41 results about "Tumor removal" patented technology

The utility model discloses a tumor electric field treatment device and a treatment system, the tumor electric field treatment device is provided with a frame body and a pole piece module, the frame body forms a skeleton structure of the treatment device, the pole piece module is attached to the frame body, the pole piece module is provided with a plurality of electrode contacts, and each electrode contact can form an active contact or a passive contact. The active contact and the radio frequency generation module can form a loop; after the treatment device is implanted into a tumor excision part, all the electrode contacts form active contacts, and all the electrode contacts and the radio frequency generation module form a loop to distinguish normal tissues from pathological tissues; after the normal tissue and the lesion tissue are distinguished, the electrode contacts in the normal tissue area form passive contacts, and the electrode contacts in the lesion tissue area form active contacts, so that targeted treatment of the lesion tissue is realized, and side effects generated by electric field treatment are reduced.

The invention relates to an estrogen receptor alpha and fibroblast activating protein dual-targeting near-infrared fluorescent probe as well as a preparation method and medical application thereof. Specifically, the probe can be used as a fluorescence probe for developing cells co-expressing the estrogen receptor alpha and the fibroblast activating protein, and can also be used as a near-infrared fluorescence imaging probe for diagnosing benign / malignant lesions such as nodules / tumors co-expressing the estrogen receptor alpha and the fibroblast activating protein. The fluorescent probe can also be applied to research on related biological events in cells for co-expressing the estrogen receptor alpha and the fibroblast activating protein, and particularly can be applied to fluorescent navigation in tumor resection operations for co-expressing the estrogen receptor alpha and the fibroblast activating protein; particularly, the composition can be applied to the synergistic treatment of an anti-estrogen therapy and a photodynamic therapy on a diseased region which co-expresses the estrogen receptor alpha and the fibroblast activating protein.

A method for a method for treatment of cholangiocarcinoma (CCA) with cold atmospheric plasma and Folfirinox. The method includes treating a patient having CCA with a low dosage FOLFIRINOX regimen, for example, 6.73 nM, giving the patient the low-dosage FOLFIRINOX regimen pre-operatively, surgically removing the cancerous tumor from the patient, continuing the low-dosage FOLFIRINOX treatment regimen intra-operatively, applying cold atmospheric plasma to the surgical margins surrounding the area in the patient from which the tumor was removed, and continuing the FOLFIRINOX post-operatively.

The present application relates to providing a doxorubicin-loaded anti-tumor hemostatic microsphere constructed by a simple, safe and low-cost method and its preparation and application, the doxorubicin-loaded anti-tumor hemostatic microsphere comprises alginate, hemostatic component A, doxorubicin or doxorubicin liposome, crosslinking agent, the hemostatic component A is selected from one or more of carboxymethyl chitosan, hyaluronic acid, collagen, silk fibroin, solve the practical pain point problems such as easy bleeding in tumor resection surgery, large toxicity of chemotherapeutic drugs, large drug dose, frequent drug administration, etc., realize rapid hemostasis in operation, postoperative precise targeted drug delivery, reduce toxic side effects, long-acting drug sustained release, at the same time, all components of the system are safe and reliable, and have good biocompatibility.

The invention relates to a compound as shown in a formula (I) and / or a formula (II) and / or a formula (III) or a tautomer or pharmaceutically acceptable salt thereof, a preparation method and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicine. Specifically, the fluorescent probe can be used as a fluorescent probe for cytological imaging, can also be used as a near-infrared fluorescent imaging probe for diagnosing benign / malignant lesions such as fibrosis, nodules and tumors, and can also be applied to research of related biological events in cytobiology and molecular biology. The fluorescent probe can be particularly applied to fluorescent navigation in tumor resection surgery.

