44 results about "Spatial memory" patented technology

The invention provides a body navigation method, device and equipment based on brain inspiration structured spatial memory, and relates to the technical field of navigation.The method comprises the steps that a work memory module is used for determining a structured spatial memory module for searching a navigation instruction according to the complexity of the received navigation instruction, and the structured spatial memory module is used for searching the navigation instruction; the structured spatial memory module comprises at least one of a landmark memory module and a cognitive map module; responding to the navigation instruction, and performing hierarchical retrieval by using a structured spatial memory module of the navigation instruction to obtain a candidate coordinate set of the target; the candidate coordinate set comprises a plurality of candidate coordinates; determining an exploration sequence based on the confidence score of each candidate coordinate and the distance between each candidate coordinate and the coordinate of the current position of the body agent; the exploration sequence represents the exploration sequence of the candidate coordinates; and controlling the body agent to execute navigation operation based on the exploration sequence. According to the method, the robust space cognition and self-adaptive navigation capability of the intelligent agent with the body in a complex environment is realized.

The invention discloses a local path planning method and system based on a spatial memory neural mechanism, and aims to improve obstacle avoidance and shortcut discovery capabilities of a robot in a complex environment. The algorithm is inspired by a hippocampus navigation neural circuit, and efficient memory search and path planning are realized by simulating functions of grid cells, position cells and boundary cells. Firstly, a robot explores a feasible path and records memory nodes including grid cell characterization, reward values and cognitive values; secondly, constructing a hierarchical memory module, realizing fine-to-sparse information abstraction from the back side to the ventral side, and realizing information inheritance and memory search through connection at fixed intervals; and finally, performing path planning by utilizing direction decoding and boundary cell neural representation, and dynamically selecting an optimal sub-target point. The algorithm does not need a large amount of training, can be quickly deployed in various robots, and realizes intelligent autonomous navigation.

The invention belongs to the technical field of mouse neuroscience research, and relates to a multi-modal mouse virtual reality and nerve recording integrated system based on skull anchoring, which comprises a skull anchoring basic support, a binocular miniature VR display module, a multi-modal fixed expansion frame and a behavior and power supply platform. According to the invention, the skull screw is used as a unique space reference, accurate limiting of the head is realized through rapid butt joint of the MMA and the external fixing rod, and rapid plugging and coordinate multiplexing of equipment for two-photon imaging, optical genetic stimulation and the like are realized in combination with an M2 anchoring hole preset in the MMA; the total mass of the whole machine is strictly controlled within 3.2 g; the optical system provides panoramic visual stimulation with a horizontal field angle of 140 degrees, completely covers a key binocular vision area on the top of the mouse head, and supports high-order cognitive task paradigms such as complex ecological visual navigation, spatial memory and social interaction.

This invention provides an occluded pedestrian re-identification method based on single-scale feature representation, belonging to the fields of pattern recognition and computer vision. A spatial memory module is embedded into the feature extraction network to obtain more discriminative pedestrian feature maps. An improved triplet loss is calculated on the pedestrian feature vectors before batch normalization, and a classification loss is calculated on the normalized pedestrian feature vectors to complete training. The Euclidean distance between the query pedestrian features and pedestrian features in the image database is calculated, and the features are sorted in ascending order of distance to obtain the nearest neighbor list of the query pedestrian, thus completing pedestrian re-identification. The advantages are that using single-scale pedestrian features to solve the occlusion problem in pedestrian re-identification not only reduces training time and model complexity but also reduces inference time, making it more suitable for re-identification systems. The spatial memory module only requires a small amount of memory to improve model accuracy.

The invention discloses armillariella mycelium polysaccharide ATMP capable of improving cognitive impairment and a preparation method and application of the armillariella mycelium polysaccharide ATMP. The polysaccharide is composed of two components, and the molecular weights of the two components are 2.30 * 10 < 4 > Da and 4.56 * 10 < 5 > Da respectively; the monosaccharide composition comprises mannose (Man), glucose (Glc) and galactose (Gal), and the molar ratio of the mannose (Man) to the glucose (Glc) to the galactose (Gal) is 1: 16.64: 1.96. Animal experiment results show that the armillariella mycelium polysaccharide ATMP can improve cognitive impairment induced by lipopolysaccharide (LPS) by improving the spatial memory ability of mice, repairing the disorder state and deletion injury of neurons in a hippocampal region and relieving neuroinflammatory response, so that the obvious neuroprotective effect is achieved. As a natural brain-benefiting active component, the armillariella tabescens mycelium polysaccharide ATMP has a wide application prospect in the related fields of brain health.

