16results about How to "Biocompatible" patented technology

The application provides a kind of iron ion Fe 3+ Doped spinel structure fluorogallate near-infrared fluorescent powder and its preparation method and medical flaw detection application.The iron ion Fe 3+ Doped spinel structure fluorogallate near-infrared fluorescent powder has the chemical formula MgGa2O4:xFe 3+ , yF ‑ ; wherein, 0.00025≤x≤0.016, 0.05≤y≤1.2. Respectively, the compound containing magnesium ion Mg 2+ , the compound containing gallium ion Ga 3+ , the compound containing fluorine ion F ‑ And the compound containing iron ion Fe 3+ As raw materials, the product is obtained by calcination treatment. The Fe 3+ Doped spinel structure fluorogallate near-infrared fluorescent powder can be applied in biomedical non-destructive flaw detection.

The present application relates to a kind of indole acetic acid ester monomer and the polymer antibacterial material containing the monomer unit, wherein indole acetic acid ester monomer has the following structure: Polymer antibacterial material has the following structure: The present application is with the biomass indole acetic acid of excellent biocompatibility as functional component, by Steglich esterification reaction, indole acetic acid ester monomer is synthesized;Again using RAFT polymerization technology successfully prepared polymer antibacterial material with excellent antibacterial activity, and the antibacterial material can be applied to antibacterial coating, agricultural antibacterial and the like.

The application relates to the technical field of drug delivery, in particular to a ZIF-8 / PDA composite material and a preparation method and application thereof. The ZIF-8 / PDA composite material provided by the application has good feasibility in terms of loading and delivering curcumin. The ZIF-8 material is modified by polydopamine, and the loading effect of the ZIF-8 material as a carrier on drugs is improved. The characterization results show that the drug loading performance of ZIF-8@PDA is obviously improved. The in-vitro release experiment results show that CuR@ZIF-8@PDA has more significant pH response drug release characteristics, shows good inhibition on Staphylococcus aureus and Escherichia coli, the hemolysis rate is 3.1%, is within a safe range, the inhibition on HepG2 cells is stronger than that of CuR@ZIF-8, and more obvious oxidative stress reaction and cell apoptosis can be induced.

This invention relates to hydroxytyrosol nanoparticles with high antioxidant capacity and stability, and a method for preparing the same. The method includes the following steps: (1) preparing a cyclic γ-polyglutamic acid solution; (2) preparing an ε-polylysine solution; (3) preparing a hydroxytyrosol solution; (4) adding the hydroxytyrosol solution to the ε-polylysine solution, stirring until homogeneous, and obtaining a mixed solution; then adding the cyclic γ-polyglutamic acid solution dropwise to the mixed solution, stirring the reaction mixture, and dialysis of the reaction solution to obtain hydroxytyrosol nanoparticles with high antioxidant capacity and stability. This invention utilizes the characteristics of cyclic γ-polyglutamic acid side chains containing a large number of negatively charged free carboxyl groups and ε-polylysine side chains containing a large number of positively charged free amino groups. By dissolving cyclic γ-polyglutamic acid, hydroxytyrosol, and ε-polylysine in water and mixing them, the antioxidant capacity and stability of hydroxytyrosol are effectively improved, solving the problem of poor stability and easy oxidation and decomposition of hydroxytyrosol under light conditions.

The present disclosure relates to a polymer film of a biosensor including a base layer formed of a first polymer, a bonding layer formed on the base layer, and an outer layer formed on the bonding layer, the base layer being formed of a first polymer, the bonding layer being formed of a second polymer, and the outer layer being formed of a third polymer, the first polymer being a homopolymer having a benzene ring or a heterocycle, the second polymer being a copolymer formed of a first monomer identical to a monomer of the first polymer and a second monomer identical to a monomer of the third polymer, wherein a mass ratio of the first monomer to the second monomer is 3:7 to 7:3, the second polymer being a water-swellable copolymer, the bonding layer having a diffusion control property, and the bonding layer being bonded to the base layer and the outer layer by at least one of a conjugation effect, a like dissolves like, a hydrogen bond interaction, and cross-linking. Thus, it is possible to provide a polymer film of a biosensor capable of expanding a response linear range and having biocompatibility.

