126 results about "Chronic ulcers" patented technology

Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.

Use of the antimicrobial cathelicidin peptide ll-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithalial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.

The invention discloses traditional Chinese medicine oil, which is mainly used for treating burn, scald or acute and chronic ulcer sore surface, surgical skin diseases, genital organ inflammation or abrasion and laceration of body surfaces. The traditional Chinese medicine oil comprises the following components by weight percent: 2-5% of polygonum cuspidatum, 0.5-2% of rhubarb, 0.5-2% of radix scutellariae, 0.5-2% of coptis root, 1-2.5% of fructus forsythiae, 1-2.5% of honeysuckle flower, 1-4% of radix angelicae, 1-3% of angelica, 1-2% of beautyberry, 0.5-2% of fresh and live centipede, 0.5-2% of earthworm, 0.5-1.5% of borneol, 0.3-2.5% of phellodendron bark, 1-2% of cortex dictamni, 1-2% of belvedere fruit, 0.5-2% of frankincense, 0.5-2% of myrrh, 1-2% of lithospermum and 57-85.7% of rapeseed oil. The invention also discloses a preparation method of the traditional Chinese medicine oil. The traditional Chinese medicine oil disclosed by the invention can relieve pain of patients, clear away heat and toxic materials, alleviate pain and eliminate swelling, eliminate dampness, remove rot and relieve itching, as well as activate blood, moisten skin and promote tissue regeneration within the shortest time, can quickly promote forming and falling of scab film, and has no toxic or side effect.

Apparatus for measuring microcirculatory flow of a target tissue without the necessity for direct contact of a probe is disclosed. The apparatus includes a probe (10) arranged to generate a pulsed source of infrared light (16) and a matched infrared sensor (18) which transduces variations in the reflected light to an electric signal and a signal processor which compares the signal at a first time when the pulsed light source is on with a second time when the pulsed light is off. The signal is processed to reduce or ameliorate the effect of the ambient light in the signal and the Tissue Perfusion Index (TPI) is then calculated. Without the need to contact tissue, the apparatus can be used to measure the TPI for chronic ulcers on the extremities, the surface of the retina, the vascular pulp within a tooth or the surface of internal organs accessed by fiber optic or endoscopic means.

Provided is a new bionic skin material with multiple functions and a high efficacy. With a compound microporous fibre net structure, the material imitates a skin barrier function, has anti-fouling properties, hygroscopic properties, moisture retention properties, air permeability, flexibility and adhesiveness, and can effectively absorb wound exudate and residues for rapid painless autolysis and debridement, ensure sufficient drainage by bidirectional regulation, maintain a semi-closed, local physiological wet environment favorable for the reparative metabolism and physiological healing of a wound, inhibit inflammation, reduce exudation, benefit the response inside and outside of cells, promote the migration of fibroblasts and epithelial cells of the body itself and the regeneration of granulation tissue and epithelial cells of the wound, accelerate the physiological healing and recovery of the wound, and reduce recurrences. It has been clinically proved that the dressing material can accelerate the healing of acute skin injuries and chronic ulcer wounds, achieve a high healing quality, avoid or reduce traumatic skin grafting to the greatest extent, reduce the pain of patients and the production of scars, and restore the physiological function and appearance of the body.

A wound care instrument to be used for measuring, probing, suctioning, cleaning, mechanically debriding, and applying creams or ointments in or onto acute and chronic ulcers or wounds, including but not limited to undermining or tunneling, surgically dehisced wounds, penetrating wounds, and burns.

The invention discloses a fusion protein with antibacterial and repairing function and a production method and application thereof. A fusion gene is prepared by splicing an anthropogenic antibacterial peptide gene and a cell growth factor gene through a segment of hydrophobic polypeptide joint; and the fusion protein is prepared by adopting the expression of a prokaryocyte or yeast expression system, and is encoded by the anthropogenic antibacterial peptide, the polypeptide joint and the cell growth factor gene from an N end to a C end of the fusion protein. The invention simultaneously provides application of the fusion protein to the preparation of medicaments for treating wounds, burns / scalds, cold injury, chronic ulcer or bedsore. The invention creatively fuses the two kinds of polypeptide genes together to successfully construct a fusion protein with dual function of preventing infection and accelerating the repair of the damaged tissue, improves the safety of clinical medicament simultaneously, and prolongs the half-life period of the fusion protein.

