14 results about "Chronic ulcers" patented technology

The invention discloses a bionic cross-linked film-forming repair dressing containing mussel mucoprotein and a preparation method of the bionic cross-linked film-forming repair dressing, and relates to the technical field of medical instruments. The bionic crosslinking film-forming repair dressing containing the mussel mucoprotein is prepared from the following components in parts by weight: 30 to 40 parts of bionic crosslinking agent, 25 to 35 parts of humectant, 10 to 20 parts of natural high polymer material, 1 to 10 parts of mussel mucoprotein, 1000 parts of purified water and 5 to 15 parts of pH regulator. PEG-DOPA is formed through cross-linking, the DOPA content and stability are remarkably improved, the adhesion-repair-anti-inflammatory effect of mussels mainly depends on the dopa content, the effect of the dressing is remarkably enhanced through improvement of the DOPA content and stability, the dressing is more convenient to use through the flexibility change of a film, the dressing is more suitable for dynamic and wet wounds, and the application range of the dressing is widened. The medicine has a remarkable effect on chronic ulcer and burn.

The application discloses a chronic ulcer wound repairing gel and a preparation method and application thereof, and belongs to the technical field of medical materials. Since bacterial cellulose has the advantages of good biocompatibility, high water retention and moisturizing capacity, strong mechanical property, good air permeability, low toxicity and the like, the bacterial cellulose is used to prepare the bacterial cellulose-based chronic ulcer wound repairing gel capable of promoting chronic wound healing by compounding functional components. The gel can bidirectionally regulate the wet balance of a wound surface; contains a large amount of hydroxyl groups, can highly retain water, has an ice-cool feeling, effectively relieves pain, simultaneously reduces irritation to a wound and a mucous membrane, reduces the sensitivity of exposed nerves, and reduces pain; the photosensitizer in the gel can inhibit bacterial infection by irradiation of near-infrared laser; active components can inhibit inflammatory diffusion, promote collagen deposition and angiogenesis, and the like, so as to promote the healing of a chronic ulcer wound surface.

Local tissue defects, liquefaction, infection, and necrosis of skin resulted from various reasons may lead to skin damage and vascular regeneration disorders. Wound hypoperfusion, metabolic disorders, and delayed epithelial cell formation disrupt the process of normal wound healing, thereby leading to the formation of chronic ulcer. To solve the aforementioned problems, a use of polymer dot is provided. The polymer dot may be used for manufacture of a component for the treatment of skin to a subject in need, in order to restore skin damage of the subject, minimize a scar on the damaged skin of the subject, and enhance recovery of the skin of the subject after cosmetic or dermatologic surgery. The polymer dot includes a carbon dot.

Wound healing is a process by which these wounds on the skin of a subject heal and eventually close. When the injured surface is large, becomes infected, or in patients with poor healing capacity such as diabetics or the elderly or bedridden patients, then wound healing can be prolonged and lead to chronic ulceration and further complications with even limb loss or increased morbidity and mortality. This invention is directed to a topical formulation for promoting wound healing, and wound dressings and bandages comprising the same.

The application belongs to the technical field of biomedical materials and regenerative medicine, and provides a composite nano hydrogel and application thereof in repair of diabetic wound surface. The three-dimensional porous nano hydrogel framework formed by composite crosslinking of HA-3APBA, PVA and lithium clay nanosheet is used as a carrier, antioxidant small molecules NAC and VC are double-loaded, and inactivated umbilical cord serum is dispersed and compounded. In view of the pathological characteristics of high oxidative stress and sustained inflammation of the diabetic wound surface, the application removes active oxygen through the antioxidant small molecules, remodels the wound microenvironment, protects and cooperates with the umbilical cord serum to play the roles of promoting angiogenesis, collagen deposition and re-epithelialization, and solves the problems of easy inactivation of growth factors, prolonged inflammation and healing stagnation of the diabetic wound surface. Animal experiments show that the composite nano hydrogel significantly improves the healing speed and quality of the diabetic wound surface, and can be used for preparing drugs for treating diabetic foot ulcers, diabetic chronic ulcers and high oxidative stress difficult-to-heal wound surfaces.

