666 results about "Healed wounds" patented technology

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and / or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.

A tissue approximation device and processes for using the device are provided. The device is an implantable, biodegradable construct (except for hernia repairs) that has attachment points emanating from a supportive backing. The device improves the mechanical phase of wound healing and evenly distributes tension over the contact area between the device and tissue. Processes for using the device include wound closure, vascular anastomoses, soft tissue attachment and soft tissue to bone attachment.

The present disclosure describes a dressing for use in a vacuum wound therapy procedure to promote healing of a wound. The dressing includes a cover layer for positioning over a wound to define a reservoir in which a reduced pressure may be maintained over the wound. A portal member is mounted relative to the cover layer and defines a fluid passage for fluid coupling with a reduced pressure supply conduit for creating the reduced pressure within the reservoir. A filter screen is mounted relative to the fluid passage and is dimensioned to minimize passage of tissue particles of predetermined dimension through the fluid passage of the portal member

Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.

The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are dispersed in a biodegradable polymer or hydrogel, or both. Methods of using the invention bioactive polymer compositions to deliver wound healing agents that promote natural healing of wounds, especially chronic wounds, are also provided.

A system for subatmospheric pressure therapy in connection with healing a wound includes a wound dressing adapted for positioning relative to a wound bed of a subject to apply a subatmospheric pressure to the wound and a subatmospheric pressure mechanism. The subatmospheric pressure mechanism may be portable and adapted to be carried or worn by the subject.

Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.

The invention discloses a medical dressing with a cooling function and a wound healing promoting function, which at least comprises a perforated non-woven fabric layer, a nanometer fiber layer with a gradient structure, a hydrogel layer and a supporting layer. The preparation method of the medical dressing includes steps of covering hydrogel onto the supporting layer; covering the nanometer fiberlayer with the gradient structure on the hydrogel; and finally reinforcing the perforated non-woven fabric layer on the surface of the nanometer fiber layer so as to obtain the medical dressing. The nanometer fiber layer has the gradient structure, and facilitates absorption and retention of liquid of wound, and medicine can reach the surface of the wound after being released, so that wound healing is promoted; the perforated non-woven fabric layer has a physical isolating effect, avoids outside bacteria, can absorb effusion of the wound, can be easily removed from the surface of the wound and is not adhered with the wound; and the hydrogel layer can realize temperature regulation and reduces the temperature of the wound. The medical dressing comprehensively utilizes a medicine loading performance of nanometer fibers and capillary mobility of liquid, and promotes wound healing while cooling.

The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.

This invention relates to methods of promoting the healing of skin wounds, products for promoting the healing of skin wounds and processes for making such products. More particularly, this invention relates to layered absorbent dressings which absorb wound exudate in conjunction with additional products for assisting the healing of wounds at each stage of wound healing, as well as methods of using these dressings and methods of making these dressings.

The invention relates to an active wound repair material, specifically to a functional dressing and a preparation method and application thereof, belonging to the field of medical materials. To overcome a technical problem, the invention provides the functional dressing, which belongs to biologically active wound repair materials. The functional dressing is prepared from the following raw materials by weight: 2 to 6 parts of biologically active glass, 12 to 20 parts of alginate, 4 to 12 parts of chitosan and 100 to 200 parts of water. Multiple dosage forms can be prepared from the above-mentioned raw materials, mainly comprising a gel, a dressing, etc. The functional dressing provided by the invention has the advantages of bacteriostatic action on a wound, promotion of wound healing and growth, adsorption of a small amount of tissue exudates, good biosecurity, waterproof performance, a bacterium blocking effect, etc. The functional dressing has a wide application scope, is applicable to mechanical trauma and operative incision (wound) and exerts a good therapeutic effect on hard-healing wounds like burns and scalds, diabetic foot, ulcer and pressure sores and a good curative effect on an infectious wound and a delayed union wound.

A wound healing bandaging kit includes a plurality of bandages, each with a flexible layer having a patient-contacting-surface and an outer surface. The outer surface on one of the bandages in the kit includes visual indicia portraying a neutral or negative message, and the outer surface on one of the bandages in the kit includes visual indicia portraying of a positive message. In the preferred embodiment, the visual indicia of a neutral or negative message includes the graphical image of a person's face with a neutral expression or a frown, and the visual indicia of a positive message includes the graphical image of a person's face with a smile. A method of treating a wound includes the steps of providing a wound healing bandaging kit with a plurality of bandages, one of which portrays a neutral or negative message, and another of which portrays a positive message. The bandage with the visual indicia portraying of a neutral or negative message is applied initially after a cut, bruise, surgical incision or trauma; the bandage with the visual indicia portraying a positive message is then applied after the cut, bruise, surgical incision or trauma has had an opportunity to heal.

The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.

Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.

The presently-disclosed subject matter includes polyurethane composites that include tissue component(s), as well as methods of making such composites and uses thereof. The polyurethane component can comprise a polyisocyanate prepolymer and a polyol. The tissue component can be a polysaccharide. Exemplary composites can be moldable and / or injectable, and can cure into a porous composite that provides mechanical strength and / or supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shaped areas, voids, or the like. Exemplary composites can be used for treating wounds.

A skin or wound contact material which comprises a polycondensate matrix and a water-absorbing polymer incorporated therein. The water-absorbing polymer is doped with a wound healing promoter substance and / or a skin care substance.

Provided is a method of treating a wound site. Also provided is a system for treating a wound site. Additionally provided is the use of reduced pressure and a nucleic acid that promotes wound healing for treatment of a wound site. Further provided is the use of a nucleic acid that promotes wound healing for the manufacture of a medicament for treating a wound site that is undergoing reduced pressure treatment.

