52 results about "Receptor molecule" patented technology

The invention discloses a specific cell targeted hybrid nano-delivery carrier and a preparation method and application thereof, and aims to solve the problems of insufficient specificity, off-target risk, low delivery efficiency and the like of an existing drug delivery system. And a bionic hybrid nano delivery platform with a natural targeting function and high drug loading capacity is constructed. The vector retains key receptor molecules and signal markers on a source cell membrane, and can actively identify and target corresponding cells; meanwhile, due to the introduction of the lipidosome, the yield and stability of the material are remarkably improved, and the immune clearance rate is reduced. Experimental results show that the nano-carrier shows good targeting and biocompatibility in various disease models, and has wide clinical application prospects in the aspects of tumor treatment, tissue repair, inflammation control, targeted imaging and the like.

The present disclosure relates to chimeric Tim4 receptors, host cells modified to include chimeric Tim4 receptor molecules, and methods of making and using such receptor molecules and modified cells.

The present disclosure relates to biosensors (10) having a receptor layer (5) and a mediator layer (6), the receptor layer including ethylene receptor molecules. The present disclosure also relates to sensor units (20) comprising one or more biosensors (10) and a controller (11). In some embodiments, one or more sensor units (20) may be in wireless communication with a receiver module or a network gateway.

An organic EL element is an organic EL element (10) provided with a laminate held between a pair of electrodes (3), (4), the laminate having an acceptor layer (1) and a donor layer (2) forming an interface with the acceptor layer (1), the acceptor layer (1) containing an acceptor molecule, the donor layer (2) containing a donor molecule that undergoes triplet-triplet annihilation, the acceptor molecule and the donor molecule satisfying a condition related to a prescribed energy level, and the like.

The application discloses a D type influenza virus isolate D / HY11 and application thereof in a mink infection model, and belongs to the field of biological medicines. The application takes the D type influenza virus isolate D / HY11 of an IDV northeast isolate as a research object, establishes a mink transmission model, evaluates the transmission dynamics characteristics of the strain among minks, identifies amino acid mutations possibly related to host adaptability through whole genome sequencing, analyzes the amino acid substitution on receptor affinity based on computer simulation of protein conformation and receptor molecule docking, explores the host adaptation evolution law of the virus in the transmission process, and provides an important scientific basis for early warning and prevention and control of a public health crisis possibly caused by the IDV.

The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

This invention discloses a circularly polarized room-temperature phosphorescent organic cocrystal, its preparation method, and its applications. The organic cocrystal is formed by the self-assembly of chiral donor and acceptor molecules. The chiral donor molecule is S / R-1-(1-naphthyl)ethanol, and the acceptor molecule is 1,2,4,5-benzenetetracarbonyl nitrile. The levorotatory or dextrorotatory chiral donor and acceptor molecules are dissolved in a good solvent, then a poor solvent is added. The mixture is sonicated until completely dissolved and allowed to stand until the solvent completely evaporates, yielding the organic cocrystal. Both the levorotatory and dextrorotatory chiral cocrystals exhibit green phosphorescence emission upon excitation. The lifetime of the levorotatory chiral cocrystal is 24.91 ms, and that of the dextrorotatory chiral cocrystal is 28.48 ms. The cocrystals exhibit excellent circularly polarized room-temperature phosphorescence performance, with the levorotatory chiral cocrystal achieving a phosphorescence efficiency of 22.43% per g. lum | is 0.03. The phosphorescence efficiency of the dextrorotatory chiral eutectic is 30.97%, | g lum | is 0.065.

The invention provides a polymerizable cross-linked micromolecular non-fullerene receptor and a preparation method thereof, and relates to the technical field of organic solar cells, the polymerizable cross-linked micromolecular non-fullerene receptor comprises a receptor molecule, the receptor molecule is formed by connecting at least two terminal receptor elements A and a central donor element D in a conjugated skeleton mode, the terminal acceptor element A is a cyano-substituted indandione derivative. According to the polymerizable cross-linked micromolecular non-fullerene receptor and the preparation method thereof, side chain functionalization and donor skeleton construction are combined into a few steps, so that the synthesis path is greatly simplified, and the purification and separation times of an intermediate are reduced; under the mild Pd (0) and Cu (I) catalytic condition, a polymerization active functional group P can be completely tolerated, side reaction is avoided, and additional protection-deprotection operation is not needed; the whole process steps are concentrated, the accumulative yield is increased by 20%-30% compared with that of a traditional multi-step route, the purity of a final product is larger than or equal to 98%, and efficient preparation can be achieved under conventional laboratory conditions.

Herein are multivalent antibody binding molecules that activate a Wnt / β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, and a VEGF binding domain. Also described herein are nucleic acids and vectors encoding said molecules and methods for their use.

