4 results about "Ornidazole" patented technology

The application belongs to the technical field of medicine synthesis and provides a preparation method of phosphonic acid levomoxiflazine disodium, which comprises the following steps: taking levomoxiflazine as raw material, performing esterification through phosphorus oxychloride and hydrolysis to obtain a reaction solution containing phosphonic acid levomoxiflazine; slowly and uniformly adding a sodium hydroxide methanol solution, first adjusting pH to 6.3-7.6, filtering out impurities, then adjusting pH to 9.1-9.8, crystallizing and drying to obtain a crude product; and performing recrystallization through a water-ethanol-acetone mixed system, filtering and drying to obtain a high-purity product. The application solves the problems of high impurity content and low yield in the prior art by optimizing the amount of esterification reagent, the pH adjustment mode and the recrystallization system, the HPLC purity of the obtained phosphonic acid levomoxiflazine disodium is greater than or equal to 99.97%, the maximum single impurity content is less than or equal to 0.02%, the process is simple, easy to operate, stable and suitable for industrial amplification production.

The application aims to provide a preparation method of high-purity phosphonic acid levonikosazol ester disodium hydrate, which has the advantages of controllable reaction condition, stable quality, high yield and suitability for industrial production, etc.

1.The name of the design product: packaging box (ornidazole injection). 2.The use of the design product: the design product is used for the outer packaging of ornidazole injection. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best shows the design points: front view. 5.The design claimed contains color.

The invention discloses a bio-responsive drug-loaded micelle targeting fusobacterium nucleatum as well as a preparation method and application of the bio-responsive drug-loaded micelle, and relates to the field of biomedicine. The preparation method comprises the following steps: firstly, synthesizing block copolymers PBA-PEG-b-PCL and GalNAc-PAE-b-PCL; then, calcipotriol (Cal) and ornidazole (ONZ) are connected through a disulfide bond, and a conjugate Cal-ONZ is prepared; the two segmented copolymers are used for self-assembly and loading of Cal-ONZ, and the drug-loaded nano micelle C-O (at) CPM-GalNAc is obtained. The micelle can realize targeted removal of fusobacterium nucleatum and release of a matrix barrier in a tumor microenvironment, and by constructing an immune transfer closed loop infiltrated and activated by T cells, the anti-tumor immune response is remarkably enhanced, and the curative effect of an alphaPD-L1 checkpoint inhibitor is improved. The strategy is expected to provide a new solution for colorectal cancer immunotherapy related to fusobacterium nucleatum.