33 results about "Receptor molecule" patented technology

The present disclosure relates to biosensors (10) having a receptor layer (5) and a mediator layer (6), the receptor layer including ethylene receptor molecules. The present disclosure also relates to sensor units (20) comprising one or more biosensors (10) and a controller (11). In some embodiments, one or more sensor units (20) may be in wireless communication with a receiver module or a network gateway.

An organic EL element is an organic EL element (10) provided with a laminate held between a pair of electrodes (3), (4), the laminate having an acceptor layer (1) and a donor layer (2) forming an interface with the acceptor layer (1), the acceptor layer (1) containing an acceptor molecule, the donor layer (2) containing a donor molecule that undergoes triplet-triplet annihilation, the acceptor molecule and the donor molecule satisfying a condition related to a prescribed energy level, and the like.

The application discloses a D type influenza virus isolate D / HY11 and application thereof in a mink infection model, and belongs to the field of biological medicines. The application takes the D type influenza virus isolate D / HY11 of an IDV northeast isolate as a research object, establishes a mink transmission model, evaluates the transmission dynamics characteristics of the strain among minks, identifies amino acid mutations possibly related to host adaptability through whole genome sequencing, analyzes the amino acid substitution on receptor affinity based on computer simulation of protein conformation and receptor molecule docking, explores the host adaptation evolution law of the virus in the transmission process, and provides an important scientific basis for early warning and prevention and control of a public health crisis possibly caused by the IDV.

This invention discloses a circularly polarized room-temperature phosphorescent organic cocrystal, its preparation method, and its applications. The organic cocrystal is formed by the self-assembly of chiral donor and acceptor molecules. The chiral donor molecule is S / R-1-(1-naphthyl)ethanol, and the acceptor molecule is 1,2,4,5-benzenetetracarbonyl nitrile. The levorotatory or dextrorotatory chiral donor and acceptor molecules are dissolved in a good solvent, then a poor solvent is added. The mixture is sonicated until completely dissolved and allowed to stand until the solvent completely evaporates, yielding the organic cocrystal. Both the levorotatory and dextrorotatory chiral cocrystals exhibit green phosphorescence emission upon excitation. The lifetime of the levorotatory chiral cocrystal is 24.91 ms, and that of the dextrorotatory chiral cocrystal is 28.48 ms. The cocrystals exhibit excellent circularly polarized room-temperature phosphorescence performance, with the levorotatory chiral cocrystal achieving a phosphorescence efficiency of 22.43% per g. lum | is 0.03. The phosphorescence efficiency of the dextrorotatory chiral eutectic is 30.97%, | g lum | is 0.065.

Herein are multivalent antibody binding molecules that activate a Wnt / β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, and a VEGF binding domain. Also described herein are nucleic acids and vectors encoding said molecules and methods for their use.

A molecular docking method based on a CIM includes: constructing a 3D molecular structure diagram based on a selected drug molecule to obtain a ligand graph; constructing an internal pseudo-atom point diagram of a receptor target based on a selected receptor molecule to obtain a receptor graph; constructing a ligand-receptor similarity graph based on the ligand graph and the receptor graph, where the ligand-receptor similarity graph includes vertices and edges between any two vertices, and any vertex of includes a point in the ligand graph and a point in the receptor graph; determining whether each edge exists; and constructing a pharmacophore model based on the ligand-receptor similarity graph to determine whether the selected drug molecule could inhibit activity of the selected receptor, where the pharmacophore model is configured to calculate a maximum weight clique between the selected drug molecule and the selected receptor to screen a drug molecule compound.

Disclosed are embodiments photonic integrated circuits with photo-switchable components. Embodiments are illustrated in the form evanescent field perturbation sensors in which receptor molecules are patterned onto the sensor substrate with precision. In particular, light patterning and molecular-based photo-responsive motifs allow for the positioning of receptor molecules on the operational elements of the evanescent field perturbation sensors. Receptor molecules are further detachable from the sensor and capable of replacement with additional receptor molecules of the same type, or one or more alternative receptor molecules capable of receiving the same or different analyte receptor molecules. In certain embodiments the light sources for patterning and receptor molecule interchange may integrated within the sensor and / or sensor platform itself. In certain embodiments a method of recharging and / or reconfiguring the receptor molecules, and a machine for carrying out the method is disclosed.

The present disclosure relates to tandem expression cassettes encoding chimeric phagocytosis receptor molecules and chimeric antigen receptor / or T cell receptor binding proteins, host cells modified to comprise the tandem expression cassettes, and methods of making and using such receptor molecules and modified cells.

