212results about How to "Improve learning and memory ability" patented technology

The invention relates to a medication composition and a process for preparation the invention which is for improving cerebral cognitive function disorder, preventing and curing senile dementia. The medication composition of the invention is composed of curcuma, ginkgo leaf and thinleaf milkwort root-bark which are prepared by the techniques of weighting, drying, crashing, marinating, poaching, ethanol extracting, condensing, merging and the like. The medication composition of the invention has the effects of opening the key to the mind, refreshing the brain, nourishing heart, invigorating the circulation of blood, recuperating yin and yang, and resisting senescence, which is capable of improving study memorizing ability, and overcoming cerebral cognitive function disorder, thereby preventing and curing senile dementia.

The invention relates to a lotus leaf extract, a monomer component and application thereof. An active monomer component of the extract is aporphine alkaloid and comprises 2-hydroxy-1-methoxy-aporphine, nuciferine and N-nornuciferine. The lotus leaf extract and the monomer component have good inhibition to acetylcholinesterase, and can be developed into medicaments for treating the diseases such as Alzheimer's disease, glaucoma, asthenic bulbar paralysis, intestinal obstruction and the like.

The invention discloses a tuckahoe extract which is prepared through ethanol extraction and macroporous absorption resin purification. The tuckahoe extract enriches more effective parts. Moreover, a rat memory disorder model test proves that the tuckahoe extract can improve the learning and memory capacity of a model rat, so that the number of errors of the model rat is reduced and the latent period is prolonged.

The invention discloses a traditional Chinese medicine formulation for curing senile dementia and a preparation method thereof. The traditional Chinese medicine formulation is made of ginseng, milk veteh, epimedium, fumitory, rhizoma gastrodiae, angelica, radid polygoni multflori preparata, sealwort and grassleaf sweelflag rhizome which are performed by an ethanol extracting technology and a poach technology. The traditional Chinese medicine formulation is ground by the theory of traditional Chinese medicine and adopts a scientific theory and an advanced technology to develop the traditional Chinese medicine formulation with good curative effect and fewer side effects and being used for curing the senile dementia. The experimental research shows that the traditional Chinese medicine formulation can improve the learning memory ability of an AD rat model. Meanwhile, the traditional Chinese medicine formulation can improve the antifatigue and anti-stress ability of an organism and has good curative effect on the kidney empty. In addition, the invention also provides an optimized preparation method suitable for the industrial production.

The invention discloses a chewable tablet helpful for improving of memory. The chewable tablet is prepared from, by weight, 100-125 parts of pineapple pulp, 30-42 parts of apple pulp, 12-16 parts of peanut kernels, 8-12 parts of walnut kernels, 28-32 parts of milk tree juice, 100-110 parts of germinated brown rice milk, 15-20 parts of millet, 5-8 parts of herbs of Russian boschniakia, 6-8 parts of grassleaf sweelflag rhizomes, 12-14 parts of poria, 16-18 parts of shepherd's purse, 4-8 parts of Chinese wolfberry fruits, 2-5 parts of germanite, 12-14 parts of spirulina, 5-9 parts of kelp, 6-10 parts of mushrooms, 12-14 parts of black fungus, 0.15-0.25 part of isomalto-oligosacharide, 0.05-0.1 part of fructo-oligosaccharide, 0.2-0.3 part of peach gum powder, 1.5-1.8 parts of gulcomannan and 0.05-0.08 part of xanthan gum. The chewable tablet has an effect on improving of memory.

The invention relates to stemona root alkaloid monomer components and applications thereof. The stemona root alkaloid monomer components are stenin, neostenine, sessilifoline B, and neotuberostemonin, and are used for preparing acetylcholinesterase inhibitors. The invention relates to the applications of the stemona root alkaloid monomer components in preparing medicines used for preventing and treating Alzheimer's disease, bowel obstruction, myasthenia gravis, or glaucoma. The stemona root alkaloid monomer components can also be used for preparing medicines used for improving intelligence.

The invention provides a health-care product for supplementing nutrition of the heart and the brain, soothing the heart and benefiting the brain, and belongs to the field of health-care food. The health-care product for supplementing the nutrition of the heart and the brain, soothing the heart and benefiting the brain comprises the following raw materials in parts by weight: 30-200 parts by weight of egg yolk lecithin, 10-180 parts by weight of rhodiola roots, 10-200 parts by weight of spina date seeds, 10-150 parts by weight of grassleaf sweetflag rhizomes, 10-100 parts by weight of tortoise shells, 10-70 parts by weight of ginseng, 8-50 parts by weight of ginkgo leaves, 7-80 parts by weight of Chinese yam, 5-120 parts by weight of radix polygalae, and 5-80 parts by weight of poria cocos. The health-care product for supplementing the nutrition of the heart and the brain, soothing the heart and benefiting the brain, disclosed by the invention, has the advantages of gentle nature, good mouth feel, outstanding efficacies, broad target users, scientific and efficient preparation technology, lower cost, zero toxic and side effects and no dependence, and has extremely obvious economic benefits and social benefits.

