39 results about "Deciduous tooth" patented technology

The invention discloses a three-dimensional clinical research method of deciduous tooth anchorage on maxilla hypoplasia under the guidance of an HPC line. According to the invention, the deciduous tooth anchorage technology guided by the HPC line breaks through the limitation of the traditional tooth support type and bone support type correction, and creates a third anchorage selection mode for osteomalocclusion. By accurately positioning the central axis of the deciduous tooth crown as a supporting point, the technology not only retains the effectiveness of the traditional method on the transverse expansion of the maxilla, but also remarkably reduces the side effects of mesial inclination, vertical lifting and the like of the permanent tooth, and realizes the dual purposes of bony reconstruction and dentition stabilization. The innovativeness is that the physiological characteristics of deciduous teeth are combined with the biomechanical principle, the technical scheme is provided for the first time in China, the blank of correction of complex malocclusion in mixed dentition is filled, and a safer and more efficient treatment path is provided for clinic.

The invention discloses an anti-neurodegeneration exosome composition as well as a preparation method and application thereof. The anti-neurodegeneration exosome composition is prepared from the following components in parts by mass: 5 to 25 parts of human exfoliated deciduous tooth stem cell exosome, 25 to 85 parts of plant-derived exosome-like nano-vesicles, 12 to 10 parts of ginsenoside Rg, 2 to 10 parts of curcumin and 10 to 20 parts of auxiliary materials. The anti-neurodegeneration exosome composition contains a large amount of cell factors, growth factors, miRNA, mRNAs and other components, is easy to fuse with cell membranes of intestinal epithelial cells, can selectively deliver bioactive substances to recipient cells through a blood-brain barrier, carries out information transmission among different cells, regulates signal transduction among the cells, and has a good anti-neurodegeneration effect. The effects of resisting oxidation, resisting inflammation, resisting aging and the like are achieved.

The invention relates to the technical field of oral cavity image recognition, and discloses a mixed tooth position recognition method of a local oral cavity image, a storage medium and a device. The method comprises the following steps: collecting local images of a clinical oral cavity, numbering tooth positions and manually marking category information to form an original data set; replacing tooth position numbers of deciduous teeth in the original data set with permanent tooth numbers corresponding to the same positions, and deleting category information to form a tooth position labeling data set; deleting tooth position numbers in the original data set, and numeralizing category information to form a classification annotation data set; training a tooth position recognition model through the tooth position labeling data set; training a classification identification model through the classification annotation data set; and obtaining a to-be-recognized oral cavity image, recognizing the tooth position numbers of the teeth in the oral cavity image through the tooth position recognition model, and recognizing the types of the teeth in the oral cavity image through the classification recognition model. The method can improve the stability and accuracy of identifying the tooth position from the local oral cavity image.

The utility model discloses a portable deciduous tooth breaking device which comprises a first holding rod and a second holding rod, one end of the first holding rod is hinged to one end of the second holding rod, an extrusion head is arranged on the first holding rod, and a groove used for containing deciduous teeth is formed in the second holding rod. When the first holding rod and the second holding rod are close to each other, the extrusion head is in clearance fit with the groove; according to the scheme, the first holding rod and the second holding rod are close to each other by holding the two holding parts with a hand, so that the extrusion head crushes the deciduous teeth placed in the grooves, and the dental pulp mesenchymal stem cells in the deciduous teeth are conveniently extracted; the protruding length of the extrusion head can be adjusted, so that the distance between the front end of the extrusion head and the bottom of the groove is adjusted when the first holding rod and the second holding rod get close to each other, deciduous teeth of different sizes can be matched, and the situation that the deciduous teeth and dental pulp are crushed together due to the too small distance, and consequently the dental pulp is difficult to extract is avoided.

