400 results about "Healed wounds" patented technology

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The invention, which relates to the technical field of image identification, discloses an intelligent analysis method for a wound image at an applet end, comprising an image acquisition port and an auxiliary end set according to the applet end; according to the invention, the image acquisition port and the auxiliary end are set, the image diffusion models under different networks are constructed, the output image influence analysis value can quantify the influence degree of network factors on image analysis, and in combination with the preset image influence virtual mechanism, the real-time image data are reasonably supplemented and recovered, so that the real-time image analysis efficiency is improved. The method comprises the following steps: preliminarily extracting demand features from two-dimensional image data, constructing a wound three-dimensional dynamic model, performing dynamic matching according to a human body standard image, analyzing and judging the healing condition in a future stage, predicting a wound recovery volume value and actual wound image data, and obtaining the healing degree between wounds. And false analysis and judgment are carried out on the wound healing process, so that false images possibly appearing in the wound healing process can be identified, and the wound identification quality is improved.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The invention discloses an aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition capable of promoting wound repair and application of the aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition. The composition provided by the invention is obtained by compounding the active ingredients such as the aloe extract, the coptis chinensis extract, the centella asiatica extract, the honeysuckle flower extract and the carboxymethyl chitosan, all the ingredients synergistically play the roles of resisting bacteria, diminishing inflammation, resisting aging, promoting wound repair and moisturizing, and the composition has a remarkable effect. Wherein the aloe extract is prepared by adopting a specific deep eutectic solvent (DES), so that the content of anthraquinone compounds in the aloe extract can be increased, and the effects of bacteriostasis, sterilization, inflammation diminishing, detoxification, moisturizing and wound healing promotion of aloe can be better exerted. Specific extract components and the aloe extract are compounded, so that the effect of the aloe extract can be enhanced, the adopted components are natural, mild, safe and low in irritation, and a basis is provided for preparing more medicine products which are antibacterial, anti-inflammatory, anti-aging, moisturizing and capable of promoting wound repair.

Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix, as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.

The invention discloses an image enhancement intelligent monitoring system for wound healing evaluation. The image enhancement intelligent monitoring system comprises an image acquisition module, an image optimization module, a feature hierarchical enhancement module, a clinical feature adaptive optimization module, a healing key index construction module and a wound healing monitoring module. The invention belongs to the field of image processing, and particularly relates to an image enhancement intelligent monitoring system for wound healing assessment, according to the scheme, a wound area is enhanced by introducing a percolate interference coefficient, a surrounding area is enhanced by introducing a skin tension coefficient, and the key clinical feature identification degree of wound healing is improved; based on dynamic optimization of credibility, setting a flexible critical value, and dynamically adapting to characteristic fluctuation rules of different wounds; the credible features are only subjected to local fine adjustment, and the low-credibility features are subjected to global gradient correction, so that abnormal value interference is avoided; through flexible mean value correction, a single error is smoothed and a dynamic trend is retained so that a wound healing evaluation monitoring effect is improved.

Disclosed is a system (100) for monitoring wound healing. The system comprises: an imaging unit (102) for capturing wound images over a predefined period of time; and a software application comprising a user interface (104) and a processing arrangement (106). The processing arrangement is configured to: receive, via the user interface, wound images captured by the imaging unit; analyse the received wound images using an artificial intelligence (AI) algorithm; generate a wound assessment report based on the analysis by the AI algorithm; and transmit, via the user interface, the wound assessment report. Disclosed also is a method for monitoring wound healing.

The present application relates to the technical field of biological medicine, and particularly relates to a stem cell culture method for promoting wound healing and application thereof. The stem cell culture method for promoting wound healing comprises the following steps: step one, providing umbilical cord-derived mesenchymal stem cells; step two, adding luteolin and baicalin as culture medium additives in a serum-supplemented culture medium, wherein the concentration of luteolin is 1-10 micromoles / L, and the concentration of baicalin is 1-10 micromoles / L; step three, inoculating the mesenchymal stem cells into the culture medium containing the additives for culture, and the culture condition is 34-40 DEG C, 4-6% CO2, and the culture time is 48-96 hours; step four, harvesting the cultured mesenchymal stem cells to obtain stem cells for promoting wound healing. The culture method can promote the stem cells to secrete various growth factors, significantly improve the secretion of PGE2 and VEGF-C growth factors, and make the wound healing rate of the stem cell treatment group reach 96%, which has a significant effect on treating diabetic foot ulcers.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The present application relates to a pharmaceutical composition for wound treatment. Specifically, the present application concerns a composition including a wound-coating material and chemokine-adsorbing particles to absorb inflammatory chemokines that cause excessive immune responses, thereby allowing active wound healing.