A liquid or solid medicine for treating sanile dementia is prepared from arasaponin, icaniiin and precipient proportionally. Its advantage is higher curative effect.

The invention discloses a traditional Chinese medicine composition with functions of treating insomnia, improving senile dementia, enhancing learning and memory abilities, resisting to depression and anxiety and soothing the nerves and benefitting intelligence.The traditional Chinese medicine composition comprises Rhizoma Gastrodiae, Radix Paeoniae Alba, Radix Acanthopanacis Senticosi and Semen Ziziphi Spinosae.The traditional Chinese medicine composition can be prepared into dosage forms acceptable clinically or pharmaceutically.Animal experiments show that the traditional Chinese medicine composition can improve the sleeping function and senile dementia and enhance learning and memory abilities, and has the anti-depression and anti-anxiety effects.

The invention discloses a uses of procyanidins from lotus seedpod in preparation medicine for prevention of senile dementia and health care food. Specifically, relating to effects of procyanidins from lotus seedpod for the improvement of young mouse on learning and memory disorder caused by scopolamine and alcohol, also discussing its mechanism of action. Kunming mouse is taken as animal test in said invention, Y maze method adopted, testing the effect of procyanidins from lotus seedpod on learning and memory of the mouse, also testing brain tissue or content or activity of MDA, NO, NOS, SOD, AchE and MAO-B.

The invention relates to a walnut-tuckahoe oral liquid with function of providing assistance to improving memory and the production method thereof. The active ingredients in each 1000ml of the oral liquid comprise 100 to 180g of walnut kernel, 80 to 150g of rhizoma polygonati, 80 to 120g of tuckahoe, 80 to 150g of wheat, 30 to 60g of Chinese date, 4 to 6g of taurine, 1.5 to 2g of zinc gluconate, 0.05 to 0.1g of vitamin B1, 80 to 120g of white sugar and 0.2g of potassium sorbate. The oral liquid is prepared after procedures of extraction, condensation, ethanol precipitation, ethanol recovery, filtration, mixing, fine filtration, diluting to volume, encapsulation, sterilization, light inspection, packing, etc are carried out. The formula of the oral liquid is preferably selected according to the modern medical theory and treatment based on syndrome differentiation in the traditional Chinese medicine, thus the formula is scientific and reasonable, and the oral liquid can be conveniently taken, and is safe and reliable.

The invention relates to a milk replacer which contains at least one non-milk component as a fat or protein source, and particularly relates to intelligence promoting flammulina velutipes nutrient powder. The intelligence promoting flammulina velutipes nutrient powder is characterized by comprising the following raw materials in parts by weight: 20-30 parts of flammulina velutipes superfine powder, 8-15 parts of flaxseed meal, 20-35 parts of cereal powder and 0.2-0.5 part of a compound emulsion stabilizer, wherein the granularity of the flammulina velutipes superfine powder is 400-1200 meshes. Flammulina velutipes powder and flaxseed meal which are obtained through superfine grinding act as main components, and other auxiliary materials are added so as to prepare the intelligence promoting flammulina velutipes nutrient powder, and the intelligence promoting flammulina velutipes nutrient powder contains multiple intelligence promoting factors, vitamins and antioxidation substances, is good in mouthfeel, and is an intelligence promoting product which is suitable for students and brain workers, is rich in nutrition, and is convenient to eat.

The invention discloses an application of Hericium erinaceus extract in the preparation of medicines, health products or foods for preventing and treating the Alzheimer's disease. In vitro cell experiment researches in the invention find that the Hericium erinaceus extract can significantly enhance the proliferation of PC12 cells and inhibit injuries of Abeta25-35 to the PC12 cells; in vivo animalexperiment researches find that the Hericium erinaceus extract can significantly improve the learning and memory abilities of Abeta25-35 and D-galactose induced senile dementia model rats; and acutetoxicity experiments of cells and animals confirm that the Hericium erinaceus extract has a broad safe dose range, and can be used in the fields of the medicines, health products or foods for preventing and treating the Alzheimer's disease.

The invention provides a system for improving learning and memory ability by using a wearable device, which includes an information processing system and a rehabilitation training system, wherein theinformation processing system includes an information collection module, an information analysis module, and a wireless transceiving module, and the rehabilitation training system includes an input module, an output module, a test module, a cognition and exercise training module, and a database module; the information analysis module includes a before-training evaluation module, an after-trainingevaluation module, and an evaluation report module. The input module includes a wearable device and a microphone device. The output module includes a display device, a voice broadcasting device and asomatosensory device. The test module is used for testing before and after the training. The cognition and exercise training module has a custom mode and a recommended mode, each of which comprises cognition training and exercise training. The invention provides a completed rehabilitation training system which integrates the somatosensory mode of the wearable device. The invention further providesa completed information processing system having the effect of assisting cognition improvement.