The utility model provides a sliding type gap retainer which comprises a left resin base, a right resin base, a left retainer with one end embedded in the left resin base and a right retainer with one end embedded in the right resin base, and artificial teeth suitable for being matched with lacked deciduous tooth gap parts are connected to the left resin base or / and the right resin base. A sliding accessory is connected to the ends, located on the anterior tooth tongue side, of the left and right resin bases, the sliding accessory comprises a left sliding block embedded in the left resin base and a right sliding block embedded in the right resin base, left and right sliding holes which are transversely through and opposite are formed in the left and right sliding blocks respectively, and sliding rods with two bent ends are slidably connected into the left and right sliding holes; grooves communicated with the sliding holes are transversely formed in the ends, away from each other, of the left and right sliding blocks, and the two bent ends of the sliding rod slide in the left and right grooves in a matched mode. The left sliding block and the right sliding block in the sliding type gap retainer can slide freely in the transverse direction of the sliding rod, and growth of the transverse width of the lower jaw dentition, the alveolar bone and the jaw bone of a child cannot be limited.

The utility model discloses an anterior tooth reverse jaw corrector. The anterior tooth reverse jaw corrector comprises an upper jaw base and a lower jaw base, the lossy spiral expansion device is mounted in the middle of the upper jaw base plate; the two sides of the upper jaw base plate are each provided with one jaw pad, and the jaw pads cover upper jaw rear teeth; the two ends of the long arrow snap ring are embedded in the upper jaw base plate, and a sleeving and hanging part in the middle of the long arrow snap ring corresponds to the outer side of the upper jaw base plate; and the adjacent hook ball clamp is provided with a retention hook which is attached and fixed outside the molar and / or the canine. The anterior tooth reverse jaw corrector provided by the utility model is suitable for various stages such as deciduous teeth, mixed dentition, initial constant dentition and the like, solves the problem that the conventional corrector comprising the hyperbolic reed is easy to break, is high in safety performance, and can effectively correct the anterior tooth reverse jaw condition of various age stages.

The application discloses a kind of based on photosensitive bioceramics deciduous tooth additive manufacturing forming process, it is related to ceramic deciduous tooth manufacturing technical field, comprising the following steps: using oral scanner to collect children's dental three-dimensional data, generate deciduous tooth restoration three-dimensional data model and export STL format deciduous tooth repair model;Using photosensitive liquid bioceramic composite material, through DLP photocuring 3D printing into initial blank, again through blue light three-stage resolidification and get blank body.In the process, the morphological characteristics of adjacent healthy deciduous teeth can be accurately extracted, and the crown height correction coefficient is automatically matched according to the age of the child, effectively compensating for the size deviation of the unerupted deciduous teeth, ensuring that the size error of the restoration is small, adjusting the occlusal surface morphology of the restoration according to the actual data of the teeth at the same time, making the occlusal contact area ratio higher, and reserving occlusal buffer space to avoid excessive local stress, significantly improving the mastication comfort and durability of the restoration.

The invention aims to provide a biodegradable deciduous tooth repairing post-core material and a preparation method thereof. Deciduous tooth caries (Deciduous tooth decay) and residual roots and crowns of deciduous teeth caused by trauma of the deciduous teeth are clinically common symptoms. A clinically common permanent tooth root pipe pile core system affects replacement of deciduous permanent teeth due to non-absorbability and cannot meet the performance requirement for repairing residual roots and crowns of the deciduous teeth. The time limit and performance requirements of clinical application are fully considered. The polylactic acid is subjected to toughening modification by a block polymerization method, so that the toughness and strength of the polylactic acid are improved, and the elasticity modulus of the polylactic acid and the elasticity modulus of deciduous teeth are within the same quantity range. According to the invention, tooth growth-promoting raw materials such as hydroxyapatite are synthesized into the post-core material, so that the post-core material has an obvious effect in the aspects of anti-caries repair. Experiments prove that the product provided by the invention has good biocompatibility, and is degradable and absorbable.

To provide safe and high-performance stem cells appropriate for clinical application, and a method for producing the stem cells.SOLUTION: Provided are a stem cell population derived from human deciduous tooth dental pulp, wherein 90% or more of the stem cell population is characterized by being CD117-negative, CD73-positive, CD90-positive, and CD105-positive, and a method for producing a stem cell population derived from human deciduous tooth dental pulp, the method comprising a step of culturing cells isolated from human deciduous tooth dental pulp in a medium that does not contain FBS (fetal bovine serum) in the presence of human platelet lysate (hPL).SELECTED DRAWING: None

