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54 results about "Protopine" patented technology
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Protopine is an alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. Protopine is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five enzymatic transformations: 1) berberine bridge enzyme to (S)-Scoulerine; 2) (S)-cheilanthifoline synthase/CYP719A25 to (S)-Cheilanthifoline; 3) (S)-stylopine synthase/CYP719A20 to (S)-Stylopine; 4) (S)-tetrahydroprotoberberine N-methyltransferase to (S)-cis-N-Methylstylopine; and ultimately, 5) N-methylstylopine hydroxylase to protopine.
Extraction of protopine from plant, and its manufacture of medicinal preparation and use
The invention discloses a preparation and application of macleyine and other medicine preparation extract from plants, its character lies in: it extracts macleyine with purity of 98% from bloodroot, and part of barberry family and buckthorn plants, and produces solid preparation, injection preparation compound with medicine accessories, the product can be used for curing heart and brain vessel diseases, and AD sufferer, at the same time, the product also has functions of analgesia, anticholinesterase functions and it can advances the bile secretion, and so on.
Owner:北京神农坛医药科技有限公司
Hotseason grow corydaline, its preparation method and its medicinal composition
Owner:河北智源医药科技有限公司 +1
New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament
InactiveCN101195627AEnhanced inhibitory effectHigh activityAntibacterial agentsOrganic active ingredientsBenzo(c)phenanthreneDouble bond
The invention relates to a new application of benzo [C] phenanthridine as formula I and original tropine alkaloid for preparing anti-drug-resistant bacterial drug, wherein R1-R10, R12-R15 are hydrogen and hydroxyl groups, cycloalkyl or alkyl groups with 1-12 carbon atoms, alkox or acyloxy groups, benzyloxy, chlorine or other halide atoms, amido, methylol, aldehydo, aldehydo, acetonyl, carboxy group, mesyloxy, 4-methyl-benzene sulfonyl oxygen group, aryl sulfonyl oxygen group, biphenyl phosphine acyloxy and -OCONH2, R11 is hydrogen, methyl or oxygen atom, R5 and R6 (or R15 of the formula I), R14 and R15 are formed with double bonds, R12 or R13 and nearby N atoms are formed with double bonds, N atom can be tertiary or quaternary N type, the substituents of nearby carbons of R1-R10 can have dioxolane structure. The inventive alkaloid can effectively restrain and kill drug-resistant bacterials as MRSA and ESBLs.
![New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament](https://images-eureka.patsnap.com/patent_img/1952f98d-dba1-4c2a-9709-072b88d30fd4/s2007100664977e00011.PNG "New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament")
![New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament](https://images-eureka.patsnap.com/patent_img/1952f98d-dba1-4c2a-9709-072b88d30fd4/s2007100664977c00011.PNG "New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament")
![New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament](https://images-eureka.patsnap.com/patent_img/1952f98d-dba1-4c2a-9709-072b88d30fd4/s2007100664977d00021.PNG "New application of benzo [C] phenanthridine and protopine in producing overriding resistant bacterium medicament")
Owner:成都军区昆明总医院
Greater celandine extract and its preparation method and application
InactiveCN1429611AProlong survival timeOrganic active ingredientsOrganic chemistryChelidonineActive component
An extract of greater celandine for anticancer and antalgic purposes has its active components containing chelidonine 0.5-10 wt. portions, protopine 0.1-8, and total alkaloid of greater celandine 0.6-200. Its preparing process is also disclosed.
Owner:张平
Corydalis decumbens extract, and its preparing method and use
The present invention discloses a Chinese medicinal material Jilong corydalis extract, its preparation method and application. Said extract contains protopine and L-tetrahydropalmatine, their summation is not less than 50% (W / W), in which the protopine content is 24%-50% (W / W), and the L-tetrahydropalmatine content is 26%-50% (W / W). The pharmological tests show that it can be used as N-methyl-D asparaginic acid acceptor antagonist and acetylcholine esterase inhibibor. Besides, said invention also provides the application of said extract in the preparation of medicine for preventing and curing the hypomnesis due to vascular dementia and senile dementia.
