27 results about "Deciduous tooth" patented technology

The utility model discloses an anterior tooth reverse jaw corrector. The anterior tooth reverse jaw corrector comprises an upper jaw base and a lower jaw base, the lossy spiral expansion device is mounted in the middle of the upper jaw base plate; the two sides of the upper jaw base plate are each provided with one jaw pad, and the jaw pads cover upper jaw rear teeth; the two ends of the long arrow snap ring are embedded in the upper jaw base plate, and a sleeving and hanging part in the middle of the long arrow snap ring corresponds to the outer side of the upper jaw base plate; and the adjacent hook ball clamp is provided with a retention hook which is attached and fixed outside the molar and / or the canine. The anterior tooth reverse jaw corrector provided by the utility model is suitable for various stages such as deciduous teeth, mixed dentition, initial constant dentition and the like, solves the problem that the conventional corrector comprising the hyperbolic reed is easy to break, is high in safety performance, and can effectively correct the anterior tooth reverse jaw condition of various age stages.

The application discloses a kind of based on photosensitive bioceramics deciduous tooth additive manufacturing forming process, it is related to ceramic deciduous tooth manufacturing technical field, comprising the following steps: using oral scanner to collect children's dental three-dimensional data, generate deciduous tooth restoration three-dimensional data model and export STL format deciduous tooth repair model;Using photosensitive liquid bioceramic composite material, through DLP photocuring 3D printing into initial blank, again through blue light three-stage resolidification and get blank body.In the process, the morphological characteristics of adjacent healthy deciduous teeth can be accurately extracted, and the crown height correction coefficient is automatically matched according to the age of the child, effectively compensating for the size deviation of the unerupted deciduous teeth, ensuring that the size error of the restoration is small, adjusting the occlusal surface morphology of the restoration according to the actual data of the teeth at the same time, making the occlusal contact area ratio higher, and reserving occlusal buffer space to avoid excessive local stress, significantly improving the mastication comfort and durability of the restoration.

The invention aims to provide a biodegradable deciduous tooth repairing post-core material and a preparation method thereof. Deciduous tooth caries (Deciduous tooth decay) and residual roots and crowns of deciduous teeth caused by trauma of the deciduous teeth are clinically common symptoms. A clinically common permanent tooth root pipe pile core system affects replacement of deciduous permanent teeth due to non-absorbability and cannot meet the performance requirement for repairing residual roots and crowns of the deciduous teeth. The time limit and performance requirements of clinical application are fully considered. The polylactic acid is subjected to toughening modification by a block polymerization method, so that the toughness and strength of the polylactic acid are improved, and the elasticity modulus of the polylactic acid and the elasticity modulus of deciduous teeth are within the same quantity range. According to the invention, tooth growth-promoting raw materials such as hydroxyapatite are synthesized into the post-core material, so that the post-core material has an obvious effect in the aspects of anti-caries repair. Experiments prove that the product provided by the invention has good biocompatibility, and is degradable and absorbable.

To provide safe and high-performance stem cells appropriate for clinical application, and a method for producing the stem cells.SOLUTION: Provided are a stem cell population derived from human deciduous tooth dental pulp, wherein 90% or more of the stem cell population is characterized by being CD117-negative, CD73-positive, CD90-positive, and CD105-positive, and a method for producing a stem cell population derived from human deciduous tooth dental pulp, the method comprising a step of culturing cells isolated from human deciduous tooth dental pulp in a medium that does not contain FBS (fetal bovine serum) in the presence of human platelet lysate (hPL).SELECTED DRAWING: None

The utility model relates to a deciduous tooth orthodontic self-locking orthodontic appliance, which relates to the technical field of medical instruments and equipment, and comprises an orthodontic appliance main body, the middle of the main body is provided with a transverse through arch wire groove, the notch side is provided with a locking plate in sliding connection with the main body, and the locking plate can slide along the surface of the main body to open or close the arch wire groove. The surface of the main body is a smooth curved surface and is provided with a limiting groove. And through the design of a sliding groove, a clamping groove, a guide part, an elastic steel needle and a guide groove, the stability and operation convenience of the locking plate are ensured. In addition, the corrector is further provided with a shifting groove, a bottom plate, a net bottom and a special geometrical shape design, so that the wearing comfort and the correction effect are improved. The purposes of simplifying the operation process and improving the comfort level and the correction effect of the patient are achieved.

The present invention relates to methods of production, isolation and application of extracellular vesicles (EV)s derived from stem cells from human exfoliated deciduous teeth. The invention also relates to the use of said EVs in therapy, such as in the treatment of Parkinson's disease.

