253 results about "Anal fissure" patented technology

A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and / or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spasm, and so forth, by topical application to or proximate the affected area.

Pharmaceutical compositions comprising tricyclic 3,4-propinoperhydropurines and uses thereof for blocking neuronal transmission which are useful in treating anal fissure and other wounds and muscle disorders are provided. Also provided are methods of treating wounds and muscle disorders by administering the composition of the invention to a muscle or in the vicinity of a muscle either topically or by injection.

The invention relates to the technical field of biogel, specifically to chitosan gel and a preparation method thereof. The gel comprises the following raw materials by weight: 0.5 to 4.5% of modified chitosan, 0.5 to 15% of glycerin, 0.5 to 5% of alum, 0.01 to 0.13% of menthol, 0.2 to 5% of carboxymethylcellulose sodium and 0.2 to 1% of carbomer. The gel is a drug delivery system with a controlled-release function, can improve availability of effective substances, can be tightly applied on an uneven wound without adhesion, avoids secondary harm, has good biocompatibility and strong antibiosis and antiphlogosis effects, incurs no local irritation and no adverse reaction, is capable of rapidly promoting wound healing and effectively treating hemorrhoids, enables hemorrhoids not to recur and is applicable to improvement of symptoms like hemorrhoidal bleeding, hyperemia and oedema of the mucous membranes of hemorrhoids, bearing-down swelling of the anus, constipation, prolapsus of hemorrhoid nuclear and the like caused by internal hemorrhoids, external piles and mixed hemorrhoids and control, nursing and the like after anal fissure and anorectal operations.

The present invention is one kind of suppository for treating piles and other anorectal diseases and its preparation process. The medicine is prepared with bezoar, pearl, muskone, notoginseng, gallnut, borneol, belladonna fluid extract and calamine. The preparation process includes crushing pearl, notoginseng and gallnut; mixing and stoving balladonna fluid extract and calamine; mixing all the medicine powder except muskone; further grinding and the mixed medicine powder; heating and melting fatty glyceride; and mixing all the components via stirring. The present invention has high treating effect on internal pile external pile, mixed pile and anal fissure.

The invention discloses a drug for treating gynecologic and andrological diseases and a preparation method thereof; calculated according to the portion by weight, the drug is prepared by taking 65 portions to 100 portions of sophora flavescens, 40 portions to 70 portions of radix stemonae, and 40 portions to 70 portions of cortex dictamni as the basic raw materials, and can also be compatible with 40 portions to 70 portions of frutus cnidii and 40 portions to 70 portions of broom cypress fruit. Compared with the prior art, the drug provided by the invention is prepared by the refining of natural Chinese medicinal herb compositions and is combined with modern advanced preparation technology; the prepared product has the functions of clearing away heat and toxic materials, killing insects and removing dirties, relieving swelling and pain, and removing dampness and stopping itching, plays the roles of obviously resisting bacteria, diminishing inflammation, stopping itching, and relieving pain, has good therapeutic effect to fungal, trichomonas, non-specific vaginitis, and can also be used for men scrotum eczema, anal fissure hemorrhoid pain and daily scrotum and anus cleaning; and the drug is safe without toxic and side effects, is not easy for producing drug resistance, is convenient for use and carryover, and has comfortable feeling after the use, thereby leading the patients to be willing to accept the drug.

The invention discloses an anus expanding device used for expanding the anus and the anal tube. The anus expanding device brings convenience to a doctor for examination or operation and comprises a chassis, a guide rail disc, an expanding rod and a connecting ring. The guide rail disc rotates on the chassis. One end of the expanding rod slides in a guide rail groove. The guide rail groove is designed in an eccentric mode or involute mode, and the other end of the expanding rod is driven to move. The connecting ring is a fixed compression part which can prevent the guide rail disc and the expanding rod from being disengaged. The anus expanding device has the advantages that the anus and the anal tube can be gradually and controllably enlarged in parallel, the anal sphincter can gradually adapt to the enlarging range of the anus expanding device, the anal fissure phenomenon can be avoided, and pains of patients are relieved.

