463results about How to "Prevent recurrence" patented technology

The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. Methods of use for activation of T lymphocytes are also provided.

Systems and methods are provided for predicting patient response to a therapy regimen for a liver disease or a disease that is treatable with an immunomodulatory disease therapy using gene expression classifiers. Systems and methods for screening for modulators of target gene expression are also provided. Systems and methods for developing therapeutics against one or more of the proteins coded for by genes of the present invention are also provided. Systems and methods for predicting a patient response to a regimen of pegylated interferon alpha and ribavirin in a therapy for hepatitis C viral infection are also provided.

Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.

A medicinal composition for treating pain resulting from an inflammatory response comprises at least one pain relieving and anti-inflammatory pharmaceutical and at least one nutraceutical in a pharmaceutically acceptable base. The pharmaceutical is preferably acetaminophen or a non-steroidal anti-inflammatory drug (NSAID). The nutraceutical is preferably an immune booster, an anti-oxidant, a liver protectant, or a joint relief agent. Methods of using these compositions to treat pain caused by inflammation are also disclosed.

Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed.

A method of treating an individual exhibiting at least one symptom of a mental disorder is provided which comprises administering to the individual an antimicrobial composition in an amount effective to inhibit or eliminate the at least one symptom of the disorder. This invention also pertains to a method of treating an individual exhibiting at least one symptom of a mental disorder by administering a probiotic mixture to replenish gastrointestinal microbes.

Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and / or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.

The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

Disclosed herein are methods and compostions comprising anti-VEGF antibodies for use in adjuvant cancer therapy.

Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is O or, when Ar has formula (i) above, then n may also be 1, R is CN, -GC(S)NH2, -C(O)NHR3 or, when R1 is 4-NO2 and R2 is H or 3-OH, then R may also be a group of formulae (iii), (iv), (v), (vi) where R3 is H, phenyl, phenyl(lower alkyl) or pyridylmethyl; R1 and R2 are each independently H, OH, NO2 or, when R is CN, also CH3, F, or CF3, provided that both R1 and R2 are simultaneously H.

The present invention provides an immunogenic composition comprising a DNA expression vector encoding both an immunopotentiating chemokine sequence as well as an immunogenic polypeptide sequence. Immunogenic polypeptide sequences are those of infectious agents or of cancerous cells. Also provided are methods of manufacturing various immunogenic compositions, and methods of using such compositions to treat cancer and infectious disease.

Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.

The invention discloses an intracranial aneurysm interventional embolization treatment device. The device comprises a plugging device and a conveying device. The plugging device is a net-shaped plugging object which is formed by knitting metal wires with a memory effect or high-elasticity polymer wires and developing wires. The plugging device comprises an upper part and a lower part which refer to an upper end intra-tumor part and a lower end extra-tumor part respectively. The upper end intra-tumor part and the lower end extra-tumor part are connected together to form a coating space for coating an aneurysmal neck. The conveying device comprises a conveying guide pipe and a conveying guide wire. In the conveying process, the plugging device is lengthened to be placed in the conveying guide pipe, and the conveying guide wire is connected with the tail of the plugging device. According to the intracranial aneurysm interventional embolization treatment device, intra-tumor thrombi can be induced to be formed, blood vessel repair of the aneurysmal neck is promoted, and therefore the purpose of healing arterial aneurysm is achieved. Moreover, parent blood vessels and normal branches cannot be affected obviously.

The invention discloses water for removing acne and controlling oil and a production process thereof. The water is mainly prepared from material components such as water, EDTA (ethylene diamine tetraacetic acid) disodium, glycerin, salicylic acid, triethanolamine, butylene glycol, Carbopol, preservatives, PEG (polyethylene glycol)-60 hydrogenated castor oil, decamethylene glycol, hamamelis virginiana extract, calendula extract, tea tree leaf oil, medicinal salvia officinalis extract, plum-leaf crab seed oil and the like in a certain proportion. Aiming at the defects of existing water for removing acne and controlling oil, the invention researches and develops the water for removing acne and controlling oil, which can be used for effectively inhibiting excessive grease secretion and improving sebum keratinization conditions by using effective components of a plant extract. The water for removing acne and controlling oil can be used for effectively promoting toxins and inflammation removal, regulating acne skin, recovering neutral skin, promoting wound healing, decomposing, converting and discharging pigments, preventing the skin from being oxidized again by free radicals and black melanin to form acne marks, fading the acne marks, and preventing acne from recurring.

A composite spot-removing liquid for removing senile plaque, chloasma, ephelides, etc and beautifying and whitening skin is prepared from 24 Chinese-medicinal materials including liquorice root, ginseng, mulberry bark, aloe, etc and 9 other raw materials including konjic acid, VA, caffeic acid, VB3, etc. Its preparing process is also disclosed.

Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.

Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.

The present invention relates to the tumor-specific expression of heterologous polynucleotides, particularly genes encoding cytotoxic products, under the control of transcriptional regulatory sequences. Particularly preferred transcriptional regulatory sequences comprise H19, IGF-1 and IGF-2 P4 transcriptional regulatory sequences, and variants thereof. The present invention also provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful for the treatment of proliferative disorders, particularly cancer.

