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A novel triterpenoid compound and its epimers from Acanthopanax senticosus, along with their extraction, separation methods, and applications.

PendingCN122079950Ahigh purityanti-inflammatoryOrganic active ingredientsOrganic chemistryEleutherococcus senticosusNew medications
This invention belongs to the field of traditional Chinese medicine chemistry and natural product separation technology, specifically relating to a novel triterpenoid compound and its epimerical form from *Eleutherococcus senticosus*, along with its extraction and separation methods and applications. The new compound is named 22α-Hydroxy-19-epi-chiisanogenin, and its epimerical form is named 22α-Hydroxychiisanogenin. The extraction and separation method provided by this invention employs acid hydrolysis / ethanol reflux extraction, macroporous resin column adsorption, silica gel column chromatography, ODS column chromatography, and high-performance liquid chromatography for separation, purification, and preparation. The compound was successfully extracted and separated. This method involves only five steps, is simple and rapid, and mainly uses conventional reagents such as ethanol, dichloromethane, and methanol. The process is simple and environmentally friendly, and the purity of the compound obtained by this method is high, exceeding 90%. Furthermore, studies have shown that this compound has anti-inflammatory effects. Therefore, the compound of this invention can be used as a lead compound for the synthesis of other compounds, as well as a raw material for new drug development and pharmacological activity research, and can also be used to prepare anti-inflammatory drugs.
Owner:LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE

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