227results about How to "Improve skin penetration" patented technology

A cosmetic composition with superior moisturizing benefits comprising from approximately 0.3% to approximately 0.9% by weight of bio-chelated mineral blend comprising silicon, magnesium, copper, iron, zinc, and calcium, and at least approximately 85.0% by weight of a humectant blend. Preferably, the bio-chelated mineral blend comprise Saccharomyces zinc ferment, Saccharomyces copper ferment, Saccharomyces magnesium ferment, Saccharomyces iron ferment, Saccharomyces silicon ferment, and Saccharomyces calcium ferment in equal amounts, more preferably from approximately 0.05% to approximately 0.15% by weight of each component. The humectant blend preferably comprises glycerin, beet root extract, and Aloe barbadensis leaf polysaccharides.

The invention discloses a human epidermal growth factor nanoliposome, which contains liposome microcapsules and human epidermal growth factor wrapped in the liposome microcapsules, wherein the mass ratio of the human epidermal growth factor to the liposome microcapsules ranges from 1: 50 to 1: 200. The invention also discloses a method for preparing the human epidermal growth factor nanoliposome. Phosphatide and cholesterol are adopted as the main membrane materials, whose biomembrane-like structures are similar to the skin structure and have good transdermal permeability, and are easier to prepare a lipid carrier with a uniform particles size and high entrapment rate by a preparation technology. According to the invention, human epidermal growth factor (hEGF) is prepared into the nanoliposome. As a raw material, the nanoliposome supplemented by other biologically-active substances such as hyaluronic acid is prepared by a corresponding preparation technology into aqua, cream and emulsion skin care products, so as to rapidly repair damaged skin, repair and remove wrinkles, nurse after sunscreen and radiation examination, nurse sensitive skin, and remove and repair various scars.

The invention discloses plant ointment for preventing and treating diaper rash of a baby and a preparation method of the plant ointment. The plant ointment is prepared from raw materials in parts by weight as follows: 3-8 parts of sea buckthorn fruit oil, 6-12 parts of tamanu oil, 13-19 parts of a calendula extracting solution, 16-22 parts of lanolin, 12-20 parts of shea butter, 9-15 parts of virgin coconut oil, 6-14 parts of sweet almond butter, 5-12 parts of chamomile butter and 6-13 parts of candelilla wax. According to the plant ointment, cold pressed virgin plant vegetable oil is adopted, no mineral oil or chemical ingredients are contained, the molecules are small, and the plant ointment has good skin-friendly permeability, high air permeability as well as good absorptivity, sterilization and itching relieving functions, forms a protecting film on the skin surface, effectively moistens skin, relieves stimulation, promotes repair growth of festering tissue, has a good curing effect on light and heavy diaper rash, is suitable for daily nursing and use, is safe and mild, has no side effect, is convenient to use and has high popularization value.

The invention provides a transdermal delivery ointment. The transdermal delivery ointment comprises 0.05-10wt% of colchicine, 5-45wt% of medical sterile water, 5-30wt% of a water-soluble excipient, 10-60wt% of an oil-soluble excipient, and 0.1-10wt% of a transdermal enhancer, wherein the sum of the percentages of the above components is 100wt%. The invention also relates to a preparation method of the transdermal delivery ointment. The transdermal delivery ointment can be directly used against foci, and can avoid the generation of side effects of colchicine.

The invention relates to a microemulsion transdermal gel agent of butylphthalide or a derivative thereof, and a preparation method thereof, and belongs to the technical field of medicaments. The technical scheme is that: the microemulsion transdermal gel agent is prepared mainly from the following ingredients in part by weight: 1 to 5 parts of oil phase, 1 to 5 parts of emulsifying agent, 0.1 to 1 part of auxiliary emulsifying agent, 1.5 to 15 parts of purified water and 0.003 to 0.5 part of transdermal accelerator. Compared with a comparison example, the microemulsion transdermal gel agent of the butylphthalide or the derivative thereof almost does not influence the microemulsion appearance and granular size under the conditions of centrifugation and high temperature, and is a dynamic and thermodynamic stable system. An in vitro transdermal performance test proves that the microemulsion transdermal gel agent of the butylphthalide or the derivative thereof has good transdermal absorbability. In conclusion, the microemulsion transdermal gel agent of the butylphthalide or the derivative thereof has the simple preparation method, does not need the procedures of high-speed cutting or homogenizing and the like, has small product granular size, and contributes to industrialization.

