619 results about "Healed wounds" patented technology

Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.

Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.

The invention discloses a medical dressing with a cooling function and a wound healing promoting function, which at least comprises a perforated non-woven fabric layer, a nanometer fiber layer with a gradient structure, a hydrogel layer and a supporting layer. The preparation method of the medical dressing includes steps of covering hydrogel onto the supporting layer; covering the nanometer fiberlayer with the gradient structure on the hydrogel; and finally reinforcing the perforated non-woven fabric layer on the surface of the nanometer fiber layer so as to obtain the medical dressing. The nanometer fiber layer has the gradient structure, and facilitates absorption and retention of liquid of wound, and medicine can reach the surface of the wound after being released, so that wound healing is promoted; the perforated non-woven fabric layer has a physical isolating effect, avoids outside bacteria, can absorb effusion of the wound, can be easily removed from the surface of the wound and is not adhered with the wound; and the hydrogel layer can realize temperature regulation and reduces the temperature of the wound. The medical dressing comprehensively utilizes a medicine loading performance of nanometer fibers and capillary mobility of liquid, and promotes wound healing while cooling.

The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.

The invention relates to an active wound repair material, specifically to a functional dressing and a preparation method and application thereof, belonging to the field of medical materials. To overcome a technical problem, the invention provides the functional dressing, which belongs to biologically active wound repair materials. The functional dressing is prepared from the following raw materials by weight: 2 to 6 parts of biologically active glass, 12 to 20 parts of alginate, 4 to 12 parts of chitosan and 100 to 200 parts of water. Multiple dosage forms can be prepared from the above-mentioned raw materials, mainly comprising a gel, a dressing, etc. The functional dressing provided by the invention has the advantages of bacteriostatic action on a wound, promotion of wound healing and growth, adsorption of a small amount of tissue exudates, good biosecurity, waterproof performance, a bacterium blocking effect, etc. The functional dressing has a wide application scope, is applicable to mechanical trauma and operative incision (wound) and exerts a good therapeutic effect on hard-healing wounds like burns and scalds, diabetic foot, ulcer and pressure sores and a good curative effect on an infectious wound and a delayed union wound.

The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.

Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.

The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell, re-epithelization, proliferation of fibroblasts or angiogenesis.

The invention discloses nutrient gel for sterilizing and healing a wound surface and belongs to the technical field of anti-bacteria gel. The nutrient gel for sterilizing and healing the wound surface is prepared from hydroxyethyl cellulose, chitosan and derivatives thereof, guanidine polymers, glycerinum and compound amino acid. The hydroxyethyl cellulose serves as a gel substrate, the gel which is used for sterilizing and healing the wound surface and contains the guanidine polymers, the chitosan and derivatives thereof and the compound amino acid is prepared through a simple process, and the nutrient gel has good skin compliance, is non-irritant, has sterilization and anti-inflammation functions, provides a certain nutrition support for the wound surface, effectively promotes healing and recovery of the wound surface, has no side effects and is safe and environment-friendly.

The invention discloses a hydrogel dressing capable of promoting wound healing and a preparation method thereof. The hydrogel dressing consists of: by mass, 25-35% of glycerin, 0.1-0.5% of sodium hyaluronate, 5-10% of a skeletal material, 0.1-0.2% of tartrate, 0.01-0.2% of disodium ethylene diamine tetraacetate, 0.1-0.2% of ethylparaben, 0.1-0.4% of a cross-linking agent, 0.5-1.5% of a filler, 0.01-0.1% of an essential component and 60-65% of deionized water. Due to the interaction between an oil phase and a water phase, a compact net structure is formed and water and the essential component are held in a gel, and after solidification and sterilization, the hydrogel dressing capable of promoting wound healing is prepared. The dressing is applicable to postoperative wound nursing of surgery and gynaecology and obstetrics, and helps to make the surface of the wound keep moist, effectively promote wound healing and inhibit scar hyperplasia.

The invention discloses an enzyme preparation method of sea collagen peptide capable of promoting the wound healing. The method comprises the following steps: (1) removing other proteins and impurities from by-products of orange rock-fish processing, opening the three-strand helical structure of collagen; (2) adding acid to extract the pre-treated collagen from the by-products of orange rock-fish processing, freeze-drying the obtained collagen, and saving the freeze-dried collagen as the substrate to prepare collagen peptide through enzymolysis in the next step; (3) adding water into the freeze-dried collagen to prepare a collagen solution, adding protease into the collagen solution to carry out enzymolysis so as to convert collagen into collagen peptide; (4) deactivating the enzyme, cooling; (5) removing the fishy smelling, decoloring; (6) subjecting the collagen peptide to centrifugation, saving the supernate for later use; (7) carrying out membrane separation to collect the collagen peptides with a molecular weight of 1000 to 3000 Da; (8) condensing the separated collagen peptides through rotation evaporation; (9) freeze-drying the condensed collagen peptide into powder. High bioactivity biological active peptide capable of healing the wounds is prepared from by-products of orange rock-fish processing through an enzyme method assisted by a membrane separation technology.