The invention relates to the technical field of antibacterial gel, in particular to antibacterial gel and a preparation method thereof. The antibacterial gel per liter comprises the following raw materials: 1.7-1.9g benzalkonium chloride, 30-50ml glycerol, 0.1-1.3g menthol, 1-1.8g alums, 0.3-0.4g lactic acid, 2.5-5g carbomer, 3-6g traditional Chinese medicine extract and the balance of purified water. The antibacterial gel contains various anti-inflammatory, antibacterial and analgesic components; an antibacterial effect is best through a synergistic effect of the raw materials; the biocompatibility of the antibacterial gel meets GB / T 16886.11-2011; a microbiological indicator of the antibacterial gel meets GB 15979-2002; and the antibacterial gel is suitable for nursing of various vaginal bacterial infection, trichomonas infection, leukorrhea, monilial infection, cervix and genital tract or mucosal wound surface infection, promotes healing of a wound surface after cervical erosion physiotherapy, and is further suitable for internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure and anorectal postoperative nursing.

The invention relates to a Chinese herbal medicine preparation for treating hemorrhoids, which is the pill or powder prepared from 18 kinds of Chinese herbal medicine, such as angelica, rehmannia root, black sanguisorba, red peony root, baikal skullcap root, yellow-corktree bark, dark plum fruit, honeysuckle, earthworm, rhizoma atractylodis, rhizoma alismatis, rhubarb, dahurian angelica root, skunk bugbane, trogopterus dung, radix stephaniae tetrandrae, weeping forsythia and sophora fruit. The preparation is suitable for treating various hemorrhoids, such as internal hemorrhoids, external hemorrhoids, mixed hemorrhoids and the like and various kinds of common anorectal diseases, such as anal fissure, prolapse of the anus and the like, has the advantages of precise and appropriate compatibility, strong pertinence of the prescription, obvious and quick curative effects, short course of treatment, high cure rate and the like, addresses both the symptoms and root causes, has low possibility of relapsing and the like.

The invention discloses a new medicinal use of butyric acid, specifically relating to the application of the butyric acid in the preparation of drugs for curing anorectal disease. Anorectal disease comprises hemorrhoids and anal fissure. The butyric acid is produced to be the required dosage form by taking the butyric acid or butyrate as the main active ingredients, with preferred sodium butyrate as the main active ingredients. Other active ingredients can be added to improve the treatment effect.

The Chinese herbal medicine for treating piles is prepared with honeysuckle, dandelion, agrimonia herb, pearl powder, skullcap root and other 12 kinds of Chinese medicinal materials. It has the functions of promoting venous blood circulation, decomposing muscle fibril, eliminating abscess around anus, preventing varicosity, etc. It has high curative effect on various piles in different stages, hematochezia and anal fissure as well as chronic colonitis, and no any irritability and toxic side effect. In addition, the medicine is prepared into capsule easy to carry about and is low in cost.

Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined in the specification.).Because of having an EDG-1 agonism, the compounds represented by formula (I) are useful in preventing and / or treating peripheral arterial disease such as arteriosclerosis obliterans, thromboangiitis obliterans, Buerger's disease or diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, stroke, myocardial infarction, edematous state, atherosclerosis, varicosity such as hemorrhoid, anal fissure or fistula ani, dissecting aneurysm of the aorta, angina, DIC, pleuritis, congestive heart failure, multiple organ failure, bedsore, burn, chronic ulcerative colitis, Crohn's disease, heart transplantation, renal transplantation, dermal graft, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, liver cirrhosis, chronic renal failure, or glomerular sclerosis.

The invention relates to a traditional Chinese medicine combination for treating haemorrhoids. The traditional Chinese medicine combination comprises the following traditional Chinese medicines in part by weight: 10-50 parts of dragon blood, 5-20 parts of frankincense, 5-20 parts of myrrh, 10-30 parts of pearl powder, 5-20 parts of borneol, 5-20 parts of notoginseng, 5-20 parts of coptis roots, 1-10 parts of calculus bovis factitius, and 5-20 parts of alum. The traditional Chinese medicine combination provided by the invention can be used for treating various types of haemorrhoids, anal fissure and anal fistula.

Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined in the specification.). Because of having an EDG-1 agonism, the compounds represented by formula (I) are useful in preventing and / or treating peripheral arterial disease such as arteriosclerosis obliterans, thromboangiitis obliterans, Buerger's disease or diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, stroke, myocardial infarction, edematous state, atherosclerosis, varicosity such as hemorrhoid, anal fissure or fistula ani, dissecting aneurysm of the aorta, angina, DIC, pleuritis, congestive heart failure, multiple organ failure, bedsore, burn, chronic ulcerative colitis, Crohn's disease, heart transplantation, renal transplantation, dermal graft, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, liver cirrhosis, chronic renal failure, or glomerular sclerosis.

The invention relates to a Traditional Chinese Medicine composition to cure hemorrhoids and a preparation method thereof. The Traditional Chinese Medicine composition comprises radices sanguisorbae, flos sophorae, snphora angustifolia, nutgall, radix rehmanniae, lithospermum, myrrh, resina draconis, semen cannabis, asparagus, mint, borneol, liquorice, etc. The Traditional Chinese Medicine composition of the invention has the functions of reinforcing insufficiency and reducing excessiveness, clearing away heat and toxic material, loosening bowel to relieve constipation, eliminating stagnation, detumescence, blood-activating, dispelling heat from blood to stop bleeding and eliminating haemorrhoids and is applied to treating internal and external hemorrhoids, internal hemorrhoids that bleed easily, mixed hemorrhoids, anal fissure, etc. The functions of clearing away heat and toxic material and loosening bowel to relieve constipation become more obvious by adding semen cannabis, asparagus, mint and borneol; the liquorice has the effects of reinforcing spleen, moistening lung, relaxing tension and recuperation drugs and can be used for treatment of swelling and toxin of sores, thus adding the liquorice can resolve sore toxin thoroughly to improve the efficiency. The invention is simple in prescription, convenient in production, prominent in curative effect, no toxicity, good in stability and easily taken and has high value in application.

The invention discloses a traditional Chinese medicine used for anorectal surgery wound healing and a preparation method thereof. The medicine is made from fourteen traditional Chinese medicinal materials such as herba schizonepetae, rheum officinale, cortex phellodendri, dandelion, radix sophorae flavescentis, Chinese parsnip roots, garden burnet, mint, cortex lycii radicis, mugwort leaves, compound of glauber-salt and liquorice, garden balsam stems, flos sophorae and fructus forsythia, and edible salt. The invention further discloses a preparation method of the medicine. According to the invention, the method of hip bath is adopted, so that the liquid medicine can directly act on the wound surface. Results of clinical researches show that the medicine has efficacy of clearing away heat and toxic materials, removing rots, eliminating pus, promoting blood circulation to remove blood stasis and generating tissue and healing wound and the medicine is applicable to anorectal diseases such as downward flow of damp-heat hemorrhoids, anal fissure, anal fistula, anal carbuncle, perianal abscess and the like. The curative effect is superior to that of metronidazole in a control group.

The invention relates to an ointment for treating perianal abscess and a preparation method of the ointment. The ointment is a traditional Chinese medicine ointment prepared from muskone, calculus bovis factitius, pearl, calcined calamine, borax, borneol, chrysophoron, dimethylsulfoxide, vaseline, and lanum. The traditional Chinese medicine ointment has the efficacies of clearing away heat, drying dampness, invigorating the circulation of blood, removing swelling, removing the necrotic tissue and promoting granulation, is mainly applied to the hemorrhoid and anal fissure caused by dampness and hotness obstruction, specifically is applied to the symptoms of defecate haemorrhage, pain, and bearing down and is also applied to the symptoms of perianal eczema and the like. Compared with the prior art, the ointment is more reasonable in prescription, obviously improved in effect of clinical pharmacodynamics experiment, high in bioavailability and free from any toxic effect and side effect.