The invention relates to the technical field of operating forceps, and discloses gynecological tumor removal operating forceps which comprise an outer rod, an inner rod movably connected to the interior of the outer rod, a first handle fixedly connected to the outer end of the inner rod and a connecting assembly arranged between the outer rod and the inner rod. A limiting mechanism is arranged between the first handle and the inner rod, the top end of the first spring is fixedly connected with the second clamping rod, the outer side of the positioning block is fixedly connected with the mounting base, the slope clamping block movably penetrates through the movable groove and is clamped with the clamping groove, one end of the second spring is fixedly connected with the movable block, and a movable hole is formed in the outer side of the inner wall of the movable groove. And a pull rod is movably connected into the movable hole. The problems that when an existing device is used, a clamping rod is inconvenient to replace, and after the clamping rod is damaged and deforms, the whole operating forceps are scrapped, so that resource loss is caused are solved.

The application belongs to the technical field of medical auxiliary devices, and is especially an endoscopic foreign body and tumor removal device, which comprises a gastroscope tube, an outer protective tube and a clamping tube. The outer protective tube is sleeved on the outside of the gastroscope tube, and the clamping tube is arranged in the inside of the gastroscope tube. The rear end of the clamping tube is fixedly connected with a control handle. The inside of the control handle is screw-connected with a T-shaped screw rod. The front end of the control handle is connected with a sliding block through a rotating shaft, and the sliding block is slidingly connected with the control handle. The front end of the sliding block is fixedly connected with a main control line, and the front end of the main control line extends to the inside of the front end of the clamping tube. The front end of the main control line is connected with a branch line one and a branch line two respectively. The application can clamp foreign bodies or circular pathological tissues, and the foreign bodies or circular pathological tissues can be covered by the semicircular clamping sleeve one and the semicircular clamping sleeve two, so that the foreign bodies or circular pathological tissues are not easy to fall off during the clamping and removal process, and the application is better.

This utility model discloses a bipolar radiofrequency electrode for bone tumor surgery, which includes a cable assembly, a handle, a scalpel, and a scalpel head connected in sequence. The scalpel head includes a suction tube and an outer steel tube that is spaced and sleeved on the suction tube, with a water outlet channel formed between the suction tube and the outer steel tube. The scalpel head includes an insulating head fixed to the distal end of the outer steel tube. The insulating head is provided with a first strip electrode and a second strip electrode arranged side by side. The insulating head located at the first strip electrode and the second strip electrode has several suction holes, which are connected to the suction tube. Several water outlet holes connected to the water outlet channel are provided on both sides of the distal end of the outer steel tube. This solution uses radiofrequency electrodes to irrigate the incision after the resection of benign spinal tumors, which can accurately stop bleeding at soft tissue bleeding points, effectively reducing the amount of bleeding. Furthermore, by utilizing the circulating supply of physiological saline, the first strip electrode and the second strip electrode are effectively wrapped by physiological saline, thereby ensuring the plasma excitation efficiency.

The invention belongs to the technical field of medical image processing, and discloses a tumor resection operation planning method and system based on a 3D model, and a storage medium. The method comprises the following steps: obtaining a first medical image and a second medical image, and extracting all blood vessel branch structures in a target organ in each medical image, registering the first medical image and the second medical image based on a common branch structure, generating a third medical image, extracting a tumor area and a blood supply branch connected with the tumor, calculating the shortest distance from the center point of the tumor to the outer surface of the target organ, judging whether the shortest distance is smaller than a first preset value or not, if yes, generating a first surgical area, and if not, generating a second surgical area; and if not, generating a second surgical area, and planning a planned resection range and a surgical approach based on the surgical area. According to the technical scheme, the accuracy and the success rate of the operation can be improved.

The invention belongs to the technical field of biomedicine, and particularly relates to a non-small cell lung cancer tissue discrimination model based on differential metabolite combination as well as a construction method and application of the non-small cell lung cancer tissue discrimination model. The differential metabolite combination is composed of lactic acid, phosphoethanolamine, decenoyl carnitine and symmetric dimethylarginine or composed of xanthine, phosphoethanolamine, N-acetyl aspartic acid, decenoyl carnitine and symmetric dimethylarginine, and the determination model establishment method comprises the following steps: collecting and treating a lung cancer tissue sample, carrying out UPLC-HRMS detection, carrying out compound identification, and carrying out quantitative determination. Differential metabolites are screened, key differential metabolites are selected through an LASSO method, the performance of all models based on the key differential metabolites is tested, and the selected optimal model is a logistic regression model. The logistic regression discrimination model based on four or five differential metabolites can effectively distinguish non-small cell lung cancer tumor tissues and normal tissues, and the accuracy, the sensitivity, the specificity, the F1 fraction and the AUC are all greater than 0.8. The model has a small quantity of metabolites, and shows the potential of assisting in clinical detection of non-small cell lung cancer tissues and the potential of assisting surgeons in determining a tumor excision range.

