Application of dental pulp mesenchymal stem cells in preparing medicament for treating Alzheimer disease

A technology of Alzheimer's disease and mesenchymal stem cells, which is applied in the field of dental pulp mesenchymal stem cells to prepare Alzheimer's disease therapeutic drugs, can solve problems such as clinical drug vacancies, and improve learning and memory ability, exercise ability, and treatment Alzheimer's disease, the effect of suppressing chronic brain inflammation

Pending Publication Date: 2020-11-24
卡替(上海)生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The aging of the population is an unavoidable fact in China and the world. The social problems caused by AD and other senile diseases are already very serious. Recently, the therapeutic drugs developed according to the related pathogenesis of AD have failed in the clinical stage one after another, and the reasonable and effective clinical drugs still vacant

Method used

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  • Application of dental pulp mesenchymal stem cells in preparing medicament for treating Alzheimer disease
  • Application of dental pulp mesenchymal stem cells in preparing medicament for treating Alzheimer disease
  • Application of dental pulp mesenchymal stem cells in preparing medicament for treating Alzheimer disease

Examples

Experimental program
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Effect test

Embodiment 1

[0065] Example 1 Treatment of Alzheimer's Disease with Dental Pulp Mesenchymal Stem Cells

[0066] First, the purpose

[0067] To observe the effect of deciduous dental pulp mesenchymal stem cells on APP / PS1 double transgenic mice learning and memory ability, exercise ability, Abeta protein expression in hippocampus CA1 region, hippocampus TMEM119 protein expression and cerebral cortex inflammatory factors (IL-1β, TNF-α and IL -4 levels) to evaluate the therapeutic effect of deciduous dental pulp mesenchymal stem cells on Alzheimer's disease in APP / PS1 double transgenic mice.

[0068] 2. Method

[0069] 1. Dental pulp mesenchymal stem cell culture and injection preparation

[0070] Resuscitate the P2 generation dental pulp mesenchymal stem cell seed bank cells, the medium composition is 90% α-MEM and 10% FBS, the cells grow to 90% confluency, and then subculture, after two passages, the P4 generation of dental pulp Mesenchymal stem cells; when the cells grow to 80-90% confl...

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Abstract

The invention relates to the field of biotechnology, and in particular to application of dental pulp mesenchymal stem cells in treatment of Alzheimer disease. According to the invention, through experimental research, it is found for the first time that transplantation of dental pulp mesenchymal stem cells can inhibit chronic inflammation of the brain, improve learning and memory capacity and movement capacity to a certain extent, reduce number of microglia in each region of the hippocampus, and effectively treat Alzheimer disease.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of dental pulp mesenchymal stem cells in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease that is difficult to prevent and cure, and it brings serious economic and living burdens to the elderly and their families. AD mainly occurs in the elderly over 70 years old. The main pathological features are senile plaques formed by abnormal aggregation of β-amyloid protein in the brain, fibrillary tangles in neurons caused by excessive phosphorylation of Tau protein, and different degrees of atrophy of brain regions. The pathogenic mechanism of AD is very complex. So far, there are different opinions on the pathogenesis of AD, and the specific mechanism is still unclear. At present, the drugs used clinically to treat AD are mainly non-competitive N-methyl-D-aspartate receptor antagonists a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K45/06A61P25/28
CPCA61K35/28A61K45/06A61P25/28A61K2300/00
Inventor 李军曹婧韩颖
Owner 卡替(上海)生物技术有限公司
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