837results about How to "Biocompatible" patented technology

The present invention relates to nano mesoporous and mesoporous-macroporous biological glass produced and through surfactant self-assembling and sol-gel process under mild reaction condition and possessing excellent bioactivity. The new type of biological glass has controllable mesoporous structure, homogeneous and adjustable mesopore distribution, relatively great specific surface area and porosity, macropores with adjustable size and porosity, and controllable shape. The present invention may be used as bone repairing material, dental material and rack material in tissue engineering and for medicine embedding and controlling releasing, etc.

The invention relates to a medicament carrier and a preparation method thereof, in particular to a medicament delivery system comprising biodegradable polymer vesicles with asymmetric membranes. The invention discloses the biodegradable polymer vesicles and preparation and application thereof. The biodegradable polymer vesicles are prepared from A-B-C type block polymer, wherein a block A is polyethylene glycol (PEG) distributed on outer surfaces of the vesicles; a block B is hydrophobic biodegradable polymer to form the nucleuses of the vesicles; and a block C is polyelectrolyte distributed on inner walls of the vesicular membranes and used for efficiently loading medicaments with opposite electric charge. The biodegradable polymer vesicles are formed in aqueous solution directly, can efficiently load protein and polypeptide medicaments, nucleic acid medicaments and micro-molecular medicaments, and are expected to be applied to the protein therapy and the combination therapy of cancers.

The invention discloses a pH-responsive polyethylene glycol-anticarcinogen conjugate, and a synthetic method and application thereof. After anticarcinogen molecules and polyethylene glycol are covalently linked through pH-sensitive phenylimide linkage, the conjugate is formed, wherein, anticarcinogen can be doxorubicin, epirubicin, daunorubicin, demethoxydaunorubicin or hydrochlorides of the above-mentioned anticarcinogens. The phenylimide linkage is stable under the condition of a normal physiological pH value but undergoes hydrolysis under the condition of a slightly acidic pH value, e.g., a solid tumor cell external pH value and a cell endosome and lysosome pH value; that is, the phenylimide linkage is sensitive to changes of pH values in a range of 7.4 to 4.5 or to below 4.5. The polyethylene glycol-anticarcinogen conjugate has amphiphilic nature and can form nanometer-scale micelle in a saline solution through self-assembly; the micelle can be used as a drug carrier to carry hydrophobic drugs and form a nanometer micelle preparation cladded with drugs, thereby realizing synergy therapy of a plurality of drugs.

The invention relates to a preparation method of a chitosan/polyvinyl alcohol/polylactic acid blended porous membrane, which comprises the following steps of: (1) using an acetic acid solution as the solvent to dissolve chitosan at 30-40 DEG C to obtain a chitosan solution of which the weight percentage is 3%; (2) using a dimethyl sulfoxide solution as the solvent to dissolve polyvinyl alcohol at room temperature to obtain a polyvinyl alcohol solution of which the weight percentage is 5%; (3) using deionized water as the solvent to dissolve polyvinyl alcohol at 80-120 DEG C, and stirring until the polyvinyl alcohol is completely dissolved to obtain a polyvinyl alcohol solution of which the weight percentage is 7%; (4) mixing the three solutions based on a certain ratio, stirring for 15-30 minutes at the constant temperature of 20-30 DEG C, standing, and defoaming; and (5) using a freeze drying method to prepare the blended porous membrane. The invention has the advantages of no toxic material in the membrane preparation process, simple membrane preparation device and process, biodegradability and convenient clinical use, and can be used for artificial skins, dressing and the like in the biomedical field.

The invention provides a gradient biocompatible polymer foaming material with an opening structure, and the gradient biocompatible polymer foaming material comprises at least two biocompatible polymers, wherein the content of the biocompatible polymer in the foaming material as well as the cell size and aperture ratio of the foaming material change in gradient along the thickness direction of a flat shaped foaming material or the radial direction of a cylindrical foaming material. The preparation method of the gradient biocompatible polymer foaming material with the opening structure comprises the following steps of: preparing a gradient parison and foaming the gradient parison.