Owner:SHANGHAI HUATUO MEDICAL SCI CO LTD
Oil removal agent for galvanized and aluminized steel plate
InactiveCN107313060APrevent mildewReduce pollutionMetallic material coating processesALLYL SUCROSEProtopine
A kind of degreaser for galvanized steel plate of the present invention is characterized in that, comprises the raw material of following parts by weight: Sodium carbonate: 0.1-5 part; Caustic soda: 0.01-1 part; Anionic surfactant: 10-1 part 20 parts; defoamer: 0.1-5 parts; polyaspartic acid: 1-5 parts; polyacrylic acid: 2-8 parts; complexing agent: 0.1-2 parts; water: 80-100 parts. The degreasing agent for galvanized steel sheets provided by the invention forms a dense protective layer on the surface of the material, overcomes the problem that the surface of galvanized materials is easily corroded, and effectively prevents the surface of the material from being damaged by primary battery corrosion or air oxidation. Mildew phenomenon, but also has a good degreasing effect, less pollution to the environment, no harm to the skin contact.
Owner:苏州日新水性涂料有限公司
Method for purifying protopine from corydalis amabilis
InactiveCN101805345AFast separationReduce lossesOrganic chemistryUltrafiltrationMedicinal herbsUltrafiltration
Owner:NANJING ZELANG MEDICAL TECH
Method for determining decumbent corydalis tuber total alkaloid extractive content with UFLC and method for establishing UFLC finger print thereof
InactiveCN101893607AHigh precisionGood reproducibilityComponent separationTetrahydropalmatineHarmine
The invention relates to determination of alkaloid content in decumbent corydalis tuber total alkaloid extractive. The determination method comprises the following steps: (1) preparing a decumbent corydalis tuber total alkaloid extractive solution; (2) preparing a standard solution; (3) respectively sucking the extractive solution and the standard solution of an equal amount, and carrying out UFLC determination to obtain a UFLC chromatogram; and (4) analyzing chromatographic peaks of protopine, bicuculline, xiawuning alkaloid, corydaline harmine, tetrahydropalmatine and palmatine in the chromatogram, and calculating contents thereof by an external standard method. Besides, the invention also provides a method for establishing a UFLC finger print of decumbent corydalis tuber total alkaloidextractive. The determination method can quickly and accurately determine contents of six main alkaloids in decumbent corydalis tuber total alkaloid extractive, and the UFLC finger print of decumbentcorydalis tuber total alkaloid extractive can be used for the overall control on substance groups in decumbent corydalis tuber total alkaloid extractive, thereby controlling the quality of extractivefrom the macro analysis perspective.
Owner:SHANGHAI INST OF PHARMA IND
Extract of corydalis impatiens total alkaloids and extraction method thereof
ActiveCN103610762AReduced activityAntineoplastic agentsPlant ingredientsCorydalis micranthaReflux extraction
The invention discloses an extract of corydalis impatiens total alkaloids, which is extracted by the following steps of grinding the corydalis impatiens medicine, performing reflux extraction by use of saturated alkaline ethanol or saturated alkaline methanol, and performing concentration and drying to obtain a corydalis impatiens extract; dissolving with an acid solution and filtering; adding an alkaline solution into the filtrate, and adjusting the pH value of the solution to 9-10 to obtain acid-alkali treatment liquid; adding an organic solvent into the acid-alkali treatment liquid for extraction to obtain a crude extract of corydalis impatiens total alkaloids; purifying the crude extract to obtain the extract of corydalis impatiens total alkaloids. In the extract of corydalis impatiens total alkaloids obtained by the method disclosed by the invention, the content of total alkaloids is not less than 50wt%, including 10-12wt% of protopine, 8-10wt% of alpha-bicuculline and 10-15wt% of ochotensimine. The study shows that the alkaloid extract has a function of resisting breast cancer, ovarian cancer, stomach cancer and lung cancer.
Owner:SHANDONG JINHE DRUG RES DEV
Uses of protopine total alkaloids in agricultural pesticide
ActiveCN101401590AIncrease lethalityGood effectBiocideFungicidesAdditive ingredientAgricultural pesticides
The invention provides an application of protopine total alkaloids in pesticide bactericide, which uses the protopine total alkaloids that are extracted and separated from natural plants as a main effective constituent in the aspect of pesticide bactericide. An inventor uses the protopine total alkaloids separately or compounds the protopine total alkaloids with other active constituents, and processes the protopine total alkaloids into wettable powder, emulsifiable solutions, suspending agents, water dispersible granules, emulsions in water and other dosage forms having good effects in the aspect of bactericide by a preparation method.
