The invention provides an intestinal
flora marker for predicting human total lifetime and a construction method of a prediction model of the intestinal
flora marker, and belongs to the technical field of biological
medicine and precise
nutrition. The invention relates to an intestinal
flora marker for predicting the total lifetime of human beings. The intestinal flora marker comprises an
eubacterium rectum genus (Agathobacter) and / or a
butyric acid genus (Butyliccus). The relative abundance of the intestinal flora marker is in significant
negative correlation with the
death risk, which indicates that the intestinal flora marker may have a protective effect. Meanwhile, survival differences among different
risk groups of human total lifetime prediction models constructed on the basis of the intestinal flora markers have
statistical significance, which prompts that the models have good survival prediction ability in a
training set. The present invention is a precise intervention design for stably predicting individual lifetime in a variety of populations and for prolonging the overall lifetime.