The invention concerns a pharmaceutical composition comprising a platelet lysate and its use to treat a wound, an anal fissure, vaginal atrophy or a wrinkle.

The invention discloses a traditional Chinese medicine combination for treating hemorrhoids and a preparation method thereof. The traditional Chinese medicine combination is prepared by mixing the following main raw materials: 70-95 of senecio scandens and 5-30 of rheum officinale; and bezoar, borneol, flos sophorae, Chinese angelica, dandelion, edible amaranth, radix angelicae and the like can be added. The medicine combination for external use is made by the following steps of: decocting raw materials, removing dregs, extracting liquid and decocting into 10% concentrated liquor; adding 95% ethanol, uniformly agitating, standing, collecting supernatant after filtering and recovering the ethanol; and adding rheum officinale powder, bezoar powder and borneol powder. The medical effect of the senecio scandens is fully utilized by the traditional Chinese medicine combination, and a novel function of the senecio scandens for treating hemorrhoids is developed. The traditional Chinese medicine combination performs the functions of clearing away heat and toxic materials, relieving swellings and stopping pain, can be used for treating hemorrhoids, various sores and ulcers, anal fissure and anus bleeding, and can be made into a plaster, an oral solution, a tablet, a capsule, a granule, a pill and the like. The traditional Chinese medicine combination has the advantages of convenience in therapy and low therapeutic cost. The traditional Chinese medicine combination not only can be used for treating hemorrhoids, but also has obvious therapeutic effect on sore toxins and snake venom.

The invention discloses an anus dilatation device for a surgical operation, comprising a hollow body and an outward-expanding broadside, wherein the broadside is connected to the near end of the body, the body comprises at least two groups of matched anus dilatation sheets between which a gap exist, and therefore the far ends of the anus dilatation sheets become gathered together from mutually departing. The anus dilatation device can gradually and controllably dilatate the anus and the anal tube of a patient so as to avoid anal fissure and lighten the pain of the patient. Meanwhile, the processes of anus pre-dilataton and anus dilatation are integrally designed, and thus the product is convenient and simple to use. The anus dilatation device can be widely applied in the surgical operations.

The present invention relates to a hygiene product or a pharmaceutical composition in the form of a gel or dressing, for topical application to the skin or mucosa including glycerol, at least one poly(meth)acrylate polymer, at least one polyethylene glycol having a molecular weight of less than 1000 g / mol, octanediol and water.The composition or dressing can be used for healing treatment of chronic dermal ulcers, healing and soothing treatment of eczema and psoriatic conditions, healing treatment of anal fissures, treatment of mouth injuries, resorption and healing of labial herpes (cold sore) and treatment of dermatitis.The hygiene product can be a shaving or aftershave product for sensitive or hypersensitive skin, a nasal decongestant product or a product for ear hygiene.

The invention discloses an anus expander seat for surgery, which is used for expanding an anus and an anal canal. The anus expander seat comprises a hollow body and an externally expanding wide edge, wherein the wide edge is connected to the near end of the body. The anus expander seat is characterized in that: the body and the wide edge of the anus expander seat for surgery have winding drum structures; each winding drum structure comprises a positioning edge and an adjusting edge which selectively move or are fixed with each other; the outer wall of the adjusting edge is firmly attached to the inner wall of the positioning edge; and the adjusting edge can slide relatively to the inner wall of the positioning edge. The anus expander seat can gradually and controllably expand the anus and the anal canal of a patient and can enable the sphincter of the anus to adapt to an amplitude opened by the anus expander seat before the anus expander seat is inserted, so that the phenomenon of anal fissure is avoided and the pain of the patient is relieved. The anus expander seat can be widely applied to surgical operation.