Owner:曾建国
Medicinal composition for treating cerebral thrombosis and preparation method of medicinal composition
InactiveCN106109564AEffective treatmentOrganic active ingredientsAnthropod material medical ingredientsCerebral thrombosisThrombus
The invention discloses a medicinal composition for treating cerebral thrombosis and a preparation method of the medicinal composition. The medicinal composition is prepared by mixing the medicinal materials including radix calendulae arvensis, herba thymus mongolicus, fructus nandinae domesticate, all-grass of Cleome vircosa L., cockroach, protopine, 19-deoxy-15-garinii cyanidin chloride. The medicinal composition can be prepared into various dosage forms according to a conventional preparation technology, and has obvious curative effects in treating cerebral thrombosis.
Owner:JINAN XINGYI MEDICAL TECH
Decumbent corydalis tuber eye drop and preparation method thereof
ActiveCN102579599AAvoid irritationMild irritationSenses disorderPharmaceutical delivery mechanismO-Phosphoric AcidDisodium phosphate
The invention relates to a decumbent corydalis tuber eye drop and a preparation method thereof. According to the decumbent corydalis tuber eye drop, the pH value is 4.6 to 6.5, and the permeation pressure is between 0.24 and 0.360 smol / kg; each 1,000 milliliters of decumbent corydalis tuber eye drop is prepared from the following substances: a decumbent corydalis tuber extract containing 0.32 to 0.43 gram of protopine, 0.0036 to 0.0048 mol of diluted phosphoric acid solution, and 0.1 to 3.0 grams of sodium dihydrogen phosphate, 3 to 8 grams of solubilizer, 0.2 to 0.8 gram of disodium edentate, 0.1 to 0.8 gram of bacteriostatic agent, 0 to 2.0 grams of thickening agent, 0 to 4 grams of medicinal ethanol solution of freshener, disodium hydrogen phosphate and glycerol which serve as auxiliary materials and the balance of water for injection, wherein the concentration of the diluted phosphoric acid solution is less than or equal to 0.5 mol / L, and a mass ratio of the freshener to medicinalethanol is 1:(1-15); the amount of the disodium hydrogen phosphate is used for regulating the pH value of the decumbent corydalis tuber eye drop; and the amount of the glycerol is used for regulatingthe permeation pressure of the decumbent corydalis tuber eye drop. The decumbent corydalis tuber eye drop has a mild effect, and the compliance of patients is improved greatly, so the decumbent corydalis tuber eye drop is an eye drop which is small in irritation and high in stability.
Owner:江西珍视明药业有限公司
Refined rhizoma corydalis decumbentis total alkaloid product, preparation method thereof, pharmaceutical composition and application of refined rhizoma corydalis decumbentis total alkaloid product and pharmaceutical composition
InactiveCN105311119AScientific and efficient methodEfficient methodNervous disorderCardiovascular disorderTetrahydropalmatineProtopine
The invention discloses a refined rhizoma corydalis decumbentis total alkaloid product, a preparation method thereof, a pharmaceutical composition and application of the refined rhizoma corydalis decumbentis total alkaloid product and the pharmaceutical composition. The refined rhizoma corydalis decumbentis total alkaloid product comprises, by weight, 15%-40% of protopine, 10%-40% of tetrahydropalmatine, 0-10% of bicuculline, 0.01%-2% of palmatine hydrochloride, 2%-10% of kikemanine, 15%-30% of egenine and 1%-5% of other alkaloids and extracts. The more scientific and efficient, simple, convenient and feasible method for extracting high-purity rhizoma corydalis decumbentis total alkaloids is established, and HPLC (high performance liquid chromatography) purity of the prepared refined rhizoma corydalis decumbentis total alkaloid product is above 98%, so that pharmacology and efficacy of the rhizoma corydalis decumbentis total alkaloids can be given to play more safely and effectively.