The invention relates to the technical field of biological deep processing and extraction, and discloses a directional preparation method of intestinal immunity-enhanced sea cucumber peptide, which comprises the following steps: (1) sea cucumber pretreatment; (2) carrying out deep penetration wall breaking on the supercritical CO2 / deep eutectic solvent; (3) performing enzymolysis treatment; (4) peptomics analysis; (5) performing molecular docking and virtual screening on the sea cucumber peptide and the TLR2 receptor; (6) membrane separation targeted enrichment; and (7) performing rotary evaporation, concentration and drying to obtain the sea cucumber peptide. Supercritical CO2 with strong permeation and diffusion characteristics is used as a carrier and cooperates with the deep-eutectic solvent to penetrate through a compact cuticle structure of sea cucumbers. The SC-CO2 acts on a stratum corneum lipid phase, a remarkable micropore expansion effect is initiated, and the pore density is greatly improved; functional ions in the deep eutectic solvent accurately destroy a salt bridge cross-linked network of cuticle key structure protein, and solvent components induce deep swelling of collagen through hydrogen-bond interaction, so that effective disintegration of the cuticle structure is realized.

The present disclosure relates to chimeric Tim receptors, host cells modified to include chimeric Tim receptor molecules, and methods of making and using such receptor molecules and modified cells.

A process (S1) for producing alternan-oligosaccharide (8), comprisingcontacting in a reactor (11) sucrose (9) with a catalytically effective amount of alternansucrase enzyme (13) and acceptor molecules (12), wherein the alternansucrase enzyme (13) and acceptor molecules (12) are present in the reactor (11) in an aqueous liquid (4) and the sucrose (9) is continuously or half-continuously fed to the reactor (11), and wherein the sucrose (9) and the acceptor molecules (12) are converted to alternan-oligosaccharide (8), and fructose (6) is formed as a by-product,continuously or half-continuously removing at least a part of the fructose (6) from the reactor (11) by membrane filtration (17).

The application discloses a SERS biomimetic taste sensing chip for cell secretion and a preparation and detection method thereof. The biological detection chip is composed of a SERS sensing array and a fixing device thereof. The chip can be directly hung on a cell culture dish. A clamping groove beside the chip is used for fixing a sensor substrate. A SERS sensing array on the substrate is composed of a dense monolayer of metal nanoparticles and an array of receptor molecules. The cell secretion can be quantitatively detected by collecting and analyzing the SERS spectrum of the array unit. The application can be adapted to the cell culture dish. In the case of not affecting the cell culture, the real-time, high-sensitivity and automatic quantitative analysis of various secretions outside the measured cell can be realized.

Disclosed are embodiments photonic integrated circuits with photo-switchable components. Embodiments are illustrated in the form evanescent field perturbation sensors in which receptor molecules are patterned onto the sensor substrate with precision. In particular, light patterning and molecular-based photo-responsive motifs allow for the positioning of receptor molecules on the operational elements of the evanescent field perturbation sensors. Receptor molecules are further detachable from the sensor and capable of replacement with additional receptor molecules of the same type, or one or more alternative receptor molecules capable of receiving the same or different analyte receptor molecules. In certain embodiments the light sources for patterning and receptor molecule interchange may integrated within the sensor and / or sensor platform itself. In certain embodiments a method of recharging and / or reconfiguring the receptor molecules, and a machine for carrying out the method is disclosed.

The invention discloses a high-sensitivity hydrogen sulfide fluorescent probe based on porphyrin-nitrobenzoxadiazole donor-acceptor molecular engineering and a synthesis method thereof. The structural formula of the probe is shown in the specification. According to the probe, a nitrobenzoxadiazole group is introduced to the periphery of a porphyrin macroring, and an intramolecular donor-acceptor system is constructed. The detection mechanism is based on a nucleophilic substitution reaction of hydrogen sulfide to a phenyl ether bond, and a nitrobenzoxadiazole group is removed, so that electron transfer under optical excitation is inhibited, and red fluorescence emission of porphyrin is recovered. After the probe reacts with hydrogen sulfide, the probe presents an obvious fluorescence signal at 653 nm under excitation of 417 nm, the Stokes shift reaches 236 nm, and the probe has the advantages of obvious fluorescence response, good water solubility, high fluorescence quantum yield and the like, can realize high-selectivity detection of hydrogen sulfide, and has wide application prospects in the fields of analytical chemistry, life science, environmental monitoring, biomedical treatment and the like.

The present invention pertains to the field of pest control. In particular, the invention pertains to bioassays to measure the response of insect cells to toxinsm. Furthermore, the invention pertains to methods for identifying receptors which play a role in the interaction of insecticidal toxins and insect cells. The invention thus also pertains to the identification of toxins having an activity against an insect cell, and to toxins that interact with receptor molecules.