The invention relates to the technical field of biosensing, and particularly discloses a sialic acid (SA) concentration detection method based on a micro-cantilever sensor. Comprising the following steps: (1) preparing a monocrystalline silicon micro-cantilever sensor, and modifying 4-mercaptophenylboronic acid (4-MPBA) on the surface of a cantilever through an Au-S bond to serve as an SA acceptor molecule; (2) constructing an optical lever detection system, and monitoring the deformation of the cantilever beam in real time through laser reflection displacement; (3) enabling a sample to be detected to be in contact with the modified sensor, and triggering surface quality change of a cantilever beam by utilizing specific binding of 4-MPBA and SA, so as to cause resonant frequency deviation; and (4) establishing a relation model of the frequency value f and the SA concentration through a regression algorithm to realize quantitative detection of the SA concentration. Through a label-free dynamic detection mechanism, an enzyme labeling step required by a traditional ELISA method is avoided, and a rapid and low-cost solution is provided for cancer marker screening.

To provide a molecular structure which allows seamless communication and cooperation between functional elements to perform multiple programmable tasks at once.SOLUTION: A programmable molecular structure (100) comprises a matrix molecule (110), one or more receptor molecules (103, 104, 105), at least one of which is linked to a portion of the matrix molecule (110), one or more molecular machines (106, 107), at least one of which is linked to another portion of the matrix molecule (110), and one or more controller molecules (101) that control at least a portion of the molecular machines (106, 107).SELECTED DRAWING: Figure 1

The invention discloses an in-situ vaccine for tumor antigen capture driven by a nano motor as well as a construction method and application of the in-situ vaccine. The preparation method comprises the following steps: mixing prepared enzyme-immobilized dendritic silicon dioxide nanoparticles and drug-loaded bacterial outer membrane vesicles, extruding, carrying out solid-liquid separation, dispersing the obtained solid with a solvent, co-incubating the obtained suspension with pH-responsive membrane disrupting peptides and receptor molecules of targeted tumor cells, and carrying out freeze-drying to obtain the drug-loaded dendritic silicon dioxide nano-particles with the pH-responsive membrane disrupting peptides. The in-situ vaccine captured by the tumor antigen driven by the nano motor is obtained. The preparation method is green, simple and easy to operate. The in-situ vaccine can rapidly capture, enrich and release tumor-associated antigens and deliver the tumor-associated antigens to APCs, so that the reduction of curative effect caused by tumor heterogeneity and antigen degradation is avoided, the antigen presentation efficiency is remarkably improved, and the immune response is further enhanced; and the method is suitable for various tumors and has universality.

A molecular docking method based on a CIM includes: constructing a 3D molecular structure diagram based on a selected drug molecule to obtain a ligand graph; constructing an internal pseudo-atom point diagram of a receptor target based on a selected receptor molecule to obtain a receptor graph; constructing a ligand-receptor similarity graph based on the ligand graph and the receptor graph, where the ligand-receptor similarity graph includes vertices and edges between any two vertices, and any vertex of includes a point in the ligand graph and a point in the receptor graph; determining whether each edge exists; and constructing a pharmacophore model based on the ligand-receptor similarity graph to determine whether the selected drug molecule could inhibit activity of the selected receptor, where the pharmacophore model is configured to calculate a maximum weight clique between the selected drug molecule and the selected receptor to screen a drug molecule compound.

Disclosed are embodiments photonic integrated circuits with photo-switchable components. Embodiments are illustrated in the form evanescent field perturbation sensors in which receptor molecules are patterned onto the sensor substrate with precision. In particular, light patterning and molecular-based photo-responsive motifs allow for the positioning of receptor molecules on the operational elements of the evanescent field perturbation sensors. Receptor molecules are further detachable from the sensor and capable of replacement with additional receptor molecules of the same type, or one or more alternative receptor molecules capable of receiving the same or different analyte receptor molecules. In certain embodiments the light sources for patterning and receptor molecule interchange may integrated within the sensor and / or sensor platform itself. In certain embodiments a method of recharging and / or reconfiguring the receptor molecules, and a machine for carrying out the method is disclosed.

The present disclosure relates to tandem expression cassettes encoding chimeric phagocytosis receptor molecules and chimeric antigen receptor / or T cell receptor binding proteins, host cells modified to comprise the tandem expression cassettes, and methods of making and using such receptor molecules and modified cells.

