637 results about "Healed wounds" patented technology

The embodiment of the invention provides an intelligent hospital guide method and system based on BERT and feature fusion. Wherein biochemical information such as humidity and temperature of a postoperative wound is collected through a dressing sensor of the intelligent medical textile, and a wound healing activity index is generated. A wound image is synchronously obtained and processed to enhance edge sharpness and texture, and a detailed wound topological structure is formed. In combination with nursing record text analysis, a semantic map describing inflammation intensity and seepage trend is generated and is associated with biochemical data. A wound healing activity index, a wound topological structure and a semantic map are dynamically associated in a cross-modal mode, and the analysis precision is improved by adjusting specific parameters, such as the association between humidity and a necrotic tissue boundary and the relationship between layering density and a pH value. And generating a wound healing deviation parameter according to a comprehensive analysis result, evaluating a risk level and triggering a corresponding hospital guide decision. According to the technical scheme provided by the embodiment of the invention, the intelligent hospital guide efficiency and accuracy can be improved.

The invention relates to a clinical wound healing monitoring method based on a three-dimensional wound evaluation tool. A 3D image of a wound is constructed through the three-dimensional wound evaluation tool based on a 3D image generation technology; using an image contour recognition algorithm to recognize and mark a wound healing contour in the 3D image, and using the three-dimensional wound evaluation tool to measure and mark contour parameters of the wound healing contour; and sending the marked wound healing contour to an HIS system, and storing the marked wound healing contour in an electronic medical record of the patient by the HIS system. Wound parameters are marked on the constructed wound three-dimensional image, so that medical staff can monitor the wound form of a patient and supervise wound healing, the wound parameters of the patient are recorded through an HIS system, the wound healing condition of the patient is determined, effective wound healing evaluation and monitoring are achieved, and practical measures which can be implemented on the ground are provided for clinic. And wound supervision and nursing management can be conveniently carried out on patients in general surgery department and the like.

The invention relates to the field of postoperative rehabilitation management, in particular to a postoperative rehabilitation management system for hand and foot surgical patients. The postoperative rehabilitation management system for the patient in the hand and foot surgery department comprises a data monitoring module, a rehabilitation plan prediction module and a rehabilitation plan dynamic adjustment module. By comprehensively analyzing the postoperative data of the patient, including the wound healing condition and the function recovery progress, the recovery trend of the patient in the postoperative training period can be predicted, a scientific initial function recovery training plan is generated, and clear guidance is provided for rehabilitation training of the patient; in the actual training process, the system further performs real-time dynamic adjustment on the rehabilitation training plan by comparing the difference between the actual recovery condition and the prediction trend; the method ensures that the rehabilitation training plan is always consistent with the actual recovery state of the patient, so that the rehabilitation effect is maximized, the rehabilitation time is shortened, and the risk of complications is reduced.

The invention discloses a hydrogel wound dressing for promoting healing of infectious wounds. The hydrogel wound dressing is prepared from the following raw materials: oxidized methacrylic acid hyaluronic acid, waterborne polyurethane, polylysine, cannabidiol, neomycin sulfate and 2-roots alcohol. The invention also provides a preparation method of the hydrogel wound dressing and application of the hydrogel wound dressing in preparation of products for repairing infectious wounds. The wound dressing provided by the invention has a microporous structure, good biocompatibility and biodegradability, and can be used for stopping bleeding, reducing wound infection and promoting cell proliferation and wound healing.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention provides a recombinant XVII type collagen with a triple helix structure, and belongs to the technical field of biological proteins. The amino acid sequence of the collagen comprises one or more amino acid residue repetitive units, each repetitive unit comprises a sequence as shown in SEQ ID NO.1 or SEQ ID NO.2, the number of repetitions is n, and n is larger than 1 and smaller than or equal to 60. The recombinant XVII type collagen provided by the invention is simple in production process, relatively high in expression quantity, low in immunogenicity, high in safety, relatively good in stability of the triple-helix structure, and strong in supporting capacity for skin cells; efficacy experiments show that the collagen has higher cell adhesion, wound healing promotion and hair follicle repair promotion capability than XVII type collagen products in the market at present, and can be widely applied to the fields of food, health care products, cosmetics, medical instruments and the like.

The invention provides a catechol functionalized gelatin microsphere and application of the catechol functionalized gelatin microsphere in preparation of a product for inhibiting formation of subcutaneous effusion and promoting tissue repair, and relates to the technical field of biological materials.According to the designed and prepared catechol functionalized gelatin microsphere, catechol groups are introduced into the gelatin microsphere, and the catechol functionalized gelatin microsphere is prepared; good liquid absorption performance and biodegradability are realized. Cell experiment results show that the catechol functionalized gelatin microspheres have super multiple interfaces and can promote cell adhesion and proliferation, and the loose structure of the catechol functionalized gelatin microspheres can promote cell migration. In-vivo rabbit chest wall defect repair experiment results show that the catechol functionalized gelatin microspheres not only can inhibit formation of subcutaneous effusion, but also can collect autologous cells in situ and promote proliferation of the autologous cells and secretion of extracellular matrixes (such as collagen). The results show that the catechol functionalized gelatin microsphere material has clinical application potentials of inhibiting formation of subcutaneous effusion and promoting healing of subcutaneous wounds.

