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Extraction of protopine from plant, and its manufacture of medicinal preparation and use

A proto-opioid and plant technology, applied in the field of traditional Chinese medicine, can solve problems such as extraction and purification methods of proto-opioid that have not been mentioned

Inactive Publication Date: 2005-02-16
北京神农坛医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN01108424.3 discloses the application of protopine in the preparation of drugs for the treatment of senile dementia. Patent CN99117412.7 discloses the effect of protopine on δ-receptors. The two patents have never mentioned the extraction of protopiate, Purification method; patent CN03118827.3 mentions the preparation method of the summer free total alkaloid preparation containing the original opium, and the patent CN02111103.0 discloses the extraction method of the summer free total alkaloids and its new application, but its summer free total alkaloids The amount of opiates is only 50% of its total

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] 1. Extraction and purification of the original opioid

[0079] Take 1000 grams of Xia Wu, crush it into a coarse powder, and reflux extract it with 95% ethanol for 3 times, each time the amount of ethanol is 6 times that of the crude drug, reflux extraction for 1-3 hours, combine the extracts, filter, and recover the solvent under reduced pressure. Obtain alcohol extract. Suspend the alcohol extract in 1% hydrochloric acid solution, dissolve it with ultrasound or slight heat, let it stand for 24 hours, filter, adjust the pH value of the filtrate to 10 with alkaline solution, keep it warm in a water bath at 60°C for 30 minutes, let it cool, and filter , dry to obtain the total alkaloid precipitate containing the original opioid, and the precipitate is dissolved in chloroform after low-temperature drying, filtered, and the filtrate is slowly added to ethanol, so that the ratio of chloroform in the solution: ethanol is 1: 3, and the chloroform-ethanol The solution was hea...

Embodiment 2

[0094] 1. Extraction and purification of the original opioid

[0095] Take 2000 grams of Xia Wu, crush it into a coarse powder, and use 95% ethanol to reflux extract 3 times, each time the amount of ethanol is 8 times that of the crude drug, reflux extraction for 3 hours, combine the extracts, filter, and recover the solvent under reduced pressure to obtain alcohol Extract. Dissolve the alcohol extract with 1% salt-alcohol solution ultrasonically or slightly heat, let it stand for 24 hours, filter, adjust the pH value of the filtrate to 12 with alkaline solution, keep it in a water bath at 60°C for 30 minutes, let it cool, filter, and dry , to obtain the total alkaloid precipitate containing the original opioid, the precipitate was dissolved in chloroform after low-temperature drying, filtered, and the filtrate was slowly added to ethanol, so that the ratio of chloroform in the solution: ethanol was 1: 5, and the chloroform-ethanol solution was dissolved in Heat on a water ba...

Embodiment 3

[0110] 1. Extraction and purification of the original opioid

[0111] Take 2000 grams of Xiawu, crush it into coarse powder, and reflux extract with 95% ethanol for 3 times, each time the amount of ethanol is 7 times that of the crude drug, reflux for 2 hours, combine the extracts, filter, and recover the solvent under reduced pressure to obtain alcohol Extract. Dissolve the alcohol extract with 1% salt-alcohol solution ultrasonically or slightly heat, let it stand for 24 hours, filter, adjust the pH value of the filtrate to 11 with alkaline solution, keep it in a water bath at 60°C for 30 minutes, let it cool, filter, and dry , to obtain the total alkaloid precipitate containing the original opioid, the precipitate was dissolved in chloroform after low-temperature drying, filtered, and the filtrate was slowly added to ethanol, so that the ratio of chloroform in the solution: ethanol was 1: 4, and the chloroform-ethanol solution was dissolved in Heat on a water bath, recover ...

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PUM

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Abstract

The invention discloses a preparation and application of macleyine and other medicine preparation extract from plants, its character lies in: it extracts macleyine with purity of 98% from bloodroot, and part of barberry family and buckthorn plants, and produces solid preparation, injection preparation compound with medicine accessories, the product can be used for curing heart and brain vessel diseases, and AD sufferer, at the same time, the product also has functions of analgesia, anticholinesterase functions and it can advances the bile secretion, and so on.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to the preparation and application of protopine extracted from plants and its pharmaceutical preparation. Background technique [0002] Protopine is one of the important active ingredients of many Papaveraceae plants and some Berberidaceae and Rhamnaceae plants. There are many research reports on proopioid at home and abroad, but the real application in the field of medicine is less. At present, domestic natural medicines containing various active ingredients of pro-opioid have been listed on the market, but they are not monomers. At present, there are no preparations or drugs with protopine alone as the active ingredient on the market both at home and abroad. [0003] The research on proto-opioids began in the 1950s abroad and in the 1960s in China. Early studies mainly focused on extracting and isolating pro-opioids from natural plants;...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/395A61P1/16A61P3/00A61P9/00A61P25/04A61P25/28A61P29/00A61P37/08
Inventor 张平
Owner 北京神农坛医药科技有限公司
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