263 results about "Healed wounds" patented technology

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The invention discloses an aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition capable of promoting wound repair and application of the aloe extract-containing antibacterial, anti-inflammatory, anti-aging and moisturizing composition. The composition provided by the invention is obtained by compounding the active ingredients such as the aloe extract, the coptis chinensis extract, the centella asiatica extract, the honeysuckle flower extract and the carboxymethyl chitosan, all the ingredients synergistically play the roles of resisting bacteria, diminishing inflammation, resisting aging, promoting wound repair and moisturizing, and the composition has a remarkable effect. Wherein the aloe extract is prepared by adopting a specific deep eutectic solvent (DES), so that the content of anthraquinone compounds in the aloe extract can be increased, and the effects of bacteriostasis, sterilization, inflammation diminishing, detoxification, moisturizing and wound healing promotion of aloe can be better exerted. Specific extract components and the aloe extract are compounded, so that the effect of the aloe extract can be enhanced, the adopted components are natural, mild, safe and low in irritation, and a basis is provided for preparing more medicine products which are antibacterial, anti-inflammatory, anti-aging, moisturizing and capable of promoting wound repair.

The invention discloses an image enhancement intelligent monitoring system for wound healing evaluation. The image enhancement intelligent monitoring system comprises an image acquisition module, an image optimization module, a feature hierarchical enhancement module, a clinical feature adaptive optimization module, a healing key index construction module and a wound healing monitoring module. The invention belongs to the field of image processing, and particularly relates to an image enhancement intelligent monitoring system for wound healing assessment, according to the scheme, a wound area is enhanced by introducing a percolate interference coefficient, a surrounding area is enhanced by introducing a skin tension coefficient, and the key clinical feature identification degree of wound healing is improved; based on dynamic optimization of credibility, setting a flexible critical value, and dynamically adapting to characteristic fluctuation rules of different wounds; the credible features are only subjected to local fine adjustment, and the low-credibility features are subjected to global gradient correction, so that abnormal value interference is avoided; through flexible mean value correction, a single error is smoothed and a dynamic trend is retained so that a wound healing evaluation monitoring effect is improved.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The present application relates to a pharmaceutical composition for wound treatment. Specifically, the present application concerns a composition including a wound-coating material and chemokine-adsorbing particles to absorb inflammatory chemokines that cause excessive immune responses, thereby allowing active wound healing.

The invention discloses recombinant human VII type collagen as well as a preparation method and application thereof, and belongs to the technical field of biochemical engineering. The recombinant human VII type collagen comprises a plurality of amino acid residue repetitive units shown as SEQ ID NO.1. Compared with natural VII type collagen, the recombinant human VII type collagen obtained by repeating the repetitive units for multiple times has the advantages that the molecular weight is smaller, the sequence is more easily and efficiently secreted and expressed in a pichia pastoris system after optimization, and the recombinant human VII type collagen can be used for preparing the recombinant human VII type collagen. The method has the characteristics of high yield, low cost, simplicity in operation and easiness in large-scale production. Meanwhile, the anti-oxidation activity is excellent, the skin moisturizing and repairing capacity and the wound healing capacity are promoted, due to the fact that the collagen is derived from human collagen, the risks of allergy and rejection reaction can be remarkably reduced, and the safety is extremely high. Therefore, the recombinant collagen can be used as a core active component to be widely applied to the fields of cosmetics, medicines and the like, and has a good application prospect.

The utility model relates to a hip joint assembly type postoperative fixing bandage. The hip joint assembly type postoperative fixing bandage comprises a bandage body, a pressurizing pad assembly, a protection pad, a support, a pressure sensor and a fixing strip arranged on the bandage body. The bandage body comprises a first bandage and a second bandage, and the outer side of the second bandage is made of waterproof materials so as to prevent excrement and urine from being polluted. A snap fastener is arranged on the fixing strip and connected with a snap fastener base on the first bandage in a matched mode. The protection pad is arranged in the protruding structure on the first bandage and used for preventing skin necrosis after pressure bandaging. The support is used for pressurizing and fixing the hip joint, and the pressure sensor is arranged in the interlayer of the first bandage. Compared with the prior art, due to the fact that the fixing strip, the snap fastener base and the snap fastener are connected in a matched mode, the hip joint fixing device can be more suitable for wounds of hip joints and is more flexible. The pressurizing pad can achieve the purposes of diminishing swelling, promoting wound healing and reducing recessive bleeding.

