24 results about "Joints inflammation" patented technology

The invention belongs to the technical field of microbial fermentation, and particularly relates to lactobacillus rhamnosus capable of maintaining bone health and improving local joint inflammation and a metagen and application of the lactobacillus rhamnosus. According to the invention, the probiotic NKU ML1-2 is subjected to fermentation culture, such that a post-generation product is prepared. Results of embodiments prove that the metagen product can enhance the oxidation resistance of cartilage and osteoblasts and promote the synthesis of anti-inflammatory factors and cartilage matrixes (type II collagen and proteoglycan), and has the potential of relieving oxidative stress and inflammatory response of local joints, relieving joint inflammation and delaying cartilage destruction. The prepared metagen product is high in safety and good in stability, and can be applied to preparation of medicines for preventing and / or treating osteoarthritis; the metagen product can also be used for promoting bone health, enhancing the antioxidant capacity of osteoblasts and / or chondrocytes, promoting osteoblast activity and / or promoting calcium absorption and fixation, and a new solution is provided for joint health management.

The invention relates to the technical field of functional food, in particular to an electrolyte composition beneficial to joint injury repair after exercise and a preparation method of the electrolyte composition. The electrolyte composition is mainly prepared from the following raw materials in parts by mass: 0.1 to 2 percent of N-acetylglucosamine, 0.05 to 0.5 percent of cartilage extract, 0.05 to 0.5 percent of enzymolysis bone meal, 0.01 to 0.05 percent of milk mineral salt, 0.1 to 1 percent of collagen peptide, 0.01 to 0.3 percent of vitamin and 0.03 to 0.3 percent of electrolyte. The nano hydrated milk mineral salt is adopted, the absorption efficiency of elements such as calcium and phosphorus in a body is improved, and the electrolyte composition is prepared by combining components such as N-acetylglucosamine and the cartilage extract, so that joint inflammation and cartilage injury caused by exercise are effectively improved while water and electrolyte are supplemented, and the activity of joints and exercises is improved. The electrolyte composition is good in taste, high in stability and suitable for joint protection and nutrition supplement after exercise.

The present invention relates to the field of nutraceuticals, specifically to a synergistic bioactive composition designed to improve joint health. This composition comprises Palmitoylethanolamide (PEA) and Cucumis sativus, aimed at reducing joint pain and protecting cartilage. It addresses the complex pain components of osteoarthritis, including both nociceptive pain, which stems from ongoing joint inflammation and tissue damage, and neuropathic pain, which indicates nerve damage. This nutraceutical composition provides a novel solution for mitigating the debilitating effects of osteoarthritis through oral administration, utilizing pharmaceutically acceptable excipients to ensure efficacy and safety.

The invention relates to a piezoelectric nano-material with ultrasonic responsiveness, which is a PVP (Polyvinyl Pyrrolidone) modified bismuth oxyiodate nano-sheet, the particle size is 100-200 nm, and a surface electric field can be generated under the ultrasonic action. The piezoelectric nano material can hyperpolarize the potential of a T cell membrane and inhibit an ion channel Kv1.3 regulated and controlled by the membrane potential, so that Th17 cell differentiation is reduced, and joint inflammation is relieved; the piezoelectric nano material is further prepared into a joint injection preparation, and the joint injection preparation can be combined with ultrasonic irradiation to be applied to treatment of rheumatoid arthritis. According to the invention, the piezoelectric nano material is successfully applied to immune microenvironment regulation and control of rheumatoid arthritis for the first time, and the product and technology blank in the field of'precisely regulating and controlling immune cell functions by using physical signals to treat autoimmune diseases' is filled.

Composition for improving inflammation in osteoarthritis, characterized in that the composition comprises the following components, measured in parts by weight: 1 to 5 parts by weight of N-acetylglucosamine and 0.1 to 2 parts by weight of calcium element in a calcium source.