The application relates to the technical field of functional food development, in particular to an immunoregulatory active newt peptide and application thereof. A new newt peptide GIGFFP is disclosed for the first time, the sequence of which is a brand-new structure which has not been reported in anderson's origin, and the peptide segment is not disclosed in the contrast documents, and no related sequence is recorded. The peptide is docked with a TLR4 / MD2 (PDB ID: 5IJD) receptor molecule for the first time, the key sites are combined through Pi-Pi interaction and van der waals force, and the immunoregulatory molecular mechanism is determined. The newt peptide has the advantages of high nutritional components, small molecular weight, easy absorption and immunoregulatory activity, provides theoretical support for further development of immunoregulatory functional food by using the newt peptide, and improves the development value of the anderson.

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a preparation method of an azulene-based dimer acceptor material and application of the azulene-based dimer acceptor material in an organic optical detector. Three Y-series dimer receptor molecules are constructed by changing bridging sites of azulene units, and the Y-series dimer receptor molecules and a PM6 blended film are used as active layers to be applied to a photoelectric detector. The structural formula of the azulene-based dimer receptor molecule is shown in the specification, a device based on the structure of the formula I1 shows high EQE response within the wavelength range of 380-860 nm under the bias voltage condition of 0 V, the EQE response reaches 60%-85%, and the responsivity (R) of the device reaches 0.51 A W <-1 >. The results show that the azulene acceptor material has application potential in a photoelectric detector.

The present application belongs to the field of biomedical detection technology, and particularly relates to a reaction solution for detecting trypsin-like transpeptidase activity and application thereof. The present application uses BAPNA as a specific substrate, which can produce a detectable signal change in the transpeptidation reaction, and a high-concentration amino group-glycine amide is added as a receptor molecule to enhance the transpeptidation reaction efficiency. Therefore, the present application solves the technical problem that the enzyme activity cannot be detected by the immunization method, has high reaction efficiency, stable and reliable detection process, shortened operation time (within 15 minutes), simple operation, strong practicability, can be used for evaluating the severity of acute allergic reaction, providing scientific guidance for the diagnosis of mast cell-related airway inflammation and mast cell activation syndrome, monitoring the effect of allergic treatment, and has clinical value in airway inflammation typing, differential diagnosis and efficacy monitoring through induced sputum or BAL fluid trypsin activity determination.

Herein are multivalent antibody binding molecules that activate a Wnt / β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, and a VEGF binding domain. Also described herein are nucleic acids and vectors encoding said molecules and methods for their use.

The present invention relates to a biocatalytic process for the production of aroma chemicals by carboligation using a transketolase (EC 2.2.1.1) as shown for transketolase from Geobacillus stearothermophilus and several sequence variants to catalyse the conversion of a donor molecule selected from 2-oxobutanoic acid and 3-methyl-2-oxopentanoic acid and an acceptor molecule selected from propanal and 2-methylbutanal, two identical or different donor molecules, or two identical or different acceptor molecules, thereby obtaining a coupling product in the presence of coenzyme thiamine diphosphate, the products being 3-hydroxy-5-methyl-heptan-4-one, 4-hydroxy-5-methyl-heptan-3-one, 5-hydroxy-3,6-dimethyl-octan-4-one and 4-hydroxy-hexan-3-one as precursor for filbertone.

Herein are multivalent antibody binding molecules that activate a Wnt / β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, and a VEGF binding domain. Also described herein are nucleic acids and vectors encoding said molecules and methods for their use.

The invention relates to the technical field of organic photoelectric materials, in particular to a high-molecular-weight oligomeric receptor, a preparation method thereof and a photovoltaic device. The structural general formula of the high-molecular-weight oligomeric acceptor is any one of the following formulas; wherein the Y is as shown in the specification, the R1 is as shown in the specification, or the R2 is as shown in the specification; x is one of H, F, Cl, Br or I, and n is one of 0, 1, 2, 3, 4, 5, 6, 7 and 8; and m is one of 0, 2, 4, 6, 8, 10 and 12. The large-molecular-weight oligomeric receptor provided by the invention can inherit an ordered structure of a small-molecular receptor, can also significantly enhance the stability of receptor molecules in an active layer, and can finely regulate and control the molecular conformation, stacking arrangement, crystallization characteristics and the like of a tetrameric receptor by constructing a triune modification strategy of element-bridging unit-connecting site and the like.

The fast attenuation heat exciton type donor-acceptor complex is characterized by being prepared from a ligand, a connector, metal ions and an organic object in a molar ratio of 1: (1-4): (1-4): (1-10) through coordination and charge transfer. The preparation method comprises the following steps: putting a metal salt, a ligand, a connector and an organic object into a mixed solution of DMF (Dimethyl Formamide), EtOH and H2O; and sealing and heating to form a complex crystalline material. The invention relates to scintillator application. A ligand, a connector and metal ions are coordinated to form a complex acceptor framework, and an organic guest is used as a donor to be filled into pores to form a donor-acceptor configuration heat exciton luminescence mechanism. By replacing ligand acceptor molecules, the photophysical mechanism of the material from delayed fluorescence to fast attenuation heat excitons can be realized, and the regulation and control of emission wavelength and attenuation life can also be realized. The complex disclosed by the invention shows better scintillator properties under ray excitation, including considerable light yield, higher exciton attenuation efficiency and lower radiation detection limit and radiation stability.