The invention relates to a preparation method of bio-based dual-network intelligent medical hydrogel, and relates to a preparation method of high polymer material medical hydrogel, the hydrogel takes bio-based material microcrystalline cellulose as a raw material, the bio-based material microcrystalline cellulose and a green cross-linking agent citric acid are esterified and cross-linked to form single-network (SN) hydrogel, and the single-network hydrogel and the green cross-linking agent citric acid are further subjected to solution treatment to form dual-network (DN) hydrogel. Anthocyanin is introduced in the process of forming the double-network hydrogel. In the SN forming process, risks possibly caused by toxic residues of a chemical cross-linking agent are effectively avoided; the anthocyanin is used as a natural antioxidant, so that the hydrogel has the functions of eliminating free radicals, resisting cancer, resisting inflammation, inhibiting bacteria and the like; meanwhile, due to the introduction of anthocyanin, the prepared DN hydrogel has excellent mechanical properties and obvious pH response, and can be applied to the field of wound dressings. The wound healing condition can be judged according to the color change caused by pH fluctuation, the unnecessary dressing replacement frequency is reduced, and the treatment efficiency is improved.

The invention relates to burn and scald repair gel and a preparation method thereof.The burn and scald repair gel is composed of amorpha fruticosa extract, acrylic resin, an antioxidant and a penetrant, the amorpha fruticosa extract serving as an effective component has a good treatment effect on skin burns and scalds, and the prepared burn and scald repair gel can promote wound healing and reduce swelling and pain, and can be used for treating skin burns and scalds. The preparation can promote epidermis recovery and reduce scars, and is a green, safe and non-irritant burn and scald repair preparation.

The present invention relates to an RNA hydrogel for tissue regeneration, and more specifically, to an RNA hydrogel for tissue regeneration, which can provide enhanced cell proliferation effect and anti-inflammatory effect, regenerate tissue through wound healing, can be efficiently delivered to cells, does not contain additional chemical components other than nucleic acids, thereby ensuring safety, can deliver a large amount of substances in vivo without toxicity, and can be used for tissue regeneration. The defect that the existing nucleic acid medicine is easy to decompose due to various enzymes in plasma is overcome, and meanwhile, the RNA hydrogel of adenosine is generated in quantity through cell metabolism.

The application belongs to the technical field of biomedical engineering, and particularly relates to a visual hydrogel wound dressing, a preparation method and application thereof. The visual hydrogel wound dressing provided by the application is a hydrogel fiber membrane; the hydrogel fiber membrane comprises PUA fibers and antibacterial agent-containing nanovesicles dispersed in the PUA fibers; the component of the PUA fibers is a PUA polymer; the preparation raw material of the PUA polymer comprises aqueous polyurethane acrylate and alginate; the antibacterial agent-containing nanovesicles comprise nanovesicles and antibacterial agents loaded in the nanovesicles; and the nanovesicles are formed by PVP-PLA-PVP amphiphilic block copolymer. The wound dressing provided by the application can effectively promote wound healing through the synergistic effect of efficient antibiosis, drug sustained release and visual diagnosis.

The utility model relates to the technical field of healing devices, and discloses an auxiliary wound healing device which comprises a patch part, a negative pressure device is installed on the upper surface of the patch part, and a drainage tube is inserted into the surface of the negative pressure device; the protective surface layer is arranged at the bottom of the patch part, a first sealing strip is mounted at the bottom of the patch part, and a second sealing strip is mounted on the surface of the protective surface layer; the rubber limiting strips are arranged on the two sides of the upper surface of the patch part, and medical gauze is wrapped between the rubber limiting strips. Medical gauze is bound to the surface of the patch part, the patch part can be extruded, so that a second sealing strip can be driven to extrude the surface of the skin, a wound is sealed in an extrusion mode, and the wound can be covered through a protective surface layer to promote wound healing; the sealing stability of the auxiliary healing device can be prevented from being reduced due to excessive body fluid, so that the wound healing effect can be improved.

The invention provides a negative pressure wound treatment device which comprises a wound dressing, a liquid storage assembly and a driving assembly which are connected in sequence, and the driving assembly is configured to provide negative pressure for the wound dressing and the liquid storage assembly; wherein the liquid storage assembly can comprise at least one first acting piece, the first end of the first acting piece is communicated with the wound dressing, and the second end of the first acting piece is communicated with the driving assembly; and the at least one second acting piece is in fluid communication with the first acting piece, and the second acting piece is configured to store fluid flowing out of the wound dressing. Therefore, through the arrangement, effective conduction of negative pressure can be improved to a certain extent, and the wound healing effect can be improved.

