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Use of lutein containing compositions to improve certain aspects of memory

A technology of lutein and memory, applied in the directions of medical preparations containing active ingredients, drug combinations, active ingredients of hydroxyl compounds, etc.

Inactive Publication Date: 2012-07-25
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lutein administration alone resulted in significant improvements only in the verbal fluency test and not in any of the other tests of cognitive ability or mood assessment administered

Method used

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  • Use of lutein containing compositions to improve certain aspects of memory
  • Use of lutein containing compositions to improve certain aspects of memory
  • Use of lutein containing compositions to improve certain aspects of memory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The role of lutein in in vitro neurotoxicity model

[0061] Glutamate is a major excitatory amino acid in the central nervous system and plays a key role in normal physiological functions. Perturbations in the normal regulatory mechanisms of glutamate function may lead to excessive neurotoxic activation of glutamate receptors in the brain, which may be detrimental to learning and memory performance in normal and aged brains. These states can be reproduced by glutamate intoxication using primary cultures of neurons. Effects on cultured neurons are indicated by morphological changes in the neurofilament cytoskeletal network of the neurons.

[0062] Neuroprotection of single compounds or combinations of compounds was assessed by analyzing network density using anti-neurofilament antibody (heavy chain 200 kD) labeling specific for mature neuronal neurites.

[0063] Riluzole (a pharmaceutical neuroprotectant) and MK801 are used as inhibitory compounds to counteract the n...

Embodiment 2

[0069] Lutein and / or zeaxanthin in a new, fully automated model of rodent learning and memory effect

[0070] In IntelliCage In , the cognitive performance of mice treated with lutein and / or zeaxanthin was compared with vehicle-treated, age-matched controls, the IntelliCage It is a system (NewBehavior AG, Zürich, Switzerland, www.newbehavior.com ; Galsworthy et al. 2005, Behav Brain Res 157: 211-217; Onishchenko et al. 2007, Toxicol Sci 97: 428-437; Mechan et al. 2009, J. Neurosci. Methods, 180: 43-51). Each mouse was identified by a sensor in the corner of the IntelliCage reading a transponder (reference identification tag) implanted in the scruff of the mouse's neck.

[0071] per IntelliCage Basically a large cage (37.5 x 55 x 20.5 cm) in which is placed a metal frame containing four recording (operating) chambers. The recording chambers were placed in the four corners of the cage, each occupying a right triangle footprint of 15x15x21 cm. Antennas in cages autom...

Embodiment 3

[0093] Preparation of soft gelatin capsules

[0094] Soft gelatin capsules may be prepared containing:

[0095]

[0096] Adults may take two capsules daily for 3 months.

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Abstract

This invention relates to a method of enhancing an aspect of memory in a healthy individual, wherein the aspect of memory is selected from the group consisting of: associative memory, spatial memory and memory under stress comprising: administering a composition consisting of: a) an effective amount of either lutein or the combination of lutein and zeaxanthin; and b) an appropriate carrier; and observing the enhanced associative memory, spatial memory or memory under stress.

Description

technical field [0001] The present invention relates to a novel nutraceutical or food composition containing lutein and / or zeaxanthin for improving certain selective memory functions such as associative learning, associative memory, learning and memory under stress, And space (orientation) learning. Background technique [0002] There is growing interest in the development of nutraceutical compositions that can be used to improve learning, memory and alertness in the elderly and young. [0003] Lutein has been described as having the ability to improve cognitive decline. See eg US2006 / 0205826 (Romero et al.), where it is suggested that lutein can protect the hippocampus of diabetic mice because it acts as an antioxidant. [0004] WO 2006 / 116755 (Trustees of Tufts College) reported a synergistic effect of docosahexaenoic acid (DHA) on the absorption and transport of lutein to the brain after long-term treatment (4 months). Such combinations are useful in the prevention or ...

Claims

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Application Information

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IPC IPC(8): A61K31/07A23L1/00
CPCA61K31/07A23V2002/00A23L1/3002A61K31/047A23V2200/322A23L33/105A61P25/00A61P25/28A61P3/02A61K2300/00A23V2250/211A61K31/025A61K31/05A23L29/035
Inventor 瑞吉娜·格拉洁克哈桑·莫哈杰瑞安尼斯·奥利维亚·麦尼-莫肯
Owner DSM IP ASSETS BV
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