144 results about "Curcuminoid" patented technology

The invention relates to a curcumin-loaded MMP response type melittin nano-pellicle vesicle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: firstly, preparing curcumin entrapped lipidosome; then carrying out culture amplification on engineering bacteria carrying melittin recombinant plasmids, extracting cell membranes after removing cell walls, and carrying out ultrasonic treatment and membrane extrusion to obtain melittin cell membrane nano-vesicles; fusing the curcumin lipidosome and the cell membrane nano-vesicles in an ultrasonic extrusion mode to obtain fused vesicles; and finally, carrying out surface calcium phosphate mineralization treatment on the fused vesicles to obtain the curcumin-loaded MMP response type melittin nano pellicle vesicles. The nano mycofilm vesicle prepared by the invention can be used for preparing antitumor drugs, and the biocompatibility and in-vivo stability of nanoparticles are improved by introducing a calcium phosphate coating; through combined delivery of melittin and curcumin, the anti-tumor effect is enhanced, so that the growth and proliferation of tumor cells are inhibited.

The invention discloses a composite curcumin nano pesticide and a preparation method and application thereof.The nano pesticide comprises a carrier and curcumin loaded on the carrier, the carrier is polydopamine-sodium lignin sulfonate, and the polydopamine-sodium lignin sulfonate is formed by polymerizing dopamine hydrochloride on the surface of lignin; the preparation method comprises the following steps: preparing a curcumin solution, adding the polydopamine-sodium lignin sulfonate powder, fully dispersing, slowly stirring under a dark condition until a yellow solution becomes dark red, and removing a solvent to obtain the polydopamine-sodium lignin sulfonate-curcumin. The nano pesticide provided by the invention takes polydopamine-sodium lignin sulfonate as a carrier, so that the drug has pH and photo-thermal response controlled release function, burst release of curcumin is avoided, and the stability and bioavailability of curcumin are improved.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention belongs to the technical field of biological engineering, and provides curcumin / dihydrocurcumin reductase MaCurA, a coding gene and application. The reductase can efficiently catalyze 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone to synthesize tetrahydrocurcumin, an efficient solution is provided for industrial preparation of tetrahydrocurcumin, and experiments prove that the recombinase can catalyze the synthesis of tetrahydrocurcumin in the catalysis of 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-diketone. In a reaction system for preparing tetrahydrocurcumin from 2, 5-diketone, actually measured enzyme activity is stabilized at 3.38 U / mg level, and compared with a traditional chemical synthesis method, the production efficiency is remarkably improved.

The invention relates to the technical field of medical instruments, in particular to a photo-piezoelectric hydrogel dressing for wound repair. The hydrogel dressing realizes self-energized micro-electrical stimulation and anti-oxidation-antibacterial-anti-inflammatory integrated treatment through'energy-drug 'double closed-loop synergy: the PVDF / ZnO nanofiber on the upper layer can convert human body micro-motion and external light into micro-electrical stimulation to promote cell migration, proliferation and angiogenesis; the curcumin at the lower layer cooperates with the nano-silver to block the'oxidative stress-inflammation-infection 'vicious circle of chronic wounds. The dressing is soft and fit, does not need an external power supply, is excellent in biocompatibility, provides a self-driven multifunctional nursing scheme for refractory wounds, and has wide clinical popularization and market application prospects.

The invention discloses a natural product composition and application thereof in reducing uric acid and blood sugar. The composition is prepared from luteolin, verbascoside and curcumin according to the weight ratio of 1: 3: 2. According to the invention, when luteolin, verbascoside and curcumin are combined according to a weight ratio of 1: 3: 2, the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase is the strongest, and the inhibitory activity is obviously superior to the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase when the luteolin, verbascoside and curcumin are independently used, so that the composition has a synergistic effect on reducing the level of uric acid and regulating blood sugar. The discovery provides a theoretical basis and a formula basis for developing novel natural-source functional products for reducing uric acid and reducing blood sugar, and has important application prospects and development values.

This invention discloses a method for preparing HVC NPs for the diagnosis and treatment of Parkinson's disease and their applications. The probe HV in the HVC NPs responds to H2O2 and viscosity, utilizing near-infrared fluorescence imaging capabilities to achieve real-time monitoring of Parkinson's disease biomarkers, helping us better understand the occurrence and development of Parkinson's disease. With the assistance of RVG29, the HVC NPs effectively cross the blood-brain barrier. The curcumin within them can reduce cell apoptosis, lower oxidative stress levels, scavenge excess reactive oxygen species, combat inflammation, and reduce α-synuclein aggregation, demonstrating effective anti-Parkinson's disease effects at the cellular and experimental animal levels. This nanomaterial provides a new strategy for integrated research on the diagnosis and treatment of Parkinson's disease.