The utility model relates to the technical field of deciduous tooth root canal treatment, in particular to a flushing auxiliary instrument for deciduous tooth root canal treatment, which comprises an injection needle body, a cylinder is arranged at the mounting end of the injection needle body, external threads are arranged on the outer surface of the cylinder, and a plug is arranged in the cylinder. The interior of the plug is of a hollow structure and is installed on the inner wall of the injection needle body in a communicated mode, the injection end of the injection needle body is arranged to be an oval pointed end, a plurality of flushing holes are evenly formed in the outer side wall of the oval pointed end, and the installation end of the injection needle body is installed on an externally-connected injector body. According to the utility model, the resistance mood of children can be avoided, a threaded retention syringe or a pluggable retention syringe can be selected according to clinical practice, and meanwhile, the bending angle of the syringe needle body can be adjusted according to different orientations of the root canals of the deciduous molar teeth for pre-bending, so that the flushing efficiency of the root canals in different orientations under non-direct vision is improved.

This invention proposes a method for preparing dental pulp stem cell exosomes and their applications, belonging to the field of exosome technology. Dental pulp stem cells from exfoliated deciduous teeth are seeded into serum-free α-MEM medium containing microparticles, insulin-like growth factor, transforming growth factor-β1, penicillin, and streptomycin for culture. Exosomes are isolated, dispersed in PBS solution, and incubated with microparticles, propylene glycol, and rhodioloside to obtain highly active dental pulp stem cell exosomes. The surface of these exosomes is then modified with shikonin and interferon to obtain dental pulp stem cell exosomes. The dental pulp stem cell exosomes prepared by this invention exhibit good affinity for titanium implant-mediated osteointegration repair materials, demonstrating good anti-inflammatory, immunomodulatory, osteogenic, and damage-reducing effects. Furthermore, the preparation method is simple, yields high output, and operates under mild conditions, showing broad application prospects.

The invention provides a dental pulp stem cell exosome as well as a preparation method and application thereof, and belongs to the technical field of exosomes. The method comprises the following steps: inoculating exfoliated deciduous tooth pulp stem cells into a serum-free alpha-MEM culture medium containing microparticles, insulin-like growth factors, transforming growth factor-beta1, penicillin and streptomycin for culturing, separating exosomes, dispersing the exosomes into a PBS solution, adding microparticles, propylene glycol and salidroside for incubation, and separating to obtain the high-activity pulp stem cell exosomes. And performing surface modification on alkannic acid and interferon to prepare the dental pulp stem cell exosome. The dental pulp stem cell exosome prepared by the invention has relatively good affinity to a titanium implant material mediated osseointegration repair material, has relatively good advantages of resisting inflammation, regulating immunity, promoting osteogenesis, reducing injury and the like, is simple in preparation method, relatively high in yield and mild in condition, and has a wide application prospect.

1. The name of the design product: mandibular deciduous teeth forceps (parrot type). 2. The use of the design product: used for children deciduous teeth forceps. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses an invisible dental arch expansion appliance and a preparation method thereof, and solves the technical problem that the opening effect of a palate center joint is poor when an upper jaw dental arch is expanded in the prior art. The appliance comprises a tractor, a left tooth socket and a right tooth socket, the left tooth socket is provided with a left jaw pad and a left traction hook, and the right tooth socket is provided with a right jaw pad and a right traction hook; an expansion driving mechanism is arranged between the left and right tooth sockets. The preparation method comprises the following steps: preparing a patient dental cast, and positioning the spiral dilator, the jaw pad and the traction hook on the dental cast; manufacturing a retention base plate covering the whole dental cast by using a dental high-molecular transparent material in a hot press molding manner; the denture is taken down, the denture tissue surface is filled with bonding resin, and the spiral expander fixing arm area is filled with bonding resin, so that the spiral expansion period fixing arm and the denture are fully bonded and fixed; and the retention base is cut into a left part and a right part along the front-back middle line of the dilator. According to the invention, the problems of dental arch stenosis and irregular dentition of moderate and severe dental arch crowding patients and the problems of insufficient maxillary development and excessive mandibular development of deciduous teeth and tooth replacement periods can be effectively solved.

