The molecular formula of the nitrogen-containing organic acid compound is C16H30N2O5, and the nitrogen-containing organic acid compound is named as 5-(diethylamino)-2-(3-(diethylamino)-3-oxopropyl)-2-hydroxy-5-oxopentanoic acid. The invention also provides the extraction and separation method of the nitrogen-containing organic acid compound. The nitrogen-containing organic acid compound is prepared by sequentially adopting water decoction extraction, silica gel column chromatography, ethyl acetate extraction, ODS medium-pressure column, SI medium-pressure column and liquid phase separation. The structure of the nitrogen-containing organic acid compound is determined to be the nitrogen-containing organic acid compound by adopting 1H-NMR, 13C-NMR and two-dimensional nuclear magnetic spectrum analysis methods. The compound has potential anti-cholinesterase activity, the preparation method is provided, and a primer and a theoretical basis are provided for developing new drugs and new components.