Owner:SHANGHAI INST OF PHARMA IND +1
Dicranostigma leptopodum (maxim) fedde alkaloid effective part preparation method
ActiveCN105250391AImprove solubilityEasy to separateAntipyreticAnalgesicsIsoquinolineChemical compound
The present invention discloses a dicranostigma leptopodum (maxim) fedde alkaloid effective part preparation method, wherein the dicranostigma leptopodum (maxim) fedde alkaloid effective part obtained through chemical steps is a brownish-black powdery solid, and comprises aporphine alkaloid, morphinane alkaloid, protopine alkaloid, protoberberine alkaloid and isoquinoline alkaloid. According to the present invention, with the method, the concentration of the active compound can be effectively improved, the drug taking dose can be lowered, and the pharmacological activity of the dicranostigma leptopodum (maxim) fedde alkaloid can be significantly improved.
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
HPLC measurement method for content of multi-index components in rhizoma corydalis pain relieving drop pills
InactiveCN105467039ARealize multi-index quality evaluationQuality improvementComponent separationPharmacy medicineTetrahydropalmatine
The invention discloses an HPLC measurement method for content of multi-index components in rhizoma corydalis pain relieving drop pills. A high performance liquid chromatography (HPLC) method is adopted; a mixed contrast solution is used as a contrast, and tetrahydropalmatine is used as a reference; meanwhile, 7 main components, including protopine, palmatine, dehydro-corydaline, tetrahydropalmatine, corydaline, imperatorin and isoimperatorin, in the rhizoma corydalis pain relieving drop pills are measured simultaneously. According to the method, QAMS is realized; measurement of multiple components is realized by adopting relative correction factors among the components; the quality of the multiple components of a traditional Chinese medicine is controlled, thus realizing evaluation on quality of multiple indexes of the rhizoma corydalis pain relieving drop pills. The method is easy and convenient to operate, and quick; the detection cost and time are greatly reduced; the working efficiency and the practicability of the method are improved; the quality of traditional Chinese medicinal products can be controlled more effectively, comprehensively and accurately; stability and uniformity of the product quality are guaranteed, so that the aim of safe and effective taking of the product is fulfilled.
Owner:GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
Corydalis impatiens total alkaloid extractive for preparing anti-cancer drugs and application thereof
ActiveCN103623066AAnti-breast cancerOvarian cancerOrganic active ingredientsAntineoplastic agentsStomach cancerLung cancer
The invention discloses corydalis impatiens total alkaloid extractive for preparing anti-cancer drugs. The content of total alkaloids in the discloses corydalis impatiens total alkaloid extractive is not less than 50wt percent; the disclosed corydalis impatiens total alkaloid extractive comprises 10 to 12wt percent of protopine, 8 to 10wt percent of alpha-bicuculline and 10 to 15wt percent of ochotensimine; the extracting steps of the extractive comprise grinding corydalis impatiens drugs, performing reflux extraction to the corydalis impatiens drugs through saturated alkaline ethyl alcohol or saturated alkaline methyl alcohol, and concentrating and trying the corydalis impatiens drugs, so as to obtain corydalis impatiens extractive, then dissolving and filtering the extractive through acid solution, adding alkali solution into filter liquor, and adjusting the pH value of the solution to be 9 to 10, so as to obtain acid and alkali treated fluid, adding organic solvent into the acid and alkali treated fluid, so as to perform extraction, obtaining corydalis impatiens total alkaloid crude extract, and then purifying the corydalis impatiens total alkaloid crude extract, so as to obtain the corydalis impatiens total alkaloid extractive. The corydalis impatiens total alkaloid extractive obtained through the method has effects of breast cancer resistance, ovarian cancer resistance, stomach cancer resistance and lung cancer resistance.
Owner:SHANDONG JINHE DRUG RES DEV
Use of protopine total alkaloids in animal drugs for economic animals
ActiveCN101518570AGood control effectGood antiparasitic effectOrganic active ingredientsAntiparasitic agentsFeed conversion ratioEomecon
The invention discloses the use of protopine total alkaloids in animal drugs for economic animals. The protopine total alkaloids are used as active ingredients in the preparation of animal drugs for expelling the eelworms in the alimentary canals of economic animals. The protopine total alkaloids are extracted from plants of macleaya cordata, macleaya microcarpa, eomecon chionantha hance, greater celandine herb. Researches on the biological activities of the protopine total alkaloids show that the protopine total alkaloids have effects of widely expelling eelworms in alimentary canals, promoting the growth of the economic animals and improving feed conversion rate.