The present disclosure relates to the field of biological technology, and in particular, to a method for improving intracerebral gamma rhythm oscillation and reducing intracerebral Aβ deposition and neurofibrillary tangles, a method for preparing an ex-vivo brain slice of an animal and use thereof, and a method for improving learning ability, spatial memory, and episodic memory. The method for improving the intracerebral gamma rhythm oscillation is for non-therapeutic purposes, and comprises: exposing an individual of interest to microwave radiation, wherein the repetition frequency of the microwave radiation is 20-100 Hz, and the frequency of the microwave radiation is 800-2500 MHz.

A method for evaluating the spatial learning and memory ability of tree shrews using a cheese board maze, which includes three steps: experimental preparation, experimental training, and determination of modeling indicators. In experimental preparation, various parameters such as the cheese board maze device, experimental layout, and environmental settings are optimized and designed. In experimental training, training is carried out before and after hippocampal lesion. A behavioral paradigm for evaluating the spatial memory of tree shrews is successfully established, and the modeling criteria and indicators are reasonably formulated. The successful establishment of the spatial learning and memory tree shrew model of the present invention provides a behavioral experimental method applicable to tree shrews for subsequent neuroscience research such as constructing AD models, in vivo electrophysiological recordings, and optical recordings, and can also provide more powerful scientific data for researchers in the research of multiple disciplines and fields such as spatial coding, learning and memory, new drug development, screening, and evaluation.

The invention particularly relates to an unknown environment zero sample object target navigation method based on common sense reasoning, which comprises the following steps of: firstly, extracting a scene semantic tag by utilizing a pre-trained open vocabulary target detection model, and constructing a global spatial memory map to realize spatial representation and memory; and meanwhile, extracting global context information in the global spatial memory map based on a large language model so as to infer the position of a target object in an unknown area, and finally outputting a robot navigation action through path planning until the robot finds the target object. According to the method, the robot can adapt to a new object and a new environment without additional training, and the robot can understand semantic information of a target object category in an unknown environment and find an instance of the target object category without seeing a specific instance of the target object, so that the target object category can be identified. The problems that an existing object target navigation method depends on a large amount of labeled training data for training, the sample efficiency is low, and the generalization ability is poor are solved.

The invention discloses an electric power operation training system based on virtual reality, which relates to the technical field of electric power equipment maintenance and comprises a training scene construction module, a risk assessment module and a training management module. The training scene construction module is used for establishing a three-dimensional model and physical constraints of power equipment, providing tool interaction and immersive presentation and collecting actions and postures of trainees so as to improve spatial memory and posture consistency of action paths; the risk assessment module is used for explicitly marking a dangerous operation method and an electric appliance element, binding the dangerous operation method and the electric appliance element with a three-dimensional object and executing risk identification, feedforward prompt and forced intervention according to a rule set and a dangerous threshold set so as to implement suppression before a high-risk action occurs; and the training management module is used for arranging training tasks, generating a standard action template and outputting a multi-dimensional score and redisk conclusion, so that high-risk actions are inhibited before occurrence, and feedforward prompt and forced intervention are realized.

The invention provides a composition for improving learning memory, spatial memory and / or cognitive functions and application thereof. The composition disclosed by the invention comprises DHA (docosahexaenoic acid) and galactose, and the mass ratio of the DHA to the galactose is 1: (8-260). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving spatial memory, working memory and / or cognitive function.

The invention discloses an application of N1, N10-dicaffeoyl spermidine in preparation of a medicine for preventing and treating Alzheimer's disease. Belongs to the technical field of biological medicine. After the N1, N10-dicaffeoyl spermidine is orally taken by an experimental animal, the working memory, the spatial memory and the learning ability of a mouse with Alzheimer's disease (AD) induced by combination of D-galactose and aluminum trichloride can be remarkably improved, the contents of inflammatory factors TNF-alpha, 1L-1beta and 1L-6 of brain tissues of the mouse with AD are remarkably reduced, and meanwhile, the levels of A beta 40 and A beta 42 are remarkably reduced. The N1, N10-dicaffeoyl spermidine is proved to have the effect of improving learning and memory of mice with the Alzheimer's disease, and can be used for preventing and treating neurodegenerative diseases such as the Alzheimer's disease.