The invention refers to a multi-component preparation for curing hemorrhoids and anal fissure, which comprises the wound surface convergence protecting agent, the antiseptic, the Ca-ion antagonistic agent and the allowed carrier, said protecting agent can be selectd from the allantoin and their allowed allantoin salt, the concentration of the allantion or the allantion salt 0.5-10%w / w; the antiseptic able to select from Chlorhexidine and the allowed Chlorhexidine salt, that of the acetic acid Chlorhexidine or the acetic acid Chlorhexidine salt 0.2-5%w / w; and the Ca-ion antagonistic agent ableto select from the nifedipine and the allowed nifedipine salt, that of the nifedipine or the nifedipine salt 0.1-5%w / w. The drug form of the carrier is suppository, frost, ointment, gel, oil, lotion,suspension, spray, external solution and cataplasm.

The invention provides a Chinese medicine used in treatment of hemorrhoidal pastille, anal fistula, anal fissure and its preparation. The raw materials and the ratio by weight: radix scutellariae 4-8g, flos lonicerae japonicae 3-7g, fructus sophorae 4-10g, fructus forsythiae 3-7g, radix sanguisorbae 3.5-8g, radix et rhizoma rhei 5-13g, radix curcumae 4-7g, cleome rutidosperma 20-50g, siegesbeckiae herba 12-25g. Preparation steps of the invention are: comminute the raw materials, add water, boil medicine liquid to yellow sauce; screen the medicine liquid with 80 meshes, the filtrate was concentrated to a pasty consistency, dried after cooling; then processed into power and screened with 100 meshes sieve; the power will then be made into powder or tablet powder, honeyed pill, medicinal granules or capsules. The invention can clear away heat and toxic material, arrest bleeding, alleviate pain, remove moisture and dampness, expel the wind, effect a permanent or temporary cure, without side-effects, fast, effective, not easily recur; 100% effective rate and 98% cure rate. The invention is of low prices, so the patients will be released from pain with very little cost and lives a healthy life.

The invention discloses a Binghuang hemorrhoid ointment and a preparation technology thereof. The hemorrhoid ointment comprises, by weight, 30-120 parts of Rhizoma Coptidis, 30-120 parts of Amur Corktree Bark, 30-120 parts of rheum officinale, 10-50 parts of dragon's blood, 10-50 parts of Lithospermum erythrorhizon, 30-120 parts of Radix Stemonae, 30-120 parts of Sophora flavescens, 30-120 parts of bletilla striata, 10-50 parts of pearls, 100-300 parts of calcined gypsum, 30-90 parts of natural borneol, 20-80 parts of mint, 1900-2100 parts of Vaseline and 25-35 parts of tea oil. The preparation method comprises the following steps: respectively crushing all above raw materials, and sieving the crushed raw materials by a 200 mesh sieve to obtain sieved raw materials for later use; and weighing the Vaseline and the tea oil, mixing and heating the Vaseline and the tea oil, cooling the obtained mixture to 60-70 DEG C, adding the Rhizoma Coptidis, Amur Corktree Bark, rheum officinale, dragon's blood, Lithospermum erythrorhizon, Radix Stemonae, Sophora flavescens, bletilla striata and calcined gypsum, stirring above materials, adding the pearls, mint and natural borneol, stirring all above raw materials, and cooling the obtained mixture to normal temperature in order to prepare the Binghuang hemorrhoid ointment. The Binghuang hemorrhoid ointment contains antibacterial medicines and inflammation preventing, swelling eliminating, pain easing and itch relieving medicines, has remarkable curative effects, and is suitable for treating internal hemorrhoids, external hemorrhoids, mixed hemorrhoids and anal fissures.

A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and / or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spasm, and so forth, by topical application to or proximate the affected area.

