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Greater celandine extract and its preparation method and application

A technology of celandine and its extract, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of small adverse reactions, poor treatment of cancer pain patients, and clinical application limitations, etc., to achieve curative effect

Inactive Publication Date: 2003-07-16
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the abuse and dependence of such drugs have increased significantly, and the resulting serious social problems have become increasingly prominent, which has severely restricted the clinical application of such drugs, resulting in many cancer pain patients still not receiving good treatment. Treatment, management of cancer pain remains a thorny issue for doctors
[0004] Currently, there is no clinically available drug that has both anticancer and analgesic effects and minimal adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Get 3500g of celandine, cut into 0.5cm sections, add 10 times the amount of 75% ethanol, heat and reflux extraction 4 times, each time for 1.5 hours, combine the alcohol extracts, recover ethanol under reduced pressure and concentrate to a relative density of 1.12, use Adjust the pH value of 1mol / L phosphoric acid solution to 3.5, refrigerate at 5°C for 72 hours, filter, adjust the pH value of the filtrate to 11 with 30% sodium hydroxide solution, extract 5 times with an equal amount of chloroform, combine the chloroform solution, and recover the chloroform, The residue was vacuum-dried to obtain the obtained product. Example 2 Preparation of Celandine Extract Powder Injection

Embodiment 2

[0019] Get 3500g of celandine, cut into 0.5cm sections, add 10 times the amount of 75% ethanol, heat and reflux extraction 4 times, each time for 1.5 hours, combine the alcohol extracts, recover ethanol under reduced pressure and concentrate to a relative density of 1.12, use Adjust the pH value of 1mol / L phosphoric acid solution to 3.5, refrigerate at 5°C for 72 hours, filter, adjust the pH value of the filtrate to 11 with 30% sodium hydroxide solution, extract 5 times with an equal amount of chloroform, combine the chloroform solution, and recover the chloroform, The residue was vacuum-dried to obtain the obtained product. Example 2 Preparation of Celandine Extract Powder Injection

[0020] Embodiment 1 celandine extract 8 grams

[0021] Mannitol 25g

[0022] Take the celandine extract of Example 1, put it in a suitable container, add about 800ml of water for injection, adjust the pH value to 3.2 with 1.2mol / L phosphoric acid solution, filter, add mannitol to the...

Embodiment 3

[0022] Take the celandine extract of Example 1, put it in a suitable container, add about 800ml of water for injection, adjust the pH value to 3.2 with 1.2mol / L phosphoric acid solution, filter, add mannitol to the filtrate and stir evenly, then add water for injection to 1000ml , mixed evenly, filtered with a 0.22um microporous membrane, and the filtrate was filled in vials under sterile conditions, partially plugged with butyl rubber stoppers, packed into plates, and freeze-dried. After the freeze-drying is finished, stoppering and capping are ready. Example 3 Preparation of Celandine Extract Injection

[0023] Embodiment 1 Celandine extract 14g

[0024] Tween-80 10ml

[0025] Sodium chloride 3.5g

[0026] Benzyl alcohol 8ml

[0027] Add water for injection to 1000ml.

[0028] Get the celandine extract of Example 1, add 800ml of water for injection, stir to dissolve, adjust the pH value to 3.5 with 1mol / L phosphoric acid solution, filter, add Tw...

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Abstract

An extract of greater celandine for anticancer and antalgic purposes has its active components containing chelidonine 0.5-10 wt. portions, protopine 0.1-8, and total alkaloid of greater celandine 0.6-200. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a celandine extract, and also relates to a preparation method of the celandine extract and its application in the preparation of anticancer and analgesic drugs. Background technique [0002] Cancer is a common and difficult disease in the world. Existing therapies such as surgery, chemotherapy, and radiotherapy cannot cure the disease. At present, although various drugs for treating tumors and cancers have certain effects, most western medicines have certain toxic and side effects, such as Pingyangmycin, which has side effects such as fever, gastrointestinal reactions, hair loss, numbness in extremities, and pulmonary toxicity. Platinum also has adverse reactions in gastrointestinal, blood, kidney and other aspects, which affects the smooth treatment of cancer diseases. The use of traditional Chinese medicine to fight cancer needs to be used in conjunction with Western medicine to produce better therapeutic effects. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4355A61P29/00A61P35/00C07D491/153
Inventor 张平
Owner 张平
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