The invention relates to a preparation method and application of a procyanidine liposome. The procyanidine liposome comprises 0.01-0.1% of procyanidine, 0.1-5% of surface modified liposome and the balance of water solution, wherein a lipid material in the surface modified liposome is one or more selected from soyabean lecithin, egg yolk lecithin and cholesterol. The preparation method comprises the following steps: dissolving the lipid material by using an organic solvent, and then, ultrasonically adding the water solution of the procyanidine to form a single-phase stable system; next, rotating and reducing the pressure to remove the organic solvent; and adding a certain amount of water solution to prepare the hydrophilic procyanidine liposome. The procyanidine liposome provided by the invention can be used for improving the stability, long-acting controlled-release property and transdermal property of the procyanidine, preparing medicinal preparations and particularly transdermal medicinal preparations and cosmetics as well as ensuring that the procyanidine-contained transdermal medicinal preparations and cosmetics are more convenient and easier in preparation.

The invention belongs to the fields of drug preparations and cosmetics, and particularly relates to madecassoside lipidosome and a preparation method and application thereof. The method comprises the following steps: dissolving or heating and fusing madecassoside and lipidosome components through an organic solvent; concentrating or drying; adding a hydration medium containing the madecassoside to hydrate, so as to prepare a lipid disperse aqueous solution; and forming the madecassoside lipidosome by homogeneous treatment. The madecassoside lipidosome can be prepared into the forms such as emulsion, cream, paste, turunda or freeze-dried powder, and all adopted traditional use forms. The lipid component is taken as a carrier, so that the transdermal performance, slow release and the bioavailability of the madecassoside can be improved, and the madecassoside can be reserved in the skin to the maximal extent. Thus, the efficacy is effectively played, and especially, transdermal absorption can be achieved by local skin or mucous membrane painting.

The invention discloses a carbon fiber skin-beautifying membrane substrate. The carbon fiber skin-beautifying membrane substrate comprises the following components in percentage by weight: 40-50wt% of biological magnetic slurry, 20-40wt% of carbon fiber spunlaced cloth and 25-35wt% of a cosmetic-grade elastic silica gel fluid. A preparation method comprises the following steps: flattening the carbon fiber spunlaced cloth; secondarily dyeing a single face of the carbon fiber spunlaced cloth by using the cosmetic-grade elastic silica gel fluid; flatly spreading a slurry injecting mould onto the carbon fiber spunlaced cloth, spraying the biological magnetic slurry onto the slurry injecting mould to spray the biological magnetic slurry onto a membrane substrate from small holes in matrix arrangement, airing by using 110-130 DEG C hot air, and taking out the slurry injecting mould to obtain the carbon fiber skin-beautifying membrane substrate. The carbon fiber skin-beautifying membrane substrate has the functions of absorbing grease and deeply cleaning skin, and can metabolize peroxidized grease in the deep skin; carbon fiber contains rich negative oxygen ions and can supply oxygen to the skin continuously, so that improvement on the self metabolizing capability of the skin is facilitated to quickly recover health and vitality of the skin.

The present invention provides pharmaceutical compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.