A wound triaging and recommendation system for wound triaging and recommendation for treatments is disclosed. A wound triaging and recommendation system includes a text and voice based conversational artificial intelligence (AI) subsystem determines data associated with at least one of: genetic predisposition, the one or more diseases influencing a wound, and a state of the wound. A wound image analytics subsystem that determines severity and risk category of wound using a machine learning algorithm. An AI based text and image analytics subsystem extracts key clinical parameters and changes in key clinical parameters over time using optical character recognition techniques. A patient treatment recommendation subsystem triages the wound to identify the severity of wound by qualifying risk score for the wound, to provide wound prognostics for wound healing, and to provide treatment recommendations associated with personalized therapeutic routes for wound healing to the patient.

The invention provides a wound nursing intelligent decision-making method and system based on high-precision image recognition. The method comprises the following steps: in response to a received wound monitoring request, extracting a patient identifier, wound image information corresponding to a multi-angle high-precision image, wound background information and multi-modal sensor information from the wound monitoring request; a pre-trained three-dimensional convolutional neural network model is used for automatically recognizing the wound state, and a wound recognition result is obtained; based on the wound image information and the wound background information, assisting in positioning through an augmented reality technology; performing wound healing environment assessment based on the information of the multi-modal sensor; retrieving matched nursing strategy information from a preset nursing scheme database based on patient historical information and personalized treatment preference information corresponding to the patient identifier, the wound identification result, the wound positioning information and the wound healing environment evaluation information; and pushing the nursing strategy information. According to the scheme, the wound nursing quality is improved.

The invention belongs to the technical field of biomedical materials, and particularly relates to a hydrogel wound dressing and a preparation method and application thereof. The hydrogel wound dressing disclosed by the invention can be matched with a sound-sensitive agent by utilizing the temperature-sensitive shrinkage performance of the temperature-sensitive compound monomer, and shows ultrasonic thermal response shrinkage performance, specifically, the hydrogel wound dressing can be rapidly heated and remarkably shrunk under the ultrasonic action to promote wound shrinkage, so that wound healing is accelerated. The obvious potential is embodied in the aspects of promoting the repair of the wound infected by the drug-resistant bacteria and the repair of the wound infected by the drug-resistant bacteria and diabetes mellitus. When the prepared hydrogel wound dressing is used, the contraction degree of the hydrogel wound dressing can be controlled by adjusting the ultrasonic time in the treatment process, and protection and treatment effects on drug-resistant bacteria wounds are achieved in a programmed mode. Meanwhile, the fixing structure of the hydrogel can anchor added drugs such as a sound-sensitive agent and the like, and the action time of the drugs is prolonged.

The invention discloses a wound healing degree evaluation method and system based on multi-data analysis, and relates to the technical field of multi-modal data analysis, and the method comprises the steps: collecting a multi-modal data set related to a wound, constructing a cross-modal extraction model, inputting the multi-modal data set, and obtaining a preliminary feature set; processing the preliminary feature set by using a dynamic time warping technology to obtain a cross-modal feature set; constructing a causal relationship graph based on the cross-modal feature set to identify an intervention path, correcting a causal effect through a backdoor adjustment method, and eliminating false correlation to obtain a causal purification cross-modal feature sequence; inputting the causal purification cross-modal feature sequence into the established wound healing prediction model, and outputting a wound healing prediction result according to time sequence characteristics; and according to a wound healing prediction result, generating a real-time wound visualization report and providing feedback. Through the wound healing prediction model, a breakthrough from a single time point to continuous evaluation is realized.

The present invention provides a dressing capable of promoting healing of a chronic wound. Specifically, provided is a multifunctional wound dressing, comprising: first active components: β-nicotinamide mononucleotide (NMN), nicotinamide adenine dinucleotide (NAD+), or a combination thereof; and a dressing matrix. Experiments of the present invention prove that the multifunctional wound dressing of the present invention has an excellent effect of promoting healing of chronic refractory wounds such as diabetic feet.