The invention discloses application of timosaponin AIII in preparation of a curative effect enhancer for CAR-T cell therapy and a product for overcoming drug resistance. The invention proves that TAIII is an allosteric inhibitor of an adenosine A2A receptor, and blocks a downstream signal channel through allosteric combination with A2AR, so that expression of a transcription factor FoxP3 is inhibited, Tregs in a CAR-T product is selectively cleared, immunosuppression of the Tregs on effector T cells is relieved, meanwhile, the proportion of central memory T cells is increased, and amplification, durability and cytokine secretion functions of the CAR-T cells are enhanced. The invention further provides a CAR-T cell composition containing the TAIII, and the TAIII and the CAR-T cells are combined or used as a pretreatment agent, so that the tumor removal capability can be remarkably enhanced, and recurrence after treatment can be effectively prevented. The invention provides a safe and effective new strategy for enhancing the anti-tumor activity of the CAR-T cells and overcoming the drug resistance of the CAR-T therapy.

Methods and systems for determining recurrence of a tumor in a subject using mutational profiles derived from cell-free DNA obtained concurrently with or prior to tumor resection and integrating mutational profiles from the resected tumor to enhance classification models. Low-depth whole-genome sequencing data can be used to obtain a variety of molecular profiles, including genetic and epigenetic profiles, from tumor tissue and blood samples obtained after the tumor is resected from the subject. The methods may also comprise using a classifier trained to recognize mutational profiles from subjects exhibiting minimal residual disease (MRD) to determine whether a tumor recurred in a subject.

The invention discloses a glioma operation boundary identification marker and application thereof. The invention confirms that SERPINA3 can be used as a marker for identifying a glioma invasion boundary for the first time, can effectively assist operation planning and tumor excision before or during glioma operation, improves the accuracy of operation excision, provides an effective molecular tool for clinical diagnosis and treatment of glioma, and has a remarkable application prospect.

The invention belongs to the field of medicines, and discloses application of macastine B in preparation of anti-inflammatory, repair-promoting and relapse and metastasis-resisting medicines after liver cancer operation. The invention discloses an application of macastine B in preparation of a medicine for recovering a liver cancer patient after partial liver resection. The macaxantin B can promote liver function recovery, reduce the level of inflammatory factors of liver tissues and serum species, and reduce the tumor recurrence rate and the tumor visceral metastasis rate after tumor excision after an orthotopic liver cancer surgical operation, and compared with simultaneous administration of a liver protection drug and an anti-tumor drug, the macaxantin B has the advantages that the liver metabolism burden is reduced, and the curative effect is improved. And a novel drug treatment choice is provided for disease management of a liver cancer patient in a perioperative period. The invention discloses a medicine for promoting postoperative recovery of an orthotopic liver cancer surgical operation. The medicine comprises an effective therapeutic dose of macastine B and pharmaceutically acceptable auxiliary materials.

A system and method is provided using a healthy side of a brain as tractography quantification standard in surgical planning. Tools are used to compare tractography in the pathological (ipsilateral) hemisphere to the contralateral hemisphere. The tool identifies bundles in the ipsilateral and contralateral hemisphere using surgical planning software that includes an auto-segmentation feature, and provides a ratio of their symmetry, and metric comparison. This gives users a more objective and clinically relevant way of interpreting the results of diffusion quantification. It also provides a metric that can be compared longitudinally as a hemisphere recovers after tumor resection, and brain symmetry is restored.