The invention discloses a Chinese medicinal ointment, in particular a Chinese medicinal ointment for treating intervertebral disc hyperosteogeny and a preparation method thereof. The Chinese medicinal ointment for treating the intervertebral disc hyperosteogeny is characterized by being prepared from the following components: Chinese angelica root, notopterygium, pubescent angelica root, clematis root, earthworm, suberect spatholobus stem, insects, white mustard seed, garter snake, drynaria, Chinese honeylocust spine, garden balsam stem, medicinal cyathula root, cassia twig, papaya, eucommia bark, divaricate saposhnikovia root, ephedra, acanthopanax bark, Chinese taxillus twig, pangolin scales, frankincense, myrrh, dragon's blood, musk and plum borneol. The Chinese medicinal ointment is specially used for treating the intervertebral disc hyperosteogeny, and by using the Chinese medicinal ointment, the concentration of the medicament applied into local tissues is significantly higher than the blood concentration, so the Chinese medicinal ointment is brought into full play, the local curative effect is obviously superior to internal treatment, and the Chinese medicinal ointment takes effect rapidly, has wide adaptation diseases, is safe to use, and has less toxic or side effect. 690 cases using the Chinese medicinal ointment for treatment show that the total effective rate reaches 96 percent.

The invention belongs to the field of cosmetics, and specifically relates to a flexible liposome cosmetic containing active polypeptides and a preparation method thereof. Due to barrier effects of cuticle of skin epidermis, the skin is difficult to be penetrated by most of active ingredients of cosmetics containing active polypeptides. In order to solve the problem, the invention provides a flexible liposome cosmetic containing active polypeptides. The flexible liposome cosmetic containing the active polypeptides is prepared by containing active polypeptides in flexible liposomes modified by hydrophobic modifying polypeptides, so that, transmittance of the cosmetic is effectively improved; and thus, the developed cosmetic is easier to absorb as well as better in anti-oxidizing and anti-aging effects. Therefore, the cosmetic has broad application prospects.

The invention discloses a granisetron hydrochloride microemulsion-based gel and a preparation method thereof. The preparation contains microemulsion and blank gel, wherein the microemulsion consists of granisetron hydrochloride or free alkali thereof, oil phase, emulsifier, co-emulsifier and water phase; and the blank gel consists of gel matrix, neutralizer, humectant and water. The preparation method of the preparation uses the conventional pharmaceutical equipment and comprises the following steps: evenly mixing microemulsion and blank gel in a certain ratio, adding a certain amount of penetration enhancer, and adjusting the pH value to obtain the granisetron hydrochloride microemulsion-based gel. The preparation has simple preparation technology, high production efficiency, low cost, stable quality and easy industrial production. The product of the invention has good effect of transdermal absorption, hardly has any stimulation on the skin and can satisfy the clinical medication requirements basically, thus the product is a novel preparation with good compliance and high therapeutic index.

A flexible vitamine A acid liposome for treating dermatopathy is disclosed, which contains lecithin, bile salt, vitamine A acid and solvent. Its medicine in the form of solution, cream, or ointment contains said flexible vitamine A acid liposome, anti-oxidizing agent, and solvent. Its advantages are high stability, durable action, high curative effect, and less or no by-effect.

Provided herein are liposomal compositions for improved delivery and penetration into the skin. Liposomal compositions as provided herein comprise one more peptides. Also provided herein are compositions and methods for targeting dermal white adipose tissue to improve fat reduction and anti-aging effects. Compositions and methods for targeting dermal white adipose tissue may comprise administering a composition comprising liposomes.

The invention belongs to the technical field of medicine, and in particular, relates to a flexible liposome containing drugs and a preparation method thereof. Because of the barrier effect of skin, many drugs have low transdermal efficiency and poor absorption. Focusing on the problems, the invention provides the flexible liposome containing the drugs, wherein the flexible liposome is prepared from the flexible liposome-contained drugs modified by hydrophobically modified polypeptide. The specially modified liposome is prepared from the following main raw materials by the weight percentage: according to the weight ratio, the ratio of lecithin to sodium deoxycholate or polysorbate 80 or a derivative thereof is 7:(2-4), and the specially modified liposome contains 0.1-1 wt% of antioxidants,1-10 wt% of a hydrophobically modified polypeptide DP7-C or PAL-DP7 or the derivative thereof, and 1-10 wt% of the contained drugs. The designed and screened flexible liposome hydrophobically modifiedby the polypeptide can effectively carry drugs into a deep layer of skin, helps the drugs to play a role in cells, and has a good application prospect.