The invention provides milk exosome composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The milk exosome composite hydrogel provided by the invention is prepared from milk exosome, hyaluronic acid, epsilon-polylysine, 3-aminophenylboronic acid and tannic acid. The exosome is extracted from milk of a non-stem cell source; the molecular weight of the hyaluronic acid is 200 to 400 KDa. The invention provides a hydrogel carrier capable of loading a large amount of milk exosomes, and the hydrogel carrier can continuously release a large amount of milk exosomes and can give full play to the anti-oxidation and inflammation inhibition effects of the milk exosomes. In the aspect of wound healing, the milk exosome and the hydrogel carrier have a synergistic effect, so that the healing effect can be remarkably improved, and the healing period is shortened.

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The invention, which relates to the technical field of image identification, discloses an intelligent analysis method for a wound image at an applet end, comprising an image acquisition port and an auxiliary end set according to the applet end; according to the invention, the image acquisition port and the auxiliary end are set, the image diffusion models under different networks are constructed, the output image influence analysis value can quantify the influence degree of network factors on image analysis, and in combination with the preset image influence virtual mechanism, the real-time image data are reasonably supplemented and recovered, so that the real-time image analysis efficiency is improved. The method comprises the following steps: preliminarily extracting demand features from two-dimensional image data, constructing a wound three-dimensional dynamic model, performing dynamic matching according to a human body standard image, analyzing and judging the healing condition in a future stage, predicting a wound recovery volume value and actual wound image data, and obtaining the healing degree between wounds. And false analysis and judgment are carried out on the wound healing process, so that false images possibly appearing in the wound healing process can be identified, and the wound identification quality is improved.

The invention discloses a preparation method of recombinant collagen nano-composite hydrogel for repairing wounds infected by multiple drug-resistant bacteria, which comprises the following steps: binding copper porphyrin pi-pi on titanium carbide nanosheets to form MXene coated CuTCPP nanoparticles, and carrying out amidation reaction on 3-aminophenylboronic acid and recombinant collagen to obtain the recombinant collagen nano-composite hydrogel for repairing wounds infected by multiple drug-resistant bacteria. MXene coated CuTCPP is doped into a modified recombinant collagen system and mixed with a polyvinyl alcohol solution, and the recombinant collagen nano-composite hydrogel is prepared. The self-healing property endowed by the dynamic cross-linking characteristic of the phenylboronic acid ester bond in the composite hydrogel disclosed by the invention can be highly adapted to irregular wounds; the nano particles with the heterojunction structure can be combined with photothermal therapy and photodynamic therapy to efficiently sterilize wounds; the hydrogel has the antibacterial property and the property of promoting wound healing, and can comprehensively and efficiently treat wounds infected by multiple drug-resistant bacteria.

The invention provides hydrogel for promoting wound healing and a preparation method thereof, and belongs to the field of hydrogel. The preparation method of the hydrogel for promoting wound healing comprises the following steps: preparing the composite synergist and preparing the dressing. According to the preparation method of the hydrogel for promoting wound healing, the biocompatibility of the hydrogel can be improved while the mechanical strength and long-term antibacterial performance of the hydrogel are improved, the problems that the hydrogel stimulates a wound and peripheral skin and hinders wound healing are avoided, and wound healing is effectively promoted; the stability of antibacterial components in the hydrogel is further improved, and the antibacterial components are prevented from losing and losing efficacy in the long-term storage or application process.

The invention belongs to the technical field of medical materials, and particularly relates to a degradable wound dressing and a preparation method thereof. Compared with the prior art, the degradable wound dressing prepared by the preparation method disclosed by the invention is a completely biodegradable Janus composite film, and a hydrophobic inner layer and a hydrophilic outer layer are obtained by selecting different materials; the material PGA with excellent biological performance is utilized, the problem that electrostatic spinning cannot be carried out through pure PGA is solved, PGA and gelatin are creatively mixed, the advantages of PGA and gelatin are combined, and the PGA / Gel electrostatic spinning film which is high in toughness, high in tensile strength, good in biocompatibility and high in medicine carrying efficiency is obtained; meanwhile, the functions of resisting bacteria, resisting inflammation, discharging seepage and promoting angiogenesis are achieved, and the wound healing rate is effectively guaranteed.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The invention discloses a preparation method and application of multifunctional antibacterial gel, and relates to the technical field of biomedical injectable hydrogel materials with antibacterial activity. The cationic guar gum (CG) is used as a cross-linked network and is loaded with a water-soluble Fe (II)-based metal organic metal cage (Fe-1SO4), and through in-situ chemical dynamic therapy (CDT) and photodynamic therapy (PDT) induced under irradiation of 660 nm laser, rapid healing of surface wounds is promoted through synergistic antibiosis. Fe-1SO4 is a water-soluble metal cage which takes Fe (II) as a metal node and 5, 10, 15, 20-tetra (4-aminophenyl)-21H, 23h-porphyrin (TAPP) as an organic ligand, and can be quickly degraded within 5 days in a biological environment. According to the present invention, with the application of the fenton-like reaction in the preparation of the antibacterial agent, the obvious PDT effect can be provided under the irradiation of 660 nm laser so as to generate a large amount of singlet oxygen (1O2), and the fenton-like reaction can convert H2O2 generated by bacterial infection into toxic hydroxyl radicals (OH) in situ, such that the excellent antibacterial activity can be provided in vivo and in vitro, and the wound healing can be promoted. The invention provides a simple strategy for the design of the rapidly degradable antibacterial hydrogel dressing, and is an important step for the clinical application of biological materials.