The invention relates to a magnetic thermometer nm particle with biocompatibility, which has biocompatibility, and double response properties of magnetism and thermometer property, and the particle diameter thereof is 20 to 60 nm, and the magnetic responsibility is strong, and magnetic saturation intensity is 10.0 to 27.0 emu/g. The synthetic method of the magnetic thermometer nm particle with biocompatibility comprises: firstly, adopting chemical coprecipitation method to prepare magnetic Fe3O4 nm particle, and using silane coupler to hold surface modification, and then using the modified magnetic Fe3O4 nm particle as a seed, and having polyreaction with dextran, N-isopropyl acrylamide, finally obtaining the magnetic thermometer nm particle with biocompatibility. The magnetic thermometer nm particle with biocompatibility synchronously has double responses of magnetism and thermometer property, and has wide application prospect in the fields of drug release, protein and enzyme separation.

The invention relates to the field of physiological monitoring sensors and discloses a wearable flexible sensor for monitoring wrist pulse, a preparation method for the wearable flexible sensor for monitoring the wrist pulse, and a monitoring system based on the sensor. The wearable flexible sensor for monitoring the wrist pulse comprises a fabric object, a blocked layer formed on the fabric object and in contact with the wrist pulse region, a sensitive layer formed at the upper surface of the blocked layer, an electrode layer comprising at least two electrodes which lead from the sensitive layer or the surface of the sensitive layer, and a skid-friendly layer, wherein the sensitive layer is made of three-dimensional porous nanometer sensitive material, the skid-friendly layer and the blocked layer are made of high-molecular polymer and have bio-compatibility, and the skid-friendly layer and the blocked layer together package the sensitive layer. The wearable flexible sensor for monitoring the wrist pulse is thin and soft, capable of being processed into different shapes, and capable of being worn on the wrist pulse or attaching to the wrist pulse to monitor the pulse information.

The invention relates to a degradable and nontoxic medical polyurethane material and a preparation method thereof, belonging to the technial field of biomedical high polymer materials. Raw materials thereof adopt poly (epsilon-caprolactone) dibastic alcohol (PCL) as a soft segment and L-lysine ethyl ester diisocyanate (LDI-E) or L-lysine methyl ester diisocyanate (LDI-M) and chain extender L-lysine ethyl ester (Lysine-E) or L-lysine methyl ester (Lysine-M) as a hard segment, wherein the number-average molecular weight of the poly (epsilon-caprolactone) dibastic alcohol ranges from 500 to 5000.The polyurethane of the invention is degradable, and degradation products thereof are harmless to human bodies; as a great amount of carbamido is contained in the polyurethane, the mechanical property and the degradation property of the polyurethane are improved; and the degradation products are completely nontoxic, the degradation product of lysine can neutralize 6- hydroxyl hexanoic acid generated by soft segment degradation, the pH value of adjacent tissues can not be changed, and therefore the polyurethane prepared by the invention has favorable biocompatibility.

The invention relates to a chitosan nano fibrous membrane adsorbing material and a preparation method thereof. The preparation method for the chitosan nano fibrous membrane adsorbing material comprises the steps as follows: chitosan spinning liquid is added into electrostatic spinning equipment; a chitosan nano fibrous membrane is prepared by an electrostatic spinning method; and the obtained chitosan nano fibrous membrane is soaked into alkaline liquid, and then is cleaned and dried to obtain the chitosan nano fibrous membrane adsorbing material. The average diameter of the nano fiber for forming the adsorbing material is 10-600nm; and the porosity of the adsorbing material is 15-60 percent. The adsorbing material has the characteristics of biocompatibility, biodegradability, hydrophilicity, low cost, large adsorption capacity and broad material sources. The adsorbing material can effectively absorb heavy metal ions comprising Cu (II), Hg (II), Cd (II) and Pb (II).

