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Multicomponent preparation for treatnig piles and fissure

A multi-component, anal fissure technology, applied in the direction of drug combination, cardiovascular system diseases, etc., can solve the problems of unproven pharmacodynamics

Inactive Publication Date: 2004-01-28
武汉市第四医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most topical medicines can relieve symptoms, such as Mayinglong Hemorrhoid Ointment, Zhiansu Ointment and Yejuhua Suppository, etc., but their exact pharmacodynamics have not been confirmed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Get 100g of semi-synthetic fatty acid ester suppository base, heat in a water bath to melt, add 1g of nifedipine, stir to dissolve, add finely ground allantoin 5g and chlorhexidine acetate 2g, under the condition of stirring, Pour it into disposable suppository moulds, 100 pieces in total, let cool and solidify, seal, and get ready. One in the morning and one in the evening, stuffed into the anus.

Embodiment 2

[0025] Embodiment 2: Get polyethylene glycol 4000 10g, heat in a water bath to melt, add polyethylene glycol 400 90g, add allantoin 5g, chlorhexidine acetate 2g, nifedipine 1g, stir to room temperature, the preparation becomes half Solid, divided into ointment tubes, packaged and ready to use. Once in the morning and evening, 1g each time, apply locally to the anus.

Embodiment 3

[0026] Embodiment 3: Get 940 1 g of Carbasan, add 30 ml of water, make the swelling completely, take 30 ml of ethanol, 15 ml of polyethylene glycol 400, 15 ml of glycerin, add 5 g of allantoin, 2 g of chlorhexidine acetate, 1 g of nifedipine, stir Make it dissolve, add it to the above-mentioned matrix, stir, add 2 g of triethanolamine, stir, and make the matrix gel. Once in the morning and evening, 1g each time, apply locally to the anus.

[0027] The present invention uses 20 volunteers suffering from hemorrhoids combined with anal fissure to carry out clinical trials. There were 9 males and 11 females, aged 28 to 56 years, with an average of 35.5 years, and the course of disease was 0.5 to 16 years, with an average of 5.7 years. After cleaning the anus in the morning and evening, put 1 suppository into the anus, and the course of treatment is 14 days. Evaluate the curative effect according to the rectal inspection examination, recovery from illness: hemorrhoid mass and ana...

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PUM

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Abstract

The invention refers to a multi-component preparation for curing hemorrhoids and anal fissure, which comprises the wound surface convergence protecting agent, the antiseptic, the Ca-ion antagonistic agent and the allowed carrier, said protecting agent can be selectd from the allantoin and their allowed allantoin salt, the concentration of the allantion or the allantion salt 0.5-10%w / w; the antiseptic able to select from Chlorhexidine and the allowed Chlorhexidine salt, that of the acetic acid Chlorhexidine or the acetic acid Chlorhexidine salt 0.2-5%w / w; and the Ca-ion antagonistic agent ableto select from the nifedipine and the allowed nifedipine salt, that of the nifedipine or the nifedipine salt 0.1-5%w / w. The drug form of the carrier is suppository, frost, ointment, gel, oil, lotion,suspension, spray, external solution and cataplasm.

Description

technical field [0001] The invention belongs to a medicine for treating anal fissure and hemorrhoid diseases, in particular to a multi-component preparation external medicine for treating hemorrhoid and anal fissure. Background technique [0002] Anal fissure is a longitudinal fissure in the skin of the anal canal, which is manifested as a full-thickness rupture of the anal canal skin, with pain as the main symptom, and the patients are mostly young and middle-aged. Modern medicine believes that anal fissures are caused by dense stools and excessive defecation, causing anal skin rupture and secondary infection; or due to damage caused by anal canal stenosis, followed by infection, and gradually forming chronic ulcers. Therefore, for the treatment of anal fissures, the methods adopted all the time include eating high-fiber foods to avoid constipation; anal dilators; medial sphincterotomy; local injection for sealing; Another effective treatment for ana...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61P9/14
Inventor 陈冠容刘忠黄丽萍宋红萍平成斌
Owner 武汉市第四医院
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