35 results about "Pingyangmycin" patented technology

The invention provides a pharmaceutical composition for treating embolism and a preparation method thereof, the pharmaceutical composition comprises a hydroxyl-contained biocompatible polymer material and a monomer containing unsaturated double bonds and anion groups, as well as a polymer generated by polymerization reaction of an optional vinyl monomer, wherein the polymerization is initiated through free radicles, and bleomycin or pingyangmycin is combined on the anion groups of the generated polymer. The preparation method combines the bleomycin or the pingyangmycin on a carrier of the polymer, thereby being capable of fully playing the dual effects of an anti-tumor antibiotic and a hardening agent owned by the bleomycin or the pingyangmycin during the embolism treatment. The anion part of the polymer can be properly combined with the bleomycin or the pingyangmycin which is rich in amino groups, thereby not only realizing the higher drug loading, but also leading the drug in an emboliaztion agent to be exchanged by cation in human body, and further realizing the slow release. In addition, the embolic carrier of the polymer has the advantages of simple prepration technology andlow cost, thereby being applicable to large-scale industrial production.

Provided is a preparation method for porous slow-release microspheres of chitosan grafting poly(N-isopropyl acrylamide / acrylamide). The method includes: first taking chitosan as a base material, adding a terminated polyethylene glycol porogenic agent, forming chitosan porous microspheres by inverse suspension dispersion and chemical cross-linking solidification, and conducting further graft copolymerizing with N-isopropyl acrylamide / acrylamide by taking the porous microspheres as substrates to obtain chitosan grafting poly(N-isopropyl acrylamide / acrylamide) porous slow-release microspheres. The microspheres have temperature sensitivity and a porous characteristic, and are uniform in pore distribution, good in dispersibility, controllable in particle size, and mild in preparation process. The microspheres can be used for embedding drug pingyangmiein. Using a microsphere dosage form helps to improve drug curative effects and reduce toxic and side effects.

The invention provides a new application of a traditional Chinese medicinal composition and in particular relates to an application of a traditional Chinese medicinal composition in preparation of a medicine used for treating xerophthalmia, and raw materials of the traditional Chinese medicinal composition comprise wolfberry, chrysanthemum, salviae miltiorrhizae, cortex phellodendri, borneol, pearl powder and menthol. The traditional Chinese medicinal composition has the advantages that pathological changes of lacrimal gland tissues of an experimental xerophthalmia mouse, lacrimal glands of which are damaged by injected pingyangmycin, in morphology can be obviously alleviated, quantity of tear fluid can be obviously increased, breakup time of a tear film is prolonged, and quantity of the tear fluid secreted by a normal domestic rabbit can be obviously increased; and meanwhile, the traditional Chinese medicinal composition has obvious anti-inflammation and anti-oxidation effects.

The invention provides a method for directionally screening a salt-tolerant body through peanut in vitro mutagenesis. The method mainly comprises the following steps: sterilizing the surface of peanut embryo; separating a leaflet, inoculating into a somatic embryo induction and mutagenesis medium added with 2,4-D and pingyangmycin, and performing mutagenesis culture treatment; and transferring a survival explant on which a somatic embryo is formed to a somatic embryo germination and screening culture medium added with bone alkaline phosphatase (BAP) and NaCl, and directionally screening the salt-tolerant body. The salt-tolerant body is directionally screened by combining in vitro mutagenesis and tissue culture, and plenty of manpower, materials and financial resources can be saved; and the salt-tolerant body is regenerated in an embryogenesis way, an somatic embryo is derived from a cell, and the chimerism of the salt-tolerant body can be avoided. A peanut mature seed is taken as a mutagenic material and cannot be limited by seasons, the operation is convenient, a novel salt-tolerant peanut germplasm can be created, the peanut genetic basis is enriched, and the difficulty that new high-yield salt-tolerant varieties are difficult to breed due to the lack of high salt-tolerant germplasm resources in peanut cultispecies is overcome.

The invention provides a kind of chemical mutagen that is used for corn genetic breeding, described chemical mutagen is the combination of Pingyangmycin and N-methyl-N-nitrosourea; Wherein the concentration of Pingyangmycin is 20ppm, The concentration of N-methyl-N-nitrosourea is 0.2%. The chemical mutagen can be used in corn genetic breeding.

The invention provides an external traditional Chinese medicinal composition for treating xerophthalmia and a preparation method thereof. The external traditional Chinese medicinal composition for treating the xerophthalmia is prepared from the following raw materials: wolfberry, chrysanthemum, salviae miltiorrhizae, cortex phellodendri, pearl powder, borneol and menthol. The external traditional Chinese medicinal composition for treating the xerophthalmia has the advantages that pathological changes of lacrimal gland tissues of an experimental xerophthalmia mouse, lacrimal glands of which are damaged by injected pingyangmycin, in morphology can be obviously alleviated, quantity of tear fluid can be obviously increased, breakup time of a tear film is prolonged, and quantity of the tear fluid secreted by a normal domestic rabbit can be obviously increased.

The invention discloses a method for producing pingyangmycin by fermentation. The invention discloses a method for fermenting and producing Pingyangmycin, which comprises fermenting Streptomyces verticillium in a fermentation medium, and adding exogenous precursors to the fermentation medium during the fermentation process to obtain the fermentation medium containing Pingyangmycin The product is isolated from the fermentation product to obtain Pingyangmycin; wherein, the exogenous precursor is substance A and / or substance B, and the substance A is adenosylmethionine or its similar amino acid derivatives, The substance B is spermidine or a salt of spermidine. The fermentative production method of Pingyangmycin provided by the present invention is simple and effective, can rapidly improve the fermentation production level of Pingyangmycin, reduce production cost, does not need additional equipment and manpower, can greatly improve the industrial fermentation level of Pingyangmycin, and is suitable for industrial scale production.