The invention provides a mesenchymal stem cell medicine for promoting knee joint cartilage regeneration as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: reacting polyethyleneimine with linoleoyl chloride to prepare linoleoyl chloride modified polyethyleneimine for preparing curcumin lipidosome, and reacting with multifunctional peptide to prepare multifunctional lipidosome; the mesenchymal stem cells are mixed with self-assembled RADA16 polypeptide embedded with TGF-beta1 and BMP-6 and subcultured mesenchymal stem cells, the mixture is added into autologous platelet-enriched plasma, and the mesenchymal stem cell medicine for promoting knee joint cartilage regeneration is prepared. According to the invention, curcumin is embedded by lipidosome, mesenchymal stem cells can promote osteogenesis differentiation by using provided nutrients, and interference of inflammatory microenvironment is effectively prevented. Meanwhile, the self-assembled RADA16 polypeptide wraps TGF-beta1 and BMP-6, the synergistic effect is beneficial to regeneration and repair of cartilage tissue, proliferation of bone cells is promoted, and cartilage repair and regeneration are facilitated.

The invention belongs to the technical field of food packaging materials, and discloses a photodynamic antibacterial modified atmosphere film as well as a preparation method and application thereof. The antibacterial modified atmosphere membrane is obtained by drying a membrane casting solution, the membrane casting solution comprises the following components in percentage by mass: 80-95% of anionic waterborne polyurethane emulsion, 5-20% of cationic quaternized nanocellulose and an antibacterial agent inclusion compound which accounts for 1-10% of the total mass of the components, and the antibacterial agent inclusion compound is a curcumin-cyclodextrin inclusion compound. The transparent film which has good compatibility and obviously improved air conditioning performance and mechanical performance is successfully prepared, the film has excellent antioxidant and photodynamic antibacterial functions, and the defect that an existing film is single in function is overcome. When the functional waterborne polyurethane film is applied to strawberry preservation, the oxidation and corruption process of strawberries is effectively delayed, the purpose of prolonging the preservation period is achieved, reliable support is provided for preparation of the functional waterborne polyurethane film and food preservation application, and the functional waterborne polyurethane film has important theoretical and practical significance.

The curcumin-coupled copper-gold bimetallic nanoszyme AuCu-Cur prepared by the application can remove ROS and relieve oxidative stress, prevent further damage to DNA, and introduce human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-EVs) to improve the bioavailability. In the system, curcumin can repair damaged DNA by promoting the expression of NEIL3. In addition, the vesicles themselves are rich in various tissue repair-related proteins and RNAs, which can promote DNA replication of notochordal cells (NPCs), reverse the aging state and stimulate extracellular matrix synthesis. In the IVDD model induced by rat tail vertebra puncture, we confirmed that the material has strong antioxidant and DNA repair capacity and can effectively delay cell aging, thereby relieving the progression of IVDD. Compared with existing intervertebral disc biomaterial treatments, the present scheme can realize continuous DNA repair, which is an active, multi-target repair program that not only interrupts the vicious cycle of intervertebral disc degeneration but also promotes tissue transformation to regeneration.

The invention relates to the technical field of medicines for treating intestinal ischemia-reperfusion injury, and discloses a medicine for treating intestinal ischemia-reperfusion injury and a preparation method thereof. Comprising 10 to 25 parts of rosmarinic acid, 5 to 15 parts of betaine, 3 to 10 parts of glutamine, 10 to 25 parts of salvianolic acid B, 5 to 15 parts of astragaloside, 3 to 10 parts of ginsenoside Rg1, 2 to 8 parts of curcumin, 5 to 12 parts of ophiopogon japonicus polysaccharide, 2 to 6 parts of notoginsenoside R1, 3 to 7 parts of total flavonoids of oldenlandia diffusa and 4 to 9 parts of angelica sinensis polysaccharide. The medicine disclosed by the invention can be used for relieving intestinal edema, repairing oxidative injury, clearing excessive ROS, improving SOD activity, blocking oxidative stress injury, inhibiting epithelial cell apoptosis, reducing intestinal permeability and maintaining mucous membrane integrity, and has an excellent treatment effect on intestinal ischemia reperfusion injury.

A chromatographic system for the simultaneous RP-HPLC quantification of aloin and curcumin, consisting of a C18 column, a PDA detector, a programmable solvent feed module and an optimized mobile phase of acetonitrile, methanol and water.

