507 results about "Healed wounds" patented technology

The embodiment of the invention provides an intelligent hospital guide method and system based on BERT and feature fusion. Wherein biochemical information such as humidity and temperature of a postoperative wound is collected through a dressing sensor of the intelligent medical textile, and a wound healing activity index is generated. A wound image is synchronously obtained and processed to enhance edge sharpness and texture, and a detailed wound topological structure is formed. In combination with nursing record text analysis, a semantic map describing inflammation intensity and seepage trend is generated and is associated with biochemical data. A wound healing activity index, a wound topological structure and a semantic map are dynamically associated in a cross-modal mode, and the analysis precision is improved by adjusting specific parameters, such as the association between humidity and a necrotic tissue boundary and the relationship between layering density and a pH value. And generating a wound healing deviation parameter according to a comprehensive analysis result, evaluating a risk level and triggering a corresponding hospital guide decision. According to the technical scheme provided by the embodiment of the invention, the intelligent hospital guide efficiency and accuracy can be improved.

The invention discloses a hydrogel wound dressing for promoting healing of infectious wounds. The hydrogel wound dressing is prepared from the following raw materials: oxidized methacrylic acid hyaluronic acid, waterborne polyurethane, polylysine, cannabidiol, neomycin sulfate and 2-roots alcohol. The invention also provides a preparation method of the hydrogel wound dressing and application of the hydrogel wound dressing in preparation of products for repairing infectious wounds. The wound dressing provided by the invention has a microporous structure, good biocompatibility and biodegradability, and can be used for stopping bleeding, reducing wound infection and promoting cell proliferation and wound healing.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

A wound triaging and recommendation system for wound triaging and recommendation for treatments is disclosed. A wound triaging and recommendation system includes a text and voice based conversational artificial intelligence (AI) subsystem determines data associated with at least one of: genetic predisposition, the one or more diseases influencing a wound, and a state of the wound. A wound image analytics subsystem that determines severity and risk category of wound using a machine learning algorithm. An AI based text and image analytics subsystem extracts key clinical parameters and changes in key clinical parameters over time using optical character recognition techniques. A patient treatment recommendation subsystem triages the wound to identify the severity of wound by qualifying risk score for the wound, to provide wound prognostics for wound healing, and to provide treatment recommendations associated with personalized therapeutic routes for wound healing to the patient.

The invention discloses a wound healing degree evaluation method and system based on multi-data analysis, and relates to the technical field of multi-modal data analysis, and the method comprises the steps: collecting a multi-modal data set related to a wound, constructing a cross-modal extraction model, inputting the multi-modal data set, and obtaining a preliminary feature set; processing the preliminary feature set by using a dynamic time warping technology to obtain a cross-modal feature set; constructing a causal relationship graph based on the cross-modal feature set to identify an intervention path, correcting a causal effect through a backdoor adjustment method, and eliminating false correlation to obtain a causal purification cross-modal feature sequence; inputting the causal purification cross-modal feature sequence into the established wound healing prediction model, and outputting a wound healing prediction result according to time sequence characteristics; and according to a wound healing prediction result, generating a real-time wound visualization report and providing feedback. Through the wound healing prediction model, a breakthrough from a single time point to continuous evaluation is realized.

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The invention, which relates to the technical field of image identification, discloses an intelligent analysis method for a wound image at an applet end, comprising an image acquisition port and an auxiliary end set according to the applet end; according to the invention, the image acquisition port and the auxiliary end are set, the image diffusion models under different networks are constructed, the output image influence analysis value can quantify the influence degree of network factors on image analysis, and in combination with the preset image influence virtual mechanism, the real-time image data are reasonably supplemented and recovered, so that the real-time image analysis efficiency is improved. The method comprises the following steps: preliminarily extracting demand features from two-dimensional image data, constructing a wound three-dimensional dynamic model, performing dynamic matching according to a human body standard image, analyzing and judging the healing condition in a future stage, predicting a wound recovery volume value and actual wound image data, and obtaining the healing degree between wounds. And false analysis and judgment are carried out on the wound healing process, so that false images possibly appearing in the wound healing process can be identified, and the wound identification quality is improved.