The invention discloses a preparation method of hypericum perforatum extractive which is rich in hyperforin, which comprises the following steps of: taking the hypericum perforatum crude extractive which is sold in the market as the raw material; ultrasonically extracting in the ice water bath; preliminarily removing the impurity by means of two-phase extraction and the like to obtain 11-18% hyperforin-containing extractive; and separating and purifying by means of the silica column chromatography technology to obtain 37-57% hyperforin-containing extractive. The pharmacological test proves that the extractive has the functions of the depression resistant and the learning and memorizing promotion. The preparation method is simple and easy, is suitable for the small-scale preparation required by the pharmacological test and the like, and can save the extracting time and space.

The invention discloses a medicament for preventing and treating senile dementia. The medicament comprises the following components by weight: 5.2-122 g of sea-buckthorn, 4.6-98 g of fructusalpiniaeoxyphyllae, 3.9-93 g of lotus seed, 3.3-73 g of glabrous greenbrier rhizome, 2.8-70 g of malt and 2.2-52 g of calcined oyster shell, wherein the components are extracted, dried and crushed to prepare extract powder; and the extract powder is prepared into different preparations through different methods. The medicament has the advantages of scientific formula and simple process; and a prepared product has a function of eliminating aluminum poison in the body and is suitable for preventing and treating the senile dementia caused by the aluminum poison.

The present invention discloses applications of a morinda officinalis how fructo oligosaccharide extract in preparation of drugs, health products or food for prevention and treatment of Alzheimer's disease. According to the present invention, the in vivo animal experiment study results show that the morinda officinalis how fructo oligosaccharide extract can significantly improve the learning memory ability of the A[beta]1-42 and D-galactose-induced senile dementia simulating model rats, and the animal acute toxicity experiment results show that the safe dose range of the morinda officinalis how fructo oligosaccharide extract is wide, such that the morinda officinalis how fructo oligosaccharide extract can be used in the fields of drugs, health products or food for prevention and treatment of Alzheimer's disease.

The invention relates to application of N-(3- pyridine formex oxygen radical)-3, 5- dimethyl-1- amantadine or pharmaceutically-acceptable salt for treating vascular dementia.

The invention provides a nutritional composition for improving intestinal micro-ecology and learning and memory ability of infants fed by elderly lying-in women and application of the nutritional composition in preparation of infant formula milk powder or probiotic products. The utritional composition comprises, in weight percent, from 20% to 35% of sialylated oligosaccharides, from 50% to 60% of fucosylated neutral oligosaccharides, from 5% to 30% of non-fucosylated neutral oligosaccharides, and / or from 0.5% to 5% of osteopontin (OPN); the sialylated oligosaccharide comprises one or two of sialylated-lactose-N-tetrasaccharide c (LSTc) or sialylated-lactose-N-tetrasaccharide b (LSTb), the fucosylated neutral oligosaccharide comprises one or more of 2-fucosyllactose (2-FL), lactyl-N-fucopentasaccharide III (LNFP III), or lactyl-N-difucohexaose II (LNDFH II); and the non-fucosylated neutral oligosaccharide comprises a lactyl-N-neotetraose (LNnT).

The invention relates to the field of biotechnology, and in particular to application of dental pulp mesenchymal stem cells in treatment of Alzheimer disease. According to the invention, through experimental research, it is found for the first time that transplantation of dental pulp mesenchymal stem cells can inhibit chronic inflammation of the brain, improve learning and memory capacity and movement capacity to a certain extent, reduce number of microglia in each region of the hippocampus, and effectively treat Alzheimer disease.

The invention relates to a Lactobacillus with the efficacy of preventing and treating diabetic encephalopathy and a separation method and application thereof. The Lactobacillus is named as a Lactobacillus paracasei LC86 strain, and the preservation unit is China General Microbiological Culture Collection Center, the preservation time is December, 2013, the preservation number is CGMCC 1.12731, andthe address is No. 3, No. 1 Courtyard, Beichenxi Road, Chaoyang District, Beijing City. According to the Lactobacillus, the increase of the content of nitric oxide caused by diabetic encephalopathy can be obviously improved, the antioxidant enzyme activity of brain tissues can be improved, and the learning and memory ability can be improved. The Lactobacillus is applied to medicines for preventing and treating diabetic encephalopathy, has no toxic or side effect, and can be used for treating clinical patients together with other nutrients.