Owner:MICOLTA BIORESOURCE INC LTD
Method for extracting protopine from japanese hylomecon rhizome
The present invention discloses a method for extracting protopine from japanese hylomecon rhizome, and belongs to the technical field of natural product extraction. The method comprises the following steps: 1) taking japanese hylomecon rhizome total alkaloid extract, adding to an alkaline silica gel column, adopting a chloroform-methanol system as an eluent to carry out gradient elution, mixing distillates, and evaporating the solvent to obtain a first collected part; 2) taking the first collected part, adding to the alkaline silica gel column, adopting a chloroform-methanol system as an eluent to carry out gradient elution, mixing distillates having the same main fleck, and evaporating the solvent to obtain a second collected part; 3) taking the second collected part, adding to a sephadex column, adopting a chloroform-methanol system as an eluent to carry out isocratic elution, mixing distillates having the same main fleck, and evaporating the solvent to obtain a third collected part; and 4) repeatedly washing the third collected part by using methanol to obtain the protopine. The method has characteristics of simple operation, low cost and high extraction efficiency, wherein the extracted protopine purity is more than 99%.
Owner:XI AN JIAOTONG UNIV
Direct oral decumbent corydalis tuber powder Chinese herbal piece
PendingCN107158090ANo pollution in the processBest crushing finenessNervous disorderDispersion deliveryMedicinal herbsPalmatine chloride
The invention provides a direct oral decumbent corydalis tuber powder Chinese herbal piece. A preparation process of the direct oral decumbent corydalis tuber powder Chinese herbal piece is as follows: (1) after being inspected, cleaned and dried, a raw material decumbent corydalis tuber is ground, so that an intermediate is obtained; (2), the intermediate is inspected, and after the intermediate is packaged, electron beam irradiation is carried out for sterilization; (3) final product standard inspection is carried out, and after packaging, the final product is obtained. In step (1), the grinding conditions are as follows: in a grade D clean area, a dust suction type cryogenic system grinding technology is applied to grind the raw material decumbent corydalis tuber into 100 to 300 meshes; and in step (2), the exposure dose of electron beam irradiation for sterilization is 3kGy to 10kGy. The total amount of an aqueous extract of the decumbent corydalis tuber (powder) product and the total amount of water-dissolved protopine and palmatine chloride in the aqueous extract can be increased by 30 to 45 percent in comparison with the total amount of an aqueous extract of the fine powder standard (100 meshes) of Chinese Pharmacopoeia and the total amount of water-dissolved protopine and palmatine chloride in an aqueous extract, and a microbial limit test result can fully come up to a related direct oral piece standard.
Owner:江苏苏轩堂药业有限公司
Detection method of corydalis impatiens medicinal material
ActiveCN103616344AComponent separationPreparing sample for investigationMedicinal herbsInterference factor
The invention discloses a detection method of a corydalis impatiens medicinal material. The detection method comprises the following steps: measuring the content of total alkaloids of the corydalis impatiens medicinal material through an ultraviolet spectrophotometric method, preparing a protopine reference solution, preparing a standard solution, making a standard curve and preparing a sample solution, wherein the preparation method of the sample solution comprises the steps of: backflow extracting corydalis impatiens medicinal material fine powder by using ethanol, dissolving filtered residue by using a sulfuric acid solution to obtain the sample solution, measuring the absorbance of the sample solution at 410nm wavelength, and calculating the content of the total alkaloids in the medicinal material according to the standard curve. According to the detection method disclosed by the invention, the protopine is used as reference; in a preparation process of the test sample, interference factors are removed by means of heating backflow and sulfuric acid solution dissolution, a characteristic reaction is carried out on alkaloid, bromocresol green and a phosphate buffer solution, the product of the characteristic reaction is extracted by dichloromethane to be measured; and since the dichloromethane only extracts the product generated in the characteristic reaction, the interference of non-alkaloid components is avoided and the accuracy and scientificity of the result are increased.