The invention belongs to the field of biological medicine, and relates to a dsRNA compound auxiliary agent and a method and application thereof for preparing RNA biopesticide, BioIon18 biological ions (BI18) are used as a main material for loading dsRNA, and the loaded dsRNA shows relatively strong stability in extreme environments such as RNase A and strong ultraviolet, and can effectively prevent degradation of the dsRNA. Meanwhile, cell uptake of dsRNA can be promoted, and the effect of improving the target gene expression inhibition effect in cotton bollworm larvae is achieved. Other aspect designs of the invention include these BI18 at dsRNA drug complexes suitable for use in the field of ecology, as well as methods of inhibiting expression of target genes by administering these dsRNA drugs, e.g., for use in agricultural pest management.

The invention discloses a medical high-purity nano cerium oxide-based suspension as well as a preparation method and application thereof. The mass concentration of the cerium oxide-based particles in the suspension is 1-200mg / L, the chemical general formula of the cerium oxide-based particles is CexM1-xO alpha D delta, M is a cation doped element, D is an anion doped element or group, x is more than 0 and less than or equal to 1.0, alpha is more than 1.0 and less than or equal to 2.0, delta is more than or equal to 0 and less than or equal to 0.2, and the cerium oxide-based particles Ce < 3 + > in the suspension account for 25-55% of the total Ce in percentage by mass; the average primary particle size of the cerium oxide-based particles is 3-50 nm, and the dispersity of the cerium oxide-based particles in the suspension is less than 0.7. The suspension prepared by the method is high in trivalent cerium content, high in oxygen vacancy content and high in biological activity and safety, and the preparation method is low in cost, stable in technical route, free of biological harmful additives and easy for large-scale industrial production.

This invention discloses a method for cryopreservation of donkey semen using antifreeze peptides, belonging to the field of animal reproductive technology. This invention involves adding 8-polyproline (L-Pro) to the donkey semen cryopreservation solution. 8 5mM and 8-polyarginine (L-Arg) 8 5mM, and reduce the glycerol concentration to 1%. L-Pro 8 and L-Arg 8 Possessing a PPII double helix structure, it can effectively inhibit ice crystal growth and protect cell membrane structure. This invention can significantly improve the motility of frozen donkey sperm, protect intracellular structures such as mitochondria and DNA, and increase the conception rate of frozen sperm insemination, thus having significant application value.

This application belongs to the field of biomedical materials and tissue engineering technology, and discloses an antibacterial coating based on MDI-cured resin osteogenic scaffold and its preparation method. It innovatively uses diphenylmethane diisocyanate (MDI) as a curing crosslinking agent. With the help of its excellent reactivity and chemical properties, a variety of antibacterial agents (including tannic acid, ornidazole and minocycline hydrochloride) are firmly bound to the surface of a 3D printed blank resin scaffold, and a coating with hydrophilicity, high efficiency antibacterial properties and low cytotoxicity is successfully constructed, which has good antibacterial effect against both Gram-positive and Gram-negative bacteria.

This invention discloses nanoparticles for loading dihydroberberine, their preparation method, and applications. The nanoparticles comprise polydopamine (PDA) and polyethylene glycol modified with the PDA. The polyethylene glycol can be amino-NH2-terminated polyethylene glycol. In preparing the nanoparticles, dopamine hydrochloride is oxidatively self-polymerized under alkaline conditions to obtain PDA nanoparticles; the PDA nanoparticles are then modified with polyethylene glycol to obtain the nanoparticles. Utilizing the aromatic ring structure of the PDA in the nanoparticles, dihydroberberine can be stably loaded onto the nanoparticle surface through π–π stacking interactions and hydrogen bonding. These nanoparticles can effectively load and stably encapsulate dihydroberberine without complex chemical modifications to the dihydroberberine molecule, and are relatively safe and biocompatible.

The utility model relates to the technical field of medical monitoring devices, in particular to a uterine contraction monitoring patch and device based on flexible stretching perception, which comprises a polyurethane elastic plastic package layer including an upper polyurethane elastic plastic package layer and a lower polyurethane elastic plastic package layer, the upper polyurethane elastic plastic package layer and the lower polyurethane elastic plastic package layer are connected with each other to form a polyurethane elastic plastic package cavity; the flexible tensile strain sensor is arranged in the polyurethane elastic plastic package cavity to form a flexible stretchable sensing front end; the substrate adhesion layer comprises an upper substrate adhesion layer and a lower substrate adhesion layer, the upper substrate adhesion layer and the lower substrate adhesion layer are connected with each other to form a substrate adhesion plastic package cavity, and the substrate adhesion plastic package cavity is used for carrying out plastic package on the flexible stretchable sensing front end to form the uterine contraction monitoring patch. The patch utilizes the flexible sensor technology to accurately capture uterine contraction signals, and can provide non-inductive signal acquisition for pregnant women.

