52 results about "Phospholipid complex" patented technology

The invention belongs to the technical field of medicines, and particularly provides a solid dispersion as well as a preparation method and application thereof. The solid dispersion comprises a carrier material, and further comprises quercetagetin and phospholipid, the mass ratio of the quercetagetin to the phospholipid is 1: (0.3-1.5), and the carrier material comprises one or more of a hydrophilic polymer and a pH-dependent polymer. Wherein the quercetagetin and the phospholipid are combined through an intermolecular force, so that the quercetagetin obtains a lipid material similar to a cell membrane structure, a cell membrane bionic phospholipid compound is formed, the cell membrane bionic phospholipid compound can be naturally compatible with an upper wall cell membrane of a small intestine, and the permeation transmembrane capability of the quercetagetin is better promoted; the quercetagetin is added into the solid dispersion, so that more quercetagetin can enter systemic circulation and lymphatic circulation, and therefore, the solid dispersion can strengthen transmembrane absorption while strengthening dissolution, so that the solid dispersion has high bioavailability.

The application relates to the technical field of traditional Chinese medicines, in particular to a uric acid reducing composition and a preparation method thereof. The uric acid reducing composition comprises 35-45 parts of a cyclodextrin inclusion compound, 25-35 parts of nano-liposomes, 20-30 parts of a chicory extract-phospholipid complex and 5-8 parts of an antioxidant complex; the preparation method of the cyclodextrin inclusion compound comprises the following steps: step 1, adding beta-cyclodextrin into water, stirring and dissolving, adding pueraria extract, drying after inclusion reaction, and obtaining inclusion compound a; step 2, adding hydroxypropyl-gamma-cyclodextrin into water, stirring, adding mulberry leaf extract, drying after inclusion, and obtaining inclusion compound b; and step 3, mixing the inclusion compound a and the inclusion compound b, and obtaining the product. The uric acid reducing composition can more comprehensively and efficiently reduce blood uric acid level, and has high safety, high stability and high bioavailability. The preparation method is simple, easy to industrialize and beneficial to large-scale industrial production.

A preparation method of the whey protein isolate-phospholipid complex embedded fucoxanthin emulsion comprises the following steps: (1) mixing and homogenizing phosphatidyl glyceride and a buffer solution to obtain a phospholipid emulsion, and the phosphatidyl glyceride is selected from DHA (docosahexaenoic acid) phosphatidyl glycerol monocaprylate, DHA phosphatidyl glycerol monocaprylate and the like; the phospholipid emulsion and the whey protein isolate solution are mixed and homogenized, and whey protein isolate-phospholipid compound O / W emulsion is obtained; and (2) dropwise adding the fucoxanthin solution into the whey protein isolate-phospholipid compound O / W emulsion, and stirring to obtain the fucoxanthin emulsion. The whey protein isolate-phospholipid compound embedded fucoxanthine emulsion disclosed by the invention is good in stability, high in encapsulation efficiency, excellent in oxidation resistance and high in bioavailability of fucoxanthine, and the particle size of the emulsion is 200 nm or less. According to the research, the application of the novel phospholipid in the aspect of stable emulsion system construction is expanded, and a new thought and direction are provided for embedding and delivery of active substances.

The invention discloses a targeted multi-channel synergistic anti-aging composition as well as a preparation method and application thereof, and belongs to the technical field of functional foods and biological medicines. According to the composition disclosed by the invention, ginsenoside, a hawthorn polyphenol-chitosan phospholipid complex and spina date seed total saponins are taken as core active ingredients, and a specific Senlytics active ingredient and a natural mTOR inhibitor are compounded, so that the synergistic regulation of five anti-aging pathways, namely Sirtuins activation, mTOR inhibition, mitochondrial autophagy activation, CD38 inhibition and senescent cell removal, can be realized at the same time. The composition is natural in raw material source, high in safety and good in stability, can be prepared into various dosage forms such as capsules, solid beverages and oral liquid, is suitable for daily anti-aging and sub-health conditioning, and has wide application prospects in the fields of anti-aging health foods and biological medicines.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The invention provides a resorcinol derivative phospholipid complex dispersion as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. A resorcinol derivative, an antioxidant, lecithin, sodium surfactin and water are used as raw materials, a strongly hydrophobic phospholipid compound is formed through interaction between hydrophilic ends of the lecithin and strong molecules of phenolic hydroxyl groups of the resorcinol derivative, then a hydrophilic cyclopeptide layer is modified on the surface of the phospholipid compound through the sodium surfactin surfactin, and the hydrophobic phospholipid compound is prepared. The dispersity of the phospholipid complex in water is improved, the stability of the resorcinol derivative can be effectively improved, and the problem of high-temperature discoloration is avoided. The particle size of the resorcinol derivative phospholipid complex dispersion provided by the invention is less than 200nm, and the resorcinol derivative phospholipid complex dispersion has good hydrophilicity and better transdermal permeation absorption effect.

