BMP microsphere loaded 3D printing porous metal stent and preparation method thereof
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A metal stent, 3D printing technology, applied in the field of biomedical materials, can solve problems such as increasing the pain of patients
Inactive Publication Date: 2015-02-18
吴志宏
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The disadvantage is also obvious, that is, pre-ordered surgery is required first, which increases the pain of the patient
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Embodiment 1
[0051] Example 1 Preparation of titanium alloy-gelatin / HA three-dimensional micro-stent
[0052] Preparation of titanium alloy-gelatin / HA three-dimensional microscaffold:
[0053] 1) Import the CT image into Mimics or CAS 3D image software to obtain a 3D image of the target bone tissue, fill and expand the image with a regular dodecahedral structural unit with a pore column of 300um and a pore diameter of 1500um, and obtain a personalized porous connected 3D image digital model;
[0054] 2) Using EOS M280 metal material 3D printer, using titanium alloy as raw material, printing porous titanium scaffold according to the design model (see figure 1 );
[0055] 3) After dissolving bovine collagen with deionized water, prepare it to a concentration of 1g / ml, then add chitosan microspheres loaded with rhBMP-2 to the collagen solution at 5mg / ml, and then add nano-hydroxylimestone powder Form a concentration of 5-10mg / ml, use EDC / NHS as a cross-linking agent, and mix the above mixt...
Embodiment 2
[0058] The characterization of embodiment 2 three-dimensional micro-stent
[0059] 1. Determination of porosity of three-dimensional micro-scaffolds
[0060]The porosity of the artificial bone scaffold was measured by the modified liquid displacement method. Put absolute ethanol with a volume of V1 in the graduated cylinder, put the three-dimensional artificial bone scaffold material into the graduated cylinder, suck air under negative pressure after Smin, so that the absolute alcohol is completely filled in the gaps of the scaffold material, record the volume at this time as VZ, then take out the material and record the volume of alcohol at this time as Vs. Calculate the porosity of the three-dimensional bionic artificial bone scaffold according to the following formula:
[0061] Porosity=(V1-V3) / (V2-V3)×100%
[0062] 2. Mechanical performance analysis of three-dimensional micro-stents
[0063] The compressive mechanical properties of the scaffold materials were measured ...
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Abstract
The invention relates to the technical field of biomedical materials, and particularly relates to a BMP microsphere loaded 3D printing porous metal stent and a preparation method thereof. According to the invention, a loaded microsphere-containing three-dimensional micro-stent is built in each hole of a 3D printing titanium stent. The problem that in the prior art, because the diameter of a hole is overlarge, cells only can be subjected to climbed growth on the two-dimensional space of the wall of the hole, and difficult to be subjected to three-dimensional hierarchical growth in the whole hole is solved, and by filling the three-dimensional micro-stent with a rhBMP-2 or rhBMP-7 loaded chitosan microsphere, a better growth and differentiation environment is provided for cells, thereby further promoting the combination of bone tissues and the stent. The three-dimensional micro-stent provided by the invention makes the complete healing of numerous patients with bone tissue defect caused by illnesses and accidents and the like possible; the three-dimensional micro-stent can also be used as a novel interbody fusion instrument, and applicable to an interbody fusion surgery, therefore, the three-dimensional micro-stent has an important clinical application value.
Description
technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a three-dimensional micro-stent containing loaded microspheres and a preparation method thereof. Background technique [0002] Due to their excellent mechanical properties and biocompatibility, titanium and its alloys are widely used in the field of clinical bone repair and bone implantation. However, the elastic modulus of dense titanium and its alloys is much higher than that of human bone, which can easily cause a "stress shielding" effect, causing problems such as osteonecrosis, distortion, and implant loosening. Due to their unique pore structure, porous titanium and its alloys have properties matching those of the replaced bone hard tissue, which can effectively weaken or eliminate the stress shielding effect. Therefore, porous titanium and its alloys have broad application prospects and become a current research hotspot. However, the traditional preparation ...
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