11results about How to "Prevent recurrence" patented technology

This invention discloses the application of a PDLIM2 gene overexpression viral vector in the preparation of drugs for treating podocyte disease, wherein the nucleotide sequence of the PDLIM2 gene is shown in SEQ ID NO:1. This invention is the first to discover and verify the core role of the PDLIM2 gene in podocyte protection, confirming its significant downregulation in DKD and FSGS disease models, and demonstrating through functional experiments that PDLIM2 overexpression can effectively stabilize the podocyte cytoskeleton, inhibit apoptosis, and reduce proteinuria, thus establishing it as a key target gene for the treatment of podocyte disease. This invention is the first to intervene at the gene level in the core link of podocyte damage—cytoskeleton stability. By specifically upregulating the expression of PDLIM2 in podocytes, it directly enhances their intrinsic cytoskeleton support and anti-damage ability, achieving a fundamental shift in treatment strategy from "symptomatic support" to "causal repair."

The present application belongs to the technical field of fruit tree disease prevention and control, and particularly relates to a method for removing sporadic citrus Huanglongbing trees in citrus orchards. According to the epidemiological characteristics of citrus Huanglongbing, the control strategy of 'completely removing diseased plants, strictly preventing and controlling citrus psyllids, and comprehensively preventing and controlling' is implemented at sporadic disease points in the diffusion front area. The sporadic disease point orchards are promptly cleaned of diseased trees, and the diffusion front area is comprehensively prevented and controlled to prevent the disease from occurring again. In this way, disease information and risk warnings can be promptly released, the removal of diseased trees and the strict prevention and control of citrus psyllids can be achieved, the invasion and reproduction of exogenous psyllids can be hindered, the risk of healthy seedlings getting sick can be reduced, and the spread of citrus Huanglongbing can be blocked. The present application provides technical support for delaying the further spread of citrus Huanglongbing and saves human and material resources.

The application discloses a blended yarn conveying and winding equipment with a deburring function, a fixed base is arranged in a hollow frame structure, a winding drum is fixedly connected to one side of the top of the fixed base, a support frame is arranged in a back-shaped frame structure, the bottom of the support frame is fixedly connected to the top of the fixed base, a deburring device is fixedly connected to the side of the support frame, a tensioning device is rotatably connected to the inner wall side of the support frame below the deburring device, the deburring device comprises a straightening drum, a deburring rod is fixedly connected to the side of the straightening drum, a driving shaft of a first motor is fixedly connected to the side of the straightening drum, the fixed end of the first motor is fixedly connected to the side of the support frame, and the side of the straightening drum is rotatably connected to the side of the support frame.

The invention relates to the technical field of biomedical materials, in particular to radio frequency responsive polyion liquid as well as a preparation method and application thereof. The radio frequency responsive polyion liquid comprises a temperature-sensitive block formed by polymerization of N-isopropylacrylamide and a functional block formed by polymerization of a monomer as shown in a formula I; formula I: [cation] X, the cation being selected from the group consisting of 1-vinyl-3-ethylimidazolium, 1-vinyl-3-butylimidazolium, 1-vinyl-3-hexylimidazolium, benzyl ethyl trimethyl ammonium, or methacryloyloxyethyl trimethyl ammonium; x is a halide ion; and in the block copolymer, anions combined with cations in the functional block are combretastatin phosphate ions. Through the innovative design of the block copolymer, temperature sensitivity, radio frequency responsiveness and treatment activity are integrated, and a multifunctional integrated intelligent material platform is successfully constructed.

This invention provides a nucleic acid aptamer that targets and binds to the IGF2BP2 protein and its application, belonging to the field of pharmaceutical technology. This invention is the first to design a highly specific nucleic acid aptamer targeting the RNA recognition protein IGF2BP2, obtaining a nucleic acid aptamer that can target and specifically bind to the IGF2BP2 protein (see SEQ ID No. 1-2). This nucleic acid aptamer can effectively inhibit the activity of tumor cells, tumor stem cells, and breast cancer brain metastases, breast cancer lung metastases, breast cancer liver metastases, breast cancer kidney metastases, and breast cancer bone metastases, providing a new drug component for the treatment of malignant and refractory tumors (especially glioblastoma and distant metastatic breast cancer). Furthermore, it was discovered that modification with N6-methyldeoxyadenosine monophosphate can further enhance the specificity of the nucleic acid aptamer and strengthen its efficacy in inhibiting tumor cell activity.

