5 results about "Phospholipid complex" patented technology

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The application relates to the technical field of biology, and particularly provides a preparation method of a metal-phospholipid complex and application thereof. The preparation method of the metal-phospholipid complex is composed of the following steps: reacting phospholipid molecules, linker molecules and metal ions to form a metal-phospholipid complex; the metal-phospholipid complex is composed of a phospholipid molecule part, a linker molecule part and a metal ion part, the phospholipid molecule part is connected with the linker molecule part, the linker molecule part is connected with the metal ion part through a coordination bond, and the metal-phospholipid complex is not a cationic lipid or an ionizable lipid. The one-step preparation method of the metal-phospholipid complex can significantly shorten the time required in the industrialization process, reduce the problems of process connection and time interval caused by step-by-step operation, greatly improve the continuity and compactness of production, thereby effectively reducing the production cost and improving the production efficiency; and the method is more suitable for the demand of large-scale production.

This invention discloses a vitamin A-functionalized polyphenol-phospholipid complex, its preparation method, and its applications, belonging to the field of pharmaceutical formulation and nanodelivery technology. The phospholipid complex comprises a polyphenol drug, a phospholipid material, and a vitamin A phospholipid ligand. The vitamin A phospholipid ligand is formed by vitamin A or its derivatives and a phospholipid derivative containing amino or other reactive groups. The phospholipid complex forms a phospholipid composite structure through non-covalent interactions between the polyphenol drug and the phospholipid material, and the vitamin A phospholipid ligand is inserted into or assembled into the surface or interior of the phospholipid composite structure. Animal experiments show that this phospholipid complex can reduce serum transaminase levels and alleviate the degree of liver fibrosis, and has good blood compatibility and tissue safety. This invention provides an industrially achievable targeted nano-formulation solution for early intervention in liver fibrosis, with promising application prospects.

The present application relates to a kind of fish oil extraction equipment and its extraction process, belong to fish oil extraction technical field, by adopting the synergies of helical guide rail and elastic limiting part, multiple stirring parts are sequentially separated from limiting under the control of driving part and swing in vertical direction, form continuous wave type stirring track, reciprocating activity part and helical guide rail being set in the center of stirring barrel, cooperate with the synergies of elastic limiting part and stirring part, realize the effective stirring of high viscosity fish oil, both realize the uniform mixing and cyclic flow of material, shear force is dispersed into multi-section progressive action, avoid the mechanical damage of traditional high-strength concentrated shearing to protein-phospholipid complex colloid structure, while the buffer characteristics of elastic limiting part further reduce impact stress, solve the problem that the high viscosity of fish oil and its sensitive colloid structure in prior art make traditional high shear stirring easily lead to active ingredient loss and system stability reduction.

This invention belongs to the field of biomedical technology, specifically relating to an oil solution of hydroxysaffron yellow pigment A, its preparation method, and its application. The hydroxysaffron yellow pigment A oil solution of this invention contains a hydroxysaffron yellow pigment A phospholipid complex and an oily medium in a mass ratio of 1:1-10. The hydroxysaffron yellow pigment A phospholipid complex contains hydroxysaffron yellow pigment A and phospholipids in a mass ratio of 1:2-4. The oily medium is mono- and di-caprylic / capric glycerides. The relative bioavailability of the hydroxysaffron yellow pigment A oil solution of this invention is increased to 418% in rats and 197% in male beagle dogs, effectively solving the technical problem of low intestinal absorption of hydroxysaffron yellow pigment A. Furthermore, the hydroxysaffron yellow pigment A oil solution of this invention has advantages such as high drug loading, good stability, and high bioavailability, showing promising prospects for medical application.