The utility model relates to a deciduous tooth orthodontic self-locking orthodontic appliance, which relates to the technical field of medical instruments and equipment, and comprises an orthodontic appliance main body, the middle of the main body is provided with a transverse through arch wire groove, the notch side is provided with a locking plate in sliding connection with the main body, and the locking plate can slide along the surface of the main body to open or close the arch wire groove. The surface of the main body is a smooth curved surface and is provided with a limiting groove. And through the design of a sliding groove, a clamping groove, a guide part, an elastic steel needle and a guide groove, the stability and operation convenience of the locking plate are ensured. In addition, the corrector is further provided with a shifting groove, a bottom plate, a net bottom and a special geometrical shape design, so that the wearing comfort and the correction effect are improved. The purposes of simplifying the operation process and improving the comfort level and the correction effect of the patient are achieved.

The present invention relates to methods of production, isolation and application of extracellular vesicles (EV)s derived from stem cells from human exfoliated deciduous teeth. The invention also relates to the use of said EVs in therapy, such as in the treatment of Parkinson's disease.

The utility model relates to the technical field of deciduous tooth root canal treatment, in particular to a flushing auxiliary instrument for deciduous tooth root canal treatment, which comprises an injection needle body, a cylinder is arranged at the mounting end of the injection needle body, external threads are arranged on the outer surface of the cylinder, and a plug is arranged in the cylinder. The interior of the plug is of a hollow structure and is installed on the inner wall of the injection needle body in a communicated mode, the injection end of the injection needle body is arranged to be an oval pointed end, a plurality of flushing holes are evenly formed in the outer side wall of the oval pointed end, and the installation end of the injection needle body is installed on an externally-connected injector body. According to the utility model, the resistance mood of children can be avoided, a threaded retention syringe or a pluggable retention syringe can be selected according to clinical practice, and meanwhile, the bending angle of the syringe needle body can be adjusted according to different orientations of the root canals of the deciduous molar teeth for pre-bending, so that the flushing efficiency of the root canals in different orientations under non-direct vision is improved.

1. The name of this design product: box. 2. Purpose of this design product: used to store and preserve fallen deciduous teeth. 3. The key point of the design of this product lies in the three-dimensional image. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

This invention proposes a method for preparing dental pulp stem cell exosomes and their applications, belonging to the field of exosome technology. Dental pulp stem cells from exfoliated deciduous teeth are seeded into serum-free α-MEM medium containing microparticles, insulin-like growth factor, transforming growth factor-β1, penicillin, and streptomycin for culture. Exosomes are isolated, dispersed in PBS solution, and incubated with microparticles, propylene glycol, and rhodioloside to obtain highly active dental pulp stem cell exosomes. The surface of these exosomes is then modified with shikonin and interferon to obtain dental pulp stem cell exosomes. The dental pulp stem cell exosomes prepared by this invention exhibit good affinity for titanium implant-mediated osteointegration repair materials, demonstrating good anti-inflammatory, immunomodulatory, osteogenic, and damage-reducing effects. Furthermore, the preparation method is simple, yields high output, and operates under mild conditions, showing broad application prospects.

The invention provides a dental pulp stem cell exosome as well as a preparation method and application thereof, and belongs to the technical field of exosomes. The method comprises the following steps: inoculating exfoliated deciduous tooth pulp stem cells into a serum-free alpha-MEM culture medium containing microparticles, insulin-like growth factors, transforming growth factor-beta1, penicillin and streptomycin for culturing, separating exosomes, dispersing the exosomes into a PBS solution, adding microparticles, propylene glycol and salidroside for incubation, and separating to obtain the high-activity pulp stem cell exosomes. And performing surface modification on alkannic acid and interferon to prepare the dental pulp stem cell exosome. The dental pulp stem cell exosome prepared by the invention has relatively good affinity to a titanium implant material mediated osseointegration repair material, has relatively good advantages of resisting inflammation, regulating immunity, promoting osteogenesis, reducing injury and the like, is simple in preparation method, relatively high in yield and mild in condition, and has a wide application prospect.