The invention relates to the field of mixture three-phase separation, and provides a shipborne three-phase separation recycling system and method.The system comprises the steps that a horizontal spiral centrifugal machine conducts three-phase separation on a fed euphausia superba solid-liquid mixture, and a first solid-phase output matter, a first liquid-phase output matter and a first oil-phase output matter are obtained; the disc centrifuge performs three-phase separation on the first liquid phase output substance and a third liquid phase output substance from the extruder to obtain a second solid phase output substance, a second liquid phase output substance and a second oil phase output substance, wherein the second solid phase output substance, the second liquid phase output substance and the second oil phase output substance are obtained from the second oil phase output substance; the first solid-phase output matter and the second solid-phase output matter are compressed, sheared and dewatered by the extruding machine, and a target euphausia superba solid matter and a third liquid-phase output matter are obtained; the heat exchange flocculation assembly is used for heating, flocculating and filtering the second liquid phase output substance to obtain the target protein phospholipid complex. The target protein phospholipid complex is obtained by fully utilizing the liquid-phase output substance, and the utilization rate is increased.

The invention discloses a brain-targeted nasal-spray amphotericin B phospholipid complex and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the brain-targeted nasal-spray amphotericin B phospholipid complex is prepared by adopting a film dispersion method, and the preparation method comprises the following steps: dissolving 15-hydroxystearic acid polyethylene glycol ester, phospholipid, cholesterol, amphotericin B and optional other auxiliary components in a solvent, removing the solvent until a film is formed, and drying to obtain the brain-targeted nasal-spray amphotericin B phospholipid complex. And carrying out hydration dispersion to obtain the amphotericin B-loaded phospholipid complex. According to the amphotericin B sodium deoxycholate injection, the problems that the traditional amphotericin B sodium deoxycholate injection is high in renal toxicity, the intrathecal injection is poor in solubility, and low in bioavailability and patient compliance, large in side effect and the like due to the fact that the traditional amphotericin B sodium deoxycholate injection is difficult to penetrate through a blood brain After nasal administration, the drug is quickly delivered into the brain, so that the slow release of the drug is realized, the intracerebral bioavailability of the drug is improved, high brain targeting and low systemic toxic and side effects are realized, and good clinical application value and market prospect are achieved.

The application discloses an anti-aging ergothioneine and nicotinamide compound preparation and a preparation method and application thereof, and belongs to the technical field of cosmetic health products. The compound preparation takes pyrroloquinoline quinone, ergothioneine and nicotinamide as the core, and is matched with betaine, trehalose, quercetin phospholipid complex, alpha-lipoic acid and N-acetyl cysteine in specific proportions. The anti-aging ergothioneine and nicotinamide compound preparation and the preparation method and application thereof are adopted, the components such as PQQ, ergothioneine, nicotinamide and quercetin phospholipid complex are synergistically used, and the synchronous activation of mitochondrial regeneration, energy metabolism, free radical targeted removal and mitochondrial mass control is realized for the first time. The compound preparation can be prepared into cosmetics for external use on the skin, and the effects of antioxidation and skin barrier repair can be achieved.

The invention relates to the field of traditional Chinese medicine synthesis and preparation, in particular to a preparation device and method of a silybum marianum phospholipid complex. According to the preparation method of the silybum marianum phospholipid complex, the preparation device of the silybum marianum phospholipid complex is used, the steps of compounding treatment, filtering and drying are optimized, the compounding rate of the prepared silybum marianum phospholipid complex is increased, and the yield of the silybum marianum phospholipid complex is improved. The prepared silybum marianum phospholipid complex product has the advantages of low solvent residue and good water solubility and fat solubility, in addition, on the basis of completing two different filtering treatment in sequence, the silybum marianum phospholipid complex can be rapidly switched to a drying treatment mode after completing the second filtering treatment, the steps of the silybum marianum phospholipid complex preparation treatment process are reduced, and the production cost is reduced. The preparation process is simple, low in cost and suitable for industrial production, the technical defects that the preparation steps of the silybum marianum phospholipid complex are complex and tedious, and the preparation treatment efficiency is poor are greatly overcome, and the preparation work efficiency of the silybum marianum phospholipid complex is improved.