The invention relates to the technical field of biological deep processing and extraction, and discloses a directional preparation method of intestinal immunity-enhanced sea cucumber peptide, which comprises the following steps: (1) sea cucumber pretreatment; (2) carrying out deep penetration wall breaking on the supercritical CO2 / deep eutectic solvent; (3) performing enzymolysis treatment; (4) peptomics analysis; (5) performing molecular docking and virtual screening on the sea cucumber peptide and the TLR2 receptor; (6) membrane separation targeted enrichment; and (7) performing rotary evaporation, concentration and drying to obtain the sea cucumber peptide. Supercritical CO2 with strong permeation and diffusion characteristics is used as a carrier and cooperates with the deep-eutectic solvent to penetrate through a compact cuticle structure of sea cucumbers. The SC-CO2 acts on a stratum corneum lipid phase, a remarkable micropore expansion effect is initiated, and the pore density is greatly improved; functional ions in the deep eutectic solvent accurately destroy a salt bridge cross-linked network of cuticle key structure protein, and solvent components induce deep swelling of collagen through hydrogen-bond interaction, so that effective disintegration of the cuticle structure is realized.

The application relates to a method and device for screening molecules and application thereof. The method for screening molecules comprises the following steps: obtaining a first mapping relationship between M ligand molecules and N molecular structures; for at least part of the M ligand molecules, performing skeleton extraction on the structure information of the simplified molecular linear formula respectively to obtain O molecular skeletons; aggregating the O molecular skeletons to obtain P molecular skeleton classes; determining a second mapping relationship between the P molecular skeleton classes and the N molecular structures based on the first mapping relationship, so as to screen a molecule matched with a target receptor molecule from a simplified molecular linear formula set comprising the simplified molecular linear formula of the M ligand molecules based on the second mapping relationship. The scheme provided by the application can improve the accuracy and convenience of the user in screening molecules.

The invention discloses an organic long-afterglow material as well as a preparation method and application thereof, and the organic long-afterglow material comprises donor molecules, acceptor molecules and multiple resonance molecules, the multi-resonance molecule is N7, N7, N13, N13, 5, 9, 11, 1-octaphenyl-5H, 9H, 11H, 15H-[1, 4] benzaza-boron [2, 3, 4-kl] [1, 4] benzaza-boron [4 ', 3', 2 ': 4, 5] [1, 4] benzaza-boron [3, 2-b] dibenzaza-borane-7, 13-diamine. According to the organic long afterglow material, multiple resonance molecules serve as a light collector, the coulomb interaction force needing to be overcome by charge separation is reduced by means of visible light effective excitation and excited state intrinsic charge separation characteristics of the multiple resonance molecules, and the coulomb interaction force needs to be overcome by means of gradual charge transfer. Electrons and holes are respectively transmitted to acceptor molecules and donor molecules, so that effective light storage is realized, and finally, the organic long afterglow material presents green ultra-long afterglow luminescence under the excitation of visible light.

The present disclosure relates to chimeric Tim receptors, host cells modified to include chimeric Tim receptor molecules, and methods of making and using such receptor molecules and modified cells.

Provided are various embodiments relating to IL13R / IL4R heterodimeric proteins derived from companion animal species and that bind to IL13 and / or IL4. Such heterodimeric proteins can be used in methods to treat IL13 and / or IL4-induced conditions in companion animals, such as canines, felines, and equines.

A process (S1) for producing alternan-oligosaccharide (8), comprisingcontacting in a reactor (11) sucrose (9) with a catalytically effective amount of alternansucrase enzyme (13) and acceptor molecules (12), wherein the alternansucrase enzyme (13) and acceptor molecules (12) are present in the reactor (11) in an aqueous liquid (4) and the sucrose (9) is continuously or half-continuously fed to the reactor (11), and wherein the sucrose (9) and the acceptor molecules (12) are converted to alternan-oligosaccharide (8), and fructose (6) is formed as a by-product,continuously or half-continuously removing at least a part of the fructose (6) from the reactor (11) by membrane filtration (17).

The application discloses a SERS biomimetic taste sensing chip for cell secretion and a preparation and detection method thereof. The biological detection chip is composed of a SERS sensing array and a fixing device thereof. The chip can be directly hung on a cell culture dish. A clamping groove beside the chip is used for fixing a sensor substrate. A SERS sensing array on the substrate is composed of a dense monolayer of metal nanoparticles and an array of receptor molecules. The cell secretion can be quantitatively detected by collecting and analyzing the SERS spectrum of the array unit. The application can be adapted to the cell culture dish. In the case of not affecting the cell culture, the real-time, high-sensitivity and automatic quantitative analysis of various secretions outside the measured cell can be realized.

The present invention discloses a macrocyclic-small molecule eutectic material with adjustable structure and luminescence, its preparation method and application, which is assembled by donor molecules and acceptor molecules through intermolecular charge transfer, wherein the donor is a triangular pyrene-based macrocyclic molecule and the acceptor is 1,2,4,5-tetracyanobenzene. The present invention is characterized in that, by regulating the crystallization solvent, the prepared macrocyclic-small molecule eutectic has the characteristics of diverse stoichiometric ratios and assembly structures, and the material exhibits excellent luminescence tunable properties. The material provided by the present invention has the advantages of simple preparation method, low cost, scalability, etc., and has potential application prospects in multicolor display devices and light-emitting devices.