This invention discloses a collaborative management system and method for river cyanobacteria based on AI-based early warning and targeted drug delivery. The system comprises an intelligent sensing and early warning layer, a central decision-making and control layer, and a precise targeted execution layer. The intelligent sensing and early warning layer collects environmental data of the target river through an air-ground-water three-dimensional monitoring network and uses an AI prediction model to provide early warning of cyanobacteria outbreak risks. The central decision-making and control layer receives the risk warnings and, in conjunction with algae spatial distribution, hydrological conditions, and weather forecasts, generates management strategies and control instructions based on a preset rule base and optimization algorithms. The precise targeted execution layer includes at least one unmanned targeted drug delivery vessel that receives the control instructions and executes drug delivery to complete the river cyanobacteria control. This invention achieves a shift from passive response to active intervention and from extensive management to precise control, offering advantages such as high efficiency, environmental friendliness, and long-term effectiveness.

The present application belongs to the technical field of steel pipe detection, and particularly relates to a seamless steel pipe toughness performance defect optimization method and system. The method compares the test output value with the preset comparison interval, identifies the test parameters that cause the test output value to deviate, and classifies the test parameters as positive parameters or negative parameters according to the deviation direction. The test parameters that cause the test output value to deviate are classified, the test parameters are determined as impact parameters or necessary parameters, the impact parameters are defined as optimization items, and the necessary parameters are defined as risk items. Key defects are identified, and the severity is quantitatively evaluated to provide a risk warning signal for production managers. The present application provides a data basis for exploring the causes of defects through identification and classification of defect causes, avoids indiscriminate treatment of all test parameters that cause deviation, improves the efficiency of problem diagnosis and solution, and realizes risk warning and active prevention.

The application relates to the technical field of emergency management, and discloses an emergency response and early warning system for a sudden combustion and explosion event, which comprises a multi-source data access module, which is used for collecting target equipment data and environment benchmark equipment data of energy storage equipment or a centralized charging site in real time, including temperature, current, voltage, fan state and smoke / odor sensor data, and pre-processing the collected target equipment data and environment benchmark equipment data; an abnormal index preset module, which is used for presetting a composite abnormal index representing early signs of thermal runaway and risk grading standards; and a same-site benchmarking module, which is based on the collected target equipment data and environment benchmark equipment data. The same-site benchmarking module is adopted, the environment benchmark data and abnormal acceleration change trend calculation are carried out, the technical effect of identifying the composite abnormal index in an extremely early stage is achieved, early warning is realized, and the problem that the safety window period for the operation party to take initial disposal actions is short is solved.

The invention relates to a dendrimer-based polypeptide nano vaccine as well as a preparation method and application thereof. The polypeptide nano vaccine is obtained by loading MnO2 nano particles on a functionalized dendrimer and wrapping a polypeptide antigen. After the polypeptide nano vaccine disclosed by the invention is injected into a mouse body through peritumoral injection, MnO2 plays a chemical kinetic treatment role through a Fenton-like reaction, and tumor cells are induced to generate immunogenic cell death, so that dendritic cell maturation is promoted; meanwhile, the polypeptide nano vaccine can activate an immune system and initiate potent immune response by activating a cGAS-STING pathway and being cooperated and combined with presentation of a polypeptide antigen OVA257-264, a new chemical kinetics / immune combined treatment strategy is provided, and the polypeptide nano vaccine has a remarkable inhibition effect on tumor growth and recurrence and has potential application value in the field of biological medicine.

The invention discloses application of a PDLIM2 gene overexpression virus vector in preparation of a medicine for treating podocytosis. The nucleotide sequence of a PDLIM2 gene is as shown in SEQ ID NO: 1. The core effect of the PDLIM2 gene in podocytosis protection is found and verified for the first time, it is confirmed that the expression of the PDLIM2 gene in DKD and FSGS disease models is remarkably reduced, and functional experiments prove that the overexpression of the PDLIM2 can effectively stabilize podocytoskeleton, inhibit apoptosis and relieve proteinuria, so that the PDLIM2 gene is determined as a key target gene for treating podocytosis. According to the invention, the stability of the cytoskeleton, which is a core link of podocyte injury, is intervened from the gene level for the first time. The expression of the PDLIM2 in the podocyte is specifically up-regulated, so that the internal cytoskeleton support and damage resistance of the podocyte are directly enhanced, and the fundamental treatment strategy conversion from symptomatic support to cause repair is realized.

A keloid mechanical balance microneedle, a preparation method and an application in preparing a product for preventing keloid recurrence, wherein the preparation method of the keloid mechanical balance microneedle is as follows: firstly, according to the average thickness of postoperative scar tissue of an object, a preliminary skin-scar finite element model composed of a scar structure and a skin structure is constructed, and the thickness of each position of the whole scar structure is the same; then, the keloid mechanical balance microneedle is finally obtained through four steps. The keloid mechanical balance microneedle is prepared according to the postoperative scar tissue of an object, and through the keloid mechanical balance microneedle, the stress distribution between the keloid and the surrounding skin can be uniform, and the keloid recurrence can be effectively prevented.