304 results about "Curcuminoid" patented technology

The invention relates to a curcumin-loaded MMP response type melittin nano-pellicle vesicle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: firstly, preparing curcumin entrapped lipidosome; then carrying out culture amplification on engineering bacteria carrying melittin recombinant plasmids, extracting cell membranes after removing cell walls, and carrying out ultrasonic treatment and membrane extrusion to obtain melittin cell membrane nano-vesicles; fusing the curcumin lipidosome and the cell membrane nano-vesicles in an ultrasonic extrusion mode to obtain fused vesicles; and finally, carrying out surface calcium phosphate mineralization treatment on the fused vesicles to obtain the curcumin-loaded MMP response type melittin nano pellicle vesicles. The nano mycofilm vesicle prepared by the invention can be used for preparing antitumor drugs, and the biocompatibility and in-vivo stability of nanoparticles are improved by introducing a calcium phosphate coating; through combined delivery of melittin and curcumin, the anti-tumor effect is enhanced, so that the growth and proliferation of tumor cells are inhibited.

The invention discloses an anti-neurodegeneration exosome composition as well as a preparation method and application thereof. The anti-neurodegeneration exosome composition is prepared from the following components in parts by mass: 5 to 25 parts of human exfoliated deciduous tooth stem cell exosome, 25 to 85 parts of plant-derived exosome-like nano-vesicles, 12 to 10 parts of ginsenoside Rg, 2 to 10 parts of curcumin and 10 to 20 parts of auxiliary materials. The anti-neurodegeneration exosome composition contains a large amount of cell factors, growth factors, miRNA, mRNAs and other components, is easy to fuse with cell membranes of intestinal epithelial cells, can selectively deliver bioactive substances to recipient cells through a blood-brain barrier, carries out information transmission among different cells, regulates signal transduction among the cells, and has a good anti-neurodegeneration effect. The effects of resisting oxidation, resisting inflammation, resisting aging and the like are achieved.

The invention belongs to the technical field of drug delivery, and particularly relates to a multi-response colitis disease targeting hydrogel microsphere as well as a preparation method and application thereof. The hydrogel microsphere comprises a calcium ion cross-linked sodium alginate microsphere and HA-Cys / Cur NPs which is encapsulated in the calcium ion cross-linked sodium alginate microsphere, the preparation method comprises the following steps: self-assembling cysteine ethyl ester modified hyaluronic acid and curcumin to form nano-particles, encapsulating HA-Cys / Cur NPs into sodium alginate microspheres by an emulsification method, and carrying out calcium ion crosslinking, so as to obtain the hydrogel. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capability, are stable in a gastric acid environment, are accurately released at a colon part and target macrophages at an inflammation part, and NPs disconnects disulfide bonds and releases curcumin in an intracellular high GSH environment, so that synergistic treatment of anti-inflammation, anti-oxidation and intestinal mucosa repair is realized, and the curative effect is good. The medicine has a good application prospect in treatment of ulcerative colitis.

The invention provides a small extracellular vesicle composite collagen hydrogel injection, and belongs to the technical field of osteoarthritis, and the small extracellular vesicle composite collagen hydrogel injection is prepared by the following steps: S1, mixing a sodium alginate solution with a type I collagen solution to obtain a mixed solution, adding a CaCl2 solution into the mixed solution to form gel, adding an FGF18 solution into the gel, and mixing to obtain FGF18 sodium alginate / collagen hydrogel; s2, transfecting a Lenti-IGF-1-EGF lentiviral vector to P3 generation human umbilical cord mesenchymal stem cells, culturing to obtain P5 generation IGF-1 overexpressed MSCs cells, namely P5 generation IGF-1-MSCs cells, co-culturing with the P5 generation IGF-1-MSCs cells by using curcumin, and separating and extracting a small extracellular vesicle solution rich in curcumin; and S3, mixing the small extracellular vesicle solution rich in curcumin with the FGF18 sodium alginate / collagen hydrogel, so as to obtain the small extracellular vesicle composite collagen hydrogel injection. The invention provides a small extracellular vesicle composite collagen hydrogel injection, which achieves the purposes of relieving inflammatory injury of osteoarthritis and enhancing the treatment effect of osteoarthritis.