The present invention provides an anti-cancer agent comprising anti-glypican 3 antibody wherein the anti-cancer agent is administered after a cancer treatment, Preferably, after a cancer treatment is after a treatment for liver cancer, and the treatment for liver cancer is in particular a resection of liver cancer cells. The anti-cancer agent according to the present invention is preferably administered if glypican 3 is expressed in the resected liver cancer cells. The anti-glypican 3 antibody is preferably a monoclonal antibody. The anti-cancer agent according to the present invention is useful for preventing cancer and for preventing the recurrence of cancer.

The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases. The invention provides new compounds having improved solubility and / or potency, and methods for their use. In various aspects, the invention relates to the treatment of cancer. The invention provides methods for chemoprevention and prevention of tumor recurrence or metastasis. The invention further provides diagnostic techniques for treatment for certain cancer types. The invention utilizes specific inhibitors of CDK8 / 19 and / or measurement of CDK8 levels in a patient.

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

The invention discloses a composite of all-trans-retinoic acid and liposome and application thereof. The composite of all-trans-retinoic acid and liposome consists of the liposome and the all-trans-retinoic acid encapsulated in the liposome. The composite is prepared by a method comprising: 1) dissolving lipid materials and the all-trans-retinoic acid to prepare a mixture of a lipid membrane and the all-trans-retinoic acid; 2) hydrating the mixture of the liquid membrane and the all-trans-retinoic acid to prepare a hydration product; and 3) performing ultrasonic on the hydration product to prepare the composite of the all-trans-retinoic acid and the liposome. Experiments of the invention prove that the composite of the all-trans-retinoic acid and the liposome can be used for inhibiting the reproduction of tumor cells, and the combined application of the composite of the all-trans-retinoic acid and the liposome and Vinorelbine invisibile liposome produces the strongest inhibitory effect on the recrudesce of tumors.

Compositions, articles, devices and methods for the treatment of fibrosis and fibrotic diseases, disorders, and conditions in humans and non-human animals.

The invention relates to an acne removal restoring mask applying camellia oleifera seed meal and a preparation method thereof. The acne removal restoring mask comprises the following components by weight percentage: a phase A: 1-5% of camellia oleifera seed oil, 0.5-4% of beta-cyclodextrin, and 2-8% of Tween 20, 0.5-1.5% of D-panthenol, and 43.5-87.58% of deionized water; a phase B: 5-20% of a camellia oleifera seed meal extracted solution, 0.02-0.2% of hyaluronic acid, 0.2-1% of allantoin, 0.5-3% of vitamin E, and 1-5% of collagen; and a phase C: 1-8% of xanthan gum, and 0.2-0.8% of essence. The mask prepared by the invention is conducive to discharge of skin epidermal toxin and elimination of free radicals, at the same time has the efficacy of enhancing skin immunity, improving skin metabolism, inhibiting acne recurrence, and strengthening skin restoration function.

The invention discloses full nutrition formulation food for tumors and belongs to the field of special medical-purpose food.The full nutrition formulation food for tumors is in the form of powder or particles or bulk, the water content is not greater than 5%, and the food comprises, by weight, 1-20 parts of compound polysaccharide extract, 10-30 parts of compound protein peptide, 1-20 parts of carbohydrate, 20-80 parts of fat, 1-10 parts of amino acid, 0.1-5 parts of compound vitamins, 0.1-5 parts of compound mineral matter and 1-10 parts of curcumin extract.The full nutrition formulation food for tumors not only can meet the nutritional requirements of a tumor patient but also can conduct immunoregulation on the tumor patient, inhibit growth, recurrence and metastasis of tumors, decrease postoperative complications of tumor surgery, improve tolerance of tumor chemoradiotherapy improve living quality of the tumor patient and prolong lifetime of the patient.

Provided are a formaldehyde scavenger capable of providing excellent formaldehyde scavenging performance without discoloring a wood material and not reemitting formaldehyde, and a wood material using the same.The formaldehyde scavenger contains urea, ammonium phosphate monobasic and ammonium phosphate dibasic. The formaldehyde scavenger contains urea, ammonium phosphate monobasic and ammonium phosphate dibasic preferably in a weight ratio of urea / ammonium phosphate monobasic / ammonium phosphate dibasic in the range of 5 to 45 / 0.5 to 15 / 1 to 20, and further preferably in a weight ratio of urea / ammonium phosphate monobasic / ammonium phosphate dibasic in the range of 10 to 35 / 1 to 10 / 2 to 15. The wood material is prepared by applying the formaldehyde scavenger thereto. The formaldehyde scavenger is preferably applied in the range of 1 to 50 g / m2 by dry weight.

The present invention relates to uses of cucurbitacins and compositions comprising cucurbitacin B. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof cucurbitacin B. The invention also encompass methods of developing a therapeutic that comprises a cucurbitacin using the signaling molecules in the Ras-Raf-Mek-Elk-STAT3 pathway.

The invention belongs to the field of image processing and pattern recognition, relating to a three-dimensional recognition method used for an online detection system of fabric defects. The method comprises the following steps: first converting three-dimensional data of fabrics to a coordinate system where the planes of the fabrics are positioned through coordinate transformation to realize computing of spatial dimension reduction, and then judging the types of the fabrics according to the distribution of X, Y and Z coordinates. Because of adopting three-dimensional coordinate information, the method can effectively get rid of the interference resulted from uneven wrinkles, willow catkins, ambient light or background light, not only can provide the information whether the defects exist but also can provide the types and reasons of the defects, thereby facilitating the operators to timely adjust production technology and avoiding the defects from appearing again.