The present invention belongs to biological preparation technology field, more specificly a siRNA for preventing hair loss and promoting hair growth and its preparation method and uses. It comprises: constructing long double-chain RNA(dsRNA) expression vector pET-SRAR related to preventing hair loss and promoting hair growth and expressing highly in E.Coli, transforming E.Coli and fermenting to produce long double-chain RNA, obtaining dsRNA, homogenizing for destroying cell wall and extracting E.Coli total RNA from fermented E.coli, purifying extract and obtaining dsRNA, hydrolyzing and purifying to obtain small interference RNA (siRNA),embedding siRNA using liposome, obtaining siRNA for preventing hair loss and promoting hair growth. The present invention has obvious effect on promoting hair growth.

The invention provides a medicinal paste for treating Chinese honeylocust spine and hyperosteogeny and its preparing process, wherein the raw material herbs include the following constituents (by weight ratio): Chinese angelica root, Chinese ephedra, rhubarb horsetails, radix paeoniae rubrathe, dried rehmannia root, goldthread root, licorice root, thunberg fritillary bulb, honeysuckle flower, safflower, stem pith of the ricepapr plant, dahurian angelica root, radix aconiti. and the preparing process steps of cooling down the plaster and charging the following fine materials: pangolin scales, camphor, musk, boneol, frankincense, myrrh, and dragon's blood resin.

The present invention relates to a hydrogel containing coenzyme Q10 and a cataplasm prepared by the hydrogel. The coenzyme Q10 of the present invention is prepared into nanoparticles, solid lipid nanoparticles, flexible nano-liposomes, nano-microemulsion, nano-micelles and the like. Especially that the flexible coenzyme Q10 nano-liposomes are preferably adopted in the hydrogel of the present invention. The coenzymes Q10 with various forms are adopted to prepare the hydrogel, the cataplasm prepared by the hydrogel, and other external application preparations or apparatuses. In the prior art, the coenzyme Q10 in the common external application preparation containing the coenzyme Q10 is easily oxidized and decomposed, and is preserved difficultly. With the present invention, the problems in the prior art are effectively solved; the skin penetration performance of the coenzyme Q10 is substantially increased. The hydrogel and the cataplasm prepared by the hydrogel can be applicable for dermal topical application and nursing of the coenzyme Q10, or percutaneous systematic administration of the coenzyme Q10, specifically for preparation into cosmetics, health products, or drugs and the like. The present invention further relates to a use of the coenzyme Q10 nano-preparation in preparation of the coenzyme Q10 hydrogel preparation.

The invention discloses a universal ointment for babies and a preparation method of the universal ointment. The universal ointment consists of the following raw materials in parts by weight: 8-12 parts of jojoba oil, 8-13 parts of a St John's wort extracting solution, 19-22 parts of a calendula and chamomile extracting solution, 17-22 parts of olive oil, 26-31 parts of sweet almond oil, 7-11 parts of candelilla wax, 0.05-0.15 part of peppermint essential oil and 0.7-1.0 part of blue chamomile essential oil. The universal ointment provided by the invention has functions of being smooth, soothing and cleaning; by adopting the cold-pressed virgin plant oils which are small in molecules, good in skin-friendly permeability and good in absorbency and on the basis of mutual compatibility and a synergistic interaction among the various raw material components, the universal ointment has outstanding moistening and repairing effects on skin and can relieve itchy skin, protect and recover irritated skin and promote the self-improvement of the skin, and the universal ointment, due to an oily texture thereof, can form a protective film on the skin better; and in addition, the universal ointment, which is free from the addition of any preservatives, alcohol, essence or hormones, is natural, safe and mild, and the universal ointment is applicable to various skin symptoms such as chapped skin, eczema, slobber rash, light diaper rash, scalds, redness and swelling and the like.