The present invention discloses a method for preparing dental pulp stem cells, comprising the following steps: transporting the dental pulp by taking a deciduous tooth and placing it in a sampling bottle, placing the sampling bottle and medical ice pack back into a transport box for transport back to the laboratory; isolating the dental pulp stem cells by clamping the tooth crown with tweezers and then using a syringe to draw physiological saline and blow it into the dental pulp cavity from the root section to loosen the pulp; extracting the dental pulp using a pulp extraction needle; amplifying and culturing the dental pulp stem cells by taking complete culture medium, resuspending the dental pulp pellet, and transferring it to a 12-well plate; fixing the dental pulp with one pulp extraction needle and using the barb on another pulp extraction needle to peel the dental pulp into small fragments, releasing the cells therein, and then culturing them. This preparation method uses a pulp extraction needle to peel the agglomerated dental pulp, releasing the stem cells therein, avoiding damage to the dental pulp stem cells caused by the use of enzymes such as collagenase, eliminating damage to the dental pulp stem cells during the digestion process, and achieving a 100% success rate in dental pulp stem cell extraction. The method is simple and convenient to use.

The invention discloses a locally hollow invisible tooth socket and a preparation method thereof. A locally-hollowed invisible tooth socket comprises a tooth socket base body, and the tooth socket base body comprises an incisors coating part used for being arranged outside incisors in a sleeving mode and a molars coating part used for being arranged outside molars in a sleeving mode; the incisor tooth coating part and the molar tooth coating part are connected through a transition connecting part, and at least one of the occlusal surface, the tongue side and the lip side appearance high point first gum of the transition connecting part is provided with a hollow structure. According to the tooth socket, a traditional semi-closed tooth socket structure is optimized, and the hollow structure is additionally arranged, so that the vertical growth of teeth is not influenced, the falling of deciduous teeth in the later period and the sprouting of permanent teeth are not influenced, and the tooth socket is suitable for 7-9-year-old patients with deciduous tooth and permanent tooth alternation early correction.

1. The name of the design product: mandibular deciduous teeth forceps (parrot type). 2. The use of the design product: used for children deciduous teeth forceps. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses an invisible dental arch expansion appliance and a preparation method thereof, and solves the technical problem that the opening effect of a palate center joint is poor when an upper jaw dental arch is expanded in the prior art. The appliance comprises a tractor, a left tooth socket and a right tooth socket, the left tooth socket is provided with a left jaw pad and a left traction hook, and the right tooth socket is provided with a right jaw pad and a right traction hook; an expansion driving mechanism is arranged between the left and right tooth sockets. The preparation method comprises the following steps: preparing a patient dental cast, and positioning the spiral dilator, the jaw pad and the traction hook on the dental cast; manufacturing a retention base plate covering the whole dental cast by using a dental high-molecular transparent material in a hot press molding manner; the denture is taken down, the denture tissue surface is filled with bonding resin, and the spiral expander fixing arm area is filled with bonding resin, so that the spiral expansion period fixing arm and the denture are fully bonded and fixed; and the retention base is cut into a left part and a right part along the front-back middle line of the dilator. According to the invention, the problems of dental arch stenosis and irregular dentition of moderate and severe dental arch crowding patients and the problems of insufficient maxillary development and excessive mandibular development of deciduous teeth and tooth replacement periods can be effectively solved.

The invention discloses a deciduous tooth pulp mesenchymal stem cell population, a separation and extraction method and a proliferation potential identification method. According to the separation method, SHED is efficiently separated from dental pulp tissues of deciduous teeth through an optimized mixed enzyme digestion method (3 mg / mL of neutral protease and 4 mg / mL of II type collagenase), and the separation success rate reaches 76% or above. According to the identification method, a proliferation-function-aging three-in-one evaluation system is constructed, and the method comprises the following steps: quantitatively evaluating proliferation potential through a clone formation rate (greater than or equal to 10%), an S-phase cell proportion (greater than or equal to 20%) and a Ki-67 positive rate (greater than or equal to 60%); the migration and paracrine capabilities are evaluated through a scratch experiment (the healing rate in 24 hours is greater than or equal to 35%) and a conditioned medium function experiment; the aging trend is evaluated through SA-beta-gal staining (the positive rate is lt; 10%). The quantitative standard of the high-quality SHED is defined for the first time, and reliable technical support is provided for quality control and standardized application of the high-quality SHED in regenerative medicine.