The invention discloses a deciduous tooth pulp mesenchymal stem cell population, a separation and extraction method and a proliferation potential identification method. According to the separation method, SHED is efficiently separated from dental pulp tissues of deciduous teeth through an optimized mixed enzyme digestion method (3 mg / mL of neutral protease and 4 mg / mL of II type collagenase), and the separation success rate reaches 76% or above. According to the identification method, a proliferation-function-aging three-in-one evaluation system is constructed, and the method comprises the following steps: quantitatively evaluating proliferation potential through a clone formation rate (greater than or equal to 10%), an S-phase cell proportion (greater than or equal to 20%) and a Ki-67 positive rate (greater than or equal to 60%); the migration and paracrine capabilities are evaluated through a scratch experiment (the healing rate in 24 hours is greater than or equal to 35%) and a conditioned medium function experiment; the aging trend is evaluated through SA-beta-gal staining (the positive rate is lt; 10%). The quantitative standard of the high-quality SHED is defined for the first time, and reliable technical support is provided for quality control and standardized application of the high-quality SHED in regenerative medicine.

The embodiment of the present disclosure provides an acquisition method of a dental retainer, and relates to the technical field of retainer manufacturing, and comprises the following steps: generating a digital three-dimensional model of a patient's dental arch, and identifying individual characteristics such as maxillary or protruding teeth, presence of deciduous teeth or conical teeth, and occlusal contact points, and the edge height and / or occlusal area thickness of the retainer three-dimensional digital model can be correspondingly personalized adjusted, so as to be 3D printed to obtain a dental retainer. Since the whole process is digitalized, a plaster model is not needed, thereby eliminating the step of trimming and grinding. Since dust pollution is completely eliminated, the manufacturing time is shortened, and the breakage and rework caused by excessive cutting are avoided, and the retainer matched with different needs of patients can be manufactured more efficiently.

The invention provides a dual-channel high-power femtosecond laser deciduous tooth selective ablation system, and relates to the field of solid ultrafast laser. Comprising a laser transmitter, a power output unit and an optical fiber clamp, the power output unit comprises a primary output module and a secondary output module, and the primary output module and the secondary output module are respectively connected with the optical fiber clamp. Through the dual-wavelength laser output system, 1 [mu] m near-infrared femtosecond laser and 6.1 [mu] m and 9.5 [mu] m intermediate-infrared tunable femtosecond laser can be output at the same time, meanwhile, a groove is further formed in the optical fiber clamp, reagents such as a decayed tooth display agent can be stored, the needed reagents can be directly and synchronously injected to a target part, and more convenient and accurate ablation experience is achieved.

A cell activator comprising an isolated component isolated from a culture supernatant of deciduous tooth pulp stem cells, where the isolated component does not contain less than 3.5 kDa.

The utility model relates to a deciduous tooth fatigue strength testing device which comprises a machine table, a mounting frame, a driving assembly, an adapter, a pressure sensor, a stamping head and a clamping table assembly, the clamping table assembly comprises a fixed base, a middle plate, a clamping piece and an adjusting screw rod, and the clamping piece and the middle plate are combined to form a clamping groove corresponding to the stamping head; the utility model mainly aims at placing a deciduous tooth sample on the middle plate when the deciduous tooth sample is installed, rotating the adjusting screw rod to enable the two groups of clamping pieces to move oppositely until the deciduous tooth sample is clamped in the clamping groove, and arranging the punching head right above the clamping groove, so that the deciduous tooth sample is centered after being clamped, the steps of installing the deciduous tooth sample are simplified, and the installation efficiency is improved. The test efficiency is improved.

The invention provides a separation and preparation method of dental pulp stem cells. The method comprises the following steps: using dental stem cells (DSC) separated from dental pulp tissues of human permanent teeth or deciduous teeth; obtaining a single-cell suspension through a double-enzyme digestion method; washing the single-cell suspension and the phosphoric acid buffer salt solution with the same volume for three times; carrying out adherent culture on the undigested tissues; culturing in an improved MEM culture medium (MEM-alpha) supplemented with fetal calf serum (FBS) with the volume fraction of 20%, penicillin with the volume fraction of 100 g / ml and streptomycin with the volume fraction of 100 g / ml in an incubator at the temperature of 37 DEG C under the condition of 5% CO2; according to the double-enzyme digestion method, the culture medium is replaced every two days; the culture medium is replaced once every 4-5 days by the tissue adherence method; after 90% confluence is achieved, performing trypsin digestion to harvest adherent cells; under the condition, the content of CD117 positive cells exceeds 96.67%. The dental pulp stem cells obtained by the method do not induce premature differentiation of cells, the cell proliferation speed is greatly increased, more sufficient nutrition is provided for the cells, synthesis of protein is promoted, proliferation of the cells is promoted, and differentiation of the cells is inhibited; the separation speed and the separation effect are improved, and the operation difficulty is also reduced. By utilizing the method disclosed by the invention, a rapid and stable separation method and an efficient amplification system can be established, and the method has a very wide clinical application prospect in the fields of life science and medicine. Along with continuous development of research, hDPSCs can play a greater role in the medical field.