The invention provides a micro-fat calcium supplement carrier, which is prepared from the following raw materials in parts by weight: 30 to 35 parts of standard index calcium, 1 to 5 parts of chondroitin, 1 to 5 parts of glucosamine, 8 to 12 parts of pure camel milk, 0.7 part of vitamin D, 2 to 70.3 parts of vitamin K, 1 to 3 parts of phospholipid complex and 8 to 10 parts of excipient. According to the invention, standard calcium, chondroitin, glucosamine, pure camel milk, vitamin D, vitamin K2-7, a phospholipid complex and an excipient are organically mixed by adopting a liposome carrier technology, so that the digestion and absorption of calcium in a body and the distribution of calcium in a specific region are effectively improved, and further the effects of rapid bone growth, increase of bone length (promotion of height increase) and increase of bone density are achieved; the health-care food has the health-care functions of reducing the fracture probability, preventing tooth decay, reducing the death rate of cardiovascular diseases and the like, so that the calcium absorption rate is remarkably improved and reaches up to 95%.

The invention relates to a quality control method for indissolvable impurities in preparation of esdoxaban tosylate, and belongs to the field of pharmaceutical analys.The quality control method comprises the steps that the indissolvable impurities and phospholipid are mixed to prepare a phospholipid compound; dissolving the phospholipid complex in a solvent to obtain a test solution; the indissolvable impurity is N, N '-bis (5-chloropyridine-2-yl) oxadiamide; and detecting the test solution by using a high performance liquid chromatography. According to the invention, a pretreatment method is creatively adopted, phospholipid is taken as a carrier, and insoluble impurities and phospholipid are co-ground, so that the dissolution barrier is effectively reduced on the premise that the original structure of the compound is not damaged, and rapid and thorough dissolution is realized. The process is mild and controllable, the chemical stability of the compound can be kept, the detectable level of the impurity is greatly improved, and meanwhile the problem that the impurity is poor in solubility in a conventional solvent and quality control is difficult to effectively conduct is solved.

The invention relates to the technical field of biological substance preparation. The invention provides a catechin-phospholipid complex and an emulsion prepared from the catechin-phospholipid complex and capable of improving DHA (docosahexaenoic acid) and improving memory activity. The invention also provides an application of the catechin-phospholipid complex or the emulsion for improving the memory activity of DHA in preparation of health-care products. The emulsion prepared by adopting the catechin-phospholipid compound as an emulsifier can efficiently and synergistically entrap, stably protect and deliver the beta-carotene and the DHA in a targeted manner, so that the bioavailability and the multi-component synergistic effect of the beta-carotene and the DHA are enhanced, and the effect of improving the memory function is realized; meanwhile, good physical and chemical stability and digestion tolerance are also shown.

The invention belongs to the technical field of biology, and particularly relates to a sialic acid derivative-modified zebrutinib phospholipid complex as well as a preparation method and application thereof, the sialic acid derivative-modified zebrutinib phospholipid complex comprises zebrutinib, phospholipid and a sialic acid derivative, and the medicine-lipid ratio of the zebrutinib to the phospholipid is (2: 1)-(1: 10) (n / n). The addition proportion of the sialic acid derivative accounts for 5-40% of the total molar weight of substances. The sialic acid derivative-modified zebrutinib phospholipid complex can be used for preparing a nano injection and improving the in-vivo targeting capability and the tumor treatment effect. Especially, lasting and effective immune memory ability on tumor cells is established in a mouse body, anti-tumor immune response of the body can be more effectively activated and maintained, and secondary tumor-bearing challenge is successfully resisted.

The invention discloses a silybum marianum lipidosome applied to a liver protection tablet product and a preparation method, the silybum marianum lipidosome comprises a core material, and an internal wall material and an external wall material which sequentially wrap the surface of the core material; the core material is a silybum marianum extract; the inner wall material is modified soybean phospholipid; the outer wall material is a combination of starch sodium octenylsuccinate and polyethylene glycol. A lipidosome membrane embedding technology is adopted, the silybum marianum extract and soybean modified phospholipid are mixed according to a certain proportion and emulsified into a membrane, phospholipid bimolecular membrane embedding is formed, and then high-molecular compounds including starch sodium octenylsuccinate and polyethylene glycol are used as external wall materials to further include the phospholipid compound of the silybum marianum extract. The prepared lipidosome can be uniformly dispersed in an aqueous solution, the angle of repose is less than or equal to 40 degrees, the fluidity and the tabletting effect are better, the lipidosome is prepared into a sustained-release tablet, the bioavailability of the lipidosome can be improved, and the application of the lipidosome in a liver protection factor system can be expanded.