This disclosure relates to the field of artificial intelligence technology, and provides a method, apparatus, antagonist, medium, and device for predicting antagonists based on artificial intelligence. The method includes: obtaining simulated drug molecules from a generator network of a trained generative adversarial neural network, wherein the generative adversarial neural network is trained based on existing antagonists corresponding to drug-like molecules and target receptor molecules; determining a database of small molecules to be screened based on the simulated drug molecules; performing virtual screening on the small molecule database based on the target receptor molecules to screen out target drug small molecules; and obtaining the antagonist of the target receptor molecules by performing cell activity tests on the target drug small molecules. This technical solution can increase the diversity of the chemical spatial structure of the simulated drug molecules and reduce the cost and time of drug development.

Herein are multivalent antibody binding molecules that activate a Wnt / β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, and a VEGF binding domain. Also described herein are nucleic acids and vectors encoding said molecules and methods for their use.

Disclosed are embodiments photonic integrated circuits with photo-switchable components. Embodiments are illustrated in the form evanescent field perturbation sensors in which receptor molecules are patterned onto the sensor substrate with precision. In particular, light patterning and molecular-based photo-responsive motifs allow for the positioning of receptor molecules on the operational elements of the evanescent field perturbation sensors. Receptor molecules are further detachable from the sensor and capable of replacement with additional receptor molecules of the same type, or one or more alternative receptor molecules capable of receiving the same or different analyte receptor molecules. In certain embodiments the light sources for patterning and receptor molecule interchange may integrated within the sensor and / or sensor platform itself. In certain embodiments a method of recharging and / or reconfiguring the receptor molecules, and a machine for carrying out the method is disclosed.

The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

The invention discloses a nanotube capable of performing in-tube multi-step fluorescence resonance energy transfer and a preparation method thereof. The preparation method comprises the following steps: S1, preparing a supramolecular nanotube with azide functional groups distributed in an inner cavity space; s2, one or more alkynyl-modified fluorescent molecules are covalently and independently or sequentially modified in the inner cavity of the supramolecular nanotube prepared in the step S1, and the nanotube capable of conducting in-tube multi-step fluorescence resonance energy transfer is prepared. According to the invention, reactive functional groups are introduced into the inner cavity of the supramolecular nanotube in advance, and a plurality of fluorescent receptor molecules are introduced into the cavity in sequence or in a combined manner by utilizing click chemistry, so that ordered arrangement of a fluorescent donor and a plurality of receptors on the nanoscale is realized; therefore, a multi-step fluorescence resonance energy transfer system with clear directivity, high energy transfer efficiency and remarkable antenna effect is obtained.

The invention discloses a method for identifying bitter substances in pandan juice by combining sensory target screening and calculation verification, which comprises the following steps of: determining phenotypes by sensory evaluation, screening components by polyphenol targeted metabonomics, reducing range by multivariate statistical analysis, predicting locked receptors by BitterX, and testing causality by molecular docking. The method comprises the following steps: firstly, establishing a standardized sensory evaluation system to determine the bitter taste intensity of the pandan juice, accurately identifying polyphenol components in the pandan juice based on polyphenol targeted metabonomics, then screening potential bitter taste compounds through PLS-DA and Pearson correlation analysis, and finally predicting the bitter taste receptor binding possibility through a BitterX database and performing molecular docking verification by using AutodocVina. According to the method, the nanogram-level trace polyphenol compound can be sensitively and qualitatively detected, the rationality of an identification result is verified by molecular docking simulation from a molecular action mechanism level, and a precise technical support is provided for regulation and control of bitter taste in hot processing of the pandan juice and extension of a pandan industry chain.

The invention relates to a method for selectively capturing, modifying, releasing, and / or sensing biological particles, such as extracellular vesicles, from a liquid sample. The method involves contacting the sample with a surface provided by a fiber section comprising electrically conductive fibers functionalized with receptor molecules for specific binding of the biological particle. A magnetic section induces motion in response to an external magnetic field to enhance interaction. The bound particle is optionally washed, modified by loading with cargo molecules through application of a loading voltage, and released by applying a release potential to the fiber section. The invention further relates to a device comprising the fiber section as a working electrode, optionally embedded in a non-electrically conductive polymer matrix, a magnetic section for motion induction, an optional insulation layer, and electrical connections to a voltage source, with optional counter and / or reference electrodes. The device enables high-throughput isolation, modification, and electrochemical sensing for applications in biomedical, chemical, and environmental fields.