The invention relates to a preparation method and an application of a stemona effective part extract. According to the invention, stemona is subjected to reflux extraction by using 95% alcohol, such that an alcohol extract is obtained; the alcohol extract is dissolved by using water; the pH of the solution is regulated to 1-2 by using concentrated hydrochloric acid; the solution is filtered; the pH value of the filtrate is regulated to 9-11 by using concentrated ammonia water or a sodium hydroxide water solution; extraction is carried out by using a moderate polarity organic solvent; reduced-pressure concentration is carried out, such that a stemona total alkaloid extract is obtained; and the stemona total alkaloid extract is dissolved by using a small amount of ethanol; the solution is subjected to macroporous resin column chromatography; ethanol-water gradient elution is carried out; 50-80% ethanol-water elution part is collected; and the part is concentrated until dry, such that the stemona effective part extract is obtained. The application of the stemona effective part extract is the application in preparing an actylcholinesterase inhibitor.

The invention discloses health herbal tea capable of improving immunity and a preparation method thereof. The herbal tea is prepared by the following steps: adding water, boiling processed bulk pharmaceutical chemicals, such as rehmannia glutinosa, dogwood, Chinese yam, Chinese-date, poria cocos, eucommia ulmoides, polygala tenuifolia, fried schisandra chinensis, fructus broussonetiae, fried foeniculum vulgare, morinda officinalis, herba cistanche, acori graminei rhizoma, wolfberry, and adding honey and white granulated sugar so as to prepare the health herbal tea. The health herbal tea provided by the invention can effectively strengthen the human immunity, reduce various immune diseases, such as the symptoms of influenza, weakness, improve the sub-health status obviously, can delay aging, remove dull yellow skin, and brighten skin to enable the skin to be smooth, white, fine and elastic.

The invention discloses application of emodin in antagonizing accumulation of amyloid beta protein, improving cognitive memory ability and reducing senile plaques. Alzheimer's disease (AD) is neurodegenerative disease characterized by neurofibrillary tangles, amyloid beta (A beta) protein plaque deposition and cognitive decline, wherein A beta protein extracellular toxicity accumulation is considered to be one of the main links in the pathogenesis of AD. The emodin is found to be capable of significantly inhibiting the accumulation of A beta protein 1-42 monomers so as to prevent the monomersfrom forming fibers, and is also found to be capable of inhibiting the formation of a beta secondary structure, improving the spatial memory learning ability of AD mice and obviously clearing amyloidplaques in brain tissues of APP / PS1 double-transgenic AD model mice; therefore, the emodin can be applied to the treatment of AD and the research and development of related drugs.

The invention belongs to the field of medicine, and relates to an aromatic acid compound separated from dry mature seeds of Prunuspersica (L.) Batsch or Prunusdavidiana (Carr.) Franch. and application of the aromatic acid compound in medicaments for preventing and treating senile dementia. The compound has the following structure, and is prepared by the steps of extraction, concentration, extraction, concentration and purification; and the compound has an obvious protective effect on damage of Abeta (25-35)-induced neuroblastoma cell strains SH-SY5Y, and has an effect of preventing and treating the senile dementia.

The invention discloses application of artemether to prevention and treatment of Alzheimer disease. The artemether is a safe and effective compound in anti-malaria treatment and activates an AMPK signal channel in the brain of an Alzheimer disease transgenic model mouse, the learning and memory ability of the Alzheimer disease transgenic model mouse is improved, apoptosis of nerve cells in the brain is reduced, the function of a choline acetyl transferase is improved, the activity of spongiocyte is inhibited, deposition of amyloid plaques, tangling of nerve fiber and the loss of nerve cells are reduced, and the experimental basis is provided for the clinical study for treating Alzheimer disease.

The invention discloses application of momordica polysaccharide to preparation of learning and memory ability improving medicines. The influences of momordica polysaccharide to the learning and memory ability of a model of rat ageing induced by D-galactose, the influences of momordica polysaccharide to the learning and memory ability of a model of rat stroke and the influences of momordica polysaccharide to the learning and memory ability of normal rats are studied respectively. It is shown through experiment results that momordica polysaccharide has an effect on improving the learning and memory ability. The application range of momordica polysaccharide is widened, and an experiment basis is provided for the clinical application on the aspect of preparing learning and memory ability improving medicines.

The invention provides a medicament for treating senile dementia, relating to the field of medicine, in particular to a pharmaceutical composition for treating senile dementia. The medicament for treating senile dementia contains compounds beta-asarone and eugenol in mass ratio of 4:1, and a pharmaceutically acceptable carrier can be added to prepared dripping pills, injections, oral solutions, soft capsules, hard capsules or tablets. A dripping pill provided by the invention is prepared from the compounds beta-asarol and eugenol by adding a polyethylene glycol substrate, and the weight ratio of the sum of the compounds beta-asarol and eugenol to the substrate is 1:7. A gastric-soluble coating can be added to the dripping pill to prepare a gastric-soluble film coated dripping pill, and the weight of the film coating is 2-4% of the total weight of the dripping pill.