The invention belongs to the technical field of biological medicines, and particularly relates to all-trans retinoic acid phospholipid complex nanoparticles as well as a preparation method and application thereof. The invention relates to sialic acid derivative modified all-trans retinoic acid and phospholipid compound nanoparticles. The sialic acid derivative modified all-trans retinoic acid and phospholipid compound nanoparticles comprise sialic acid derivatives, all-trans retinoic acid and phospholipid, wherein the sialic acid derivative accounts for 5-40% of the total mass of the phospholipid, and the drug-lipid molar ratio of all-trans retinoic acid to the phospholipid is (1: 4)-(1: 10). According to the sialic acid derivative modified all-trans retinoic acid phospholipid complex nanoparticles, the problem that all-trans retinoic acid is poor in solubility is solved, the bioavailability of an existing all-trans retinoic acid oral product is improved, the tumor inhibition effect of all-trans retinoic acid in solid tumors is improved, and the bioavailability of all-trans retinoic acid is improved. And the drug resistance of all-transretinoic acid in solid tumors is overcome. The nano preparation is simple and convenient in process, high in reproducibility and convenient for industrial production. In addition, a combined treatment strategy of the nano preparation and a low-dose chemotherapeutic drug shows a very excellent synergistic effect, which is shown as a tumor healing condition.

The application belongs to the technical field of pharmacy, and particularly relates to a minoxidil liniment and a preparation method thereof. The application wraps minoxidil by using a lichen extract-phospholipid complex to prepare nano-liposomes, utilizes the synergistic drug loading mechanism of the lichen extract and the phospholipid complex, avoids the common allergic dermatitis phenomenon in the use process of the minoxidil liniment through anti-inflammatory and antioxidant effects, protects the drug structure, and prolongs the action time of the minoxidil liniment; the gel-like substance formed by using a polyvinyl alcohol-carboxymethylcellulose sodium complex coating solution reduces the surface exposure of minoxidil, avoids the precipitation of minoxidil crystals, and guarantees the delivery and absorption efficiency of minoxidil drugs.

This invention discloses a vitamin A-functionalized polyphenol-phospholipid complex, its preparation method, and its applications, belonging to the field of pharmaceutical formulation and nanodelivery technology. The phospholipid complex comprises a polyphenol drug, a phospholipid material, and a vitamin A phospholipid ligand. The vitamin A phospholipid ligand is formed by vitamin A or its derivatives and a phospholipid derivative containing amino or other reactive groups. The phospholipid complex forms a phospholipid composite structure through non-covalent interactions between the polyphenol drug and the phospholipid material, and the vitamin A phospholipid ligand is inserted into or assembled into the surface or interior of the phospholipid composite structure. Animal experiments show that this phospholipid complex can reduce serum transaminase levels and alleviate the degree of liver fibrosis, and has good blood compatibility and tissue safety. This invention provides an industrially achievable targeted nano-formulation solution for early intervention in liver fibrosis, with promising application prospects.

The present application relates to the technical field of medicine, provide a kind of rhizoma Corydalis compound granular material and its preparation method and application, to solve the problem of low oral bioavailability and poor stability of rhizoma Corydalis alkaloids.The granular material is composed of rhizoma Corydalis microcapsule granules, chuanqiong extract, baeckea fruit extract microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate etc.Rhizoma Corydalis alkaloids are coated by forming phospholipid complex with medicinal grade soybean lecithin, which significantly improves the stability and oral bioavailability of alkaloids.The preparation method includes the following steps: raw material pretreatment, mixing, granulation, drying, whole granulation, mixing and packaging.The granule has good application prospect in the preparation of analgesic oral solid preparations.