The invention relates to the field of composite materials and medical instruments, in particular to a preparing method for a high-strength high-isolation condom comprising a modified graphene/latex interlayer. The preparing method includes the steps that stable dispersion liquid prepared by modified graphene, latex liquid and common auxiliaries are mixed evenly to prepare compound latex liquid; a three-time impregnation process is adopted for forming, conventional latex liquid is used for impregnation in first-time and third-time impregnation, and the modified graphene/latex compound latex liquid is used as impregnation liquid in second-time impregnation to obtain the condom which is provided with conventional latex films on the innermost surface and the outermost surface and a modified graphene/latex compound material film interlayer in the middle to be of a sandwich structure finally. The prepared composite grapheme condom has the characteristic of blocking penetration of small-size viruses. Tear resistance and other indexes are obviously improved, and the blasting volume and the ultimate elongation rate are obviously increased on the premise of the same size. The high-strength high-isolation condom has the advantages of being scientific in principle, poisonless, harmless, stable in performance and capable of being matched with the current condem production process easily, and characteristics are remarkable.

The invention discloses a modifiable fluorescent compound with the maximum emission wavelength range of 1000-1600nm (the II region of a near infrared window) and a preparation method of the modifiable fluorescent compound. A modifiable group is introduced to a structural compound of a diazosulfide group (D-A-D), the increased modifiable site is connected with a bioactive substance, and furthermore, the water solubility and biological compatibility of the compound are improved. The modifiable fluorescent compound is an organic small-molecular compound and is nontoxic, good in absorbability, extremely good in biocompatibility, extremely high in developing sensitivity, capable of playing an important role in the future medical and optical check, and extremely favorable in application prospect. The compound disclosed by the invention can be used as an infrared window II-region reporter molecule for in-vitro detection and in-vivo imaging and can be used for detecting cell markers and tissue specimens and realizing early diagnosis of diseases, diseases staging, intraoperative navigation treatment, postoperative evaluation of therapeutic efficiency and the like.

This invention relates to a preparation method for poly-asparagic acid resin, which takes poly-pyrrolidine dione as the raw material to make crosslink poly-pyrrolidine dione with method of non-even phase suspended emulsion crosslink or non-even phase suspension crosslink and processes poly-asparagic acid resin by hydrolyzation characterizing that the crosslink poly-pyrrolidine dione is prepared by multi-section crosslink reaction, in which, the crosslinker is fed in for 2-4 times in equal volume and equal time interval, the crosslink poly-pyrrolidine dione and the resin are aged and crystallized and quickly dried, A ageing and crystallization process for 1-10 days under room temperature, B, quick drying process is carried out under -54-40deg.C.

The invention belongs to the technical field of nano-imprinting and spectra, and in particular relates to a multilayer structure surface enhanced Raman scattering base and a preparation method thereof. The surface enhanced Raman scattering base is simple in process, high in efficiency, high in enhancement factor and biocompatible. The base consists of a substrate and a periodic nano columnar structure which is positioned on the substrate, wherein the nano columnar structure is a multilayer structure; the multilayer structure consists of alternation layers and a gold layer; the alternation layers consist of silver and media; the gold layer is positioned on the topmost layer. A nano-imprinting technology is used as a core technology, and a reactive ion etching process, a metal evaporation process, a silicon dioxide plating process, a metal peeling process and the like are combined to prepare a multilayer nano structure, so that the technical problems that a silver structure base is not biocompatible and a gold structure base is low in enhancement factor are solved; on the basis of ensuring biocompatibility, the enhancement factor of the base is greatly improved, the detection is efficient and sensitive, and the base can be applied to biological detection after further treatment.

The invention provides a nickel doped copper sulfide nano material. The chemical general formula of the nickel doped copper sulfide nano material is Cu1-xNixS, wherein CuS refers to a substrate, Ni<2+> refers to doping ions, and the value range of x is that x is larger than 0 and is smaller than or equal to 0.8; the nickel doped copper sulfide nano material provided by the invention is a multifunctional nano material and simultaneously has a magnetic resonance imaging function and a photothermal therapy effect, so that the nickel doped copper sulfide nano material can be used as a magnetic resonance imaging probe and a photothermal therapy reagent and is a nano material integrating detection and therapy. The invention further provides a preparation method and an application of the nickel doped copper sulfide nano material.

