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Alkaloid oleraurea in purslane and extraction and separation method thereof

A separation method, the technology of purslane, applied in food extraction, chemical instruments and methods, food ingredients containing natural extracts, etc., can solve the problem of low structural novelty, and achieve environmentally friendly process methods, simple and fast operation methods Effect

Active Publication Date: 2018-05-29
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Alkaloid oleraurea in purslane and extraction and separation method thereof
  • Alkaloid oleraurea in purslane and extraction and separation method thereof
  • Alkaloid oleraurea in purslane and extraction and separation method thereof

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Embodiment 1

[0031] The invention provides an alkaloid compound, the molecular formula is C 19 h 34 N 2 o 3 , named oleraurea. The chemical structural formula is:

[0032]

[0033] The alkaloid compound is named oleraurea according to the structure, and table 1 is the NMR data of the alkaloid compound: 1 H-NMR with 13 C-NMR in deuterated DMSO.

[0034] Table 1: NMR data of alkaloid compounds of the present invention

[0035]

[0036]

[0037] refer to Figure 1-10 , The structure identification and deduction of the alkaloid compound of the present invention.

[0038] Oleraurea: white powder, easily soluble in methanol, insoluble, slightly soluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the bromocresol blue test solution were sprayed to appear blue, suggesting that the compound contained a carboxyl group. UV(MeOH)λ max :226, 290nm, IRν N-H 3442cm -1 , ν CH 2932cm -1 , 2861cm -1 ν C＝O 1650, 1606cm -1 ,δ CH 1355cm -1 ....

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an alkaloid compound extracted, separated and identified from purslane and an extraction and separation method thereof. The alkaloid compound has a molecular formula of C19H34N2O3 and is named oleraurea. The invention also provides an extraction and separation method of the novel compound, which sequentially adopts 50-percent ethanol reflux extraction, polyamide column chromatography, silica gel column chromatography, an ODS medium pressure column, and Sephadex LH-20 to successfully extract and separate a novel alkaloid compound. The novel compound has anti-cholinesterase and anti-inflammatory effects, and the novel compound and a salt or a derivative thereof can be used as asynthetic precursor for other compounds and a raw material for new drug development and pharmacological activity research, and can be used for preparing anti-cholinesterase and anti-inflammatory drugsor health products.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an alkaloid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, five-element grass, is an annual succulent herb of the family Purslaneceae. Purslane is drought and waterlogging resistant, light and shade tolerant, widely distributed and rich in resources. Most of them are wild, and few people plant them. It is one of the 78 kinds of wild plants with the same origin of medicine and food stipulated by the Ministry of Health of my country. It was included in the menu of the 2008 Beijing Olympic Games. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects ...

Claims

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Application Information

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IPC IPC(8): C07C277/08C07C279/14A61P29/00A23L33/105
CPCA23L33/105A23V2002/00C07C279/14A23V2200/30A23V2250/21A23V2300/14
Inventor 英锡相迪迪尔·史蒂恩修芬英哲铭张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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