The invention discloses a fibroin porous material loading insulin / fibroin microspheres and a preparation method thereof, belonging to the technical field of biomedical materials. The fibroin microspheres loading insulin are prepared by using a coaxial high voltage electrostatic technique and a freeze drying method and the porous material loading insulin / fibroin microspheres is prepared by using a layer-by-layer assembly and freeze drying method. The porosity of the porous material is 70-90% and the bore diameter is 50-200 microns. The microspheres are uniformly distributed inside the porous material and are firmly combined with the material. Insulin loaded in the material can be sustainably and slowly released for over 20 days and the releasing rate is over 94%. Insulin released from the fibroin porous material loading insulin / fibroin microspheres prepared by the invention has bioactivity and can stimulate epidermis cells and endothelial cells to migrate so as to increase the wound healing speed and improve the wound healing quality. The fibroin porous material loading insulin / fibroin microspheres disclosed by the invention provides wound dressing with a good performance for treating such defects of skins as wounds and burn and chronic ulcer of skins.

The invention relates to a wound dressing with high moisture absorption and a preparation method and an application thereof. The wound dressing comprises a bottom layer formed by non-sol fibers and a stuffed layer formed by sol fibers, wherein the sol fibers are woven on the bottom layer through a weaving mode and have the free stuffed length of 1-100mm, preferably 5-50mm. The wound dressing can be used for nursing chronic wounds such as venous stasis ulcers, pressure ulcer, diabetic foot ulcer and other chronic ulcer wounds comprising hole type or recessed type ulcer wounds.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia / reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention belongs to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composite for treating the body surface ulcer or fester. The traditional Chinese medicine composite for treating the body surface ulcer or fester is prepared by the following raw materials in parts by weight: 5-10 parts of muschus, 25-50 parts of borneol, 100-200 parts of daemonorops draco, 100-200 parts of rhizoma bletillae, 100-200 parts of coptis chinensis and 100-200 parts of indigo naturalis. The traditional Chinese medicine composite for treating the body surface ulcer or fester provided by the invention can quickly relieve and effectively cure the varicose ulcer, the ulcer caused by the bedsore, the ecthyma leg, the furuncle and the carbuncle, the body surface ulcer caused by the poor healing of operative incision, the wound, the poor wound healing, the wound hemostasis and the like or the chronic ulcer, can quickly relieve and eliminate the clinical symptoms such as the red, the swell, the hot and the pain, and has the advantages of being quick in becoming effective, exact in curative effect, and free of side effects.

The invention provides a method of treating a wound (for example, a chronic ulcerous skin lesion) in a human or non-human mammal (particularly a human). The wound is contacted with a topical hydrogel composition comprising a hydrophilic polymer carrying multiple pendant sulphonyl groups, optionally with multiple pendant carboxylic groups, on each polymer molecule.

Methods of ameliorating episodes of accute or chronic colitis are provided by using methimazole derivatives and tautomeric cyclic thiones in combination with another pharmaceutical compound.

A medicine "Suyusan" for treating intractable ulcer is prepared from phenytoin sodium, sodium benzoate, VC and 5 Chinese medicinal materials including pearl layer powder, borax, borneol, etc. throughuniformly mixing according to defined quantity. Its advantages include speeding up healing, no any toxic by-effect, high cure rate up to 98.7%, and no recurrence.

The invention provides a medicine for treating ulcer by using radix tetrastigme. The prepared medicine is characterized by containing radix tetrastigme, pharmaceutic adjuvant is added or not, and the prepared medicine can be made into oral preparation and external preparation. The medicine can be taken orally or applied externally. The medicine is effective and non-toxic when used for treating intertrigo, bedsore, diabetes mellitus, chronic ulcer caused by varicosity and ulcer or mucosa disease caused by chemoradiotherapy.

This invention relates to a topical gel drug product preparation containing a composition comprising an isolated polypeptide having a carboxy-terminal amino acid sequence of an alpha connexin (ACT peptide), peptide stabilizers, excipients, buffering agents, and the like. A formulation and preparation steps are disclosed for the manufacturing of a stable, elegant, and pourable topical gel. The resulting formulation possesses long term stability suitable for aesthetic as well as therapeutic applications including the prevention of scaring and accelerated healing of wounds. Methods for treatment of chronic wounds, including chronic ulcers, are also provided.

The invention provides an artificial substrate membrane emulsifying paste as well as a preparation method and an application thereof. An artificial substrate membrane emulsifying paste composite biological preparation comprises the following components in percentage by weight: 1-60 percent of human-like collagen, 0.001-0.01 percent of epidermal growth factor, 0.5-5 percent of flamazine, 20-95 percent of distilled water and 1-20 percent of medical emulsifying paste matrix. The artificial substrate membrane emulsifying paste can be used for treating wound surfaces of burning, scalding, frostbite and cauma, a skin donor site wound surface, and the like and promoting various fresh wound surfaces and chronic ulcer wound surfaces (including diabetes mellitus, vascellum and radiation ulceration), and the like to be healed and being applied to treat injurious and ulcerous eye diseases and prepare cosmetics and facial beautifying products. The artificial substrate membrane compound has the function of protecting the wound surfaces and can promote epidermal cell growth and wound surface restoration. The emulsifying paste has the advantages of simple and convenient preparation technology, stable product quality and wide application range and is suitable for industrialized production.