The present application relates to the technical field of wound repair material, in particular to a chronic wound dressing and a preparation method thereof, the wound dressing is prepared from a first contact layer, an intermediate transition layer and a backing layer which are in direct contact with the wound, through the unique three-layer structure design, a chronic wound dressing with fast healing speed, strong anti-inflammatory and antibacterial properties, high liquid absorption and effective regulation of the microenvironment of the wound is prepared, the first contact layer is in direct contact with the wound, absorbs the exudate, plays an anti-inflammatory and antioxidant role, the intermediate transition layer guides the exudate from the first contact layer to the backing layer through the asymmetric fiber membrane structure on both sides and does not back permeate, the backing layer has a connected microporous structure, has strong air permeability and can absorb a large amount of exudate, provides a humid environment for the wound, inhibits bacterial growth and promotes wound healing, compared with the prior art, has a wide application prospect.

Provided according to one aspect of the present disclosure is a composition for wound healing or tissue regeneration that comprises a genomic DNA fragment extracted from human placenta-derived mesenchymal stem cells and a placental growth factor and which exhibits excellent tissue regeneration ability. Provided according to another aspect of the present disclosure is a preparation method which enables the efficient, biocompatible, economical, and environmentally friendly production of a composition for wound healing or tissue regeneration having excellent tissue regeneration ability.

The application discloses an artificial intelligence-based wound pH detection method and a matched enzymatic in-situ forming hydrogel dressing and a preparation method, and belongs to the technical field of biomedical materials.The application identifies and analyzes a hydrogel image with a pH response reagent through a convolutional neural network algorithm, generates an optimal identification model to identify pH, and further evaluates a wound healing state, so that a new strategy is provided for monitoring and instant diagnosis.The matched enzymatic in-situ forming hydrogel dressing can be flexibly attached to various irregular wounds by consuming glucose through glucose oxidase to generate free radicals to initiate in-situ polymerization of the hydrogel.Meanwhile, the added quaternary amine chitosan has antibacterial function, and can better promote wound healing.The application can improve treatment efficiency and save treatment cost, and has the characteristics of safety, high efficiency and multifunction.

Disclosed is an engineered exosome, comprising (a) an EGF polypeptide, fused to a first anchoring polypeptide, (b) a NGF polypeptide, fused to a second anchoring polypeptide, and (c) a PDGF-BB polypeptide, fused to a third anchoring polypeptide, wherein (a), (b) and (c) are anchored on a membrane of the exosome via the first, second and third anchoring polypeptide, respectively, and wherein the EGF polypeptide, the NGF polypeptide and the PDGF-BB polypeptide are exposed on an outer surface of the membrane of the exosome. Also disclosed are compositions, nucleic acid constructs, and uses of the exosome for wound healing.

This application relates to the fields of biomedicine and wound repair technology, and particularly to the application of platelet exosomes in the treatment of diabetic wound healing. This application discloses the use of platelet exosomes in the preparation of products having one or more of the following functions: 1) prevention and / or treatment of diabetic foot; 2) promotion of wound healing and / or tissue repair; 3) shortening wound healing time; 4) promoting granulation tissue growth; 5) enhancing wound angiogenesis; 6) alleviating inflammatory responses; 7) inhibiting the expression of pro-inflammatory factors; 8) promoting the expression of anti-inflammatory factors; 9) reducing MMP-9 expression; and 10) increasing MMP-2 expression. It is particularly suitable for the treatment of diabetic foot ulcers, delayed wound healing, and related complications, and also covers the use of this product in the preparation of diabetic foot treatment drugs and medical dressings.

This invention provides a dressing containing Ligusticum striatum microspheres and its preparation method, to solve the problem of safe and precise application of Ligusticum striatum extract or Ligustrazine in difficult-to-heal wounds; the dressing containing Ligusticum striatum microspheres and its preparation method, wherein the dressing is composed of Ligusticum striatum microspheres loaded with pHEMA hydrogel as the main body, wherein the Ligusticum striatum microspheres are formed by coating Ligusticum striatum extract or Ligustrazine with PLGA, and the pHEMA hydrogel partially encapsulates the Ligusticum striatum microspheres.

This invention belongs to the field of pharmaceutical technology, specifically relating to the application of a composition in the preparation of a drug for treating diabetic wounds. The composition comprises the following components: *Artemisia capillaris* exosomes, epi-suberol, and 3-hydroxymorinogenone, with a mass ratio of 1:0.1-0.25:0.02-0.05. In this composition, *Artemisia capillaris* exosomes can penetrate the thickened inflammatory exudate layer and glycosylated extracellular matrix of diabetic wounds, reshaping the wound's immune repair microenvironment, promoting fibroblast activation and proliferation, regulating collagen synthesis and deposition, and reducing scar hyperplasia. 3-hydroxymorinogenone can increase vascular endothelial growth factor, promote angiogenesis, and thus promote the repair and healing of diabetic wounds. The synergistic effect of *Artemisia capillaris* exosomes, epi-suberol, and 3-hydroxymorinogenone in this composition significantly shortens the healing cycle of difficult-to-heal diabetic wounds and improves the quality of wound healing.