The invention discloses recombinant human VII type collagen as well as a preparation method and application thereof, and belongs to the technical field of biochemical engineering. The recombinant human VII type collagen comprises a plurality of amino acid residue repetitive units shown as SEQ ID NO.1. Compared with natural VII type collagen, the recombinant human VII type collagen obtained by repeating the repetitive units for multiple times has the advantages that the molecular weight is smaller, the sequence is more easily and efficiently secreted and expressed in a pichia pastoris system after optimization, and the recombinant human VII type collagen can be used for preparing the recombinant human VII type collagen. The method has the characteristics of high yield, low cost, simplicity in operation and easiness in large-scale production. Meanwhile, the anti-oxidation activity is excellent, the skin moisturizing and repairing capacity and the wound healing capacity are promoted, due to the fact that the collagen is derived from human collagen, the risks of allergy and rejection reaction can be remarkably reduced, and the safety is extremely high. Therefore, the recombinant collagen can be used as a core active component to be widely applied to the fields of cosmetics, medicines and the like, and has a good application prospect.

The invention discloses a blood vessel adhesive bandage, a preparation method of the blood vessel adhesive bandage and application of the blood vessel adhesive bandage in promoting healing of a sutured port after a vascular surgical operation. An electrostatic spinning technology and a photo-crosslinking technology are combined to construct a high-porosity superfine methacrylic acid gelatin (GelMA) hydrogel fiber membrane patch; then tannic acid (TA) functional modified fiber surface is endowed with immunoregulation ability, finally, matrix-derived factor-1 alpha (SDF-1 alpha) is grafted to TA to endow the TA with stem cell collection ability, and finally, the SDF-1 alpha (at) TA (at) GelMA system patch is obtained. The patch can utilize SDF-1alpha to collect stem cells and gather the stem cells at a vascular suture to accelerate vascular endothelium regeneration, and TA is used for relieving local injury and performing immunoregulation, so that healing of a sutured wound is accelerated finally.

The invention discloses oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel. The oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel is prepared from oxidized konjac glucomannan, hydrazide hyaluronic acid, neomycin sulfate, cannabidiol and 2-roots alcohol. The invention further provides a preparation method of the oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel and application of the oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel in preparation of hemostatic materials. The composite hydrogel disclosed by the invention has high adhesion and excellent antibacterial property, is suitable for various wounds, and has excellent effects of stopping bleeding, relieving pain, reducing wound infection and promoting wound healing.

The utility model relates to a hip joint assembly type postoperative fixing bandage. The hip joint assembly type postoperative fixing bandage comprises a bandage body, a pressurizing pad assembly, a protection pad, a support, a pressure sensor and a fixing strip arranged on the bandage body. The bandage body comprises a first bandage and a second bandage, and the outer side of the second bandage is made of waterproof materials so as to prevent excrement and urine from being polluted. A snap fastener is arranged on the fixing strip and connected with a snap fastener base on the first bandage in a matched mode. The protection pad is arranged in the protruding structure on the first bandage and used for preventing skin necrosis after pressure bandaging. The support is used for pressurizing and fixing the hip joint, and the pressure sensor is arranged in the interlayer of the first bandage. Compared with the prior art, due to the fact that the fixing strip, the snap fastener base and the snap fastener are connected in a matched mode, the hip joint fixing device can be more suitable for wounds of hip joints and is more flexible. The pressurizing pad can achieve the purposes of diminishing swelling, promoting wound healing and reducing recessive bleeding.