The invention provides a preparation method of an oral three-dimensional occlusion induction type high-angle bone face type appliance, which comprises the following steps: acquiring upper and lower jaw dentition digital models of a child patient, constructing upper and lower jaw tooth digital models of the child patient after occlusion reconstruction of the upper and lower jaws, and then designing a back tooth occlusion relation and a maximum occlusion contact mode after occlusion reconstruction, a design scheme of the invisible tooth socket containing the gap part is obtained, and a design scheme of the flexible filler is constructed. The invisible tooth socket containing the gap part prepared according to the design scheme can be independently used and can also be matched with flexible filler for use. The orthodontic appliance can solve the technical problem that the existing orthodontic appliance is difficult to simultaneously and effectively control the perpendicularity and inclination of front and rear teeth, adjust occlusion induction and tooth uniformity and adjust the inclination of an occlusion plane during deciduous tooth shedding and permanent tooth eruption of a child patient.

The invention discloses a deciduous tooth additive manufacturing forming process based on photosensitive biological ceramics, and relates to the technical field of ceramic deciduous tooth manufacturing, and the process comprises the following steps: collecting dental three-dimensional data of a child patient by adopting an oral cavity scanner, generating a deciduous tooth restoration three-dimensional data model, and exporting an STL format deciduous tooth restoration model; a photosensitive liquid biological ceramic composite material is subjected to DLP photocuring 3D printing to form an initial blank, and then a blank body is obtained through blue light three-stage recuring. According to the process, the morphological characteristics of adjacent healthy deciduous teeth can be accurately extracted, a dental crown height correction coefficient is automatically matched according to the age of a child patient, the size deviation of incomplete eruption of the deciduous teeth is effectively compensated, the small size error of the prosthesis is ensured, meanwhile, the shape of the occlusal surface of the prosthesis is adjusted according to the actual data of the jaw teeth, and the occlusal contact area is relatively high; and an occlusion buffer space is reserved, so that overlarge local stress is avoided, and the chewing comfort and the durability of the prosthesis are remarkably improved.

According to the deciduous tooth root canal filling paste and the preparation method, iodoform, metronidazole, ZnO and Ca (OH) 2 are adopted as main components, the components have a wide application basis in the field of oral medicine and are high in safety and good in biocompatibility, and it can be ensured that the performance of the paste is stable and reliable by accurately controlling the proportion of all the components; iodoform and metronidazole are used as main components of the paste, have a remarkable antibacterial effect and can effectively kill bacteria in root canals, reduce infection risks and create a sterile environment for healing of periapical tissues, and due to the antibacterial effect, the success rate of root canal treatment is increased, the treatment cycle is shortened, and the treatment cost is reduced. The number of times of re-consultation and pain of the patient are reduced; znO and Ca (OH) 2 have excellent biocompatibility and cannot stimulate or damage periapical tissues, so that the safety of a treatment process and the comfort of a patient are guaranteed, and meanwhile, the components can also promote regeneration and repair of the periapical tissues.

The present invention relates to a pacifier, by means of which it is possible to detect whether a user has generated a negative pressure in the oral cavity necessary to maintain the tongue in contact with the maxilla, thereby stimulating the expansion of the maxilla to guide the normal growth of associated structures in the face and the mouth-nose respiratory system. Further, the pacifier serves as a guide for initiating the eruption of deciduous teeth exposed from the gums, where the pacifier is thus adapted to companion with users in different growth stages.

The embodiment of the invention provides a method for acquiring a tooth retainer, which relates to the technical field of retainer manufacturing and comprises the following steps: generating a digital three-dimensional model of a tooth jaw of a patient, and identifying individual characteristics such as an upper jaw or tooth protrusion condition, a deciduous tooth or conical tooth existence condition and an occlusion contact point according to the digital three-dimensional model; and the edge height and / or the occlusal area thickness of the three-dimensional digital model of the retainer can be correspondingly and individually adjusted, so that 3D printing forming is facilitated, and the tooth retainer is obtained. Due to the fact that the whole process is digitized, a plaster model is not needed, the step of adjusting and grinding is omitted, dust pollution is thoroughly eliminated, the manufacturing time is shortened, breakage and reworking caused by excessive cutting are avoided, and the matched retainers can be manufactured with higher efficiency for patients with different requirements.