The invention provides a local anti-inflammatory external medicinal composition using a glycerol DMSO mixed solvent, which comprises alum, a medicament with anti-inflammatory effective dose, and a mixed solvent which is used for dissolving the alum and the medicament and consists of dimethyl sulfoxide and glycerol in a volume ratio of 1:0.5-5. The external medicinal composition is a new dimethyl sulfoxide and glycerol external anti-inflammatory medicament, is used for treating various refractory and inflammatory mucocutaneous diseases, has the local anti-inflammatory effect by inhibiting inflammatory, and promotes injuries such as local blister, erosion, effusion, herpes and chronic ulcers to quickly heal.

The invention relates to an intelligent assistant diagnostic system for skin ulcer with a machine vision 3D reconstruction technique. A calibration method is adopted and the internal and external parameters of two cameras are obtained respectively; through a set of fixed points in the same world coordinate system, the position relation between the two cameras is set up, through a 3D reconstructionmodel, the color feature of a wound surface, a 3D surface area feature and a texture feature of the wound surface are digitally extracted, at the same time, the color characteristics of the ulcer wound in traditional Chinese medicine are digitally converted, and the therapeutic effect is dynamically evaluated by using the change of skin wound characteristics. The intelligent assistant diagnosticsystem has the advantages that the surface shape and surface area information of chronic wound surface can be calculated directly, which provides the digitized basis for the diagnosis and treatment ofulcer in traditional Chinese medicine, so as to create a more direct and convenient observation and evaluation method for the diagnosis and treatment of chronic ulcer, at the same time, the system accumulates 3D image information, thus establishing a first digital differentiation AI resource database of skin ulcer in the whole process of treatment.

The invention provides a method of treating a chronic ulcer, such as a diabetic ulcer, comprising administering a therapeutic amount of a hydrogel matrix to the ulcer, the matrix composition comprising gelatin and a long chain carbohydrate. The matrix may further include polar amino acids, nitric oxide inhibitors and super oxide inhibitors. Injection is a preferred method of administration. The matrix may be injected into one or more locations within the ulcer, underneath the ulcer and / or around the periphery of the ulcer.

The invention provides tissue regeneration promoting styptic powder used for curing traumata, injuries, scald, infection or skin and external diseases of human beings caused in daily life at home, work, travel, soldiery and war, and because of the autoimmunity of human bodies and so on. The tissue regeneration promoting styptic powder is prepared from Chinese compound traditional herb medicaments which are porphyrized by adopting the modern technology. The tissue regeneration promoting styptic powder is characterized in that the formula ingredients of the tissue regeneration promoting stypic powder include Malan Straw, hyacinth bletilla, madeira vine, agrimony, madder and so on. The tissue regeneration promoting styptic powder has the functions of hemostasia, antiinflammation, eliminating erosion and promoting regeneration of tissues, improving the content of secretion and serum lysozyme, improving the resistance of the surfaces of wound, and accelerating the healing of surfaces of wound. The tissue regeneration promoting styptic powder can solve new and old injuries, acute and chronic ulcer syndromes effectively and safely. In addition, little time is needed for the powder to stanch bleeding, and wound can be healed quickly. The powder is effective for cure comprehensively. In the areas short of medical and sanitary conditions, or in particular cases, the tissue regeneration promoting styptic powder can ensure the health of the sick and wounded , and relieve the pain of the sufferers,and is in particular significant for war on battleground. The tissue regeneration promoting styptic powder can bring high economic benefits and social benefits.

The invention relates to a wound dressing having bacteriostasis and hygroscopicity, and especially relates to a wound dressing containing chitosan fibers and modified cellulose fibers, a preparation of the wound dressing, and an application of the wound dressing in chronic wounds, such as venous stasis ulcers, pressure ulcers, diabetic foot ulcers and other chronic ulcers.

