Compound undecylenic nanoemulsion and preparation method thereof
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A technology of nanoemulsion and enoic acid, which is applied in the field of medicine, can solve the problems of low bioavailability, high irritation, and high volatility, and achieve the effects of improving solubility, storage stability, and high thermodynamic stability
Inactive Publication Date: 2012-07-04
NORTHWEST A & F UNIV
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Ointments or alcohol solvents have the disadvantages of high irritation, po
Method used
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[0050] Above-mentioned each component is made compound undecylenic acid nano-emulsion, comprises the following steps:
[0051] 1) Weigh the surfactant according to the formula, use it alone or compound it with the surfactant or co-surfactant in proportion, calculate the HLB value of the system, and stir well;
[0052] 2) Mix undecylenic acid, cinnamaldehyde, and eugenol according to the formula or mix them with one or more oils, and stir well;
[0053] 3) Mix the surfactant obtained in step 1) with the oil obtained in step 2), stir evenly, then slowly add distilled water dropwise to the mixture, and stir while adding, the mixture system will change from thin to viscous during the process of adding water and stirring Thick, and finally a series of changes from thick to thin, until the formation of nanoemulsions....
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Abstract
The invention discloses a compound undecylenic nanoemulsion, which is formed by the following raw materials in mass percent: 18.05%-38.62% of surfactant, 0-9.15% of cosurfactant, 0-3.50% of oil, 0.50%-5.18% of undecylenic acid, 0.50%-3.00% of cinnamyl aldehyde, 0.50%-3.00% of eugenol and the balance of distilled water, wherein the sum of the mass percents of the raw materials is 100%. According to the compound undecylenic nanoemulsion disclosed by the invention, the solubility of the undecylenic acid is enhanced, the drug stability and the bioavailability of the undecylenic acid are improved, and the metabolic time of the undecylenic acid in vivo is retarded; and the undecylenic acid is in compatible with the cinnamyl aldehyde and the eugenol, the antimicrobial spectrum is enlarged, the drug consumption is reduced, and the cost for drug consumption is lowered, so that the compound undecylenic nanoemulsion has broad market prospects in the medicine field.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to a new drug dosage form of compound undecylenic acid which can resist fungi and treat skin fungal infections such as tinea capitis, jock itch, tinea pedis and pet dermatophytosis, and particularly relates to a A clear and transparent compound undecylenic acid nanoemulsion and a preparation method thereof. Background technique [0002] Undecylenic acid is a light yellow liquid; the color is affected by light and air, and it turns into a milky white crystalline mass when it is cold. Its antibacterial mechanism is to effectively inhibit the reproduction of fungi. Undecylenic acid can treat skin fungal infections such as tinea capitis, jock itch, athlete's foot and dermatophytosis of pets, and the effect is remarkable. However, undecylenic acid is almost insoluble in water, and the dosage forms of undecylenic acid currently used clinically include ointment and alcohol solvent. Ointments or alc...
Claims
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