In nerve diseases, cell dysfunction due to amyloid aggregate accumulation in nerve cells has attracted attention, but dysfunction of nerve axons responsible for neurotransmission is also considered to be one of the causes. However, no therapeutic agent that focuses on the repair and maintenance of nerve axons has been found. An object of the present invention is to provide a therapeutic agent that activates oligodendrocytes having a function of preserving nerve axons.SOLUTION: Transcriptome analysis with a psychotropic drug is carried out using an oligodendrocyte marker as an indicator, and it is found that the combined use of DPZ and NFN characteristically increases the expression of a transcriptional factor OLIG1 inducing the differentiation-maturation of the oligodendrocyte. Moreover, the drug concentration at this time was much lower than the expected clinical dose. The combined use of NFN and DPZ was observed to improve spatial memory in the mouse Y-maze test. The combination of NFN and DPZ can provide a novel treatment for cognitive and memory functions associated with neurological disorders.SELECTED DRAWING: None

The application provides a spatial memory task device and a paradigm method based on a self-center and heterocentric navigation strategy. The device comprises an open field, a reward plate and a rest box. The open field is formed by a bottom plate and four side plates and has an open top end. The rest box opening is formed in the middle of the four side plates. The rest box door is installed at the rest box opening. The rest box is installed outside the side plate and is arranged correspondingly to the rest box opening. The reward wells are uniformly distributed on the reward plate. The reward wells are used for containing water. The reward plate is placed on the bottom plate. The experimental process comprises water limiting of the rats before the experiment and the experimental stage, i.e. a free exploration stage and a spatial memory task stage. The beneficial effects of the application are as follows: the paradigm method is used to measure the navigation strategy priority of the rats when the rats navigate, and to evaluate the strategy damage of the rats with Alzheimer's disease and how the rats with Alzheimer's disease navigate after the damage.

The invention provides an artificial intelligence simulation interactive teaching method and system based on holographic data. The method comprises the following steps: acquiring a multi-modal interactive data stream; constructing a behavior causal graph according to the multi-modal interaction data stream and the spatial region set; according to the behavior causal graph and all the interaction behavior nodes, generating an anti-fact path possibly existing in the teaching behavior of the student, and constructing a feedback fragment script of the anti-fact path; acquiring position data and action events of each frame of the student, constructing a basic space access counting graph through an indicator function to obtain an interactive memory score of the student, and performing measurement analysis on the interactive memory score to obtain a space memory score; generating a feedback strategy set and a node feedback priority ranking list; and mapping the feedback strategy set and the node feedback priority ranking list into a holographic feedback behavior, and executing the holographic feedback behavior in the actual teaching process of the student to guide the student to complete correct cognitive correction and operation repair.

The application provides a robot movement control method and a robot, wherein the method comprises: in response to the robot reaching a current waypoint corresponding to a current time step, acquiring image information and attitude information of the robot at the current waypoint; determining a current semantic point cloud according to the image information and the attitude information; determining environment memory topological information of the current time step according to the current waypoint and the current semantic point cloud; determining a next waypoint of the current waypoint according to the environment memory topological information, and controlling the robot to move to the next waypoint. The application can convert instantaneous observation into structured environment memory information through the binding of the waypoint, the semantic point cloud and the environment memory topological information, realize the continuous accumulation of long-term spatial structure knowledge, realize the online mapping of an unknown environment, solve the problems of spatial memory fragmentation and the lack of long-term structure knowledge accumulation in the prior art, and further improve the robustness and efficiency of navigation decision-making.