A method for providing negative pressure wound healing in a deep wound having a cavity includes the steps of (a) fashioning at least a first part of a therapeutic dressing to fit generally within the cavity, (b) operably associating a fluid moving means with the therapeutic dressing for enabling one of compressing the therapeutic dressing and transferring fluid across at least part of the therapeutic dressing, and (c) enabling the fluid moving means in a manner to deliver therapy to the patient. A therapeutic member for use in negative pressure wound healing includes a porous member formed and includes a hydrogel coating on a side thereof.

Assays employing fibronectin-depleted substrates are described to identify invasion inducing agents. Such agents are useful for in vivo wound healing, including but not limited to deep wounds and chronic wounds.

The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage / monocyte and endothelial cell, re-epithelization, proliferation of fibroblasts or angiogenesis.

Methods and compositions based on chemical analogs of angiotensin II and analogs of angiotensin II fragments useful for accelerating wound healing in mammals.

The present invention relates to a method of treating a wound and an apparatus for promoting wound healing. An enclosure is applied over the site of a wound and filled with a physiologically acceptable rinse solution. The physiologically acceptable rinse solution treats the wound and can promote the growth of tissue cells in the wound. Following exposure to the wound, the physiologically acceptable rinse solution is analyzed by a data sensor to determine the wound bed biology.

The invention discloses nutrient gel for sterilizing and healing a wound surface and belongs to the technical field of anti-bacteria gel. The nutrient gel for sterilizing and healing the wound surface is prepared from hydroxyethyl cellulose, chitosan and derivatives thereof, guanidine polymers, glycerinum and compound amino acid. The hydroxyethyl cellulose serves as a gel substrate, the gel which is used for sterilizing and healing the wound surface and contains the guanidine polymers, the chitosan and derivatives thereof and the compound amino acid is prepared through a simple process, and the nutrient gel has good skin compliance, is non-irritant, has sterilization and anti-inflammation functions, provides a certain nutrition support for the wound surface, effectively promotes healing and recovery of the wound surface, has no side effects and is safe and environment-friendly.

A method and device for providing intermittent negative pressure wound healing which includes equipped to (a) apply a negative pressure compressible therapeutic dressing about a wound; (b) compress the therapeutic dressing using negative pressure to subject the wound and the therapeutic dressing to a first predetermined pressure which is low enough to provide therapy to the wound and high enough to maintain a seal between the dressing and the wound; and (c) decompress the therapeutic dressing to a second sub-atmospheric pressure above the first predetermined pressure sufficient to maintain the dressing in a generally sealed contact with the wound while relaxing compression about the wound.

The invention discloses a hydrogel dressing capable of promoting wound healing and a preparation method thereof. The hydrogel dressing consists of: by mass, 25-35% of glycerin, 0.1-0.5% of sodium hyaluronate, 5-10% of a skeletal material, 0.1-0.2% of tartrate, 0.01-0.2% of disodium ethylene diamine tetraacetate, 0.1-0.2% of ethylparaben, 0.1-0.4% of a cross-linking agent, 0.5-1.5% of a filler, 0.01-0.1% of an essential component and 60-65% of deionized water. Due to the interaction between an oil phase and a water phase, a compact net structure is formed and water and the essential component are held in a gel, and after solidification and sterilization, the hydrogel dressing capable of promoting wound healing is prepared. The dressing is applicable to postoperative wound nursing of surgery and gynaecology and obstetrics, and helps to make the surface of the wound keep moist, effectively promote wound healing and inhibit scar hyperplasia.

The invention discloses an enzyme preparation method of sea collagen peptide capable of promoting the wound healing. The method comprises the following steps: (1) removing other proteins and impurities from by-products of orange rock-fish processing, opening the three-strand helical structure of collagen; (2) adding acid to extract the pre-treated collagen from the by-products of orange rock-fish processing, freeze-drying the obtained collagen, and saving the freeze-dried collagen as the substrate to prepare collagen peptide through enzymolysis in the next step; (3) adding water into the freeze-dried collagen to prepare a collagen solution, adding protease into the collagen solution to carry out enzymolysis so as to convert collagen into collagen peptide; (4) deactivating the enzyme, cooling; (5) removing the fishy smelling, decoloring; (6) subjecting the collagen peptide to centrifugation, saving the supernate for later use; (7) carrying out membrane separation to collect the collagen peptides with a molecular weight of 1000 to 3000 Da; (8) condensing the separated collagen peptides through rotation evaporation; (9) freeze-drying the condensed collagen peptide into powder. High bioactivity biological active peptide capable of healing the wounds is prepared from by-products of orange rock-fish processing through an enzyme method assisted by a membrane separation technology.

The invention discloses a recombinant human collagen containing hydroxyproline and hydroxylysine and a production method of the recombinant human collagen. The nucleotide sequence of the recombinant human collagen containing the hydroxyproline and the hydroxylysine is shown as SEQ ID NO.1; and the amino acid sequence of the recombinant human collagen containing the hydroxyproline and the hydroxylysine is shown as SEQ ID NO.5. The recombinant human collagen is obtained by performing co-expression on four different vectors pKLAC1-hlCOL, pKLC-P4HA, pKLC-PDI and pKLC-LH respectively by using Kluyveromyces as a base cell through a series of fermentation and purification manners. The hydroxylation rates of proline and lysine of the recombinant human collagen are similar to those of natural humantype I collagen, and reaches 30.7% and 43.1%, respectively; and compared with unhydroxylated recombinant human collagen, the recombinant human collagen provided by the invention has better functionsof promoting cell adhesion and wound healing.