The utility model discloses a rheumatism immune joint heating device, which relates to the technical field of rheumatism immunization and comprises a device body, telescopic columns are fixedly connected to the inner bottom walls of the edges of the two sides of the device body, a heating physiotherapy assembly is fixedly connected to the tops of the telescopic columns, and a protection assembly is connected to the inner side wall of the heating physiotherapy assembly in a limiting manner. Massage beads are fixedly connected to the outer surface of the top of the device body; through the arrangement of the telescopic column and the massage balls, the effects of accurate adjustment and comfort are achieved when a person operates the device, the flexible telescopic characteristic of the telescopic column enables the heating device to be tightly attached to unique curved surfaces of different patients and different joint parts, the heating device can adapt to individual differences of different patients, it is guaranteed that heat evenly covers all the joints, and the heating effect is improved. No local overheating or insufficient heating condition exists, the joints are always in the best heating state, an ideal environment is created for relieving joint inflammation, the massage beads can apply moderate pressure to muscular tissue around the joints, and the comfort degree is improved.

This invention relates to the field of traditional Chinese medicine (TCM) technology, specifically to a TCM composition for treating rheumatoid arthritis and its application. The TCM composition comprises the following raw materials: mulberry twigs, Gentiana macrophylla, Phellodendron chinense, earthworm, stir-fried Arctium lappa, Achyranthes bidentata, stir-fried Bombyx mori, Lonicera japonica, and Spatholobus suberectus. This TCM composition can reduce arthritis scores and paw volume in rats with rheumatoid arthritis, reduce the spleen coefficient in rats with rheumatoid arthritis, significantly reduce TNF-α, IL-6, and IL-1β in rat serum, improve joint inflammation, and has no toxic side effects. This indicates that the TCM composition for treating rheumatoid arthritis in this application can alleviate symptoms in patients with rheumatoid arthritis, exert its anti-inflammatory and analgesic effects, and thus treat rheumatoid arthritis.

A composition is provided comprising an effective amount of a combination of gamma linolenic acid (GLA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The composition comprises about 5% w / w to about 25% w / w GLA, and about 5% w / w to about 25% w / w of a mixture of DHA and EPA. Methods of modulating fatty acid profiles or treating an inflammatory condition in a horse include administering an effective amount of the composition to the horse. The inflammatory conditions capable of being treated include gastric ulcers, airway inflammation, joint inflammation, or combinations thereof.

This invention discloses a nutritional composition and preparation method for improving joint health in senior pets. The nutritional composition comprises: N-acetylglucosamine, chondroitin sulfate, methanesulfonylmethane, unsaponifiable avocado and soybean extract, hyaluronic acid, curcumin microcapsule powder, and high-concentration fish oil. This invention uses a lipid / polysaccharide bilayer microcapsule structure to encapsulate curcumin and fish oil, and prepares the product through low-temperature homogenization, spray drying, and granulation processes. The composition of this invention works synergistically through multiple pathways, simultaneously exerting effects on three key levels: anti-inflammation, lubrication, and cartilage repair. It can significantly inhibit joint inflammation, improve joint lubrication, and promote cartilage repair. This invention solves the problems of existing pet joint products, such as single pathways of action, low stability and bioavailability of lipid-soluble active ingredients, and lack of overall formulation optimization tailored to the characteristics of aging pets. It is suitable for daily joint health maintenance or adjunctive treatment in middle-aged and senior dogs and cats.

This invention relates to a compound gel for treating joint inflammation based on a modified ancient Chinese medicine formula, belonging to the fields of pharmaceutical preparations and traditional Chinese medicine. The compound gel consists of active ingredient extracts, a poloxamer thermosensitive gel matrix, a penetration enhancer, a humectant, and deionized water. The active ingredient extracts are obtained from *Terminalia chebula*, *Amla emblica*, lavender, wild watermelon, *Artemisia annua*, and chamomile through ultrasonic-microwave coupling extraction. Using ultrasonic-microwave coupling extraction combined with a low-temperature drying process, small-molecule active ingredients are obtained. A body temperature-responsive gel is constructed based on poloxamer 407 / 188, achieving in-situ phase transition on the skin surface and stable sustained release over 6-8 hours, significantly improving transdermal absorption. The gel is combined with an integrated medication container and biomimetic protective gear to form a synergistic drug delivery system, achieving closed-loop controlled release, leak-proof design, and motion adaptation. This gel is non-irritating and non-allergenic, suitable for topical treatment of osteoarthritis, rheumatoid arthritis, and soft tissue injuries caused by cold and dampness in high-altitude regions.