Owner:SHANDONG JINHE DRUG RES DEV
Optimal decumbent corydalis tuber stir-frying with vinegar process based on Critic-G1 method in combination with response surface method
The invention discloses an optimal decumbent corydalis tuber stir-frying with vinegar process based on a Critic-G1 method in combination with a response surface method. The decumbent corydalis tuber vinegar-moxibustion process comprises the following components in parts by weight: 5 parts of decumbent corydalis tubers and A20% of rice vinegar. The optimal processing technology of decumbent corydalis tuber stir-frying with vinegar comprises: 30% of vinegar is used, the infiltration time is 1h, the stir-frying temperature is 170-190 DEG C, and the stir-frying time is 5 min. According to the method, key influence factors and ranges in the processing process are determined through a single-factor test; in combination with test and design of the response surface method, four factors of rice vinegar dosage A, the infiltration time B, the stir-frying temperature C and the stir-frying time D are investigated; the content of four alkaloids including moisture, ash, extract, protopine, palmatinehydrochloride, tetrahydropalmatine and bicuculline is taken as a measurement index, a weight coefficient is calculated by combining a CRITIC method with a G1 method, an OD value is calculated, and theoptimal decumbent corydalis tuber stir-frying with vinegar process in combination with the response surface method can be used for quality control of a decumbent corydalis tuber medicinal material.
Owner:龚千锋 +4
Purification method for lobule protopine
InactiveCN102863329APromote dissolutionHigh extraction rateCarboxylic compound separation/purificationHydrolysateAlcohol ethyl
The invention discloses a purification method for lobule protopine. The method includes: (1), taking raw materials isodon parvifolius dried leaves, subjecting to crushing treatment, soaking by enzyme solution, performing water bath enzymolysis and fully stirring; (2), filtering enzymatic hydrolysate, taking filter residue for extraction for 2-3 times with ethanol water in amount of 5-10 folds, merging extraction liquid, and decompressing and concentrating to obtain extract; (3) subjecting the extract to go through a macroporous adsorption resin column, eluting with alcohol-water mixed solution, and collecting eluted liquid; and (4), depressing the eluted liquid to recycle ethanol, extracting with chloroform, placing extraction liquid after concentration onto a silica column, performing gradient elution with ethyl acetate-ethanol, adopting TLC (thin layer chromatography) for tracking and monitoring, collecting lobule protopine fraction, decompressing and concentrating, cooling and drying to obtain the product. The purification method for lobule protopine is simple in operation, high in yield of obtained products, low in cost and suitable for large-scale production.
Owner:NANJING ZELANG AGRI DEV
Transparent Solid Glue and Manufacturing Method Thereof
ActiveUS20170355884A1Control drying timeGood molding effectNon-macromolecular adhesive additivesMacromolecular adhesive additivesGlycerolPaperboard
A transparent solid glue, in mass percentage comprises: 10.0%-50.0% of glycerol, 5.0%-20.0% of propylene glycol, 5.0%-30.0% of sticky substance, 1.0%-10.0% of stearic acid, 0-5.0% of vegetable oil, 0.5%-5.0% of protopine, 0.1%-5.0 of excipient, 0.1%-0.5% of preservative, and 5.0%-70.0% of deionized water, wherein the excipient is C12-16 saturated or unsaturated fatty acid salt. The prepared transparent solid glue has high initial viscosity; and the drying time is controllable so that the gluing position of the objects to be glued can be adjusted according to actual requirements, which is convenient to use, and the glue exhibits strong adhesion after completely drying. Meanwhile, the addition of protopine causes the pH of the solid glue to be between 10.49-10.99, and accordingly the solid glue is an environmentally friendly solid glue. Within a temperature range from −5° C. to 40° C., this solid glue is widely applicable to gluing paper, wood pieces, photographic paper, paperboards and etc.