The application relates to the technical field of animal learning ability testing, in particular to a ring-shaped runway for detecting the space learning and memory ability of small animals, which comprises a ring-shaped bottom plate, an inner baffle is arranged on one side of the inner ring of the ring-shaped bottom plate, an outer baffle is arranged on one side of the outer ring of the ring-shaped bottom plate, an experimental area for placing experimental objects is arranged on the ring-shaped bottom plate, and a water drinking area for water drinking of research objects is arranged on the ring-shaped bottom plate. The application has the beneficial effect that in the behavioral study of animal space memory, the application can reduce the information interference suffered by the research objects and can truly reflect the space memory of the research objects under normal conditions.

The invention discloses an intelligent chess intelligence device based on induction and guidance. The intelligent chess intelligence device comprises a chessboard panel composed of a plurality of polygonal bodies and a plurality of chess pieces with different chess piece characteristics. A gap for allowing the chess pieces to pass through is formed between any two adjacent polygonal bodies; a chess piece sensing assembly used for sensing chess piece characteristics and real-time positions of chess pieces and a guiding assembly used for identifying a game starting point, a game ending point and chess piece moving tracks are arranged below the chessboard panel. According to the device, a puzzle game based on path planning and conflict warning is achieved, the hand-eye coordination, spatial memory and logical thinking ability of players can be exercised, and the device achieves distinguishing and real-time positioning of a plurality of chess pieces through cooperation of the magnetic sensor array and the chess pieces with the differentiated magnetic force, so that the intellectual property of the players is improved. Meanwhile, the starting point, the ending point, the path and the path conflict are marked for each chess piece through lamplight, visual feedback is formed, the game immersion sense is effectively improved, and the game playability is improved.

The invention provides a work memory ability training method based on electroencephalogram neural feedback, a storage medium and equipment, and the method comprises the steps: obtaining electroencephalogram signal data of a tested object in a process of executing a training task, and obtaining task execution result data of the tested object, the training task at least comprising a digital memory breadth task and a spatial memory breadth task; extracting physiological features of the electroencephalogram signal data, and calculating a cognitive state index and a global cognitive ability index according to the physiological features and the task execution result data; the training task is adjusted according to the global cognitive ability index, and the tested object is trained again according to the adjusted training task; and when it is judged that at least one of the training times, the global cognitive ability index and the cognitive state index meets a preset training condition, generating a training report at least including the cognitive state index of the tested object during each training. The computing resource consumption, the training delay and the deployment cost in the multi-dimensional training of the working memory ability are reduced.

The invention discloses application of walnut peptide in improving abundance of ackermania muciniphila in intestinal flora, and relates to the technical field of functional peptide. The walnut peptide prepared by the method disclosed by the invention is mainly used for improving cognitive function decline caused by natural aging by regulating ackermania muciniphila in intestinal flora. Specifically, (1) the spatial memory function of a naturally aged mouse is obviously improved; (2) the diversity of intestinal microorganisms of naturally aged rats is recovered; (3) reversing the F / B ratio to remodel the intestinal microenvironment; and (4) the abundance of Ackermania muciniphila is obviously increased.

The invention provides a method for training the visual clue-dependent positioning reward capability of animals by using an animal behavior training and testing system, and the system realizes that one set of system covers multiple types of experiments through the opening and closing logic of an access door of an adjusting arm, the reward region reward putting rule and the free conversion of visual clues. A visual clue-reward association learning scene is constructed, and animals are guided to establish memory association between clues and reward positions. A three-stage visual clue navigation and memory ability testing method is established, the memory retention ability associated with clue rewards is evaluated in the association stage, the spatial memory ability is independently evaluated in the blank stage, and the regulation and control mechanism of visual clues on animal spatial memory is analyzed in the non-association stage.

The invention belongs to the field of biological medicines, and discloses application of a theabrownin extract in preparation of a product for improving cognitive impairment. The theabrownin extract can improve learning and memory ability and / or spatial memory ability, thereby improving cognitive impairment. The new application of the theabrownin extract is found, and it is verified that the theabrownin extract can be used as a medicine for preventing and treating cognitive impairment and particularly can be used for preparing a medicine for preventing and treating senile dementia. The pharmaceutical composition can be prepared into various dosage forms with proper pharmaceutic adjuvants, and is suitable for being developed into new drugs. The theabrownin is derived from tea and has safety, the theabrownin extract can be developed into functional food for daily eating or drinking, and the application range of the theabrownin extract is widened.