The invention discloses a pH-stimulation response type intelligent nanometer container and a preparation method thereof. The method comprises the following steps of preparing mesoporous silica microspheres; performing dealcoholization on the dried mesoporous silica microspheres and an alkynyl-containing silane coupling agent in dried methylbenzene; preparing 2-bromo-ethyoxyl-2-azido radical-ethyoxyl propane; after the product obtained through dealcoholization is dried in vacuum, performing click chemical reaction on the product, excessive 2-bromo-ethyoxyl-2-azido radical-ethyoxyl propane and the dried N,N-dimethyl formamide to generate a five-membered ring; after the obtained product is dried in vacuum, dispersing the product in a buffer solution of NaH2PO4/Na2HPO4 which contains absorbed molecules, adding amino-beta-cyclodextrin into the buffer solution, and performing substitution reaction to obtain the final product, i.e. the PH-stimulation response type intelligent nanometer container. The pH-stimulation response type intelligent nanometer container provided by the invention is high in sensitivity to pH and simple and convenient in response operation; automatic opening/closing of a valve can be realized; releasing of molecules absorbed in the nanometer container is promoted; the pH-stimulation response type intelligent nanometer container has a good application prospect.

The invention provides a preparation method of a gamma-polyglutamic acid/Pulullan composite hydrogel. The hydrogel contains gamma-polyglutamic acid, Pulullan and water. The preparation method comprises the following steps: dissolving 8-20% of gamma-polyglutamic acid in distilled water to obtain a first reaction solution; adding Pulullan according to different gamma-polyglutamic acid/Pulullan ratios to obtain a second reaction solution; and adding a crosslinking agent into the second reaction solution, stirring uniformly, regulating the pH value of the system, and reacting at 50 DEG C for 24 hours. The gamma-polyglutamic acid/Pulullan composite hydrogel prepared by the method has favorable adsorbability for brine. The hydrogel is applicable to a brine environment, and is especially applicable to an environment of soil, sweat, blood or the like.

The invention discloses preparation methods of a nanometer piezoelectric film and a nanometer composite piezoelectric generator. The methods are characterized in that biocompatible bacterial cellulose is taken as a substrate, and nanometer (or submicron) piezoelectric particles having high piezoelectric coefficients are taken as a filling material, the piezoelectric film is obtained by compounding the bacterial cellulose and the piezoelectric particles, and the piezoelectric film is used for constructing the flexible nanometer composite piezoelectric generator. Through the unique spatial three-dimensional network structure of the bacterial cellulose, the piezoelectric particles are naturally and uniformly distributed in the bacterial cellulose, and the internal stress of the film is uniformly, thereby greatly improving the output performance of the nanometer composite piezoelectric generator. The nanometer composite piezoelectric generator is biocompatible, and can be implanted into a living body to collect energy. Moreover, a preparation process is simple, the cost is low, and the nanometer piezoelectric film and the nanometer composite piezoelectric generator have very good application prospects.

The invention discloses a nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material and a preparation method thereof. The drug sustained-release material comprises nanometer cellulose, polydopamine and a drug loaded on the polydopamine, can be applied to the field of various drug sustained release and is especially suitable for the aspects of wound treatment, tumor postoperative treatment, and the like. The drug sustained-release material disclosed by the invention can load hydrophilic and hydrophobic drugs, is simply prepared, is mild and is capable of saving cost. The nanometer cellulose and the polydopamine both have biocompatibility, can completely degrade, are easy for waste treatment and are beneficial to environmental protection. The drug sustained-release material is especially suitable for wound healing and later treatment of tumor operation.