The invention provides hydrogel for promoting wound healing and a preparation method thereof, and belongs to the field of hydrogel. The preparation method of the hydrogel for promoting wound healing comprises the following steps: preparing the composite synergist and preparing the dressing. According to the preparation method of the hydrogel for promoting wound healing, the biocompatibility of the hydrogel can be improved while the mechanical strength and long-term antibacterial performance of the hydrogel are improved, the problems that the hydrogel stimulates a wound and peripheral skin and hinders wound healing are avoided, and wound healing is effectively promoted; the stability of antibacterial components in the hydrogel is further improved, and the antibacterial components are prevented from losing and losing efficacy in the long-term storage or application process.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The composition is of a network structure and is composed of strontium ions and chlorogenic acid, and the weight ratio of the strontium ions to the chlorogenic acid is 1: (9-11). The composition and hydrogel are mixed to prepare a microneedle patch, and the microneedle patch is prepared into a medical instrument for wound repair. Through verification, the SrC-MPNs is continuously released by the SrC-MPNs (at) MN-PP, so that the substances are dissolved and absorbed into tissue fluid around a wound, and strontium ions and chlorogenic acid in the SrC-MPN can stably and continuously exert the effects of resisting bacteria and oxidation, promoting angiogenesis, promoting wound healing and the like. An in-vivo experiment result shows that the SrC-MPNs (at) MN-PP can promote in-vivo and in-vitro wound healing, promote M2 macrophage polarization, remove excessive ROS and promote angiogenesis and tissue regeneration so as to promote healing of diabetic wounds.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention discloses an aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition capable of promoting wound repair and application of the aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition. The composition provided by the invention is obtained by compounding the active ingredients such as the aloe extract, the coptis chinensis extract, the centella asiatica extract, the honeysuckle flower extract and the carboxymethyl chitosan, all the ingredients synergistically play the roles of resisting bacteria, diminishing inflammation, resisting aging, promoting wound repair and moisturizing, and the composition has a remarkable effect. Wherein the aloe extract is prepared by adopting a specific deep eutectic solvent (DES), so that the content of anthraquinone compounds in the aloe extract can be increased, and the effects of bacteriostasis, sterilization, inflammation diminishing, detoxification, moisturizing and wound healing promotion of aloe can be better exerted. Specific extract components and the aloe extract are compounded, so that the effect of the aloe extract can be enhanced, the adopted components are natural, mild, safe and low in irritation, and a basis is provided for preparing more medicine products which are antibacterial, anti-inflammatory, anti-aging, moisturizing and capable of promoting wound repair.

Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix, as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.

The present invention discloses a preparation method of CFS nanozyme. This nanozyme has broad-spectrum bactericidal property, has low toxicity to normal cells, and there is no problem of bacterial drug resistance, and is expected to be used in the field of antibiotic-free sterilization. The CFS-ion-MN wound repair microneedle patch provided by the present invention, as a wound dressing, can transdermally deliver the antibacterial CFS nanozyme to the deep part of the wound, effectively kill bacteria. The CFS nanozyme can also inhibit inflammation in the body through its superoxide dismutase-like activity, promote wound healing, and promote the antibacterial and healing of the wounds of mice infected with Staphylococcus aureus. Among them, Co 2+ and Fe 3+ can inhibit the IL-17 and NF-κB signaling pathways, thereby accelerating wound closure.

The invention discloses an image enhancement intelligent monitoring system for wound healing evaluation. The image enhancement intelligent monitoring system comprises an image acquisition module, an image optimization module, a feature hierarchical enhancement module, a clinical feature adaptive optimization module, a healing key index construction module and a wound healing monitoring module. The invention belongs to the field of image processing, and particularly relates to an image enhancement intelligent monitoring system for wound healing assessment, according to the scheme, a wound area is enhanced by introducing a percolate interference coefficient, a surrounding area is enhanced by introducing a skin tension coefficient, and the key clinical feature identification degree of wound healing is improved; based on dynamic optimization of credibility, setting a flexible critical value, and dynamically adapting to characteristic fluctuation rules of different wounds; the credible features are only subjected to local fine adjustment, and the low-credibility features are subjected to global gradient correction, so that abnormal value interference is avoided; through flexible mean value correction, a single error is smoothed and a dynamic trend is retained so that a wound healing evaluation monitoring effect is improved.