The embodiment of the present disclosure provides an acquisition method of a dental retainer, and relates to the technical field of retainer manufacturing, and comprises the following steps: generating a digital three-dimensional model of a patient's dental arch, and identifying individual characteristics such as maxillary or protruding teeth, presence of deciduous teeth or conical teeth, and occlusal contact points, and the edge height and / or occlusal area thickness of the retainer three-dimensional digital model can be correspondingly personalized adjusted, so as to be 3D printed to obtain a dental retainer. Since the whole process is digitalized, a plaster model is not needed, thereby eliminating the step of trimming and grinding. Since dust pollution is completely eliminated, the manufacturing time is shortened, and the breakage and rework caused by excessive cutting are avoided, and the retainer matched with different needs of patients can be manufactured more efficiently.

The invention provides a dual-channel high-power femtosecond laser deciduous tooth selective ablation system, and relates to the field of solid ultrafast laser. Comprising a laser transmitter, a power output unit and an optical fiber clamp, the power output unit comprises a primary output module and a secondary output module, and the primary output module and the secondary output module are respectively connected with the optical fiber clamp. Through the dual-wavelength laser output system, 1 [mu] m near-infrared femtosecond laser and 6.1 [mu] m and 9.5 [mu] m intermediate-infrared tunable femtosecond laser can be output at the same time, meanwhile, a groove is further formed in the optical fiber clamp, reagents such as a decayed tooth display agent can be stored, the needed reagents can be directly and synchronously injected to a target part, and more convenient and accurate ablation experience is achieved.

A cell activator comprising an isolated component isolated from a culture supernatant of deciduous tooth pulp stem cells, where the isolated component does not contain less than 3.5 kDa.

The present invention discloses a mandibular full dentition occlusal splint appliance, which includes an occlusal splint and an orthodontic wire disposed within the occlusal splint. The orthodontic wire includes an intermediate component and two side components; the intermediate component includes an arc-shaped main body and a double-curved labial bow. An interdental groove is provided in the middle of the arc-shaped main body, and the end of the double-curved labial bow is folded back and extends towards the arc-shaped main body; the two side components include a front section, a middle section, and a rear section that are integrally formed; a first arrow clasp is provided between the front section and the middle section, and a second arrow clasp is provided between the middle section and the rear end. Both the first arrow clasp and the second arrow clasp are located outside the teeth. The present invention is applicable to patients in the deciduous tooth stage or the mixed dentition stage. Since the tooth roots are not fully developed and cannot be force-applied, after using the device of the present invention, only the crossbite treatment can be started. It is comfortable to wear, has no obvious foreign body sensation, and can effectively improve and treat crossbite.

The utility model relates to a deciduous tooth fatigue strength testing device which comprises a machine table, a mounting frame, a driving assembly, an adapter, a pressure sensor, a stamping head and a clamping table assembly, the clamping table assembly comprises a fixed base, a middle plate, a clamping piece and an adjusting screw rod, and the clamping piece and the middle plate are combined to form a clamping groove corresponding to the stamping head; the utility model mainly aims at placing a deciduous tooth sample on the middle plate when the deciduous tooth sample is installed, rotating the adjusting screw rod to enable the two groups of clamping pieces to move oppositely until the deciduous tooth sample is clamped in the clamping groove, and arranging the punching head right above the clamping groove, so that the deciduous tooth sample is centered after being clamped, the steps of installing the deciduous tooth sample are simplified, and the installation efficiency is improved. The test efficiency is improved.

1. Name of the design product: Deciduous Tooth and Lanugo Box (Solid Wood Lion). 2. Use of the design product: A box that can independently store deciduous teeth and lanugo on the same product. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view.