The invention belongs to the fields of high polymer materials and biomedical engineering and particularly relates to a method for preparing pH-responsive graft copolymer taking ethyl cellulose as a main chain. The method comprises the following steps of: performing esterification reaction on residual hydroxyl in the ethyl cellulose main chain and a bromine-containing compound under the protection of inert gas nitrogen or argon to convert the hydroxyl into a bromine group; and performing atom transfer radical polymerization on a methacrylic acid-N,N-lignocaine ethyl ester monomer by using the bromine group as a macroinitiator to form pH-responsive polymer so as to finally obtain the pH-responsive graft copolymer taking the ethyl cellulose as the main chain. The pH-responsive graft copolymer taking the ethyl cellulose as the main chain has biodegradability, biocompatibility and pH value sensitivity and can be self-assembled into stable nano micelles in water, so the pH-responsive graft copolymer can be widely applied to the fields such as medicament release control carriers, biological intelligent switches, biological sensors, biological nano devices and the like. The method has the advantages of simpleness, practicability, industrialized production of raw materials and high popularization and application value.

The invention discloses a preparation method of composite fiber of cellulose nanometer fibrils/alginate. The method includes steps of evenly dispersing cellulose nanometer fibrils under ultrasound wave function, and preparing aqueous suspension; then evenly mixing with alginate solution and obtaining the mixed solution of cellulose/ sodium alga acid as spinning raw liquid; spinning by wet method and obtaining the composite fiber of cellulose nanometer fibrils/alginate. The preparation method is simple and easy to operate, the technique is green and environmental-friendly; the prepared composite fiber of cellulose nanometer fibrils/alginate is an environment-friendly recycled material, and has the same excellent biocompatibility and biological degradability as the pure alginate fiber; the oriental controllability of cellulose nanometer fibrils is enhanced, and the cellulose nanometer fibrils and the base alginate are formed to be an interpenetrating polymer network structure, thereby effectively improving the intensity and flexibility of composite fiber and greatly improving the adaptation of alginate fiber in textile and garment and medical treatment health domain.

A human corneal limbal stem cell-amnion tissue engineering complex using human corneal limbal fibroblasts as the trophoblast is characterized in that: it is close to the human corneal epithelium form in histology form, and is analogous to the human corneal epithelium in immunology phenotype, its ultrastructure shows that the connection between the cells grows mature and the connection between the epithelia and the amnion carrier is a close conglutination. The culture method includes the following steps: (1) preparing the amnion for culturing the human corneal limbal stem cell in vitro; (2) preparing the human corneal limbal fibroblast trophoblast; (3) preparing the human corneal epithelia suspension; (4) culturing the human corneal limbal stem cell-amnion complex. The human corneal limbal stem cell-amnion complex has analogous phenotype to the human corneal epithelium, and provides a safe and effective biology tissue engineering product to treat corneal limbal stem cell defective eye diseases.

The invention discloses a breeding method of a night fluorescent pearl oyster, comprising the following steps of: uniformly mixing night fluorescent powder with epoxide resin; coating an obtained mixture on the surface of a pearl nucleus; curing, and coating methyl methacrylate as a protecting layer; treating by using a pearl nucleus adjusting agent prepared from algal polysaccharides and aureomycin; treating cell shells by using an adjusting agent prepared from shellfish meat hydrolyzate same as that for a pearl oyster (mussel), and aureomycin, and carrying out an pearl-nucleus-inserting operation; and then fostering a freshwater mussel or pearl-breeding shellfish in a recuperation pool temporarily after the pearl-nucleus-inserting operation, then placing the freshwater mussel or pearl-breeding shellfish in a breeding water area for hoisted breeding, and harvesting after maturity to obtain a pearl, namely a night fluorescent pearl. According to the breeding method of the night fluorescent pearl oyster, the problems that the traditional pearls have single kind and low added value as well as the pearl-nucleus-inserting operation has low nucleus reserving rate and great repelling force are mainly solved; the ornament and the added value of the pearls are increased; and the nucleus splitting rate and the repelling force of the pearl oyster subjected to the operation are reduced.

A tissue-engineered complex of human limbus stem cell and amnion for treating the limbus stem cell-deficiency eye diseases is disclosed. It is perpared through removing epithelium from amnion, using it as carrier, using fibroblast 3T3 as nutritive layer, culturing by cell suspension method, and promoting differentiation of cells by air-lifting technique.