The invention relates to a formula of health protection wine. The formula is composed of green pepper, green pepper essential oil, ginger, medlar, cortex cinnamomi, raspberry, edible white spirit and crystal sugar. A preparation method comprises the following steps: cutting medlar, ginger and cortex cinnamomi; adding green pepper and raspberry; soaking by edible white spirit; filtering; and mixing filter liquor, crystal sugar and green pepper essential oil to obtain the health protection wine. With the adoption of the formula, green pepper which can be used for warming spleen and stomach for dispelling cold, promoting blood circulation to remove meridian obstruction and warming the kidney to tonify Yang, and ginger which can be used for warming channel and expelling coldness, promoting blood circulation, removing cold-dampness, returning Yang, enabling people to excite and nourishing bodies serve as monarch drugs; medlar which can be used for nourishing the kidney and strengthening the essence, strengthening Yang channels and removing rheumatism, and cortex cinnamomi which can be used for promoting blood circulation, tonifying fire and helping yang, eliminating coldness to stop pain and activating blood to promote menstruation serve as ministerial drugs; raspberry which can be used for tonifying liver and benefiting kidney, warming spleen and stomach to remove cold, strengthening Yin and Yang, tonifying qi and lightening weight, and green pepper essential oil which can be used for warming spleen and stomach to remove coldness, removing humidity and supporting Yang serve as assistant drugs; and white spirit which can be used for promoting blood circulation, removing coldness, rousing Yang and scattering efficacy of a drug is used, so that the formula is capable of dispelling wind and eliminating dampness, promoting blood circulation to remove meridian obstruction, adjusting qi and blood, nourishing kidney and tonifying Yang, resuscitating and building bodies.