The application discloses a space-time memory task paradigm method combining time discrimination and space memory, and a space-time memory task device, which comprises a treadmill, an arc-shaped track and two connecting bottom plates, the two ends of the arc-shaped track are respectively fixed with one end of one connecting bottom plate, and the edges of the other ends of the two connecting bottom plates are respectively close to the two ends of the treadmill, so that the treadmill, the arc-shaped track and the two connecting bottom plates form a closed ring-shaped track, and rodents move on the track; and the arc-shaped track is provided with interval mark points, and the number of the mark points is 10. The space-time memory task device contacts the time length information with the accurate position information, simulates the complex situation that the scene memory time and the space information are combined, enhances the comprehensiveness of data analysis, and provides a feasible experimental paradigm for mechanism research related to the scene memory, and the influence of time reconstruction and dynamic interaction of brain function connection.

The invention discloses a space-time memory task paradigm method and a space-time memory task device.The space-time memory task paradigm device comprises a treadmill, an arc-shaped track and two connecting bottom plates, the two ends of the arc-shaped track are fixedly installed with one ends of the connecting bottom plates respectively, the edges of the other ends of the two connecting bottom plates are close to the two ends of the treadmill respectively, and the arc-shaped track is connected with the two ends of the treadmill. The treadmill, the arc-shaped track and the two connecting bottom plates form a closed annular track, and a rodent moves on the track; ten marking points are arranged on the arc-shaped track at intervals, and the number of the marking points is ten. According to the space-time memory task device, the time length information and the accurate position information are associated, the complex situation that scene memory time and space information are combined is simulated, the comprehensiveness of data analysis is enhanced, and the space-time memory task device has great significance in mechanism research related to scene memory. And a feasible experimental normal form is provided for the influence of time reconstruction and dynamic interaction of brain function connection.

Here, the Inventors show that chronic IL- 1 -induced H2A.X signaling, which mediated DNA DSB response, in hippocampal neurons is a critical driver of cognitive deficits in chronic low grade neuroinflammation. They show that mice chronically infected with the brain- persisting T. gondii parasite display deficits in spatial memory consolidation without general memory loss. Extensive mapping of the neuroinflammatory landscape, beyond a latent T. gondii infection elicited type 1-like neuroinflammation, display elevated production of IL-1α and IL-1β in the hippocampus. Using a mouse model to specifically delete the IL-1 receptor from excitatory neurons, they uncovered that neuronal IL-1 signaling is required for the spatial memory deficits caused by latent T. gondii infection. By singling out a chronic exposure to IL- ip they found that IL-1β signaling in neurons indeed impairs spatial memory. Moreover, they showed that chronic exposure to IL-1β increases DNA DSB levels in neurons, and that neuronal H2A.X-dependent DSB response mediates the IL-1β-induced memory deficits. Importantly, neuronal DSBs were also increased upon T. gondii infection and the deficit in hippocampus- dependent spatial memory caused by T. gondii infection was prevented by the abrogation of neuronal H2A.Xdependent signaling. These results highlight the instrumental role of cytokine- induced DSB-dependent signaling in spatial memory defects elicited by a chronic infectious neuroinflammatory process. Accordingly, the present invention relates to a method of treating a subject suffering from cognitive deficit comprising administering to said subject a therapeutically effective amount of an inhibitor of IL- 1 -induced H2A.X signaling.

The invention discloses a visual cognition information training method, device and system based on VR virtual reality, and relates to the technical field of virtual reality and artificial intelligence, and the method comprises the steps: S1, collecting position movement data of a user in a VR environment in real time through a sensor, S2, analyzing a movement mode of the user according to the position movement data, and generating a movement mode report, s3, evaluating spatial memory path characteristics of the user based on the mobile mode report; S4, adjusting a spatial memory path prompting mechanism in a personalized manner according to an evaluation result so as to optimize a memory coding strategy effect; according to the visual cognition information training method, device and system based on VR virtual reality, personalized adjustment is performed on a spatial memory path prompting mechanism according to the position movement mode of the user in the VR environment, so that the problem of poor memory coding strategy effect is solved.