The invention relates to the technical field of skin dilators, and discloses an external skin dilator which comprises a main body assembly, an external skin dilator body and an external skin dilator body. The adjusting assembly is located on the bonding plate and comprises a fixing piece, the fixing piece comprises a first fixing block, a second fixing block and a third fixing block, and the first fixing block is fixed to the bonding plate. The dilator has the advantages that the dilator integrates the preoperative skin dilation function and the postoperative tension reduction function, the preoperative dilation function can continuously generate outward tension on the skin around a pre-operation, the slack area of the skin around the pre-operation is relatively enlarged, meanwhile, the tension reduction function can be achieved after the operation, the tension of the edge of a wound is reduced, and the wound healing effect is improved. The dilator is simple in structure and convenient to use, wound healing is facilitated, tension can be adjusted, the tension borne by skin is always within a safe and reasonable range, the dilator cannot shield an operation site in an operation, and it is guaranteed that a doctor can clearly observe and operate the operation area.

The invention discloses a hydrogel wound dressing and a preparation method thereof, and belongs to the technical field of medical wound dressing preparation. The preparation method comprises the following steps: S1, preparing chitosan-silver nanoparticles CS-Ag; s2, preparing aminated chitosan-silver nano particles (CS-Ag-NH2), and preparing the chitosan-silver nano particles, s3, a hydrogel wound dressing CNF / CS-Ag-NH2 is prepared; the CNF is a carboxylated cellulose nanofiber. According to the prepared CNF / CS-Ag-NH2 hydrogel wound dressing, through the synergistic effect of the carboxylated cellulose nanofibers and the aminated chitosan-silver nanoparticles, the organic combination of the antibacterial property and the healing promoting property is realized; the hydrogel wound dressing not only can effectively control wound infection, but also can promote wound healing, and has a wide application prospect.

Disclosed is a system (100) for monitoring wound healing. The system comprises: an imaging unit (102) for capturing wound images over a predefined period of time; and a software application comprising a user interface (104) and a processing arrangement (106). The processing arrangement is configured to: receive, via the user interface, wound images captured by the imaging unit; analyse the received wound images using an artificial intelligence (AI) algorithm; generate a wound assessment report based on the analysis by the AI algorithm; and transmit, via the user interface, the wound assessment report. Disclosed also is a method for monitoring wound healing.

The present application relates to the technical field of biological medicine, and particularly relates to a stem cell culture method for promoting wound healing and application thereof. The stem cell culture method for promoting wound healing comprises the following steps: step one, providing umbilical cord-derived mesenchymal stem cells; step two, adding luteolin and baicalin as culture medium additives in a serum-supplemented culture medium, wherein the concentration of luteolin is 1-10 micromoles / L, and the concentration of baicalin is 1-10 micromoles / L; step three, inoculating the mesenchymal stem cells into the culture medium containing the additives for culture, and the culture condition is 34-40 DEG C, 4-6% CO2, and the culture time is 48-96 hours; step four, harvesting the cultured mesenchymal stem cells to obtain stem cells for promoting wound healing. The culture method can promote the stem cells to secrete various growth factors, significantly improve the secretion of PGE2 and VEGF-C growth factors, and make the wound healing rate of the stem cell treatment group reach 96%, which has a significant effect on treating diabetic foot ulcers.

The invention discloses a novel absorbable wound dressing and a preparation method thereof. The novel absorbable wound dressing is prepared from collagen, acellular extracellular matrix powder and purified water. The novel absorbable wound dressing with activity is prepared by compounding the acellular extracellular matrix powder and the collagen, the acellular extracellular matrix powder contains various growth factors, various growth factors do not need to be additionally added, and compared with a common collagen sponge dressing, the novel absorbable wound dressing has the better effect of promoting wound healing, and the wound healing effect is better. Meanwhile, collagen is directly adopted as a hemostasis carrier of the acellular extracellular matrix powder and is subjected to freeze-drying forming, seepage of the wound surface can be absorbed, the mechanical strength of the acellular extracellular matrix powder can be enhanced, and therefore the wound can be rapidly and effectively bonded, and the hemostasis effect is achieved. The safety is high; and the manufacturing method is simple.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The present application relates to a pharmaceutical composition for wound treatment. Specifically, the present application concerns a composition including a wound-coating material and chemokine-adsorbing particles to absorb inflammatory chemokines that cause excessive immune responses, thereby allowing active wound healing.