The invention discloses a medical chitosan haemostatic wound dressing and a preparation method thereof. The medical chitosan haemostatic wound dressing comprises the following raw materials in parts by weight: 25-40 parts of chitosan, 10-25 parts of succinyl-chitosan, 5-15 parts of sodium hyaluronate, 1-5 parts of an antibacterial agent, 2-8 parts of anti-inflammatory analgesic, 5-20 parts of starch and 2-10 parts of a plasticizer. The wound dressing provided by the invention is applied in the aspects of medical bleeding promoting, antisepsis and anti-inflammation, wound healing promoting and the like.

The invention relates the medical biomaterial technology field. The existing clinical hemostasis dressing is only used for stopping blood, while the new biological dressing is only used for cleaning and healing superficial wounds and lacks a specific direction for treating posttraumatic wound, in particular, sea battle injury. The aim of the invention is to provide a method for preparing a hemostasis dressing with good volume expansibility, permeability, as well as obvious direction to deal with high-permeability seawater. The method for preparing the hemostasis dressing uses sodium alginate mixed by chitosan and various Na<+>/Ca<2+> as the basic material to form a hemostasis sponge with good mechanical strength after being cooled and dried, and prepares asymmetric seawater hemostasis dressing with porous layer and compact layer by using polyvinyl alcohol as the surface coating material. The dressing shows high expansibility and good permeability according to the results of volume expansibility, permeability and sem observation, has rich porous layer and compact water-resistant layer in microstructure, and is applied for stooping blood and healing wounds in high-permeability seawater environment.

The invention relates to a hydrogel dressing, comprising a non-woven fabric layer and a hydrogel layer arranged thereon. The hydrogel is poured on the non-woven fabric and cross-linked by an electron accelerator with an irradiation dose of 15-90 kGy; The hydrogel of the adhesive layer contains water-soluble polymers and monomers and water-soluble chitosan derivatives, the mass percentage of water-soluble polymers and monomers is 15-30%, and the mass percentage of water-soluble chitosan derivatives The percentage content is 0.5-3%; the water-soluble polymer and monomer are one or more of polyvinyl alcohol, hydroxyethyl methacrylate, sodium polyacrylate and gelatin, and the water-soluble chitosan derivative is the shell Polysaccharide hydrochloride. The hydrogel dressing has excellent water absorption performance and good air permeability, and has the functions of antibacterial, anti-inflammatory and promoting wound healing, and is suitable for wound protection and treatment of burns, scalds and traumatic wounds.

Provided herein is a topical wound dressing that comprises a collagen and a flexible paste. Also provided is a wound dressing with a first layer of a sterilized mixture of collagen and a second adhesive layer effective to adhere to surrounding skin and to keep the first layer in contact with the wound. In addition there is provided a wound dressing foil that comprises collagen and a plastic compound that can provide a foil shape. Furthermore, methods of dressing wounds utilizing the wound dressings and wound dressing foil are provided herein.

The invention relates to antibacterial compound hydrogel. The hdyrogel comprises the following components in percentage by mass: 2 percent to 3.5 percent of carboxymethyl chitosan, 4 percent to 6 percent of oxidized sodium alginate, and 0.3 percent to 0.6 percent of tannic acid, wherein a solution of the hydrogel is a PBS buffering solution. According to the antibacterial compound hydrogel disclosed by the invention, by utilizing a dynamic Schiff base bond way, under a physiological condition, based on carboxymethyl chitosan and oxidized sodium alginate, the carboxymethyl chitosan, the oxidized sodium alginate and the tannic acid are mixed to prepare CMC/OSA/TA hydrogel. The hydrogel disclosed by the invention has the advantages of being high in degradation capability, high in biocompatibility, high in antibacterial performance and high in mechanical performance, and can effectively promote a wound healing process.

The present invention relates to a matrix material comprising a pharmaceutical composition such as a matrix material with a pharmaceutical composition printed on the surface. In one embodiment the pharmaceutical composition comprises thrombin. The invention further describes a method for making the matrix material with a pharmaceutical composition printed on the surface. In one specific embodiment the invention also relates to the use of said matrix material for promotion of hemostasis and/or wound healing. The invention also relates to a kit-of-parts comprising a matrix with a pharmaceutical composition and a container with a peelable lid.

The invention provides chitosan petrolatum gauze. The chitosan petrolatum gauze is prepared according to the following steps: dissolving a chitosan mixture in a weak acid solution to prepare a chitosan mixed solution; subsequently soaking medical gauze in the chitosan mixed solution to prepare chitosan gauze; soaking the chitosan gauze in a melt petrolatum and paraffin oil mixed solution to prepare the chitosan petrolatum gauze of which the concentration is 1% to 5%. The chitosan petrolatum gauze is a novel medical dressing which is prepared in combination with the advantages of the chitosan and the traditional petrolatum gauze, anti-bacterial, capable of retaining moisture, stopping bleeding and prompting healing of wounds, and low in price. The chitosan petrolatum gauze provided by the invention has the effect of enhancing the original moisture retention properties and also has anti-bacterial properties and unique properties of stopping bleeding, relieving pain, prompting the healing of wounds, reducing formation of scars and the like. The chitosan petrolatum gauze is free of irritation to the human body, free of obvious toxicity, rich in raw materials and low in preparation cost and can be widely applied to wound surface treatment.

The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.