The invention discloses a deciduous tooth preformed crown with a resin ceramic structure, the deciduous tooth preformed crown comprises a crown circumference and a crown top, an elastic sealing film is arranged on the inner wall of the crown circumference, at least two accommodating cavities are formed between the elastic sealing film and the crown top, sodium bicarbonate powder and an acid solution are respectively stored in the accommodating cavities, the crown top is provided with a removable first magnetic body, and the elastic sealing film is provided with a second magnetic body which is used for being attracted with the first magnetic body to keep the containing cavity closed before teeth are installed. When the deciduous tooth preformed crown with the resin ceramic structure falls off, the elastic sealing film is blown to be large like blowing a balloon, so that the originally small deciduous tooth preformed crown which is easy to swallow by mistake is rapidly enlarged to form a foreign matter with one side in a balloon shape, and therefore, the deciduous tooth preformed crown is effectively prevented from being swallow by mistake.

The utility model discloses a combined orthodontic appliance which comprises an orthodontic appliance main body and a chain-shaped leather collar, the orthodontic appliance main body comprises a metal belt ring I, a metal belt ring II, a metal belt ring III and a lateral positioning assembly for connecting the metal belt ring I, the metal belt ring II and the metal belt ring III in series. In the application, the tail end of the chain-shaped leather collar is wound on the binding ring, the tail end of the chain-shaped leather collar is fixed by matching with the metal belt ring III, the chain-shaped leather collar covers the outer sides of the first permanent tooth, the second permanent tooth and the deciduous tooth, and the lateral limiting of the chain-shaped leather collar is realized through the two groups of side rings; at the moment, traction force towards the cheek side is applied to the first permanent molar through the elastic force of the chain-shaped leather ring, so that teeth are corrected, meanwhile, the corrector is subjected to bonding operation by a doctor and does not need to be taken off and worn by a child patient at home, operation of the child patient and parents is reduced, treatment convenience is improved, the corrector is smooth, the jaw pad is lifted and occluded uniformly, and the treatment effect is good. Compared with a bracket and the like, the comfort is improved, and the child patient acceptability is high.

This application discloses a method, apparatus, device, medium, and product for detecting dental defects in children, relating to the field of image processing technology. The method includes preprocessing an acquired panoramic radiograph of a child to be detected to obtain a standard image of a child's teeth; extracting local and global feature vectors from the standard image of the child's teeth, and then weighted and fused the extracted local and global feature vectors to obtain a fused feature image of the teeth; extracting geometric anchor points and calibrating the coordinates of each tooth region based on the fused feature image of the teeth to obtain the positional information of each tooth; matching the defect type of a single tooth region according to the fused feature image of the teeth and the positional information of each tooth to obtain a defect identification result; and generating a detection result based on the defect identification result and the positional information of each tooth. This application improves the detection accuracy and positioning precision of permanent and deciduous teeth in children on panoramic radiographs, avoiding missed detection of small teeth.

To provide a composition having a hair-growing effect, a gray hair-improving effect and a wrinkle-improving effect, and to provide a method for producing the composition.SOLUTION: The composition having hair-growing effect, gray hair-improving effect and wrinkle-improving effect comprises a culture supernatant obtained by culturing human deciduous tooth dental pulp stem cells in a serum-free medium under ultrasonic stimulation and a culture supernatant obtained by culturing dermal papilla cells in a serum-free medium under ultrasonic stimulation. A method for producing a composition having a hair growth effect, a gray hair improving effect, and a wrinkle improving effect, comprising a culture supernatant obtained by culturing deciduous tooth dental pulp stem cells in a serum-free medium under ultrasonic irradiation, and a culture supernatant obtained by culturing dermal papilla cells in a serum-free medium under ultrasonic irradiation.SELECTED DRAWING: Figure 13

The invention discloses a biological ceramic additive manufacturing forming process for deciduous teeth, and relates to the technical field of ceramic deciduous tooth manufacturing. The green body with the supporting structure removed is put into a degreasing furnace, segmented heating is conducted in the degreasing furnace to degrease the green body, inert gas is introduced for protection in the whole degreasing process, the inert gas is controlled to circulate, waste gas generated by degreasing is subjected to impurity recovery through a gas purification assembly, and the degreased green body is subjected to high-temperature sintering; performing surface treatment on the deciduous tooth ceramic piece; a gas circulation mechanism and a gas purification assembly are adopted to purify organic waste gas generated by degreasing, the gas circulation mechanism returns to a degreasing furnace for recycling, and temperature fluctuation in the furnace is controlled through controllable airflow disturbance to ensure that the heating rate and the binder decomposition rate of each area of a green body are consistent; decomposition products on the surface and in the green body are taken away, and the forming quality of the deciduous tooth biological ceramic is guaranteed.