The invention relates to the field of Chinese medicines, in particular to Chinese herbal medicine preparation burn oil, which is used for preventing and removing scars and treating burn and is prepared by sesame oil and the following Chinese herbal medicine components: sensitive plants, hibiscus, folium hibisci, wintersweet flowers, white pear flowers, rheum officinale, radix zanthoxyli, polygonum cuspidatum, radix scutellariae, golden cypress, jasmine, angelica sinensis, saffron crocus, radix angelicae, stone-like omphalia, syzygium aromaticum and gleditschia xylocarpa hance. A preparation method for the scar preventing and removing burn oil is further disclosed. The scar preventing and removing burn oil can enable the heal time for large-area burn to be shortened, is good in pain stopping, fast in flesh regeneration and small in scar after heal, has good curative effects on bedsore, diabetic gangrene fester and chronic ulcer, and has good application prospects.

The invention discloses an externally-used medicament for the treatment of burns, bedsore and chronic ulcer, as well as the process for preparation, the medicament is prepared from the following medicinal herbs: Chinese angelica root 30-80 parts, coptis root 30-180 parts, garden burnet root 30-120 parts, giant knotweed rhizome 30-90 parts, rheum officinale 30-90 parts, borneol 30-90 parts, emollient 30-90 parts and water 3000-5000 parts.

The invention discloses a method for preparing a skin regeneration material loaded with bioactive glass particles. The method specifically comprises the steps of 1, preparing glass powder; 2, preparing silk fibroin concentrated aqueous solution; and 3, mixing and evenly stirring the glass powder, polyvinyl alcohol, chitosan solution and the silk fibroin solution, conducting vacuum defoamation to obtain blended solution, obtaining a four-dimensional porous support with the freezing-drying method, cross-linking the four-dimensional porous support with glutaraldehyde solution, and conducting freeze drying again after repeated cleaning to obtain the finished product. The skin regeneration material is a high-performance skin substitute for treatment of serious skin defects like wounds and burns as well as chronic ulcers of skin, and can remarkably promote healing of a wound surface and reduce scar hyperplasia, so as to relieve pain for patients. The skin regeneration material can be widely applied to wounds, burns, plastic surgery and other aspects. The preparing method is simple, raw materials are widely available, production efficiency is high, and the preparing method is suitable for industrialized production.

The present invention provides compositions and methods for treating burns and chronic wounds, particularly compositions comprising an oil extract or oily suspension of a combination of plant material derived from several plant species for treating burns and chronic sores.

This invention relates to a topical gel drug product preparation containing a composition comprising an isolated polypeptide having a carboxy-terminal amino acid sequence of an alpha connexin (ACT peptide), peptide stabilizers, excipients, buffering agents, and the like. A formulation and preparation steps are disclosed for the manufacturing of a stable, elegant, and pourable topical gel. The resulting formulation possesses long term stability suitable for aesthetic as well as therapeutic applications including the prevention of scaring and accelerated healing of wounds. Methods for treatment of chronic wounds, including chronic ulcers, are also provided.

The invention discloses an adhesive bandage type artificial active tissue constructed by using a culture solution without serum or bovine pituitary extracts and a construction method of the adhesive bandage type artificial active tissue. A cell culture solution without the serum or bovine pituitary extracts is adopted, and a biological film carrier is specially treated to ensure that a niche suitable for cell interaction is formed on a biological film, and promote human fibroblasts and epidermal cells to give play to self potentials, proliferate, disintegrate and excrete growth factors, so that an artificial tissue with active cells can be formed on the biological film in 4-7 days. The artificial tissue is high in cell activity and strong in division and migration ability, can home back to wound surfaces, and can promote tissue regeneration by serving as seed cells for curing burns and chronic ulcer. The adhesive bandage type artificial active tissue disclosed by the invention completely avoids immunological rejection of animal derived products including serum, pituitary extracts and collagen and the risk of infection of viruses transmitted to humans from animals, and a thin cell tissue taking the biological film as a scaffold and an infection barrier is formed, so that the adhesive bandage type artificial active tissue with biological safety is truly realized.

The invention relates to a technical field of decellularization of animal skin tissues in biomedical engineering, and specifically provides an ADM-bFGF (acellular dermal matrix-base fibroblast growth factor) complex and application thereof. The method is as below: treating the animal skin tissues in a solution containing SDS (sodium dodecylsulfate) and NaOH to obtain ADM; and wrapping the bFGF DNA into liposome, placing the bFGF DNA with ADM, adhering the bFGF DNA on the acellular dermal matrix through electrostatic adsorption, so as to form an ADM-bFGF complex. Through a large amount of verifications, the acellular dermal matrix is suitable for covering of wounds, granulation wounds, chronic ulcers and bedsore, and playing the effects of preventing water evaporation, loss of protein and heat, and microbial infection, and promoting wound healing. The acellular dermal matrix has good biocompatibility, no immunogenicity or low immunogenicity, no toxicity and no allergy, and is safe and easy to use.