The invention provides a composite nanoparticle with active substance sequential release capability, a multifunctional microneedle patch based on curcumin-loaded ZIF-67 nanoparticles, preparation methods of the composite nanoparticle and the multifunctional microneedle patch and application of the multifunctional microneedle patch, and belongs to the technical field of biology. The composite nano-particles with the active substance sequential release capability are CurZIF-67NPs, the average particle size is 403 + / -7 nm, the microstructure is dodecahedral structure particles with rough textures on the surface, and the composite nano-particles have the effects of slowly releasing bioactive substances, improving the inflammatory microenvironment and regulating and controlling osteogenesis under certain conditions. The composite nano-particle comprises curcumin powder and a ZIF-67 nano-material, the ZIF-67 nano-material can be decomposed to quickly release Co < 2 + >, macrophages are regulated and controlled to be polarized to an M2 type, and excessive immune inflammation reaction is improved; the curcumin powder is slowly released, so that the periodontal ligament stem cells can be regulated and controlled to be differentiated into osteoblasts, and the osteogenic activity is enhanced.

The invention discloses a composite curcumin nano pesticide and a preparation method and application thereof.The nano pesticide comprises a carrier and curcumin loaded on the carrier, the carrier is polydopamine-sodium lignin sulfonate, and the polydopamine-sodium lignin sulfonate is formed by polymerizing dopamine hydrochloride on the surface of lignin; the preparation method comprises the following steps: preparing a curcumin solution, adding the polydopamine-sodium lignin sulfonate powder, fully dispersing, slowly stirring under a dark condition until a yellow solution becomes dark red, and removing a solvent to obtain the polydopamine-sodium lignin sulfonate-curcumin. The nano pesticide provided by the invention takes polydopamine-sodium lignin sulfonate as a carrier, so that the drug has pH and photo-thermal response controlled release function, burst release of curcumin is avoided, and the stability and bioavailability of curcumin are improved.

The invention discloses a preparation method of photo-thermal-MMP dual-response matrix hydrogel and application of the photo-thermal-MMP dual-response matrix hydrogel in diabetic wound repair, and belongs to the technical field of biological medicine. According to the present invention, the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is composed of an amnion source photo-crosslinked matrix hydrogel, curcumin-loaded ZIF-8 nanoparticles and MMP2 peptide modified polydopamine, and the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is obtained; the ZIF-8 nanoparticles decline in an acid environment to release zinc ions, destroy bacterial cell membranes, enhance the permeability of a biological membrane and cooperatively kill drug-resistant bacteria in combination with a photothermal effect, Cur is loaded through ZIF-8 to form Cur-coated ZIF-8, then a Cur-coated ZIF-8-coated MMPDA / dAMG double-drug-loading system is constructed through an MMPDA medium, and a photothermal antibacterial, anti-inflammatory and regeneration-promoting multi-mode therapy is formed for a wound surface in the acid environment. Therefore, wound healing is accelerated.

The invention discloses an oral joint protection composition containing ergothioneine and a preparation method thereof, and relates to the technical field of joint protection compositions. The oral joint protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.05 to 5 parts of the ergothioneine, 20 to 50 parts of glucosamine salt, 10 to 30 parts of chondroitin sulfate, 2 to 10 parts of curcumin, 30 to 70 parts of a diluent, 1 to 10 parts of an adhesive, 0.5 to 5 parts of a lubricant, 2 to 10 parts of a disintegrating agent and 0.1 to 0.5 part of an antioxidant stabilizer. Through synergistic compatibility of active ingredients such as ergothioneine, curcumin and the like, a multi-dimensional action network of oxidation resistance, inflammation resistance and cartilage metabolism regulation is formed, the inhibition effect on joint inflammation is remarkably improved, and the limitation of a single ingredient is broken through.