The invention relates to the technical field of nano-drugs, in particular to sialic acid modified ibrutinib phospholipid complex nanoparticles capable of being used for treating sepsis. The sialic acid modified ibrutinib phospholipid complex nanoparticle prepared by the invention comprises ibrutinib, egg yolk phosphatidyl glycerol and a sialic acid-cholesterol derivative, and the nanoparticle can obviously improve the accumulation of a preparation at an inflammation part and the targeting of the preparation on inflammation-related macrophages; the BTK inhibitor has the advantages that the BTK inhibitor can be used for treating sepsis, so that the sepsis treatment effectiveness and safety of the BTK inhibitor are greatly improved, more importantly, sepsis survivor mice can be helped to relieve the immunosuppression state, strong immune memory is generated, the reinfection risk is greatly reduced, and the BTK inhibitor has guiding significance in solving the problem that the death rate of sepsis survivors is relatively high after the sepsis survivors are discharged from hospitals clinically; meanwhile, the sialic acid modified ibrutinib phospholipid complex nanoparticles can also reduce the risk of secondary infection of diseases caused by pathogens containing LPS antigens by the organism.

The invention relates to a traditional Chinese medicine preparation, an alkaline preparation, a phospholipid-based drug-loaded preparation and a preparation method. The traditional Chinese medicine preparation comprises 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei, 5-10 parts of wine-prepared fructus corni, 5-10 parts of rose, 7-12 parts of lucid ganoderma, 3-5 parts of poria cocos, 3-5 parts of rhizoma alismatis, 7-10 parts of dendrobe, 70-100 parts of sodium hydroxide and 5-15 parts of egg white. The invention discloses a traditional Chinese medicine preparation based on phospholipid complex drug loading. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight through a phospholipid complex drug loading technology: 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei, 5-10 parts of wine-prepared fructus corni and 70-100 parts of sodium hydroxide. The phospholipid complex is formed by traditional Chinese medicine extract and phospholipid according to the mass ratio of (0.5-2): 1, and the particle size of the complex is 100-500 nm. The osmotic pressure of the traditional Chinese medicine preparation is 280-310 mOsm / L, and the pH value is 4.5-10.

The invention discloses a solid-phase extraction process method for detecting veterinary drug residues in an animal-derived sample, and belongs to the technical field of analysis of harmful residues in food. The method comprises the steps of sample pretreatment, solid-phase extraction column activation balance, sample loading, multi-stage washing and core collaborative elution. Especially, core collaborative elution adopts a collaborative elution method combining three-stage pH gradient elution and two-time competitive acetone pulse injection. The method comprises the following steps: firstly, eluting sulfonamides and quinolones under an acidic condition; then injecting acetone to competitively remove phospholipid; then, the tetracycline and macrolide drugs are eluted under the neutral condition; injecting acetone again for deep purification; and finally, eluting the chloramphenicol medicine under an alkaline condition. According to the method, the problem that the recovery rate and the purification degree are difficult to consider when multiple types of veterinary drug residues in the egg high-phospholipid complex matrix are synchronously detected is effectively solved, and the accuracy, the sensitivity and the reproducibility of subsequent LC-MS / MS analysis are remarkably improved.

The invention relates to the field of pharmaceutical preparations, and particularly provides a ropivacaine sustained-release solution preparation based on a phospholipid complex and a preparation method thereof, and the preparation has the advantages of increased drug loading capacity, good safety, no obvious stimulation to administration tissues and long sustained-release time.

The present application relates to a kind of fish oil extraction equipment and its extraction process, belong to fish oil extraction technical field, by adopting the synergies of helical guide rail and elastic limiting part, multiple stirring parts are sequentially separated from limiting under the control of driving part and swing in vertical direction, form continuous wave type stirring track, reciprocating activity part and helical guide rail being set in the center of stirring barrel, cooperate with the synergies of elastic limiting part and stirring part, realize the effective stirring of high viscosity fish oil, both realize the uniform mixing and cyclic flow of material, shear force is dispersed into multi-section progressive action, avoid the mechanical damage of traditional high-strength concentrated shearing to protein-phospholipid complex colloid structure, while the buffer characteristics of elastic limiting part further reduce impact stress, solve the problem that the high viscosity of fish oil and its sensitive colloid structure in prior art make traditional high shear stirring easily lead to active ingredient loss and system stability reduction.

