The invention relates to the technical field of medicament delivery by a carrier, in particular to a
lung targeting medicament carried proliposome used for injection and an application method thereof.
Solid dispersion technology is adopted to obtain solution A by dissolving active medicament,
phospholipid liposome,
cholesterol liposome, surface
active agent and acid type carrier in absolute ethyl
alcohol or the mixed
solvent of absolute ethyl
alcohol and absolute
ether;
active carbon which is used for injection and has the volume being 0.1-1% of the volume of the solution A is added into the solution A; stirring, standing and filtering of the solution by a millipore filter are carried; therefore, aseptic solution B free of pyrogen is obtained; aseptic additives are added into the solution B under an aseptic condition;
organic solvent is removed; and
solid granular medicament carried proliposome or powdered medicament carried proliposome are obtained. The invention has the advantages that the preparation process is simple; the cost is low; the quality is controllable; the stability is good; and the invention is suitable for industrial production. The medicament carried proliposome prepared by effervescency dispersion technology has small and uniform particle
diameter, the
electric charge ranges from -10mv to -30mv, the proliposome can deliver over 90% medicament to a
lung, and remarkable
lung targeting effect is achieved, and thus being the best preparation delivering medicament by a carrier for treating lung diseases.