The invention discloses high-flame-retardant fireproof biomass composite aerogel as well as a preparation method and application thereof, and belongs to the technical field of thermal insulation materials. The preparation method comprises the following steps: by taking the sea grass as a base material, extracting sea grass cellulose, and matching with chitosan (CS), phytic acid (PA) and kaolin (IM) to construct a ternary synergistic system. Wherein the sea grass cellulose provides a skeleton structure, the chitosan forms a condensed-phase flame-retardant barrier through a charring effect, the phytic acid releases phosphorus free radicals to inhibit gas-phase combustion, and the kaolin serves as an inorganic filler to enhance the physical barrier property. The material has excellent flame-retardant and heat-insulating properties, light weight characteristics and environmental friendliness, and meets the application requirements in the fields of building heat preservation, electronic fire prevention, new energy battery flame-retardant layers and the like.

The application discloses a preparation method of konjac glucoside-based hydrophobic biomass film, and comprises the following steps: S1, purification: eluting konjac powder, drying, grinding and screening to obtain konjac glucoside; S2, modification: fully stirring and mixing the konjac glucoside obtained in the step S1 with an ethanol solution to configure a homogeneous solution, adding a sodium hydroxide solution to carry out a deacetylation reaction, and obtaining deacetylated konjac glucoside; and S3, film preparation: blending the deacetylated konjac glucoside with agar, pullulan and glycerol in a solvent, heating and stirring to form a film solution, removing bubbles, and drying to obtain the konjac glucoside-based hydrophobic biomass film formed by the deacetylated konjac glucoside, agar and pullulan; the konjac glucoside-based hydrophobic biomass film prepared by the method has good hydrophobic performance and mechanical performance, can help to reduce the dependence on fossil energy, promote the development of circular economy, and make contributions to environmental protection and sustainable development.

The present application provides a kind of irradiation crosslinking collagen injection filling agent and its preparation method and purposes.The collagen injection filling agent includes collagen gel microparticle, the collagen gel microparticle has porous structure;The collagen gel microparticle has connected fiber structure, the fiber structure is formed by collagen self-assembly, and the fiber structure includes fiber bundle and / or fiber mesh lamellar structure;The collagen gel microparticle in the collagen injection filling agent of the present application has the fiber structure formed after collagen self-assembly, i.e. collagen is spontaneously assembled from collagen molecule to fiber bundle and fiber mesh lamellar structure, and the degradation rate is delayed.The fiber network structure of the present application has good mechanical support and slow degradation rate, and simulates the three-dimensional microenvironment of natural extracellular matrix (ECM), promotes cell adhesion proliferation and tissue regeneration.The fiber structure of the present application is beneficial to the crawling proliferation of cells, and promotes the regeneration and repair of skin cells.

The invention belongs to the field of biological medicines, relates to delivery and stability of nucleic acid medicines, and particularly relates to a method for preparing a nucleic acid medicine based on biological ions and application of the nucleic acid medicine. The invention provides a zwitterionic biological material which is a cationic polyelectrolyte-nucleic acid micelle formed by inorganic salt and nucleic acid, has biocompatibility, degradability and mild preparation conditions, and can deliver nucleic acid into a living body. Meanwhile, as one of important plant nutrient sources, the plant source has a long coexistence history in the fields of human beings and ecological environments and complements each other. The invention further discusses the structural characteristics of the gene and provides a scheme for multi-scene application of plant genetic transformation, RNA delivery of human medicine mRNA, siRNA and the like, RNA biopesticide on agricultural pest control and the like.

This invention provides a polyurethane, its preparation method, and its applications. The polyurethane has the following structure: where n is 5-500. The polyurethane of this invention exhibits both narrow dispersibility and good biocompatibility, thus it can be used as a medical and health material and food packaging, and has potential application value in fields such as drug delivery, gene transfer, tissue engineering, and regenerative medicine.