The present invention relates to a kit of parts for an oral care device, comprising a light-emitting element and an oral composition comprising curcumin, curcuminoids, curcumin derivatives, or hypericin.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The present invention relates to a stable curcumin composition for prevention improvement and maintenance of arthritis more particularly to osteoarthritis. The stable curcumin composition is comprised of curcuminoids either alone or along with at least one pharmaceutically and / or nutraceutically accepted excipient to form the stable curcumin compositions having enhancement in absorption and bioavailability. The composition is safe for consumption, possess enhanced stability and bioavailability due to selective percentage of amorphous and crystalline polymorphic form of curcumin along with selective excipient such as pH modifier and / or stabilizer and optionally hydrophilic carrier, antioxidant, diluents, anticaking agent, emulsifier, fat and surfactant which result in improvement of symptoms of arthritis and associated conditions, when administered to subjects, in need thereof.

This invention discloses an environmentally friendly curcumin nanocrystal and its preparation method, relating to the field of nanoparticle technology. The nanocrystal has a core-shell structure, with a core of curcumin crystals and a shell of hepatin peptide molecules bonded together by intermolecular forces. The average particle size of the nanocrystal is 50-200 nanometers, and it is completely dispersed and stable in an aqueous phase, containing no organic solvents or synthetic surfactants. This invention utilizes a pectin-chitosan complex to microencapsulate the nanocrystal, enabling it to resist gastric acid degradation and target release to the colon, thus precisely acting on the gut-hepatic axis and significantly improving bioavailability and hepatoprotective efficacy. While completely avoiding organic solvents and synthetic stabilizers, it simultaneously solves four major industry challenges related to curcumin: solubility, stability, targeted delivery, and synergistic efficacy, providing a new technical path for developing high-end, naturally derived hepatoprotective products.

The invention belongs to the technical field of biology and new medicine, and discloses a preparation method of acoustic resonance driven glycyrrhizic acid nano-composite responsive gel, glycyrrhizic acid is used as a drug carrying system, berberine, ursolic acid, baicalein, luteolinin, curcumin, baicalin or ginsenoside Rh2 is used as a water-insoluble natural small molecule drug, and the acoustic resonance driven glycyrrhizic acid nano-composite responsive gel is prepared. Glycyrrhizic acid is an amphiphilic compound composed of one molecule of glycyrrhetinic acid and two molecules of glucuronic acid, a hydrophobic cavity can be formed in a water environment to wrap the water-insoluble natural small molecule medicine, a glycyrrhizic acid nano-composite solution is formed, and meanwhile the solubility of the water-insoluble natural small molecule medicine such as baicalein is improved.

This invention relates to the field of biopharmaceutical technology, and more particularly to the application of curcuminoid compounds in the preparation of drugs for treating schistosomiasis, and pharmaceutical compositions thereof. The curcuminoid compounds used in this invention contain different substituents on their benzene rings, which can effectively regulate the electrophilic and lipophilic properties of the compounds, making them easier to enter the schistosomiasis cell. They interact with redox enzymes within the schistosomiasis cell, disrupting the redox balance and promoting schistosomiasis death. Therefore, they exhibit highly effective therapeutic activity against schistosomiasis and show great promise for application in the preparation of drugs for treating schistosomiasis.

This invention relates to the fields of biomedicine and nanomaterials, specifically to a curcumin-containing metal-organic framework nanocomposite material, its preparation method, and its applications. The metal-organic framework nanocomposite material uses the metal-organic framework MIL-101(Cr) as a substrate and introduces Ag... + As a functional component and Cr 3+ A bimetallic node is formed, and curcumin, as an active functional ingredient, is encapsulated within the pores of MIL-101(Cr) and / or modified on its surface, forming a carrier-bimetallic-functional ingredient composite structure. This composite material exhibits excellent performance and good biocompatibility. The preparation method is simple and highly controllable, making it suitable for industrial production. Furthermore, it expands the application scenarios of this composite material, providing new solutions for the treatment of clinical bacterial infections and the repair of skin lesions.

The invention belongs to the technical field of medicine preparation, and provides an ophthalmic external preparation and a preparation method thereof. According to the ophthalmic external preparation, curcumin included by hydroxypropyl-beta-cyclodextrin loaded on exosome modified by polylysine is adopted as an effective component. The preparation can improve the drug concentration of cornea tissues and realize accurate delivery of ocular surfaces; meanwhile, the exosome and curcumin form a synergistic effect, so that the release of proinflammatory factors such as IL-1beta and TNF-alpha can be inhibited, the secretion of goblet cell mucoprotein and the proliferation of corneal epithelial cells can be promoted, and the tear film rupture time is prolonged; in addition, the preparation is excellent in biocompatibility, free of ocular surface stimulation reaction and high in safety.