The invention relates to a preparation method of bio-based dual-network intelligent medical hydrogel, and relates to a preparation method of high polymer material medical hydrogel, the hydrogel takes bio-based material microcrystalline cellulose as a raw material, the bio-based material microcrystalline cellulose and a green cross-linking agent citric acid are esterified and cross-linked to form single-network (SN) hydrogel, and the single-network hydrogel and the green cross-linking agent citric acid are further subjected to solution treatment to form dual-network (DN) hydrogel. Anthocyanin is introduced in the process of forming the double-network hydrogel. In the SN forming process, risks possibly caused by toxic residues of a chemical cross-linking agent are effectively avoided; the anthocyanin is used as a natural antioxidant, so that the hydrogel has the functions of eliminating free radicals, resisting cancer, resisting inflammation, inhibiting bacteria and the like; meanwhile, due to the introduction of anthocyanin, the prepared DN hydrogel has excellent mechanical properties and obvious pH response, and can be applied to the field of wound dressings. The wound healing condition can be judged according to the color change caused by pH fluctuation, the unnecessary dressing replacement frequency is reduced, and the treatment efficiency is improved.

The invention relates to burn and scald repair gel and a preparation method thereof.The burn and scald repair gel is composed of amorpha fruticosa extract, acrylic resin, an antioxidant and a penetrant, the amorpha fruticosa extract serving as an effective component has a good treatment effect on skin burns and scalds, and the prepared burn and scald repair gel can promote wound healing and reduce swelling and pain, and can be used for treating skin burns and scalds. The preparation can promote epidermis recovery and reduce scars, and is a green, safe and non-irritant burn and scald repair preparation.

The present invention relates to an RNA hydrogel for tissue regeneration, and more specifically, to an RNA hydrogel for tissue regeneration, which can provide enhanced cell proliferation effect and anti-inflammatory effect, regenerate tissue through wound healing, can be efficiently delivered to cells, does not contain additional chemical components other than nucleic acids, thereby ensuring safety, can deliver a large amount of substances in vivo without toxicity, and can be used for tissue regeneration. The defect that the existing nucleic acid medicine is easy to decompose due to various enzymes in plasma is overcome, and meanwhile, the RNA hydrogel of adenosine is generated in quantity through cell metabolism.

The application belongs to the technical field of biomedical engineering, and particularly relates to a visual hydrogel wound dressing, a preparation method and application thereof. The visual hydrogel wound dressing provided by the application is a hydrogel fiber membrane; the hydrogel fiber membrane comprises PUA fibers and antibacterial agent-containing nanovesicles dispersed in the PUA fibers; the component of the PUA fibers is a PUA polymer; the preparation raw material of the PUA polymer comprises aqueous polyurethane acrylate and alginate; the antibacterial agent-containing nanovesicles comprise nanovesicles and antibacterial agents loaded in the nanovesicles; and the nanovesicles are formed by PVP-PLA-PVP amphiphilic block copolymer. The wound dressing provided by the application can effectively promote wound healing through the synergistic effect of efficient antibiosis, drug sustained release and visual diagnosis.

This invention provides a platelet-inspired gel repair formulation, its preparation method, and its use in promoting wound healing. The formulation comprises the following growth factors: PDGF-BB, EGF, FGF-2, SDF-1α, VEGF, and IGF-1. The platelet-inspired gel repair formulation of this invention exhibits excellent wound healing effects, providing a new option for clinical wound treatment.

The utility model relates to the technical field of healing devices, and discloses an auxiliary wound healing device which comprises a patch part, a negative pressure device is installed on the upper surface of the patch part, and a drainage tube is inserted into the surface of the negative pressure device; the protective surface layer is arranged at the bottom of the patch part, a first sealing strip is mounted at the bottom of the patch part, and a second sealing strip is mounted on the surface of the protective surface layer; the rubber limiting strips are arranged on the two sides of the upper surface of the patch part, and medical gauze is wrapped between the rubber limiting strips. Medical gauze is bound to the surface of the patch part, the patch part can be extruded, so that a second sealing strip can be driven to extrude the surface of the skin, a wound is sealed in an extrusion mode, and the wound can be covered through a protective surface layer to promote wound healing; the sealing stability of the auxiliary healing device can be prevented from being reduced due to excessive body fluid, so that the wound healing effect can be improved.