The invention provides a space intelligent dynamic environment modeling method and device and a medium, belongs to the technical field of space intelligence, can solve the problem of insufficient time consistency, and also can improve historical backtracking and future prediction capabilities. The method comprises the following steps: acquiring real-time environment data from a sensor, and preprocessing the real-time environment data; mapping the preprocessed real-time environment data to a learnable spatial memory unit, and realizing continuous modeling and long-term memory of a spatial state by using gradient propagation; updating the spatial memory unit according to the time sequence information; according to the time domain, historical environment data and future environment data are obtained in a bidirectional reasoning mode. The invention discloses a spatial intelligent dynamic environment modeling device and a computer storage medium.

The invention discloses application of fenofibrate to improvement of learning and memory ability decline caused by a microgravity effect. Experiments show that fenofibrate can effectively improve the reduction of the spatial memory ability of a mouse with a suspended tail. Experimental results show that fenofibrate has the value of being developed into drugs for preventing and treating related learning and memory ability decline.

Scene reconstruction is an image processing technique that creates a model of a scene from a given input, typically involving the creation of a three-dimensional (3D) scene model from one or more input two-dimensional (2D) images of the scene. High-quality scene reconstruction and rendering are useful for various applications, such as autonomous agent applications and scene editing applications. Existing scene reconstruction methods reach their limits with dynamic scenes where moving objects are inconsistent across different views at different times. These methods generally lack the motion cues essential for effective object-environment decomposition, which, moreover, leads to incomplete environment reconstruction of new views due to persistent occlusion of environmental structures.The present disclosure integrates spatial memories or a spatial memory from previous iterations of a scene when learning a representation of a temporally changing scene, thereby providing observations of obscured areas and contextual information for road users to enable more comprehensive and efficient learning of the scene representation.

The invention discloses an application of H1152 in preparation of a medicine for treating metabolism-related cognitive impairment, belongs to the technical field of medicine, breaks through the limitation that an existing medicine singly regulates metabolism or cognition, and the H1152 can synchronously inhibit abnormal weight growth induced by high fat diet and remarkably improve spatial memory water maze experiments and short-term memory new object recognition experiments. Dual intervention of metabolism and nerves is realized; compared with statins, the H1152 does not observe creatine kinase rise or liver enzyme abnormity under the equivalent lipid-lowering dosage, and animal experiments show that the H1152 has better safety; the ROCK signal channel is regulated and controlled, and the ROCK signal channel acts on vascular endothelial function improvement and neuronal synaptic plasticity enhancement at the same time, so that the problem of co-disease of metabolism and cognition is solved from the multi-target level; the body weight growth rate, the water maze escape latency and the new object recognition index are integrated as the combined curative effect markers for the first time, and quantifiable objective standards are provided for clinical curative effect evaluation.

Here, the Inventors show that chronic IL- 1 -induced H2A.X signaling, which mediated DNA DSB response, in hippocampal neurons is a critical driver of cognitive deficits in chronic low grade neuroinflammation. They show that mice chronically infected with the brain- persisting T. gondii parasite display deficits in spatial memory consolidation without general memory loss. Extensive mapping of the neuroinflammatory landscape, beyond a latent T. gondii infection elicited type 1-like neuroinflammation, display elevated production of IL-1α and IL-1β in the hippocampus. Using a mouse model to specifically delete the IL-1 receptor from excitatory neurons, they uncovered that neuronal IL-1 signaling is required for the spatial memory deficits caused by latent T. gondii infection. By singling out a chronic exposure to IL- ip they found that IL-1β signaling in neurons indeed impairs spatial memory. Moreover, they showed that chronic exposure to IL-1β increases DNA DSB levels in neurons, and that neuronal H2A.X-dependent DSB response mediates the IL-1β-induced memory deficits. Importantly, neuronal DSBs were also increased upon T. gondii infection and the deficit in hippocampus- dependent spatial memory caused by T. gondii infection was prevented by the abrogation of neuronal H2A.Xdependent signaling. These results highlight the instrumental role of cytokine- induced DSB-dependent signaling in spatial memory defects elicited by a chronic infectious neuroinflammatory process. Accordingly, the present invention relates to a method of treating a subject suffering from cognitive deficit comprising administering to said subject a therapeutically effective amount of an inhibitor of IL- 1 -induced H2A.X signaling.