The special ointment for burns and scalds comprises the following substances in parts by weight: 20-30 parts of dragon's blood; 40-60 parts of rheum officinale; 4-6 parts of borneol; 80 to 120 parts of gypsum; and 120 to 180 parts of a greasy matrix. Compared with the prior art, the prepared special ointment for burns and scalds has the advantages of quick effect, quick wound healing, no need of binding, no need of hospitalization treatment for light and moderate burns and scalds which do not endanger life, simple operation, economy and applicability. And moreover, wound infection can be greatly reduced by using the product, and good news can be brought to burn and scald patients.

Disclosed herein are topical compositions for treating wounds. The topically compositions include a Serp-1 polypeptide or a nucleic acid encoding a Serp-1 polypeptide. Also disclosed are methods of treating a wound in subject. The methods include administering a topical formulation that includes a Serp-1 polypeptide or a nucleic acid encoding a Serp-1 polypeptide to the wound.

The invention discloses recombinant human VII type collagen as well as a preparation method and application thereof, and belongs to the technical field of biochemical engineering. The recombinant human VII type collagen comprises a plurality of amino acid residue repetitive units shown as SEQ ID NO.1. Compared with natural VII type collagen, the recombinant human VII type collagen obtained by repeating the repetitive units for multiple times has the advantages that the molecular weight is smaller, the sequence is more easily and efficiently secreted and expressed in a pichia pastoris system after optimization, and the recombinant human VII type collagen can be used for preparing the recombinant human VII type collagen. The method has the characteristics of high yield, low cost, simplicity in operation and easiness in large-scale production. Meanwhile, the anti-oxidation activity is excellent, the skin moisturizing and repairing capacity and the wound healing capacity are promoted, due to the fact that the collagen is derived from human collagen, the risks of allergy and rejection reaction can be remarkably reduced, and the safety is extremely high. Therefore, the recombinant collagen can be used as a core active component to be widely applied to the fields of cosmetics, medicines and the like, and has a good application prospect.

The invention relates to the field of biomedical materials, in particular to an Nb2C MXene composite functional film capable of promoting angiogenesis and a preparation method of the Nb2C MXene composite functional film, the Nb2C MXene composite functional film is particularly suitable for diabetes wound healing, and the Nb2C MXene composite functional film comprises an Nb2C MXene functionalized collagen vitrified film layer, and a carboxymethyl chitosan vitrification film layer, wherein a nano interlocking interface is formed between the Nb2C MXene functionalized collagen vitrified membrane layer and the carboxymethyl chitosan vitrified membrane layer; the Nb2C MXene functionalized collagen vitrified membrane layer is hydrophobic, the carboxymethyl chitosan vitrified membrane layer is hydrophilic, through the double-layer asymmetric structural design, the inner layer is tightly attached to a wound, the outer layer prevents adhesion of bacteria and tissues, and the barrier function in the wound healing process is effectively guaranteed; the adopted Nb2CMXene has excellent ROS (reactive oxygen species) removal capacity, oxidative stress of wound parts can be effectively relieved, cell damage is avoided, and cell functions are recovered.

The invention belongs to the technical field of biomedical materials, and particularly relates to a natural hydrogel dressing for promoting wound healing and a preparation method and application thereof. The natural hydrogel dressing for promoting wound healing is prepared from 10wt% of an oxidized bletilla striata polysaccharide aqueous solution, 10wt%-20wt% of a dopamine grafted epsilon-polylysine aqueous solution and 1wt%-2wt% of a vitamin B1-loaded phenylboronic acid grafted chitosan micelle aqueous solution through a Schiff base dynamic cross-linking reaction. The natural hydrogel dressing for promoting wound healing has the multifunctional characteristics of injectability, self-healing ability, biocompatibility, tissue adhesion, mechanical strength and pH / glucose dual responsiveness. In addition, the compound also has anti-sugar, anti-inflammatory and antibacterial biological activities, and can improve the diabetes wound inflammation microenvironment and promote rapid healing and regeneration of infectious diabetes wounds by inhibiting AGEs formation, regulating macrophage M2 phenotypic polarization and preventing / treating bacterial infection.