The invention discloses a nanoscale high-stability alcohol-in-oil transparent system and a preparation method thereof. The system comprises the following components in percentage by mass: 20-30% of PPG-13-decyl tetradecanol polyether-24, 20-30% of polydimethylsiloxane, 20-30% of polydimethylsiloxane, 20-30% of a 40 to 68% of methyl propylene glycol; 2 to 6% of propylene glycol dibenzoate; and 6-32% of polar grease. The preparation method comprises the following steps: heating and uniformly stirring the propylene glycol dibenzoate and the grease at 55-75 DEG C to obtain an oil phase; adding PPG-13-decyl tetradecyl alcohol polyether-24 into the oil phase, and stirring to obtain a mixed phase; adding methylpropanediol into the mixed phase, and stirring; and cooling to room temperature. The alcohol-in-oil transparent system prepared by a rapid and convenient process has the characteristics of small particle size and high stability, can load tetrahydrocurcumin and other active matters, and has important application value in the field of cosmetics.

The invention relates to a modified superoxide dismutase pH response type nano-liposome and a synergistic anti-photoaging after-sun repair composition capable of achieving accurate targeting. The modified superoxide dismutase pH response type nano-liposome is obtained by modifying a superoxide dismutase nano-liposome with hyaluronic acid, and the modified superoxide dismutase pH response type nano-liposome has the advantages that the modified superoxide dismutase pH response type nano-liposome can be accurately targeted by the aid of the synergistic anti-photoaging after-sun repair composition; the superoxide dismutase nano-liposome is of a core-shell structure, a core layer is superoxide dismutase, a shell layer is a ternary composite liposome, and the ternary composite liposome is formed by compounding HSPC, DSPC and cholesterol. By constructing a pH response type nano delivery system, the pH drop characteristic of an ultraviolet damage area can be accurately recognized, controlled release of SOD at a target site is triggered, O2 <-> and H2O2 are synchronously removed, an oxidative stress chain reaction is blocked, and in cooperation with the inhibition of tetrahydrocurcumin on a tyrosinase signal channel and the anti-inflammatory repair effect of the aloe extract, the anti-inflammatory repair effect of the aloe extract on the tyrosinase signal channel is achieved. A three-dimensional action network of targeted removal-activity regeneration-barrier reconstruction is formed, and the photoaging prevention and treatment effect is improved.

Methods and compositions comprising one or more dopamine neuronal activity enhancers (e.g., dopamine receptor agonists), pantethine and solubilized curcumin for use in treating NAFLD and NASH are provided.Methods and compositions comprising one or more dopamine neuronal activity enhancers (e.g., dopamine receptor agonists), pantethine and solubilized curcumin for use in treating NAFLD and NASH are provided.

The invention relates to an apolipoprotein E detection reagent and application thereof, and belongs to the technical field of biomedicine. The invention provides application of a plant derivative in preparation of an APOE epitope exposure agent. The plant derivative is selected from at least one of curcumin, emodin, EF24 and FLLL-32. The invention also provides an APOE epitope exposure agent which comprises a surfactant, salts, a reducing agent and plant derivatives. According to the present invention, the sample and the protein are pre-treated by using the epitope exposure agent containing the plant derivative to improve the sufficiency of the ApoE protein epitope exposure so as to achieve the accurate typing of the ApoE gene based on the immunological detection method and the accurate quantification of the proteins with different genotypes. Genetic typing of ApoE and quantitative detection of proteins with different genotypes are carried out based on an immunological detection method, and the genotype detection result is highly consistent with a fluorescent PCR (Polymerase Chain Reaction) result.

The invention discloses a preparation method of a drug-loaded glycoprotein-like network hybridization tissue engineering valve material, which comprises the following steps: carrying out a one-pot hybridization cross-linking reaction on a decellularized biological material, oxidized hyaluronic acid, phenylboronic acid grafted silk fibroin and curcumin to construct and form a drug-loaded glycoprotein-like network on the biological material; the biological material is animal tissue, including but not limited to any one of pericardium, valve, intestinal membrane, meninx and the like. The method comprises the following steps: soaking a decellularized biological material in a solution A containing OHA, SF-PBA and curcumin, and continuously oscillating for 48 hours to carry out a cross-linking reaction; and then washing with phosphate buffer saline water and distilled water to obtain the drug-loaded glycoprotein-like network hybrid tissue engineering valve material. The prepared tissue engineering valve material overcomes the defects that traditional decellularized valve and glutaraldehyde cross-linked valve materials are easy to calcify, have toxicity and are poor in immunogenicity.