The invention discloses a donor-receptor supramolecular compound as well as a preparation method and application thereof. The donor-acceptor supramolecular compound is formed by supramolecular self-assembly of donor molecules and acceptor molecules according to a molar ratio of 1: 1, and the donor molecules are any one of trans-1, 2-stilbene, naphthalene, anthracene, pyrene, triphenylene, perylene, carbazole, 9, 9-dimethyl acridine, phenoxazine, 2, 3, 6, 7, 10, 11-hexamethoxy triphenylene, tetrathiafulvalene or dibenzotetrathiafulvalene; the receptor molecule is 1, 4, 5, 8, 9, 11-hexaazabenzonitrile, and the receptor molecule is 1, 4, 5, 8, 9, 11-hexaazabenzonitrile. The donor-acceptor supramolecular compound obtained by the invention not only has near-infrared long-wavelength absorption, but also has a wide absorption range; in addition, the material also has relatively high photothermal conversion performance and relatively good photothermal stability, and has a good application prospect in the aspect of heater materials.

Disclosed are embodiments photonic integrated circuits with photo-switchable components. Embodiments are illustrated in the form evanescent field perturbation sensors in which receptor molecules are patterned onto the sensor substrate with precision. In particular, light patterning and molecular-based photo-responsive motifs allow for the positioning of receptor molecules on the operational elements of the evanescent field perturbation sensors. Receptor molecules are further detachable from the sensor and capable of replacement with additional receptor molecules of the same type, or one or more alternative receptor molecules capable of receiving the same or different analyte receptor molecules. In certain embodiments the light sources for patterning and receptor molecule interchange may integrated within the sensor and / or sensor platform itself. In certain embodiments a method of recharging and / or reconfiguring the receptor molecules, and a machine for carrying out the method is disclosed.

The invention discloses a high-sensitivity hydrogen sulfide fluorescent probe based on porphyrin-nitrobenzoxadiazole donor-acceptor molecular engineering and a synthesis method thereof. The structural formula of the probe is shown in the specification. According to the probe, a nitrobenzoxadiazole group is introduced to the periphery of a porphyrin macroring, and an intramolecular donor-acceptor system is constructed. The detection mechanism is based on a nucleophilic substitution reaction of hydrogen sulfide to a phenyl ether bond, and a nitrobenzoxadiazole group is removed, so that electron transfer under optical excitation is inhibited, and red fluorescence emission of porphyrin is recovered. After the probe reacts with hydrogen sulfide, the probe presents an obvious fluorescence signal at 653 nm under excitation of 417 nm, the Stokes shift reaches 236 nm, and the probe has the advantages of obvious fluorescence response, good water solubility, high fluorescence quantum yield and the like, can realize high-selectivity detection of hydrogen sulfide, and has wide application prospects in the fields of analytical chemistry, life science, environmental monitoring, biomedical treatment and the like.

The present invention pertains to the field of pest control. In particular, the invention pertains to bioassays to measure the response of insect cells to toxinsm. Furthermore, the invention pertains to methods for identifying receptors which play a role in the interaction of insecticidal toxins and insect cells. The invention thus also pertains to the identification of toxins having an activity against an insect cell, and to toxins that interact with receptor molecules.

The application relates to the technical field of functional food development, in particular to an immunoregulatory active newt peptide and application thereof. A new newt peptide GIGFFP is disclosed for the first time, the sequence of which is a brand-new structure which has not been reported in anderson's origin, and the peptide segment is not disclosed in the contrast documents, and no related sequence is recorded. The peptide is docked with a TLR4 / MD2 (PDB ID: 5IJD) receptor molecule for the first time, the key sites are combined through Pi-Pi interaction and van der waals force, and the immunoregulatory molecular mechanism is determined. The newt peptide has the advantages of high nutritional components, small molecular weight, easy absorption and immunoregulatory activity, provides theoretical support for further development of immunoregulatory functional food by using the newt peptide, and improves the development value of the anderson.

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a preparation method of an azulene-based dimer acceptor material and application of the azulene-based dimer acceptor material in an organic optical detector. Three Y-series dimer receptor molecules are constructed by changing bridging sites of azulene units, and the Y-series dimer receptor molecules and a PM6 blended film are used as active layers to be applied to a photoelectric detector. The structural formula of the azulene-based dimer receptor molecule is shown in the specification, a device based on the structure of the formula I1 shows high EQE response within the wavelength range of 380-860 nm under the bias voltage condition of 0 V, the EQE response reaches 60%-85%, and the responsivity (R) of the device reaches 0.51 A W <-1 >. The results show that the azulene acceptor material has application potential in a photoelectric detector.