The invention provides a separation and preparation method of dental pulp stem cells. The method comprises the following steps: using dental stem cells (DSC) separated from dental pulp tissues of human permanent teeth or deciduous teeth; obtaining a single-cell suspension through a double-enzyme digestion method; washing the single-cell suspension and the phosphoric acid buffer salt solution with the same volume for three times; carrying out adherent culture on the undigested tissues; culturing in an improved MEM culture medium (MEM-alpha) supplemented with fetal calf serum (FBS) with the volume fraction of 20%, penicillin with the volume fraction of 100 g / ml and streptomycin with the volume fraction of 100 g / ml in an incubator at the temperature of 37 DEG C under the condition of 5% CO2; according to the double-enzyme digestion method, the culture medium is replaced every two days; the culture medium is replaced once every 4-5 days by the tissue adherence method; after 90% confluence is achieved, performing trypsin digestion to harvest adherent cells; under the condition, the content of CD117 positive cells exceeds 96.67%. The dental pulp stem cells obtained by the method do not induce premature differentiation of cells, the cell proliferation speed is greatly increased, more sufficient nutrition is provided for the cells, synthesis of protein is promoted, proliferation of the cells is promoted, and differentiation of the cells is inhibited; the separation speed and the separation effect are improved, and the operation difficulty is also reduced. By utilizing the method disclosed by the invention, a rapid and stable separation method and an efficient amplification system can be established, and the method has a very wide clinical application prospect in the fields of life science and medicine. Along with continuous development of research, hDPSCs can play a greater role in the medical field.

The invention discloses application of deciduous tooth pulp stem cell membrane sheet secretions in bone marrow mesenchymal stem cell osteogenic differentiation and promotion of bone tissue regeneration and repair. According to the research, it is clear that the osteoblast-induced deciduous tooth pulp stem cell sheet (SS-E) has the inflammation regulation effect on macrophages, the SS-E promotes bone marrow mesenchymal stem cell osteoblast differentiation by regulating the macrophage inflammation microenvironment, and bone defect regeneration and repair are promoted through the inflammation microenvironment; it is clear that SS-E promotes rat mandible defect repair by inhibiting inflammation. The invention further provides a culture medium for promoting osteogenic differentiation of the mesenchymal stem cells and a preparation method of the culture medium. The milk tooth pulp stem cell membrane secreta concentrated essence can be efficiently utilized, stem cells in the milk tooth period can be possibly stored in advance in the future, the milk tooth pulp stem cell membrane secreta concentrated essence is used for repairing bone defects caused by tumors, trauma and the like, inflammation at the bone defects can be effectively reduced, and regeneration of bone tissue can be promoted.

The invention provides a preparation method of an oral three-dimensional occlusion induction type high-angle bone face type appliance, which comprises the following steps: acquiring upper and lower jaw dentition digital models of a child patient, constructing upper and lower jaw tooth digital models of the child patient after occlusion reconstruction of the upper and lower jaws, and then designing a back tooth occlusion relation and a maximum occlusion contact mode after occlusion reconstruction, a design scheme of the invisible tooth socket containing the gap part is obtained, and a design scheme of the flexible filler is constructed. The invisible tooth socket containing the gap part prepared according to the design scheme can be independently used and can also be matched with flexible filler for use. The orthodontic appliance can solve the technical problem that the existing orthodontic appliance is difficult to simultaneously and effectively control the perpendicularity and inclination of front and rear teeth, adjust occlusion induction and tooth uniformity and adjust the inclination of an occlusion plane during deciduous tooth shedding and permanent tooth eruption of a child patient.

The invention discloses a deciduous tooth additive manufacturing forming process based on photosensitive biological ceramics, and relates to the technical field of ceramic deciduous tooth manufacturing, and the process comprises the following steps: collecting dental three-dimensional data of a child patient by adopting an oral cavity scanner, generating a deciduous tooth restoration three-dimensional data model, and exporting an STL format deciduous tooth restoration model; a photosensitive liquid biological ceramic composite material is subjected to DLP photocuring 3D printing to form an initial blank, and then a blank body is obtained through blue light three-stage recuring. According to the process, the morphological characteristics of adjacent healthy deciduous teeth can be accurately extracted, a dental crown height correction coefficient is automatically matched according to the age of a child patient, the size deviation of incomplete eruption of the deciduous teeth is effectively compensated, the small size error of the prosthesis is ensured, meanwhile, the shape of the occlusal surface of the prosthesis is adjusted according to the actual data of the jaw teeth, and the occlusal contact area is relatively high; and an occlusion buffer space is reserved, so that overlarge local stress is avoided, and the chewing comfort and the durability of the prosthesis are remarkably improved.