Whitening and freckle removing active polypeptide

A whitening and freckle-removing, active peptide technology, which is applied in the field of whitening and freckle-removing active peptide compositions, can solve problems such as difficulty in fully exerting the whitening effect, reduced peptide activity, and poor peptide stability, and achieves good transdermal effect, improved stability and safe use Sexual, good whitening effect

Pending Publication Date: 2019-03-08
宇肽生物(东莞)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing whitening products, the peptide ingredients are often directly added to the prescription, and the resulting problem is that the stability of the peptide in the product is poor, so that the whitening peptide with high-efficiency activity cannot fully exert its due effect
In addition, due to the existence of the skin barrier, the exchange of substances inside and outside the body is limited, and the whitening peptides in the product cannot be smoothly absorbed through the skin barrier, so it is difficult to fully exert its whitening effect
In order to increase transdermal absorption, chemical modification of polypeptides is a common method, but not all polypeptides are suitable for chemical modification such as fatty acids. After modification, while increasing transdermal absorption, it may also be due to steric hindrance. effect and affect the combination of the peptide and the corresponding target, so that the activity of the peptide is reduced, and it is still necessary to increase the amount of feed to achieve the whitening effect

Method used

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  • Whitening and freckle removing active polypeptide
  • Whitening and freckle removing active polypeptide
  • Whitening and freckle removing active polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] prescription

[0034]

[0035]

[0036] Preparation:

[0037] 1. Take soybean lecithin, cholesterol, propylene glycol, and 1,2-hexanediol in phase A according to the prescription ratio, stir and dissolve under heating at 40°C, and set aside;

[0038] 2. Take nonapeptide-1, Tween 20, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase B according to the prescription ratio, add warm water (20°C-35°C), stir to dissolve, and set aside;

[0039] 3. Mix phase A and phase B, and pre-emulsify under the condition of 20000rpm through high-speed shearing;

[0040] 4. The above-mentioned mixed solution was subjected to high-pressure homogeneous treatment under the condition of 22500 psi, and was circulated 5 times to obtain the whitening and freckle-removing active polypeptide encapsulated in nanometers.

[0041] 5. The particle size of the whitening and freckle-removing active polypeptide nano-inclusions was detected, and the particle size of the inclusio...

Embodiment 2

[0043] prescription

[0044]

[0045]

[0046] Preparation:

[0047] 1. Take soybean lecithin, cholesterol, propylene glycol, and 1,2-hexanediol in phase A according to the prescription ratio, stir and dissolve under heating at 40°C, and set aside;

[0048] 2. Take tetrapeptide-27, Tween 20, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase B according to the prescription ratio, add warm water (20°C-35°C), stir to dissolve, and set aside;

[0049] 3. Mix phase A and phase B, and pre-emulsify under the condition of 20000rpm through high-speed shearing;

[0050] 4. The above-mentioned mixed solution was subjected to high-pressure homogeneous treatment under the condition of 22500 psi, and was circulated 5 times to obtain the whitening and freckle-removing active polypeptide encapsulated in nanometers.

[0051] 5. The particle size of the whitening and freckle-removing active polypeptide nano-inclusions was detected, and the particle size of the inclus...

Embodiment 3

[0053] prescription

[0054]

[0055] Preparation:

[0056] 1. Take soybean lecithin, cholesterol, propylene glycol, and 1,2-hexanediol in phase A according to the prescription ratio, stir and dissolve under heating at 40°C, and set aside;

[0057] 2. Take decapeptide-12, Tween 20, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase B according to the prescription ratio, add warm water (20°C-35°C), stir to dissolve, and set aside;

[0058] 3. Mix phase A and phase B, and pre-emulsify under the condition of 20000rpm through high-speed shearing;

[0059] 4. The above-mentioned mixed solution was subjected to high-pressure homogeneous treatment under the condition of 22500 psi, and was circulated 5 times to obtain the whitening and freckle-removing active polypeptide encapsulated in nanometers.

[0060] 5. The particle size of the whitening and freckle-removing active polypeptide nano-inclusions was detected, and the particle size of the inclusions was 50.4nm...

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Abstract

The invention discloses a whitening and freckle removing active polypeptide. The polypeptide is wrapped into a nano wrapping body by a lipid ingredient; the nano wrapping body is further prepared fromthe ingredients of polyalcohol, a surface active agent and a pH buffer agent; the mass percentage concentration of the whitening and freckle removing active polypeptide is 0.0001% to 5%, the mass percentage concentration of the lipid ingredient is 2% to 20%, the mass percentage concentration of the polyalcohol is 2% to 20%, the mass percentage concentration of the surface active agent is 0.1% to10%, and the mass percentage concentration of the pH buffer agent is 0.001% to 1%. The whitening and freckle removing active polypeptide disclosed by the invention has the advantages of good stability, high safety and easiness in transdermal absorption; furthermore, after being wrapped, the whitening and freckle removing active polypeptide can achieve a good transdermal effect without being modified by fatty acid; compared with active polypeptide which is not nano wrapped, the whitening and freckle removing active polypeptide which is nano wrapped has a high sand volume on the skin; furthermore, the same feeding amount can achieve excellent whitening and freckle removing effects.

Description

technical field [0001] The invention belongs to the field of external skin care medicines, and relates to a whitening and freckle-removing active polypeptide composition. Background technique [0002] In recent years, with the development of society and the enrichment of material life, people pay more and more attention to the whitening problem. [0003] The most important factor that determines skin color is melanin, and the content and distribution of melanin have a major impact on skin color. Melanin is produced by melanocytes in the skin and is transferred to keratinocytes through the dendrites of melanocytes. As keratinocytes continue to proliferate and differentiate, and gradually move upward, melanin finally reaches the stratum corneum, and deposits on the outermost layer of the skin to form freckles, dark spots and other spots, resulting in darkening of the skin. Protein glycation is also a major factor in determining skin tone. Proteins in the skin undergo glycos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K38/07A61K38/05A61K9/127A61K8/64A61K8/14A61Q19/02A61P17/16
CPCA61K8/14A61K8/64A61K9/127A61K38/05A61K38/07A61K38/08A61Q19/02A61P17/16A61K2300/00
Inventor 丁文锋
Owner 宇肽生物(东莞)有限公司
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