Procyanidine liposome as well as preparation method and application thereof

A proanthocyanidin and liposome technology, which is applied in the fields of chemistry and cosmetics, can solve the problems of unfavorable human absorption of cosmetics, easy to be affected by external conditions, sensitive to light and heat value, etc., so as to avoid systemic adverse reactions and improve skin penetration. , the effect of improving stability

Inactive Publication Date: 2013-12-11
SHANGHAI INOHERB COSMETIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, its stability is poor, it is easily affected by external conditions, it is easy to oxidize, and it is sensitive to light and heat values, etc., which limits its application.
At present, proanthocyanidin microcapsules are studied more, and industrial production has been carried out, but their particle size is relatively large, which is not conducive to human absorption and cosmetic application

Method used

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  • Procyanidine liposome as well as preparation method and application thereof
  • Procyanidine liposome as well as preparation method and application thereof
  • Procyanidine liposome as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation method of proanthocyanidin liposome comprises the following steps:

[0056] 1) Take 60 grams of egg yolk lecithin and 20 grams of cholesterol as lipid materials, and dissolve them in 10,000 ml of ethanol to make a lipid solution;

[0057]2) Add 3000ml of 1g / L proanthocyanidin phosphate buffer solution, 20g of PEG1500, 10g of Tween80, 10g of Span80 to the lipid solution, and ultrasonicate in a water bath for 2min to form a single-phase stable water-in-oil (W / O) system;

[0058] 3) The water-in-oil system was transferred to a 15000ml round bottom flask, and the organic solvent ether was removed by rotary evaporation (135 rpm) to form a gel state;

[0059] 4) Add the balance of 10000ml phosphate buffer solution (pH=6.5), vacuumize, rotate and hydrate for 1 hour to make crude liposome;

[0060] 5) After post-processing the crude product, proanthocyanidin liposomes were prepared.

Embodiment 2

[0062] The preparation method of proanthocyanidin liposome comprises the following steps:

[0063] 1) Take 80 grams of soybean lecithin and 40 grams of cholesterol, which are the lipid materials, and dissolve them in 5000 ml of dichloromethane to make a lipid solution;

[0064] 2) Add 4000ml of 2g / L procyanidin phosphate buffer solution, 40g of PEG1500, 10g of Tween80, 10g of Span80 to the lipid solution, and ultrasonicate for 2min in a water bath to form a single-phase stable water-in-oil (W / O) system;

[0065] 3) The water-in-oil system was transferred to a 15000ml round bottom flask, and the organic solvent dichloromethane was removed by rotary evaporation (135 rpm) to form a gel state;

[0066] 4) Add the balance of 10000ml phosphate buffer solution (pH=6.5), vacuumize, rotate and hydrate for 1 hour to make crude liposome;

[0067] 5) After post-processing the crude product, proanthocyanidin liposomes were prepared.

Embodiment 3

[0069] The preparation method of proanthocyanidin liposome comprises the following steps:

[0070] 1) Take 120 grams of soybean lecithin and 30 grams of cholesterol, which are the lipid materials, and dissolve them in 5000 ml of chloroform to make a lipid solution;

[0071] 2) Add 0.5g / L proanthocyanidin phosphate buffer solution 5000ml, PEG1500 to the lipid solution 20 grams, Tween80 10 grams, Span80 10 grams, water bath ultrasonic 2min, forming a single-phase stable water-in-oil (W / O) system;

[0072] 3) The water-in-oil system was transferred to a 15000ml round bottom flask, and the organic solvent dichloromethane was removed by rotary evaporation (135 rpm) to form a gel state;

[0073] 4) Add the balance of 10000ml phosphate buffer solution (pH=6.5), vacuumize, rotate and hydrate for 1 hour to make crude liposome;

[0074] 5) After post-processing the crude product, proanthocyanidin liposomes were prepared.

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Abstract

The invention relates to a preparation method and application of a procyanidine liposome. The procyanidine liposome comprises 0.01-0.1% of procyanidine, 0.1-5% of surface modified liposome and the balance of water solution, wherein a lipid material in the surface modified liposome is one or more selected from soyabean lecithin, egg yolk lecithin and cholesterol. The preparation method comprises the following steps: dissolving the lipid material by using an organic solvent, and then, ultrasonically adding the water solution of the procyanidine to form a single-phase stable system; next, rotating and reducing the pressure to remove the organic solvent; and adding a certain amount of water solution to prepare the hydrophilic procyanidine liposome. The procyanidine liposome provided by the invention can be used for improving the stability, long-acting controlled-release property and transdermal property of the procyanidine, preparing medicinal preparations and particularly transdermal medicinal preparations and cosmetics as well as ensuring that the procyanidine-contained transdermal medicinal preparations and cosmetics are more convenient and easier in preparation.

Description

technical field [0001] The invention belongs to the field of chemistry and relates to the field of cosmetics, in particular to proanthocyanidin liposome and its application in cosmetics. Background technique [0002] Proanthocyanidins (PC for short) is a mixture of polyphenols that widely exist in nature. This kind of compound has a variety of biological activities and is famous for its high efficiency, low toxicity and high bioavailability. Proanthocyanidins are currently internationally recognized natural antioxidants for scavenging free radicals in the human body. Its ability to resist oxidation and scavenge free radicals is 50 times that of VE (tocopherol, vitamin E) and 20 times that of VC (ascorbic acid, vitamin C). In recent years, it is often used as an active ingredient of anti-cancer, anti-cardiovascular and other disease drugs. Therefore, it has become a research hotspot to develop proanthocyanidins into functional cosmetics for whitening, moisturizing and preven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/86A61Q19/08A61Q19/02A61Q19/00
Inventor 奚朝晖林苗王一宇顾钰郭芳
Owner SHANGHAI INOHERB COSMETIC
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