This invention relates to the field of medical device technology, specifically disclosing a tumor resection device, including a resection mechanism, a body, a handle, a drive mechanism, a transmission mechanism, and an adsorption mechanism. The handle, body, and resection mechanism are sequentially connected. The drive mechanism is installed inside the handle, and the transmission mechanism is installed inside the body and connected to the drive mechanism and the resection mechanism. The drive mechanism drives the resection mechanism to perform tumor resection via the transmission mechanism. The adsorption mechanism is installed inside the handle and body, and when the resection mechanism removes the tumor, the adsorption mechanism removes the removed tumor. The tumor resection device has an elongated structure, and the maximum outer diameter of the cross-section of the tumor resection device is less than or equal to 10 mm. This invention's resection mechanism removes the tumor through the adsorption mechanism, effectively reducing the wound, alleviating patient pain, and lowering surgical risks.

The application discloses a kind of biomimetic 3D printing hydrogel scaffold and its preparation method and application, belong to medical instrument technical field.The biomimetic 3D printing hydrogel scaffold includes 3D printing hydrogel scaffold and in 3D printing hydrogel scaffold surface imitating mussel catalytic coating;The biological ink of 3D printing hydrogel scaffold includes methacrylated gelatin, calcium ion pre-crosslinking sodium alginate, dendritic cell-derived exosome loaded with STING agonist and methacrylated modified osteogenic growth peptide;Imitate mussel catalytic coating is by polydopamine layer and the dopa-manganese metal polyphenol network nanoenzyme loaded on the surface of polydopamine layer jointly constitute.By the synergistic effect of each component, effectively solve the technical problem that existing scaffold lacks time sequence treatment mechanism, realize the dual effect of tumor removal and bone defect repair in bone metastasis tumor treatment.

The present invention provides methods for detecting and predicting minimal residual disease in a subject who has undergone tumor resection surgery. Method of the invention utilize a personalized cutoff for determining the likelihood for MRD. In some embodiments, the cutoff is determined on a patient-specific basis and may be used in subsequent assays to analyze samples, evaluate MRD, select therapeutics, and / or evaluate therapeutic efficacy.

This invention discloses a tumor electric field therapy device and system. The tumor electric field therapy device consists of a frame and electrode modules. The frame forms the skeleton structure of the therapy device, and the electrode modules are attached to the frame. Each electrode module has several electrode contacts, and each electrode contact can be either an active or passive contact. The active contacts can form a circuit with a radio frequency generation module. When the therapy device is implanted into the tumor resection site, all electrode contacts become active contacts, and each electrode contact forms a circuit with the radio frequency generation module, distinguishing between normal tissue and diseased tissue. After distinguishing between normal tissue and diseased tissue, the electrode contacts in the normal tissue area become passive contacts, and the electrode contacts in the diseased tissue area become active contacts, enabling targeted treatment of the diseased tissue and thus reducing the side effects of electric field therapy.

Provided herein are methods and systems for detecting and monitoring cancer. The methods may include minimal residual disease analysis. The method may include using nucleic acids from a urine sample or a urine cell precipitate sample. The method may include determining nucleic acids in urine to detect a panel of biomarkers from a sample. The method may include monitoring the subject after transurethral bladder tumor resection.

The application belongs to the technical field of biomedical materials, and more particularly relates to a drug-loaded hydrogel for postoperative tumor treatment, a preparation method and application thereof. Two reaction substrates, dopamine and 3-aminobenzene boronic acid, are grafted onto a hyaluronic acid skeleton through an amide condensation reaction by a one-pot method to prepare a hydrogel scaffold material. The flexible rheological properties and excellent biological adhesion can ensure that the hydrogel is stably adhered to the resection wound without displacement, slow and pH-responsive release, and in-vivo drug retention for a long time, so that the hydrogel can respond to the tumor microenvironment and maintain the tumor resection microenvironment at a sufficient drug concentration for a long time. The hydrogel prepared by the application can simultaneously load an antitumor chemotherapeutic drug and a drug capable of improving the tumor microenvironment, so that the tumor microenvironment is significantly improved while the chemotherapeutic drug inhibits the tumor, and the two synergistically promote the intervention and inhibition of postoperative tumor recurrence and metastasis.