The invention provides a biotinylated Angiopep-2 modified targeting nano material as well as a preparation method and application of the biotinylated Angiopep-2 modified targeting nano material. According to the preparation method of the biotinylated Angiopep-2 modified targeting nano-material, Angiopep-2 is directionally anchored through a high-affinity biotin-streptavidin system, ligand conformation inactivation caused by chemical coupling is avoided, targeting activity is maintained, the used Angiopep-2 can help nanoparticles to be specifically recognized and combined and mediate the nanoparticles to cross a blood brain barrier to enter the brain, and the targeting nano-material can be used for preparing the targeted nano-material. The drug concentration in brain tissues is increased, so that the cure rate of brain diseases is improved, the brain targeting efficiency is far higher than that of transferrin and lactoferrin, and the application value is great; by entrapping curcumin and quercetin, a hydrophilic shell is provided, so that the water solubility of curcumin and quercetin is improved, and the bioavailability of curcumin and quercetin is improved.

The invention relates to the technical field of biological medicines, and discloses a dual-targeting adhesion-immune activation fusion peptide, an anti-escherichia coli O157: H7 monoclonal antibody GS2-D3, curcumin nanoparticles and a probiotic composition composed of the curcumin nanoparticles. The fusion peptide solves structural conflicts by inserting an alpha helix stable domain composed of four EAAAK repetitive units and a GPGP flexible buffer domain, a targeting domain YIGSR and an MUC2 binding domain PTPSFTT are introduced to improve the targeting efficiency, and the enzymolysis resistance is enhanced through site mutation; the monoclonal antibody GS2-D3 can be used for specifically recognizing escherichia coli O157: H7; the curcumin nanoparticles improve the stability and bioavailability of curcumin. The probiotic composition contains the components, has the effects of efficient colonization, bacteriostasis, inflammation resistance and intestinal flora regulation, can effectively treat intestinal inflammation, is low in cost and high in safety, and has good clinical transformation potential.

The application discloses a method for coating a PLA layer of Ag-DCPD film layer surface with doped Ca-Cur submicron modified material, and relates to the technical field of medical material surface biological coating. The method comprises the following steps: an LPBF-NiTi alloy base is manufactured by using a laser powder bed fusion additive manufacturing technology and is pretreated; the pretreated LPBF-NiTi alloy base is subjected to electrochemical deposition in an electrolyte solution to obtain an LPBF-NiTi alloy base with a deposited Ag-DCPD film layer; CaCl2 and curcumin are dissolved in anhydrous ethanol, and are placed in a sealed container containing (NH4)2CO3 for constant-temperature reaction to obtain Ca-Cur submicron modified material; polylactic acid is dissolved in dichloromethane, and then the Ca-Cur submicron modified material is dispersed in the polylactic acid to obtain a leaching solution; the LPBF-NiTi alloy base with the deposited Ag-DCPD film layer is repeatedly immersed and pulled in the leaching solution to obtain an LPBF-NiTi alloy base coated with an Ag-DCPD / PLA / Ca-Cur composite film layer. Through the method, the corrosion resistance, biocompatibility and antibacterial and anti-inflammatory performance of the Ag-DCPD film layer are successfully improved.

The application discloses application of a Chinese medicine pair effective component composition of Astragalus membranaceus and Curcuma zedoary in preparation of anti-tumor metastasis drugs. The composition is composed of calycosin-7-glucoside and curcumin. The composition can effectively inhibit transendothelial invasion and vasculogenic mimicry generation of tumor cells at a non-toxic dose, and has the advantages of high efficiency and low toxicity in treating tumor metastasis. The important point of the application is that the preferred composition can significantly reduce the exosome LAP-TGF-beta1 protein loading level, thereby greatly inhibiting the tumor metastasis process caused by the exosome-mediated TGF-beta signal pathway. The finding provides a new perspective for the development of drugs for targeting exosome LAP-TGF-beta1 protein loading to resist tumor metastasis, and overcomes the defects of unclear effective components, uncontrollable proportioning and unclear treatment effect of traditional Chinese medicine compatibility. Therefore, the Chinese medicine effective component composition has application prospects in preparation of anti-tumor metastasis drugs.