The present disclosure is directed to peptide-polymer conjugates, and to their use in treating intra-articular diseases or disorders.

This invention relates to alginate–pectin polymer-based quercetin microspheres as an anti-inflammatory drug delivery system for intra-articular application in osteoarthritis. The microspheres were prepared using an ionic gelation method through an ionotropic aerosolization technique, in which a solution of quercetin and alginate–pectin polymer with a total concentration of approximately 3% was sprayed into a calcium chloride (CaCl₂) solution using a pressure of approximately 40 psi and a spray distance of approximately 8 cm. The alginate–pectin ratios used included 1:1 and 1:2, with the addition of lyophilisate in the form of lactose or maltodextrin during the lyophilization process. The results showed that increasing the pectin fraction and the use of maltodextrin increased drug loading and entrapment efficiency of quercetin, while a 1:1 ratio produced microspheres with a more compact structure and higher yield.The present invention provides a formulation and method for producing quercetin microspheres with adjustable properties, thus potentially being used as a controlled-release intra-articular injectable preparation for the therapy of joint inflammation.

A method for detecting inflammation in a body joint of a subject, including: providing at least one thermal image of at least one body joint, wherein the at least one thermal image includes indications of temperature of the at least one body joint; marking at least one region of interest (ROI) in the at least one thermal image, wherein the marked ROI is a region in the at least one thermal image which includes pixels representing elevated temperatures and less elevated temperatures in the at least one thermal image; extracting values of one or more parameters of distribution of the temperature indications in the at least marked ROI; detecting inflammation in the body joint based on the extracted values.

1. Name of the product in this design: Handheld Medical Laser Device. 2. Purpose of this design: For surface irradiation to relieve muscle and joint inflammation and pain through photobiological regulation. 3. The key design points of this product are: 1. the shape of the product; 2. the shape and color of the product. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Design 1 requests protection of its shape, and Design 2 requests protection of both its shape and color.

The present application belongs to the technical field of microbial fermentation, and particularly relates to Lactobacillus rhamnosus for maintaining bone health and improving local inflammation of joints, postbiotic and application thereof. The present application prepares a postbiotic product by fermenting and culturing probiotic NKU ML1-2. The results of examples prove that the postbiotic drug can enhance the antioxidant capacity of chondrocytes and osteoblasts, promote the synthesis of anti-inflammatory factors and cartilage matrix (type II collagen and proteoglycan), has the potential to reduce local oxidative stress and inflammatory response of joints, relieve joint inflammation, and delay cartilage destruction. The postbiotic drug prepared by the present application has high safety and good stability, and can be applied to the preparation of drugs for preventing and / or treating osteoarthritis; the postbiotic drug can also be used to promote bone health, enhance the antioxidant capacity of osteoblasts and / or chondrocytes, promote osteoblast activity and / or promote calcium absorption and fixation, and provides a new solution for joint health management.

The present invention relates to a polyherbal tablet formulation for the treatment of gouty arthritis and hyperuricemia. The formulation comprises ethanol extracts of six medicinal plants, each contributing specific bioactive compounds with xanthine oxidase (XO) inhibitory, antioxidant, and anti-inflammatory properties. The tablet includes Colchicum autumnale (50mg), Berberis vulgaris (100 mg), Apium graveolens (25 mg), Capparis decidua (25 mg), Fagonia cretica (25 mg), and Trachyspermum ammi (75 mg), combined with a liquid glucose solution to form a 300 mg tablet. The manufacturing method involves ethanol extraction of each plant (70% ethanol, 72 hours), filtration, solvent evaporation under reduced pressure, blending of equal amounts of the extracts with glucose, and drying at 50°C for 12 hours. The resulting formulation demonstrates enhanced therapeutic efficacy in reducing uric acid levels and alleviating joint inflammation, supported by in vitro and in vivo pharmacological assays.