The application belongs to the technical field of medical devices, and specifically discloses an anti-tumor electrospun scaffold and a preparation method thereof. The anti-tumor electrospun scaffold comprises a drug-loaded electrospun scaffold body and tumor cell-derived drug-loaded micro-particles loaded on the surface of the scaffold body. The drug-loaded electrospun scaffold body comprises amino polymers, hydrophilic polymers and celecoxib with a mass ratio of (2-10):(2-13):1, which are prepared by using an electrospinning technology, and has a high specific surface area and a high porosity. The loading amount of the tumor cell-derived doxorubicin-loaded micro-particles on the anti-tumor electrospun scaffold is 0.6 μg / mg-6.1 μg / mg. The drug is directly delivered to a tumor resection cavity in the form of in-situ implantation, long-term drug retention, continuous drug release and complete degradation of the scaffold material are achieved. Residual tumor cells are effectively killed, the tumor immune microenvironment is reshaped, and the recurrence and metastasis of the tumor are inhibited.

The invention discloses a brain glioma detection device for mechanical arm assisted light sheet optical coherence elastography, which is characterized in that a millimeter-level air coupling ultrasonic excitation probe and a virtual scanning light sheet probe are jointly integrated to a mechanical arm, and non-destructive and non-contact excitation is performed on brain glioma tissues by utilizing air coupling ultrasound; the scanning light sheet is used for detecting and collecting three-dimensional structure and elasticity modulus information of brain glioma tissues; an integrated mechanical arm is used for clamping an X-ray plate scanning probe to carry out large-range elastic imaging scanning on a suspicious focus area of brain tissue, and mechanical scanning positioning and self-adaptive registration of a three-dimensional structure of the brain tissue are achieved through programming according to irregular morphology characteristics of the brain tissue; according to the system device, use of a coupling agent is avoided, nondestructive, non-contact, high-spatial-resolution and large-view-field-range self-adaptive elastic imaging of the brain glioma boundary is achieved, a doctor can be assisted in tumor excision in an operation, and it is guaranteed that normal brain tissue is not damaged while tumor excision is conducted in the maximum range.

Methods for treating and differential diagnosis between ACTH-Dependent and ACTH-Independent Cushing's syndrome are disclosed, in which a glucocorticoid receptor antagonist (GRA) is administered to a Cushing's syndrome patient with a basal ACTH level less than about 25 pg / mL. If i) the patients blood ACTH and ii) the patients blood cortisol, or adrenal hormone, or adrenal pre-hormone levels rise, or if the ACTH:cortisol ratio increases, then ACTH-Dependent Cushing's syndrome is diagnosed. If those levels do not rise, or if the ACTH:cortisol ratio decreases, then ACTH-Independent Cushing's syndrome is diagnosed. In some instances, the patient is recovering from surgery to remove an ACTH secreting tumor, and the method described herein is used to determine if the tumor resection was successful or complete. The GRA may be mifepristone, or a non-steroidal GRA having a heteroaryl-ketone fused azadecalin backbone, an octahydro fused azadecalin backbone, a cyclohexyl pyrimidine backbone, or a fused azadecalin backbone.

The application provides a kind of double-layer hydrogel microneedle combined with photothermal therapy and chemotherapy and its preparation method and use, belong to the field of biomedical materials.The microneedle in the hydrogel of the application is composed of a needle tip layer prepared from FG MN needle tip premixing solution and a backing layer prepared from CS / PEG-CHO / SA / CuSO4 double network hydrogel.The hydrogel microneedle of the application has good cell compatibility and biocompatibility, and is safe;At the same time, the hydrogel microneedle has good mechanical strength and drug loading capacity, can be dissolved after penetrating into the skin, release drugs to play effect.The hydrogel microneedle also has good photothermal performance, good effect on oral squamous carcinoma, can avoid tissue defect caused by tumor resection, and avoid inconvenience to patients' life.In addition, the hydrogel microneedle of the application has antibacterial effect, can promote the repair of infected soft tissue defect, and has good wound repair effect.The hydrogel microneedle of the application has good application prospect.

