Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof

A technology of pyrrole dicarboxylic acid and separation method, which is applied in the field of pyrrole dicarboxylic acid compounds and their extraction and separation, can solve the problems of low structural novelty and the like, and achieves the effects of environmental protection of the process method, simple and fast operation method

Active Publication Date: 2019-09-24
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof
  • Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof
  • Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof

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Embodiment 1

[0029] The invention provides a kind of pyrrole dicarboxylic acid compound, molecular formula is C 7 h 8 N 2 o 5 , named 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid, the chemical structure is.

[0030]

[0031] The pyrrole dicarboxylic acid compound is named 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid according to the structure, and Table 1 is the NMR data of the pyrrole dicarboxylic acid compound: 1 H-NMR with 13 C-NMR in DMSO.

[0032] Table 1 NMR data of pyrrole dicarboxylic acid compound 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid of the present invention

[0033] Numbering δC type δH,mult(J in Hz) 1 NH 2 124.81 C 3 147.74 C 4 113.95 CH 6.66(1H,d,3.30) 5 115.25 CH 6.78(1H,d,3.84) 6 161.60 C 7 N 8 160.35 C 9 O 10 51.36 CH 3

3.77(3H)

[0034] The invention discloses a structure identification and deduction of a pyrrole dicarb...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicine, in particular to a pyrrole dicarboxylic acid compound extracted, separated and identified from herba portulacae and an extraction and separation method thereof. The molecular formula of the pyrrole dicarboxylic acid compound is C7H8N2O5, and the pyrrole dicarboxylic acid compound is named as 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid. The extraction and separation method of the pyrrole dicarboxylic acid compound is further provided. The compound is prepared by sequentially adopting water for decoction extraction, ethyl acetate for extraction, a silica gel column for chromatography, an ODS medium pressure column and Sephadex LH-20 for purification and a liquid phase for separation. The novel pyrrole dicarboxylic acid compound is structurally determined by means of an approach including 1H NMR, 13C NMR and two-dimensional NMR wave spectrum analysis. The compound has potential activity such as inflammation resistance and cholinesterase resistance, a preparation method is provided, and a leading compound and a theoretical basis are provided for development of new drugs and new components.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a pyrrole dicarboxylic acid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources, and it is more common in Northeast my country. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/34A61P29/00A61P25/28A61P11/06A61P27/02
CPCC07D207/34A61P29/00A61P25/28A61P11/06A61P27/02
Inventor 英锡相崔馨予张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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