The invention provides a traditional Chinese medicinal composition for treating infantile diaper rash and a preparation method of the traditional Chinese medicinal composition. The preparation method comprises the following steps: grinding 35-45 parts of calcined gypsum into superfine powder, grinding 3-7 parts of borneol into fine powder, heating and dissolving 5-15 parts of beeswax, 35-45 parts of sesame oil and 3-7 parts of lanolin, filtering and cooling to about 65-70 DEG C; adding the borneol fine powder and dissolving the borneol fine powder, then adding the calcined gypsum superfine powder, completely stirring uniformly to be semi-solidified so as to obtain the traditional Chinese medicinal composition in ointment form. The traditional Chinese medicinal composition disclosed by the invention is used for treating infantile diaper rash caused by accumulation of damp heat, and the composition is adaptive to such fundamental symptoms as skin flushing, swelling, rash, vesicle, drainage, diabrosis and the like; and meanwhile, the traditional Chinese medicinal composition also has a relatively good treatment effect on skin mucosa diseases including inflammatory hemorrhoid, anal fissure, bedsore, herpes zoster, mosquito bite and the like.

The invention relates to a capsule for both external use and oral administration, which can be used for treating burns, scalds, bedsore, anal fissure, diabetes, lower limb ulcer and skin trauma impairment, wherein the raw materials include ginseng 20-100g, astragalus root 20-100g, Chinese angelica root 20-100g, notoginseng 20-100g, rhizoma corydalis 20-100g, earthworm 20-100g, silver flower 20-100g, coptis root 20-100g, capsule of weeping forsythia 20-100g, bornyl alcohol 5-25g, yellow corktree bark 20-100g, baikal skullcap root 20-100g, and beeswax 20-500g and sesame oil 1000-5000g.

The invention relates to the technical field of antibacterial gel, in particular to antibacterial gel and a preparation method thereof. The antibacterial gel per liter comprises the following raw materials: 1.7-1.9g benzalkonium chloride, 30-50ml glycerol, 0.1-1.3g menthol, 1-1.8g alums, 0.3-0.4g lactic acid, 2.5-5g carbomer, 3-6g traditional Chinese medicine extract and the balance of purified water. The antibacterial gel contains various anti-inflammatory, antibacterial and analgesic components; an antibacterial effect is best through a synergistic effect of the raw materials; the biocompatibility of the antibacterial gel meets GB / T 16886.11-2011; a microbiological indicator of the antibacterial gel meets GB 15979-2002; and the antibacterial gel is suitable for nursing of various vaginal bacterial infection, trichomonas infection, leukorrhea, monilial infection, cervix and genital tract or mucosal wound surface infection, promotes healing of a wound surface after cervical erosion physiotherapy, and is further suitable for internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure and anorectal postoperative nursing.

The invention relates to a liquid dressing for treating hemorrhoids, and a preparation method thereof. The liquid dressing is prepared from the following components: alginate, modified chitosan, allantoin, tetracaine hydrochloride, glycerinum, hyaluronic acid, human collagen, growth factor, polyethylene glycol, didecyl dimethyl ammonium chloride, phmg, N-isopropyl acrylamide, and the like. The dressing is used for improving bleeding pain, porta hepatis fall-swell and other syndromes caused by internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure, anal fistula surgery, promoting hemorrhoid reduction, preventing hemorrhoid prolapse, relieving the syndromes of prolapsed and hemorrhoids congestion and the like, and performing treatment and anti-bacterial nursing of porta hepatis diseases of hemorrhoids and the like.

The invention discloses an anus stretching device base. The anus stretching device base comprises a hollow body and an externally stretched wide edge, wherein the wide edge is connected with the near end of the body. The anus stretching device base is characterized in that: a first opening which can be opened or closed selectively penetrates the body; a second opening which also can be opened or closed selectively penetrates the wide edge; and the first opening is communicated with the second opening. The anus stretching device base can gradually and controllably stretch the anus and the anal tube of a patient and can adapt the anal sphincter to the amplitude stretched by the anus stretching device base before the anus stretching device base is inserted so as to prevent anal fissure and relieve the pain of the patient. At the same time, in the anus stretching device base, pre-anus stretching and anus stretching are integrally designed, so that the product is more easy and convenient to use. The anus stretching device base can be widely applied to surgical operations.