2 results about "Ornidazole" patented technology

The application belongs to the technical field of medicine synthesis and provides a preparation method of phosphonic acid levomoxiflazine disodium, which comprises the following steps: taking levomoxiflazine as raw material, performing esterification through phosphorus oxychloride and hydrolysis to obtain a reaction solution containing phosphonic acid levomoxiflazine; slowly and uniformly adding a sodium hydroxide methanol solution, first adjusting pH to 6.3-7.6, filtering out impurities, then adjusting pH to 9.1-9.8, crystallizing and drying to obtain a crude product; and performing recrystallization through a water-ethanol-acetone mixed system, filtering and drying to obtain a high-purity product. The application solves the problems of high impurity content and low yield in the prior art by optimizing the amount of esterification reagent, the pH adjustment mode and the recrystallization system, the HPLC purity of the obtained phosphonic acid levomoxiflazine disodium is greater than or equal to 99.97%, the maximum single impurity content is less than or equal to 0.02%, the process is simple, easy to operate, stable and suitable for industrial amplification production.

The application aims to provide a preparation method of high-purity phosphonic acid levonikosazol ester disodium hydrate, which has the advantages of controllable reaction condition, stable quality, high yield and suitability for industrial production, etc.