A negative pressure sealing drainage wound protecting device for a body cavity wound comprises a drainage tube (1) and is characterized in that one end of the drainage tube (1) is inserted into a central blind hole of a porous sponge (3), the drainage tube (1) is arranged in the length direction of the porous sponge (3), and the other end of the drainage tube (1) extends out of the porous sponge (3). A plurality of drainage holes (4) are formed in the side wall, located in the porous sponge (3), of the drainage tube (1), and the distance from the drainage holes (4) in the top of the drainage tube (1) in the porous sponge (3) to the top of the porous sponge (3) is 1 / 3-1 / 2 of the length of the porous sponge (3). In the wound healing stage, tight sealing can still be achieved after multiple times of adjustment, the situation that sealing is not tight is avoided, and the negative pressure sealing drainage effect is good.

The invention provides a negative pressure wound treatment device which comprises a wound dressing, a liquid storage assembly and a driving assembly which are connected in sequence, and the driving assembly is configured to provide negative pressure for the wound dressing and the liquid storage assembly; wherein the liquid storage assembly can comprise at least one first acting piece, the first end of the first acting piece is communicated with the wound dressing, and the second end of the first acting piece is communicated with the driving assembly; and the at least one second acting piece is in fluid communication with the first acting piece, and the second acting piece is configured to store fluid flowing out of the wound dressing. Therefore, through the arrangement, effective conduction of negative pressure can be improved to a certain extent, and the wound healing effect can be improved.

The present invention relates to compositions and methods of promoting wound healing, inhibiting or eradicating infection, and avoiding the pain associated with conventional wound dressing and treatment.

The present application relates to the technical field of wound repair material, in particular to a chronic wound dressing and a preparation method thereof, the wound dressing is prepared from a first contact layer, an intermediate transition layer and a backing layer which are in direct contact with the wound, through the unique three-layer structure design, a chronic wound dressing with fast healing speed, strong anti-inflammatory and antibacterial properties, high liquid absorption and effective regulation of the microenvironment of the wound is prepared, the first contact layer is in direct contact with the wound, absorbs the exudate, plays an anti-inflammatory and antioxidant role, the intermediate transition layer guides the exudate from the first contact layer to the backing layer through the asymmetric fiber membrane structure on both sides and does not back permeate, the backing layer has a connected microporous structure, has strong air permeability and can absorb a large amount of exudate, provides a humid environment for the wound, inhibits bacterial growth and promotes wound healing, compared with the prior art, has a wide application prospect.

Provided according to one aspect of the present disclosure is a composition for wound healing or tissue regeneration that comprises a genomic DNA fragment extracted from human placenta-derived mesenchymal stem cells and a placental growth factor and which exhibits excellent tissue regeneration ability. Provided according to another aspect of the present disclosure is a preparation method which enables the efficient, biocompatible, economical, and environmentally friendly production of a composition for wound healing or tissue regeneration having excellent tissue regeneration ability.

The application discloses an artificial intelligence-based wound pH detection method and a matched enzymatic in-situ forming hydrogel dressing and a preparation method, and belongs to the technical field of biomedical materials.The application identifies and analyzes a hydrogel image with a pH response reagent through a convolutional neural network algorithm, generates an optimal identification model to identify pH, and further evaluates a wound healing state, so that a new strategy is provided for monitoring and instant diagnosis.The matched enzymatic in-situ forming hydrogel dressing can be flexibly attached to various irregular wounds by consuming glucose through glucose oxidase to generate free radicals to initiate in-situ polymerization of the hydrogel.Meanwhile, the added quaternary amine chitosan has antibacterial function, and can better promote wound healing.The application can improve treatment efficiency and save treatment cost, and has the characteristics of safety, high efficiency and multifunction.

The invention discloses a gallic acid-based cationic photodynamic antibacterial agent with sterilizing, anti-infection and wound healing promoting effects and a preparation method thereof, and belongs to the technical field of antibacterial agent synthetic chemistry. The cationic photodynamic antibacterial agent EY-QEGDM-MG is prepared by taking a natural compound gallic acid as a raw material and carrying out ring opening polymerization and quaternization reaction with photosensitizer eosin EY and ethylene glycol diglycidyl ether (EGDE), and the polymer shows an excellent antibacterial effect on escherichia coli and multi-drug-resistant MRSA germs under the action of illumination, and can be used for preparing a cationic photodynamic antibacterial agent EY-QEGDM-MG. The polymer has good blood compatibility and cell compatibility, in addition, the polymer can kill bacteria around infected wounds and can rapidly promote wound healing, and therefore the polymer can provide a new method for photodynamic antibacterial agents for treating the infected wounds in hospitals.