The invention discloses a customized earphone based on a 3D (three-dimensional) printing technology and a manufacturing method of the customized earphone. The earphone comprises an earphone shell, a hard sound induction tube, a unit clamping groove, a sounding unit, a sound outlet connection device, a frequency dividing circuit, a seal cover and a wire socket; the earphone shell, the unit clamping groove, the hard sound induction tube and the seal cover are formed by a 3D printer in a printing manner; the frequency dividing circuit is connected with the sounding unit and the wire socket; the sounding unit is arranged in the unit clamping groove; the sounding unit is communicated with the hard sound induction tube through the sound outlet connection device; the seal cover is used for sealing the earphone shell to form the customized earphone. The thickness, internal structure, mechanical characteristics and acoustics characteristics of the customized earphone shell can be precisely controlled, the sound induction tube material can be optimized, the limitation on a soft material can be broken through, the labor and time cost can be greatly reduced, and the yield of the customized earphone can be greatly increased.