The invention relates to the field of Chinese herbal medicine, in particular to a drug for activating blood circulation, dredging vessels and anti-thrombosis, which can solve the problems of great side effects, long administration time and low efficiency of the prior anti-thrombosis western drugs and unreasonable compatibility and poor efficacy etc. of the traditional Chinese medicines, the drug is prepared by Chinese angelica, Szechuan lovage rhizome, white paeony root, earthworm, membranous milkvetch root, safflower, peach seed, red paeony root, dwarf lilyturf tuber, ginseng, dried rehmannia root and Chinese magnoliavine fruit for the treatment of mild thrombotic diseases, leech, danshen root, garter snake, pangolin scales, glabrous greenbrier rhizome and liquoric root are increased on the basis of the medicines for the treatment of severe thrombotic diseases, the medicines are combined for usage and mutual promotion and have the effects of improving microcirculation, reducing blood viscosity, expanding arterial blood vessels, promoting blood circulation, inhibiting thrombus formation, improving brain blood supply and protecting brain cells, so the drug is the better drug for the treatment of ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, cerebral embolism and other diseases and can carry out the targeted treatment of mild and severe thrombotic diseases with short administration time, good efficacy and no toxicity or side effects.