The invention discloses a Cabazitaxel phospholipid complex and a method for preparing a lipid microsphere injection which contains the phospholipid complex. The lipid microsphere injection consists of Cabazitaxel, injection phospholipid, injection oil, an emulsifying agent, a stabilizing agent, an antioxidant, an isoosmotic adjusting agent and water for injection. The lipid microsphere injection has the characteristics of high drug-loading rate, slow releasing, small adverse reaction, simplicity and practicability in preparation technology, good product stability and the like and is beneficial to clinic application and industrial production.