31 results about "Tumor-Specific Antibody" patented technology

The present invention provides a drug delivery system wherein a "parachute" structure is coupled to a therapeutic compound. The "parachute" structure comprises hydrophilic branched molecules with a defined action diameter. The complex (a parachute structure coupled with a therapeutic compound) is either fixed at a cell membrane or delivered to a defined distance from the membrane within the cell. The membrane-anchoring / localizing effect of the parachute is achieved by hydrophilic structures linked with a branching unit of desired therapeutic compounds. Furthermore, the parachute structures can be connected by a spacer (e.g. beta-amino acids, gamma-amino butyric acid, or poly-amino acids) instead of directly binding to the therapeutic compound, so that the therapeutic compounds can be localized within the cells at a defined distance from the cell membrane. A spacer containing a breaking point can determine the time span, during which the drug exhibits its therapeutic activity. The hydrophilic residues can also carry signals for targeting the parachute-therapeutic complex to a defined tissue type. This can be mediated by an antibody which is specific for a tumor marker. Alternatively, a Biotin can be attached at C6 position of the sugar and then react with an Avidin-labeled tumor-specific antibody. The parachute function may also be achieved by other, more bulky hydrophilic structures such as oligosaccharides connected to the branching unit. Such sugar oligomers have specific attachment points to cell selectins, and therefore do not need additional molecular structures to target a specific tumor tissue. The use of the parachute structure gives the advantages of being able to localize a photosensitizer or chemotherapeutic drug at the site within a cell where it can destroy the tumor cell most effectively. This reduces the level of necessary systemic doses of the drugs, promotes drug excretion, and therefore considerably reduces side effects of the therapy.

Provided are isolated antibodies, and fragments and derivatives thereof, which bind to tumor antigens. Also provided are compositions and delivery agents that include the disclosed antibodies and fragments and derivatives thereof; cells that produce the same; methods for producing the same; methods of using the same for detecting, targeting, and / or treating tumors and / or metastatic cells derived therefrom and / or tumor stem cells; and methods for predicting the recurrence of cancer in a subject.

The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.

The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a tumor specific antibody. In addition, the invention provides tumor-specific antibodies and immunoconjugates comprising the tumor-specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the tumor-specific antibodies of the invention.

The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.

The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.

The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.

The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.

Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.

The invention relates to a tumor specific antibody connected with a LIGHT protein or a LIGHT protein fragment, a composition containing the antibody, a method for preventing and treating cancers, and application to prevention and treatment of cancers. The LIGTH-antibody and the composition provided by the invention can be used for preventing or treating primary tumors and / or metastatic tumors, and reducing, inhibiting and lowering the growth of primary tumors and / or cancer metastasis.

The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.

The invention discloses a B cell vaccine based on Hepal-6 hepatoma cell autophagosome-DRibbles and a preparation method of the B cell vaccine. The invention firstly finds that the Hepal-6 hepatoma cell autophagosome-DRibbles used as a novel antigen carrier with an adjuvant function can be used for activating a B lymphocyte to generate a specific antibody and effectively present an antigen, and an immune mouse can induce a specific cell and humoral immune response. In addition, the Hepal-6 hepatoma cell autophagosome-DRibbles are firstly used for inducing a B cell to generate a tumor specificity antibody and effectively present a tumor antigen. The Hepal-6 hepatoma cell autophagosome-DRibbles are natural exocytosis components of a cell, and the vaccine based on the Hepal-6 hepatoma cell autophagosome-DRibbles can be used for reducing the possible harms to an organism on the basis of improving the immune response capacity, so that the vaccine is a novel antigen carrier with broad prospects.