The invention discloses a curcumin-loaded targeted cell membrane derived vesicle delivery system and application thereof, and belongs to the field of biological medicine. The invention relates to a curcumin-loaded targeted cell membrane derived vesicle delivery system, which comprises a cell membrane vesicle; the IETP2 ear-targeted polypeptide is modified on the surface of the cell membrane vesicle; and the curcumin is encapsulated in the cell membrane vesicles. Compared with the prior art, the curcumin has the advantages that the curcumin is systematically illuminated for the first time to improve the mitochondrial function and inhibit oxidative stress and apoptosis to prevent and treat the drug-induced deafness by regulating cAMP / PKA / CREB pathways; the cell membrane derived vesicles modified by the IETP2 polypeptide are used as a targeted delivery system of curcumin, and accumulation of drugs in cochlea is remarkably improved; an animal model verifies that the delivery system has a stronger hearing protection effect and better biological safety compared with free curcumin.

The application provides a kind of bioactive citric acid-based polymer and its preparation method and application, comprising: citric acid is melted under inert gas protection, and hydroxyl-containing bridging agent and hydroxyl-containing natural bioactive small molecule are added, and long-chain water-soluble hydroxyl-containing molecule is added simultaneously, and melt reaction is carried out under vacuum condition, and poly citric acid-octanediol-curcumin-polyethylene glycol polymer is obtained by reaction;Poly citric acid-octanediol-curcumin-polyethylene glycol polymer is purified and freeze-dried to obtain bioactive citric acid-based polymer.The preparation method of the application is simple, convenient to operate, low in cost, and suitable for large-scale production.The experimental results prove that the bioactive citric acid-based polymer prepared by the method has good biocompatibility in vivo and in vitro and good biological effect, can exhibit good antioxidant and anti-inflammatory performance, can eliminate inflammation and can promote tissue repair.

The invention relates to an anti-inflammatory and lipid-lowering-based nano preparation for treating fatty liver and a preparation method of the nano preparation. Galactose modified polyethylene glycol-polylactic acid-glycolic acid copolymer (PEG-PLGA) is used as a targeting carrier, and a lipid-lowering drug fenofibrate and an anti-inflammatory drug curcumin are co-loaded; the particle size of the nano preparation is 150-200nm, and the drug encapsulation efficiency is greater than or equal to 85%. Galactose modified PEG-PLGA is adopted as a carrier, galactose can be specifically combined with an asialoglycoprotein receptor (ASGPR) specifically expressed on the surface of liver cells, active targeting of the liver is achieved, the drug enrichment amount of the liver lesion position is remarkably increased, meanwhile, accumulation of drugs in extrahepatic tissue is reduced, extrahepatic toxicity is effectively reduced, and the drug delivery effect is improved. According to the present invention, the anti-inflammatory drug curcumin and the fenofibrate are combined, such that the biological safety of the preparation is improved, the lipid lowering drug fenofibrate and the anti-inflammatory drug curcumin are innovatively co-loaded, and the fenofibrate and the anti-inflammatory drug curcumin form the synergistic effect system: fenofibrate can activate peroxisome proliferator-activated receptor alpha (PPAR alpha), promote liver lipid catabolism, and reduce lipid deposition;

This invention relates to the field of adhesive technology, specifically to an interface-stabilizing adhesive for silicon anodes and its preparation method. The adhesive comprises curcumin-modified silicon-containing waterborne polyurethane-acrylate, a terpolymer, and a multifunctional monomer, wherein the mass ratio of the curcumin-modified silicon-containing waterborne polyurethane-acrylate, the terpolymer, and the multifunctional monomer is 3-5:1-2:1-1.2. The curcumin-modified silicon-containing waterborne polyurethane-acrylate is synthesized using acrylate and γ-methacryloyloxypropyltrimethoxysilane as modifiers and curcumin as a chain extender via an interpenetrating polymer network method. Through chemical bonding such as grafting and crosslinking, and supramolecular interactions such as hydrogen bonding and coordination, an intelligent network integrating elastic buffering, rigid support, interface passivation, self-healing, and ion conduction is constructed. After cycling, the electrode thickness expansion rate is controlled to <40%, with no macroscopic cracks and high electrode peel strength retention.

An injectable hydrogel for inhibiting osteosarcoma growth and its component preparation method are disclosed. The hydrogel is composed of curcumin nanoparticles, nano-hydroxyapatite, and methacryloxychitosan. This injectable hydrogel for inhibiting osteosarcoma growth combines the antitumor properties of curcumin nanoparticles, the osteogenic ability and good mechanical strength of nano-hydroxyapatite, and the porous structure and injectability of methacryloxychitosan. This injectable hydrogel for inhibiting osteosarcoma growth exhibits a significant killing effect on osteosarcoma cells and simultaneously promotes the proliferation of mouse embryonic pre-osteoblasts. Through its synergistic antitumor and osteogenic dual functions, this hydrogel shows promising application prospects in postoperative treatment of osteosarcoma.