The invention discloses a microneedle application packaged by liquid metal, and relates to the technical field of microneedle application, the microneedle application comprises gauze, the microneedle application further comprises a first application and a second application, the first application and the second application are the same in structure and are arranged on the two sides of the gauze, and the first application comprises a pressing part and an attaching part; the microneedles are arranged below the attaching piece in a linear array mode, the interiors of the microneedles are of hollow structures, and the inclination direction of the microneedles located in the first application body is opposite to the inclination direction of the second application body. The microneedles of the two microneedle application bodies are arranged to be inclined, the inclination directions of the microneedles of the two microneedle application bodies are opposite, so that a structure similar to a clamping jaw is formed, the attaching strength of the application body and the skin of a patient is improved, meanwhile, liquid metal is added into the microneedle application bodies and powered on, an electric field is formed at the wound of the patient, and the wound of the patient is wound. Therefore, continuous electrical stimulation is performed on the wound, and wound healing is actively promoted.

The composition is of a network structure and is composed of strontium ions and chlorogenic acid, and the weight ratio of the strontium ions to the chlorogenic acid is 1: (9-11). The composition and hydrogel are mixed to prepare a microneedle patch, and the microneedle patch is prepared into a medical instrument for wound repair. Through verification, the SrC-MPNs is continuously released by the SrC-MPNs (at) MN-PP, so that the substances are dissolved and absorbed into tissue fluid around a wound, and strontium ions and chlorogenic acid in the SrC-MPN can stably and continuously exert the effects of resisting bacteria and oxidation, promoting angiogenesis, promoting wound healing and the like. An in-vivo experiment result shows that the SrC-MPNs (at) MN-PP can promote in-vivo and in-vitro wound healing, promote M2 macrophage polarization, remove excessive ROS and promote angiogenesis and tissue regeneration so as to promote healing of diabetic wounds.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention discloses a wound healing degree evaluation method and system based on multiple models, and relates to the technical field of medical treatment. According to the method, the wound edge, the wound color, the wound type and the outer layer dressing color of the patient are combined, the multiple neural network models are used for comprehensively detecting the wound, intelligent detection of the wound of the patient is achieved, medical staff are assisted in treatment management of the wound of the patient, the burden of the medical staff is relieved, and the infection risk of the wound of the patient is reduced.

The invention discloses a preparation method of a composite spray for improving the hemostatic ability of a wound part, the composite spray comprises a liquid A and a liquid B. The liquid B is a sodium alginate aqueous solution, a preparation method of the solution A comprises the following steps: 1, dissolving a lipopeptide conjugate, cholesterol, distearoyl phosphatidylcholine, distearoyl phosphatidylserine and dimethyl sulfoxide in a chloroform-methanol mixed solution to obtain a mixed system; 2, preparing the mixed system into a precursor solution by utilizing a film hydration method; 3, adding calcium chloride into the precursor solution, and reacting in a dark place to obtain a solution A; a precursor solution is designed according to the function of natural platelets, the function of the precursor solution is equivalent to that of nano platelets, the precursor solution is matched with sodium alginate, adverse effects on a blood coagulation system caused by fibrin degradation, platelet activation capability reduction and the like of a wound part due to blood loss can be relieved in a targeted manner, and the preparation has the advantages of rapid hemostasis, good biological activity, no toxic or side effects and the like. And the wound healing is rapid.

The invention discloses an aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition capable of promoting wound repair and application of the aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition. The composition provided by the invention is obtained by compounding the active ingredients such as the aloe extract, the coptis chinensis extract, the centella asiatica extract, the honeysuckle flower extract and the carboxymethyl chitosan, all the ingredients synergistically play the roles of resisting bacteria, diminishing inflammation, resisting aging, promoting wound repair and moisturizing, and the composition has a remarkable effect. Wherein the aloe extract is prepared by adopting a specific deep eutectic solvent (DES), so that the content of anthraquinone compounds in the aloe extract can be increased, and the effects of bacteriostasis, sterilization, inflammation diminishing, detoxification, moisturizing and wound healing promotion of aloe can be better exerted. Specific extract components and the aloe extract are compounded, so that the effect of the aloe extract can be enhanced, the adopted components are natural, mild, safe and low in irritation, and a basis is provided for preparing more medicine products which are antibacterial, anti-inflammatory, anti-aging, moisturizing and capable of promoting wound repair.

Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix, as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.