The application discloses macrophage membrane-coated methacrylated hyaluronic acid hydrogel microspheres and application, relates to the technical field of drug synthesis, and technical solution points are that a kind of macrophage membrane-coated methacrylated hyaluronic acid hydrogel microspheres EMM@HMs can efficiently neutralize key proinflammatory factors, the proinflammatory factor includes TNF-alpha and IL-1 beta, to relieve joint inflammation.It is good in the curative effect and biocompatibility in OA model, especially its effect in the regulation of macrophage polarization, inhibition of chondrocyte hypertrophy and neutralization of proinflammatory factors.EMM@HMs can not only significantly reduce inflammation by targeting the key link in the pathogenesis of OA, but also has the potential to delay disease progression, providing a new strategy with a breakthrough significance for the treatment of OA.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a Huihui decoction and application thereof in treating interstitial pneumonia. The Huhui decoction is prepared from radix bupleuri, radix paeoniae rubra, fructus aurantii immaturus, fructus perillae, rhizoma pinelliae, cortex magnoliae officinalis, apricot kernels and radix glycyrrhizae, has the effects of soothing the liver, regulating the lung and promoting qi to activate blood and can be used for treating various symptoms such as liver depression, lung closure, qi stagnation and blood stasis. Clinical practices show that the traditional Chinese medicine composition can be added or reduced along with symptoms on the basis of the traditional Chinese medicine composition, can effectively relieve clinical symptoms of ILD patients, and has a good application prospect. Animal experiments prove that the loopback decoction has a definite overall treatment effect on multi-phenotype abnormalities such as joint inflammation and pulmonary function impairment of RA-ILD mice, and can effectively improve joint inflammation, pulmonary fibrosis and abnormal inflammatory response caused by RA-ILD.

The invention discloses compound essential oil for relieving pain and application thereof, and belongs to the field of natural medicines and aromatherapy. The compound essential oil consists of the following components in parts by volume: 3-6 parts of frankincense essential oil, 5-10 parts of angelica sinensis essential oil, 10-15 parts of holly essential oil, 3-6 parts of ginger essential oil and 2-4 parts of sweet osmanthus essential oil. Through the synergistic effect of the five components, multi-dimensional analgesia of anti-inflammation, blood activating, analgesia, circulation promoting and mood dredging is achieved, external massage preparations, aromatherapy products and transdermal absorption preparations can be prepared, and the traditional Chinese medicine composition is suitable for multiple scenes such as exercise soreness, joint inflammation and menstrual spasm. Experiments prove that the compound essential oil can remarkably prolong the incubation period of mouse writhing and reduce the number of writhing times, is natural, safe and free of side effects, has indispensable components and scientific range matching, solves the problems that an existing analgesic is large in side effect and the essential oil is poor in analgesic effect, and has important clinical and market values.

1. Name of the product in this design: Microwave Therapy Device. 2. Purpose of this design: For use in medical devices to relieve muscle and joint inflammation, soft tissue injury and neuralgia, reduce inflammation, reduce swelling, relieve pain and promote tissue repair. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention relates to the technical field of beer brewing, in particular to dark tea flavored alcohol-free beer suitable for gout people and a preparation method of the dark tea flavored alcohol-free beer. The beverage is prepared from the following components in percentage by weight: 10 to 15 parts of an aged golden flower dark tea extract, 35 to 45 parts of a barley malt extract, 20 to 25 parts of an oat malt extract, 10 to 15 parts of a rice extract, 0.2 to 0.3 part of beer yeast, 2 to 5 parts of modified montmorillonite, 0.05 to 0.1 part of a compound enzyme preparation, 0.5 to 1 part of maltitol, 0.1 to 0.15 part of humulus lupulus and 80 to 100 parts of brewing water. The black tea beer has the advantages that malt aroma and fine foam of traditional beer are reserved, layering sense is increased due to the mellow flavor of the black tea, and tea polyphenol, theaflavin and other ingredients in the black tea have antioxidant and anti-inflammatory characteristics, so that generation of uric acid can be inhibited, excretion can be promoted, and joint inflammation can be relieved. In addition, caffeine in the dark tea can stimulate kidney diuresis and assist discharge of uric acid.