Owner:NINGBO PASCO UNITED IND
A kind of preparation method of effective part of bald acne flower alkaloid
ActiveCN105250391BImprove solubilityEasy to separateOrganic active ingredientsAntipyreticIsoquinolineMedicine
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Decumbent corydalis tuber eye drop and preparation method thereof
ActiveCN102579599BAvoid irritationMild irritationSenses disorderPharmaceutical delivery mechanismO-Phosphoric AcidDisodium phosphate
Owner:江西珍视明药业有限公司
Extraction and enrichment technology for protopine monomer in dactylicapnos roots and application thereof
The invention discloses an extraction and enrichment technology for a protopine monomer in dactylicapnos roots. The extraction and enrichment technology comprises the following steps: taking a properamount of dried dactylicapnos root medicinal materials and crushing; putting into an extraction pot; adding a water solution which is 10 to 20 times of the weight of the dried dactylicapnos root medicinal materials; stirring and impregnating for one night; removing an impregnation solution on the next day; adding a 9 to 10 percent acid water solution which is 8 to 13 times of the weight of the dried dactylicapnos root medicinal materials; and carrying out hot refluxing and extracting for 2 to 5 times. The invention further discloses application of the protopine monomer in the dactylicapnos roots to cough and asthma relieving preparations, pain alleviating preparations, anti-arrhythmia preparations or anti-tumor preparations. The technology disclosed by the invention is suitable for extracting, enriching and purifying the protopine in the dactylicapnos roots and the purity of the protopine reaches 80 percent or more and can reach 95 percent or more after the protopine is further refined; and the whole technology has simple and feasible operation steps, high yield and low cost.
Owner:HARBIN VOCATIONAL & TECHN COLLEGE
Total alkaloid of xiatianwu (a Chinese medicinal material), its preparation method and application
InactiveCN100424085CIntrinsic quality can be controlledNervous disorderOrganic chemistrySolventImpurity
The present invention relates to total alkaloid of Chinese medicinal material corydalis amabilis, its preparation method and application in medicine. Said total alkaloid mainly includes protopine 25-65%, tetrahydropalmatine 10-25%, bikukuling 5-10% and palmatine 10-20% and other alkaloid and extract 5-20%. Its preparation method includes the following steps: using corydalis amabilis as raw material, adding proper quantity of polar solvent, making diacolation extraction, collecting diacolate until there is not alkaloid reaction, combining diacolates, concentrating to obtain concentrate, making said concentrate pass through macroporous adsorption resin to make adsorption chromatography, using soda lye to make elution and remove impurity or using resin to adsorb impurity, using polar eluent to total alkaloid of corydalis amabilis, collecting eluent, recovering solvent, concentrating and crystallizing so as to obtain the invented product. Said invention also provides its application for preparing medicine.
Owner:湖南医药工业研究所有限公司 +1
Ointment for promoting recovery of injured meniscus during plaster immobilization and preparation method thereof
InactiveCN105726957APromote recoveryImprove protectionHydroxy compound active ingredientsAerosol deliveryTreatment effectBlood flow
The invention discloses an ointment for promoting recovery of injured meniscus during plaster immobilization and a preparation method thereof.The ointment is prepared from catechinic acid, thymol crystals, ecdysterone, neottianthe pseudo-diphylax extract, quercetin, hyperoside, diphenhydramine hydrochloride, protopine, bufexamac, kaempferol, aescin, an ointment substrate and an antioxidant.Based on reasonable matching, the various effective ingredients are combined, and the ointment has the effects of promoting blood flow to remove stasis, diminishing inflammation to relieve pain, strengthening the bones and muscles, resisting infection and irritability and preventing skin rotting, is used before plaster immobilization is adopted for non-surgical treatment of injured meniscus and applied to the wound to promote body recovery, can prevent skin infection and irritability symptoms caused by long-time plaster immobilization, and is good in treatment effect, convenient and easy to use and applicable to clinic application.
Owner:李金戈
New protopine alkaloid and preparing method and application thereof
ActiveCN109942592ANovel structureGood antidepressant activityNervous disorderOrganic chemistryIntellectual propertyPhytochemistry
The invention relates to a new protopine alkaloid and a preparing method and application thereof, and belongs to the technical field of phytochemistry. The molecular formula of the new protopine alkaloid is C31H34N2O6, and the new protopine alkaloid is a new compound separated and extracted from active parts of rhizoma corydalis decumbentis; meanwhile, the new compound of the new protopine alkaloid has significant anti-depression activity, and an important theoretical foundation and an experiment basis are laid for China to develop anti-depression drugs with independent intellectual property from the rhizoma corydalis decumbentis.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Method for preparing greater celandine extract with anticancer action
InactiveCN1247223CProlong survival timeOrganic active ingredientsOrganic chemistryMedicineChelidonine
An extract of greater celandine for anticancer and antalgic purposes has its active components containing chelidonine 0.5-10 wt. portions, protopine 0.1-8, and total alkaloid of greater celandine 0.6-200. Its preparing process is also disclosed.
Owner:张平
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