The present disclosure relates to the treatment of solid cancers, such as breast cancer, colon cancer, and lung cancer (particularly non-small cell lung cancer (NSCLC)), in human subjects using anti-PD-1 antibodies as monotherapy or as combination therapy with, for example, chemotherapy and / or surgery. The treatments provided may be a combination of tiralizumab and chemotherapy prior to surgery, using different doses of tiralizumab in an auxiliary stage after surgery. Administration regimens may include administration of 200 mg of an anti-PD-1 antibody (e.g., tiralizumab) (e.g., every three weeks) followed by tumor resection, followed by administration of 400 mg of the anti-PD-1 antibody (e.g., every six weeks). Furthermore, the chemotherapy may be platinum-based (e.g., carboplatin and / or cis-platinum), and may further include pemetrexed (e.g., for non-squamous cancer) or paclitaxel (e.g., for squamous cancer).

FIELD: neurosurgery and neurology.SUBSTANCE: after surgical access, a vessel located on the surface of the tumor tissue and extending into adjacent areas of the cortex is visualized. On both sides of the vessel, a bipolar electrode is used to coagulate the areas of the cortex affected by the tumor. Then, using microscissors, the arachnoid membrane is opened in the area of coagulation zones. An encephalotomy is performed. Next, subpial resection of the tumor in these areas is performed using an ultrasonic destroyer-aspirator, preserving the arachnoid membrane in which the preserved vessel passes. When visualizing a vessel located deep in the groove, dissection of the groove is performed while preserving the arachnoid membrane in which the vessel passes. The tumor around the vessel is resected using an ultrasonic destroyer-aspirator. In this case, first the part of the tumor on one side of the vessel is resected, then the part on the other side. These resection areas are connected to each other under the vessel. Then the residual tumor fragments on the vessel are removed. When visualizing a vessel passing through a tumor to healthy areas of the brain, this vessel is preserved, and the tumor tissue is separated from it along the periphery using an ultrasonic destroyer-aspirator. During the isolation of cortical and subcortical vessels, they are irrigated with saline solution. Then, through the resulting “intervascular windows,” deeply located tumor fragments are removed.EFFECT: method allows for the preservation of blood flow in cortical vessels during the removal of glial brain tumors, reducing the risk of developing ischemic complications in functionally significant areas of the cortex adjacent to the tumor resection zone, as well as in the subcortical structures of the brain, which, as a consequence, is associated with lower risks of developing postoperative neurological deficit.1 cl, 3 ex

The invention relates to the technical field of implantable medical instruments, in particular to a tissue strengthening material for thoracoabdominal surgery and a preparation method of the tissue strengthening material. According to the material, glycerol-lactic acid-glycolic acid hyperbranched polyester is used as a strength supporting layer, acylhydrazone bond-containing pH response antibacterial and anti-inflammatory microcapsules and chitosan-polylactic acid growth factor microcapsules are loaded, and an integrated system is formed through chemical grafting and crosslinking of 1, 4-butanediol diglycidyl ether. Time sequence coordination of mechanical support, preferential release of antibacterial components in an inflammatory environment and subsequent slow release of growth factors is realized. The material degradation path is clear, products are human body metabolizable substances such as lactic acid and glycerol, toxicity risks are avoided, biocompatibility and safety are achieved, the material is suitable for postoperative wound repair such as digestive tract reconstruction and tumor resection, the infection rate can be remarkably reduced, tissue regeneration is accelerated, adhesion is prevented, and an efficient repair scheme is provided for complex surgical operations.

The application discloses a vertebral plate reduction fixing system and an operation method thereof, and particularly relates to the technical field of medical instruments, which comprises a vertebral plate reduction fixing plate, a vertebral plate reduction fixing screw and a mounting instrument for grabbing the vertebral plate reduction fixing screw; the vertebral plate reduction fixing plate is provided with at least three first mounting holes and at least two second mounting holes, the vertebral plate reduction fixing screw is mounted in the first mounting hole and the second mounting hole, adjusting sliding grooves for the sliding of the vertebral plate reduction fixing screw are arranged between the at least three first mounting holes, and the head of the vertebral plate reduction fixing screw is provided with a double nut mechanism. The vertebral plate reduction fixing plate, the vertebral plate reduction fixing screw and the mounting instrument are arranged, the vertebral plate reduction fixing system in the intraspinal tumor resection is improved, especially for the intraspinal tumor of multiple segments, the vertebral plate and the spine are fixed in the vertebral plate spinous process complex reduction operation after the tumor resection, and anatomic reduction is achieved.