The invention relates to a traditional Chinese medicinal gel plaster and a substrate thereof, belongs to the technical field of traditional Chinese medicinal composition gel plasters, and aims at providing the traditional Chinese medicinal gel plaster substrate and eliminating dialysis spots caused by substrate crosslinking on the premise of not adopting emulsifying agents. In order to achieve thetechnical purposes, the traditional Chinese medicinal gel plaster substrate is composed of, by weight, 3-5 parts of sodium polyacrylate, 0.1-0.3 part of an aluminium-ion crosslinking agent, 0.1-0.45part of a crosslinking adjusting agent, 34-52 parts of a moisturizing agent, 5-15 parts of a tackifying agent, 1-3 parts of a penetration enhancer, 0.2-0.8 part of a preservative, and 32-42 parts of water. According to the traditional Chinese medicinal gel plaster substrate, specific components and proportions are adopted, after being spread and cut well, a raw traditional Chinese medicinal gel plaster can be directly bagged, crosslinking/aging reactions are conducted in an inner-package sealed dark environment and completed within a proper period of time, finally, no airing processes are required, the dialysis spots produced in the traditional Chinese medicinal gel plaster can be eliminated, and meanwhile, the moisturizing and adhesion properties of the traditional Chinese medicinal gel plaster are ensured.

The invention relates to Chinese and western medicament compound cream for preventing and treating onychomycosis infected by candidiasis albrican and a preparation method thereof. The cream is yellow cream formed by evenly dispersing mixture of a Chinese medicament extract and a western medicament in a substrate by use of the action of a mixed emulsifying agent. The cream prepared by the method has the advantages of even dispersed main medicament, even and smooth cream, proper viscosity, as long as easily coating on skin, mucous membrane and wound surface, and meeting the requirement of Chinese pharmacopoeia with controllable quality. Pharmacodynamic research proves that the cream has actions of preventing and treating the onychomycosis infected by Candida albicans, and has assistant treatment action on secondary inflammation because of mycotic infection, such as whitlow.

The invention discloses a compound undecylenic nanoemulsion, which is formed by the following raw materials in mass percent: 18.05%-38.62% of surfactant, 0-9.15% of cosurfactant, 0-3.50% of oil, 0.50%-5.18% of undecylenic acid, 0.50%-3.00% of cinnamyl aldehyde, 0.50%-3.00% of eugenol and the balance of distilled water, wherein the sum of the mass percents of the raw materials is 100%. According to the compound undecylenic nanoemulsion disclosed by the invention, the solubility of the undecylenic acid is enhanced, the drug stability and the bioavailability of the undecylenic acid are improved, and the metabolic time of the undecylenic acid in vivo is retarded; and the undecylenic acid is in compatible with the cinnamyl aldehyde and the eugenol, the antimicrobial spectrum is enlarged, the drug consumption is reduced, and the cost for drug consumption is lowered, so that the compound undecylenic nanoemulsion has broad market prospects in the medicine field.

The invention relates to linoleic acid modified glucan and a preparation method of a polymeric liposome. Glucan reacts with linoleic acid to form an amphiphilic high-molecular linoleic acid modified glucan. Then the linoleic acid modified glucan is dissolved in dichloromethane, and prepared into high-molecular liposome according to a reverse evaporation method.

The present invention relates to a novel hydrophilic-lipophilic gel membrane and a preparation method thereof; the dual hydrophilic gel is prepared from a styrene-isoprene-styrene segmented copolymer as a framework material, and also comprises oil and an organic fibrinolytic agent which have the good compatibility with the copolymer, as well as an anti-oxygen, and a hydrophilic/water-absorbing assistant. The membrane has the big characteristic of being capable of being used as a drug carrier under a condition that a surface active agent is not added, a water-soluble drug can be added, a lipophilic drug also can be added, the universality as the drug carrier is expanded, a defect that only the water-soluble drug can be added into a conventional hydrophilic gel, and only the lipophilic drug can be added into a conventional lipophilic gel is solved, each functional component can be kept in a dissolved state and can not be prone to absorb, and a dose-effect ratio relationship (have to meet) of drug components can be met; the novel hydrophilic-lipophilic gel membrane can enhance the transdermal action of the drug components to enable the drug components to fast penetrate through the skins within a short time to be absorbed.