The invention discloses a chicken freshness detection method and system combining a colorimetric gel label and a convolutional neural network, and belongs to the technical field of food safety detection. An indicating gel dot matrix label is prepared from curcumin, anthocyanin and betacyanin, the optimal load concentration of curcumin, anthocyanin and betacyanin is optimized and determined, and sensitive color response is generated to volatile biogenic amine gas such as dimethylamine and trimethylamine; gel label images are collected, the images are divided into fresh samples, secondary fresh samples and decayed samples in combination with the TVB-N content, the samples are subjected to data enhancement and then input into an OfficientNet-B0 model for training, and efficient classification is achieved. According to the method, a detection system combining the natural pigment-based multi-channel colorimetric gel and the lightweight convolutional neural network is constructed, lossless, rapid and intelligent detection of the freshness of the fresh chicken is realized, and a green and efficient solution is provided for real-time monitoring of the freshness of food and application of a mobile terminal.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention discloses a curcumin ion-based composite material for cobalt separation, a preparation method and application, the material is prepared by compounding curcumin ionic liquid and a porous material, and the porous material is a carbon-based material, an inorganic porous material or a resin material. The problem that efficient separation of Co in wastewater cannot be achieved in the prior art is solved. Compared with the prior art, amino acid modified curcumin is introduced into the ionic liquid as anions for the first time and is loaded on the porous material, and the prepared composite material can quickly and specifically adsorb Co metal ions and can be prepared into a membrane or column separation resin so as to recover cobalt from waste power batteries and remove cobalt from radioactive wastewater. The adsorption rate is high, desorption is not prone to occurring, the capture capacity and capture rate are high, and recycling can be achieved.

The invention belongs to the technical field of biological engineering, and provides curcumin / dihydrocurcumin reductase MaCurA, a coding gene and application. The reductase can efficiently catalyze 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone to synthesize tetrahydrocurcumin, an efficient solution is provided for industrial preparation of tetrahydrocurcumin, and experiments prove that the recombinase can catalyze the synthesis of tetrahydrocurcumin in the catalysis of 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone. In a reaction system for preparing tetrahydrocurcumin from 2, 5-diketone, actually measured enzyme activity is stabilized at 3.38 U / mg level, and compared with a traditional chemical synthesis method, the production efficiency is remarkably improved.

The invention relates to the technical field of nano-materials, in particular to a monatomic nano-enzyme drug delivery system for IBD treatment and a preparation method and application of the monatomic nano-enzyme drug delivery system. The monatomic nano enzyme delivery system provided by the invention comprises an iron-doped monatomic nano enzyme Fe-SA, curcumin Cur and hyaluronic acid grafted dopamine HAD, the Fe-SA and the Cur form a Fe-SA / Cur compound through a coordination effect, and the surface of the Fe-SA / Cur compound is coated with the HAD. According to the iron-doped monatomic nano-enzyme Fe-SA, Fe atoms in the iron-doped monatomic nano-enzyme Fe-SA are distributed in a graded carbon-based matrix of the Fe-SA in a Fe-N4 co-doping form, and the iron-doped monatomic nano-enzyme Fe-SA has efficient SOD and CAT nano-enzyme activity, and can realize antioxidant self-cascade nano-enzyme reaction, effectively remove active oxygen and improve the pathological environment. According to the preparation method disclosed by the invention, a coordination compound Fe-SA / Cur is constructed by utilizing the iron-doped monatomic nano-enzyme and the curcumin, so that the anti-inflammatory effect is improved, and the characteristic of poor water solubility of the curcumin is effectively improved. According to the invention, HAD is loaded on the outer layer of a coordination compound Fe-SA / Cur to construct an oral monatomic antioxidant cascade nano-enzyme system, high acid resistance and targeted delivery capability are realized by using the remarkable stability and negative charges of HAD, and oral administration is effectively realized. In-vivo and in-vitro experiments show that the monatomic nano-enzyme delivery system provided by the invention can effectively remove intestinal free radicals, improve the intestinal environment, reduce the expression of inflammatory factors, promote the recovery of damaged tissues and effectively treat colitis. The invention provides a new thought and method for biomedical research and drug development of inflammatory bowel diseases.