The invention relates to the technical field of skin care products, and discloses an okra polysaccharide-based skin care product and a preparation method thereof.The method comprises the steps that a beta-glucan phospholipid complex and a glycyrrhetinic acid phospholipid complex are prepared, and the skin permeation characteristics of the beta-glucan phospholipid complex and the glycyrrhetinic acid phospholipid complex are regulated and controlled through the amphipathy of phospholipid; the preparation method comprises the following steps: entrapping a beta-glucan phospholipid complex in calcium alginate microspheres to form a pH sensitive carrier; preparing a water-phase matrix containing okra polysaccharide and prebiotics, and adjusting the pH value to 6.0-6.5; dispersing calcium alginate microspheres in a water phase matrix to construct a first layer of time-sharing release mixed liquid; adding a glycyrrhetinic acid phospholipid complex, a lactic acid-sodium lactate buffer pair and an emulsifier for low-temperature emulsification to construct a second layer of time-sharing release emulsion; and adjusting the texture and filling. According to the invention, permeation synergy of the water-soluble immune activation component and the fat-soluble anti-inflammatory component is realized, so that the concentration peak value overlapping degree of the two components in the epidermis-dermis junction area is effectively improved.

The invention discloses an anti-aging compound nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of foods. The composition is prepared from the following components in unit dose: 150 to 250 mg of nicotinamide ribose, 10 to 30 mg of pyrroloquinoline quinone disodium salt, 100 to 200 mg of quercetin phospholipid complex, 300 to 500 [mu] g of (6S)-5-calcium methyltetrahydrofolate, 30 to 80 [mu] g of methyl cobalamin, 5 to 15 mg of pyridoxine hydrochloride, 50 to 100 mg of radix astragali seu hedysari extract, 50 to 100 mg of fructus lycii extract, 50 to 100 mg of rhizoma polygonati extract and auxiliary materials. Through the synergistic effect of the nutrients and the traditional Chinese medicine extracts, NAD < + > improvement, mitochondrial protection, oxidation resistance and energy metabolism regulation are achieved, and the nutrient composition has novelty, safety and industrial practicability and can be used for preparing anti-aging nutritional supplements or health-care foods.

The invention discloses a phospholipid complex with high bioavailability as well as a preparation method and application thereof. The compound consists of 30-70 parts of nutrients, 15-50 parts of phospholipid, 2-10 parts of a membrane layer framework material, 0.2-2 parts of an antioxidant, 5-30 parts of a wall material and 2-5 parts of an adhesive, and has a phospholipid-wall material double-layer or multi-layer embedding structure. The preparation method comprises the following steps: preparing membranized phospholipid powder by spray drying, modifying a wall material by plasma, co-crushing, granulating by a wet method, and cutting, spraying and coating. The product has good fluidity and low solvent residue lt; the nutrient loss rate is 100 ppm, and the nutrient loss rate is 1t; 2%, the retention rate gt after 20 days of acceleration at 60 DEG C; 90%; and the bioavailability is 2-3 times that of the raw materials, and the process can realize large-scale production and is low in cost. The compound is suitable for food, health care products or medicines and is used for efficiently delivering nutrients such as vitamins and minerals.

The invention relates to the technical field of skin care products, and discloses a phospholipid complex for preparing a nano-emulsion and a preparation process, the phospholipid complex contains hydrogenated phosphatidylcholine and hydrogenated lysophosphatidylcholine, the ratio of hydrogenated phosphatidylcholine to hydrogenated lysophosphatidylcholine is 200-10: 1, the phospholipid complex is a phospholipid complex, and the phospholipid complex is a phospholipid complex. The nano-emulsion prepared by the invention can be efficiently absorbed in a transdermal manner, the bioavailability of active ingredients is improved, and the product is low in irritation and high in safety.

The invention belongs to the technical field of medicines, relates to a composition of mitoxantrone hydrochloride and ibrutinib and application of the composition, and particularly relates to a composition of sialic acid modified mitoxantrone hydrochloride liposome and sialic acid modified ibrutinib phospholipid complex nanoparticles and an effect of the composition in preparation of antitumor drugs. The sialic acid modified mitoxantrone hydrochloride liposome and the sialic acid modified ibrutinib phospholipid compound nanoparticle can be respectively prepared into injections, injections, injections, injections, injections, injections, injections, injections, injections, injections and injections. Or the sialic acid-modified mitoxantrone hydrochloride liposome and the sialic acid-modified ibrutinib phospholipid complex nanoparticles are respectively prepared into injections, the injections are subpackaged in the same medicine box, and the medicine is administered in a sequential manner or is administered at the same time. The sialic acid modified mitoxantrone hydrochloride lipidosome and the sialic acid modified ibrutinib phospholipid compound nanoparticles are combined for use, so that the anti-tumor activity can be obviously improved, immune memory and anti-tumor immune response can be established, and the secondary attack of tumors can be resisted.