The invention provides a biological dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: thawing in still water; unhairing and degreasing; cutting and segmenting; fine trimming and punching; performing iodophor soaking treatment; soaking in purified water; soaking in a mixed solution of protease and alkali metal hydroxide; soaking in purified water; antibacterial agent brushing treatment is carried out; and packaging and irradiating. The product obtained by the invention can be used for purifying, cleaning and protecting wound surfaces, promoting granulation tissue growth, covering granulation wound surfaces, chronic ulcers and bedsores, shortening the healing time and improving the healing effect.

The invention relates to nano hydrogel for treating diabetic chronic ulcer as well as a preparation method and application of the nano hydrogel. The nano hydrogel comprises a drug nano aggregate formed by sildenafil citrate and glycosylated naringin serving as a solubilizer and an antioxidant through molecular self-assembly, the hydrogel matrix is formed by crosslinking carboxymethyl chitosan and oxidized bletilla striata gum through a dynamic Schiff base reaction; wherein the drug nano aggregate is uniformly dispersed in the hydrogel matrix, and the drug nano aggregate and the hydrogel matrix jointly form the injectable and self-healing slow-release gel dressing. The method has the advantages that the hydrogel is formed through Schiff base reaction, conditions are mild, ultraviolet light or high temperature is not needed, and degradation of drugs and auxiliary materials is avoided. The gel process is rapid, and the formed gel has self-healing and injectable characteristics, can perfectly fit an ulcer wound surface with an irregular shape, and can automatically recover the structure after being damaged by shear force.

The application discloses a kind of biological membrane dressings and its application in the treatment of multiple types of injuries, the dressing with egg white, fibrinolysin, soybean small molecule peptide as main film-forming matrix, can be selectively added to one or more active ingredients of Chinese herbal medicine, such as radix cirsii japonici, bletilla striata, portulaca oleracea, radix pteroxygoni, sophora flavescens, panax notoginseng, menthol powder, according to different wound types, can be made into ready-to-use gel or freeze-dried powder.The biological membrane dressing provided by the application can quickly form a dense protective film on the wound surface, physically seal the wound, effectively prevent fluid loss and bacterial infection, so as to skip the shock period and inflammation period.The dressing has the effects of rapid analgesia, detumescence, scabbing and promoting healing, and can significantly inhibit scar formation, and is suitable for the treatment of burns and scalds, surgical incisions, abrasions, chronic ulcers, diabetic foot, urticaria, herpes zoster, frostbite, penetrating wounds, lacerations, sprains, strains, contusions, arthritis, bone repair, animal bites, fungal infections and skin inflammation and the treatment of various injuries.

The invention discloses an external traditional Chinese medicine composition with the effects of promoting blood circulation to subdue swelling, relieving pain and stopping bleeding and promoting tissue regeneration, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-15 parts of male ground beetles, 8-20 parts of arisaema cum bile, 10-25 parts of dragon's blood, 8-20 parts of myrrh, 3-10 parts of nux vomica (processed), 10-25 parts of fossil fragments, 10-25 parts of angelica sinensis, 5-15 parts of flos carthami, 8-20 parts of Sichuan notopterygium roots, 5-15 parts of crab bones, 8-20 parts of clean frankincense, 8-20 parts of divaricate saposhnikovia roots, 10-30 parts of hylocereus undatus, 10-25 parts of radix angelicae, 5-15 parts of paris polyphylla, 8-20 parts of rhizoma acori graminei, 8-20 parts of ligusticum wallichii and 3-12 parts of borneol. Through unique compound compatibility of nineteen components, not only is a complete trauma spectrum from an open wound to subcutaneous swelling covered, but also granulation tissue regeneration of chronic ulcer can be effectively promoted through sore astringing and detoxification effects of the dragon bone, the radix angelicae and the rhizoma paridis.

The invention relates to a preparation method of a hydrophobic natural-drug-effect micromolecule self-assembled hydrogel sustained-release drug delivery system and wound repair application. Belongs to the technical field of biological materials and pharmaceutical preparations. The hydrogel has antibacterial, anti-inflammatory and wound repairing capabilities, can selectively inhibit drug-resistant bacteria and fungi, and does not influence the activity of probiotics; the entrapment performance on exosomes and various pharmacodynamic molecules is good. Wherein the coptisine and chrysin self-assembled hydrogel is uniform and stable in form, has dual antibacterial activity superior to those of penicillin G, ketoconazole and the like, and has a value of being developed into a carrier-free supramolecular nano-drug. In the preparation process, compared with the traditional technology, the method is simpler and more environmentally friendly, high in repeatability and has industrial production potential. In application, the sustained-release delivery system can remarkably shorten the wound healing period and reduce the infection risk, and shows good applicability and treatment effect on complex wounds such as acute skin wounds, chronic ulcers and diabetic feet.