The invention relates to the technical field of kneading equipment, and particularly discloses water-soluble curcumin kneading equipment which comprises an equipment base, the top of the equipment base is fixedly connected with an outer roller through a support, the inner wall of the outer roller is rotatably connected with a kneading device, the side face of the kneading device is fixedly connected with the output end of a gear transmission device, and the output end of the gear transmission device is fixedly connected with a motor. The input end of the gear transmission device is fixedly connected with a transmission device, the side, away from the gear transmission device, of the transmission device is fixedly connected with the fixed end of a motor, the side face of the outer roller is fixedly connected with a cooling device, the top of the outer roller is fixedly connected with a feeding device, and the side face of the kneading device communicates with a guide-out pipe. The bottom of the motor is fixedly connected with the top of the equipment base, and the water-soluble curcumin kneading equipment achieves the purpose of being easy to cool.

The invention relates to the technical field of medical instruments, in particular to a photo-piezoelectric hydrogel dressing for wound repair. The hydrogel dressing realizes self-energized micro-electrical stimulation and anti-oxidation-antibacterial-anti-inflammatory integrated treatment through'energy-drug 'double closed-loop synergy: the PVDF / ZnO nanofiber on the upper layer can convert human body micro-motion and external light into micro-electrical stimulation to promote cell migration, proliferation and angiogenesis; the curcumin at the lower layer cooperates with the nano-silver to block the'oxidative stress-inflammation-infection 'vicious circle of chronic wounds. The dressing is soft and fit, does not need an external power supply, is excellent in biocompatibility, provides a self-driven multifunctional nursing scheme for refractory wounds, and has wide clinical popularization and market application prospects.

The invention discloses a preparation method of a pegylation acoustic catalysis effect black phosphorus loaded biological enzyme nano particle, which is a novel nano composite material based on material chemistry and pharmaceutical chemistry, and bacterial keratitis is treated by using the unique acoustic catalysis property of the nano particle. Nanoparticle synthesis mainly comprises the following steps: 1) pretreatment of commercial black phosphorus; (2) uploading biological enzyme iron-curcumin to black phosphorus in situ; and (3) synthesizing hyaluronic acid coupled phospholipid polyethylene glycol (DSPE-coated PEG2000-HA) and modifying the biological enzyme black phosphorus nanoparticles. The finally obtained nano composite material has good biocompatibility, ocular surface adhesion, biological enzyme activity and acoustic catalytic treatment effect on bacterial biofilm infection of eyes.

The invention belongs to the technical field of biological medicine, and particularly relates to a curcumin synthetase mutant as well as a preparation method and application thereof, and the curcumin synthetase mutant is obtained by performing one or more of the following mutations on an amino acid sequence as shown in SEQ ID NO.1: phenylalanine at the 93rd site is mutated into tyrosine; phenylalanine at the 152nd site is mutated into leucine; phenylalanine at the 152nd site is mutated into serine; threonine at the 218th site is mutated into alanine; serine at the 259th site is mutated into glycine; valine at the 288 site is mutated into glycine; valine at the 288 site is mutated into glutamic acid; histidine at the 316th site is mutated into tyrosine; valine at the 343rd site is mutated into methionine. According to the invention, curcumin synthetase is subjected to directional modification, a basic group of a CUS gene is subjected to random mutation through error-prone PCR, and five CUS mutants with improved activity are screened. The curcumin synthesis capacities of the five CUS mutants are respectively 2.489 times, 3.887 times, 5.23 times, 6.439 times and 11.567 times of those of a wild type.

The invention discloses a natural product composition and application thereof in reducing uric acid and blood sugar. The composition is prepared from luteolin, verbascoside and curcumin according to the weight ratio of 1: 3: 2. According to the invention, when luteolin, verbascoside and curcumin are combined according to a weight ratio of 1: 3: 2, the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase is the strongest, and the inhibitory activity is obviously superior to the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase when the luteolin, verbascoside and curcumin are independently used, so that the composition has a synergistic effect on reducing the level of uric acid and regulating blood sugar. The discovery provides a theoretical basis and a formula basis for developing novel natural-source functional products for reducing uric acid and reducing blood sugar, and has important application prospects and development values.

This invention discloses a method for preparing HVC NPs for the diagnosis and treatment of Parkinson's disease and their applications. The probe HV in the HVC NPs responds to H2O2 and viscosity, utilizing near-infrared fluorescence imaging capabilities to achieve real-time monitoring of Parkinson's disease biomarkers, helping us better understand the occurrence and development of Parkinson's disease. With the assistance of RVG29, the HVC NPs effectively cross the blood-brain barrier. The curcumin within them can reduce cell apoptosis, lower oxidative stress levels, scavenge excess reactive oxygen species, combat inflammation, and reduce α-synuclein aggregation, demonstrating effective anti-Parkinson's disease effects at the cellular and experimental animal levels. This nanomaterial provides a new strategy for integrated research on the diagnosis and treatment of Parkinson's disease.

The curcumin extraction device comprises a container body and a first shaft rod, the first shaft rod is inserted into the container body and can rotate along the axis of the first shaft rod, a plurality of stirring rods are installed on the circumferential outer wall of the first shaft rod, a connecting plate is installed on the side, away from the first shaft rod, of each stirring rod, a wheel body is installed on the connecting plate, and the axis of the wheel body is parallel to the axis of the first shaft rod. A bottom plate is mounted on the inner bottom surface of the container body, a second shaft rod is mounted at the upper end of the bottom plate, the axis of the second shaft rod is parallel to the axis of the wheel body, a rotating plate is mounted on the second shaft rod, the second shaft rod penetrates through the rotating plate, the rotating plate is provided with a wall surface, the wall surface is an arc surface, and when the wheel body rotates along the axis of the first shaft rod, the wheel body can roll on the wall surface. The utility model provides a curcumin extraction device which can improve the curcumin extraction efficiency.

The present invention relates to a method for producing a bioactive component-containing nanocomposite, specifically a method for producing a montmorillonite-based, bioactive component-containing nanocomposite, as well as to a montmorillonite-based nanocomposite containing a bioactive component, particularly curcumin or dexketoprofen.

The invention provides a 3-hydroxypyrone derivative as well as a preparation method and application thereof, the compound can effectively inhibit release of proinflammatory cytokines in lipopolysaccharide-induced microglial cells, inhibit release of NO by the lipopolysaccharide-induced microglial cells, inhibit apoptosis of polysaccharide-induced microglial cells, and inhibit apoptosis of lipopolysaccharide-induced microglial cells. The compound has excellent anti-neuroinflammation activity and neuroprotective effect, the activity of the compound is superior to that of positive controls such as curcumin and hydrocortisone, and the compound can be used for preventing and / or treating neuroinflammation and neurodegenerative diseases.

A turmeric composition having enhanced self-dispersibility and bioavailability includes a solvent free, fresh turmeric rhizome extract and a dried turmeric rhizome extract (standardized to 35-95% total curcuminoids). The turmeric composition may be devoid of externally added excipients / bio-enhancing agents / dispersing agents. A process for preparation of the bioavailable turmeric composition is disclosed herein.

The present invention relates to a kit of parts for an oral care implement, the kit of parts comprising a light emitting device and an oral composition, the oral composition comprising curcumin, curcuminoid, curcumin derivative or hypericin.

The invention provides a mesenchymal stem cell medicine for promoting knee joint cartilage regeneration as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: reacting polyethyleneimine with linoleoyl chloride to prepare linoleoyl chloride modified polyethyleneimine for preparing curcumin lipidosome, and reacting with multifunctional peptide to prepare multifunctional lipidosome; the mesenchymal stem cells are mixed with self-assembled RADA16 polypeptide embedded with TGF-beta1 and BMP-6 and subcultured mesenchymal stem cells, the mixture is added into autologous platelet-enriched plasma, and the mesenchymal stem cell medicine for promoting knee joint cartilage regeneration is prepared. According to the invention, curcumin is embedded by lipidosome, mesenchymal stem cells can promote osteogenesis differentiation by using provided nutrients, and interference of inflammatory microenvironment is effectively prevented. Meanwhile, the self-assembled RADA16 polypeptide wraps TGF-beta1 and BMP-6, the synergistic effect is beneficial to regeneration and repair of cartilage tissue, proliferation of bone cells is promoted, and cartilage repair and regeneration are facilitated.