To provide an antimicrobial and / or anti-inflammatory composition for cleaning and / or wiping biological and / or biomaterial surfaces, for example, insitu implants and / or surfaces in the oral cavity.SOLUTION: The present invention relates to a novel multifunctional wiping and / or anti-fouling composition comprising a composite hydrogel formulation comprising H2O2 at final concentrations of 0. 1-5% v / v and pluronic acid at a concentration of 10-40% w / v, wherein the composition is in liquid form at ambient temperature. The compositions disclosed herein are antimicrobial and / or anti-inflammatory, and are particularly useful in peri-implantitis treatment and implant health maintenance, in periodontitis and periodontal health, and in wound care and chronic ulcer care.SELECTED DRAWING: None

The invention relates to a traditional Chinese medicine composition for treating chronic refractory wounds and a paste, a preparation method and application thereof, the traditional Chinese medicine composition comprises silkworm cocoon shells, lithospermum, bletilla striata, andrographis paniculata, astragalus membranaceus, pseudo-ginseng powder and borneol, and the traditional Chinese medicine composition has an anti-oxidative stress effect, can promote the generation of capillaries in wounds of patients, and has a good curative effect on the wounds of the patients. The inflammatory response can be relieved by down-regulating the expression of IL-6 and TNF-alpha in wound tissues, and wound healing is facilitated; after the prepared external paste is smeared on an affected part, a medicine film which is good in breathability and does not need to be isolated by external gauze can be formed, and the formed medicine film is not adhered to the wound surface of a patient, can be cleaned with water and is convenient to change medicine; the traditional Chinese medicine composition has a good curative effect on chronic ulcerative diseases caused by diabetes, lower limb vascular diseases including vasculitis, burn and paralysis basic diseases. The traditional Chinese medicine composition can clearly grasp the pathology of chronic refractory wounds, is appropriate and reasonable in formula, does not contain harmful substances such as heavy metals, and is low in toxicity, good in curative effect, simple to prepare and convenient to use.

The invention discloses a probiotic EcN lpp-A5-alpha TN strain as well as a construction method and application thereof, Escherichia coli Nissle 1917 is taken as a chassis, CRISPR (clustered regularly interspaced short palindromic repeats) is used for knocking out an outer membrane lipoprotein gene lpp, and an Lpp-OmpA-Annexin V fusion protein expression cassette is integrated in situ, so that the probiotic EcN lpp-A5-alpha TN strain which is stable in heredity and free of exogenous resistance is obtained. The strain retains the beneficial characteristics of EcN, and meanwhile, realizes targeted colonization, long-time retention and continuous secretion of anti-TNF-alpha nano antibody alpha TN in intestinal tracts, inhibits immune cell infiltration and rebuilds the immune microenvironment of the intestinal tracts. Animal experiments prove that the traditional Chinese medicine composition has a remarkable curative effect on acute and chronic ulcerative colitis, can be used in combination with 5-aminosalicylic acid, glucocorticoid or a biological preparation, and is safe to orally take, mature in process, low in cost and suitable for large-scale production.

The invention discloses a method for establishing a stable damp-heat ulcerative colitis animal model. A DSS, high-glucose and high-fat diet and artificial climate box combined induced damp-heat type ulcerative colitis model is adopted, and the method comprises the following steps: (1) high-glucose and high-fat diet: mice freely eat high-glucose and high-fat feed from the first day until an experiment is finished; (2) artificial climate box treatment: from the eleventh day, putting the mice into an artificial climate box with the temperature of 35 DEG C and the humidity of 90% for 6-8 hours every day; the mouse is not placed in the artificial climate box during DSS induction; and (3) DSS treatment: starting from the 21st day, the mice freely drink a DSS sterile aqueous solution for 7 days, then the mice are put into the artificial climate box in the step (2) to freely drink water for 7 days to serve as a recovery period, high-glucose and high-fat feeding is adopted in the period, the period is a molding period, and the period is performed for 3 periods. The built model is similar to ulcerative colitis in traditional Chinese medicine clinical symptoms and signs, good in repeatability and stability and suitable for traditional Chinese medicine screening for treating ulcerative colitis through a traditional Chinese medicine heat clearing and diuresis promoting method.