The invention belongs to the technical field of fruit and vegetable healing agents, and particularly relates to a healing agent for rhizome fruits and vegetables and a preparation method of the healing agent. According to the healing agent, the tannic acid modified sodium alginate is used as a core film-forming base material and is matched with the natural plant source composition, the plant source active composition and the low-molecular chitosan oligosaccharide to achieve the synergistic antibacterial and anti-inflammatory effects, the differentially compounded compound amino acid provides targeted nutrition, the wound healing time can be remarkably shortened through the synergistic effect of the multiple components, the rotting rate is reduced, and the wound healing effect is improved. The composition is high in safety, capable of remarkably promoting wound healing and effectively inhibiting pathogenic bacteria infection, suitable for various rhizome type fruits and vegetables, simple in preparation process, low in energy consumption and easy for industrial production. Compared with the prior art that a rhizome fruit and vegetable healing agent has the defects of poor safety, low healing efficiency, narrow applicability, complex preparation process and the like, the prepared healing agent is suitable for various rhizome fruits and vegetables, a formed protective film is high in stability and good in air permeability and can be attached for a long time to play a role, and the storage period is effectively prolonged.

The invention belongs to the technical field of medical materials, and particularly discloses a primary battery effect hydrogen production anti-oxidation hydrogel microneedle patch and preparation and application thereof.The method comprises the following steps that a polyvinyl alcohol solution, a hydroformylated bacterial cellulose solution, a quaternized chitosan solution and a silver nanowire dispersion liquid are prepared; preparing a needle tip solution; preparing a lower substrate solution; preparing an upper-layer substrate solution; preparing a microneedle patch primary product; and carrying out salting-out treatment on the primary product of the microneedle patch by using a sulfate solution to obtain the hydrogen-producing antioxidant hydrogel microneedle patch based on the primary battery effect. According to the primary battery effect hydrogen production anti-oxidation hydrogel microneedle patch and preparation and application, the patch can spontaneously generate therapeutic micro-current and hydrogen in a wound microenvironment, photo-thermal antibiosis and drug activity are cooperated, and then multi-mechanism synergistic treatment of chronic refractory wounds such as diabetes and the like is achieved.

The invention discloses hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological materials, N-[tris (hydroxymethyl) methyl] acrylamide (THMA) and recombinant collagen (CF-1552) are taken as frameworks, a hydrogel dressing is formed through crosslinking of a hydrogen bond and a Schiff base bond, mesoporous nanoparticles and MXene are doped in the hydrogel dressing, and the hydrogel dressing has the advantages that the hydrogel dressing can be used for preparing the hydrogel dressing; the mesoporous nano particles are loaded with ginsenoside Rg3. According to the hydrogel as well as the preparation method and the application thereof, the obtained hydrogel can be tightly attached to burn infected wounds, efficiently absorb tissue exudate and realize drug sustained release, has excellent biological effects of resisting bacteria, resisting inflammation, resisting oxidation, inhibiting scars and the like, and can remarkably promote healing of the burn infected wounds.

The present application belongs to the technical field of wound dressing, and particularly relates to a multifunctional hydrogel precursor patch and a preparation method thereof. The patch is a fibrous hydrogel precursor obtained by chemical bonding of an organic polymer and a ferrocene derivative. The hydrogel precursor patch of the present application is triggered by exudate to form a 3D hydrogel in situ gelation, which is a wound healing strategy. No drug is needed, and no pre-crosslinking process of a solution-state matrix under acid-base, oxidation or light irradiation conditions is involved. In use, the solid patch is placed on the wound bed, and in a wet liquid environment, the sandwich structure ferrocene in the novel ferrocene-organic copolymer material promotes the rearrangement of the polymer chain through the "double-arm conjugation" effect, so that the irregular coil structure is mainly formed, the fluidity of the molecular chain is increased, and the hydrogel capacity is enhanced. In the gelation structure transformation process, the exudate is effectively absorbed in one direction, and the wound surface is kept clean.

This invention belongs to the field of biomedical materials technology, specifically disclosing a core-shell microneedle, a core-shell microneedle patch, its preparation method, and its application. Through structural design and carrier material optimization, this invention provides a core-shell microneedle with a programmed sequential release of tannic acid in the outer shell and verteporfen in the core layer, successfully matching the dynamic physiological rhythm of wound healing and ensuring effective wound repair. In vitro and in vivo biological evaluations have confirmed that the core-shell microneedle patch prepared using the core-shell microneedles of this invention possesses excellent antibacterial, antioxidant, and immune microenvironment-regulating abilities. It can effectively induce macrophage polarization towards the M2 type, specifically inhibit YAP protein expression, and significantly accelerate the closure process of infected wounds. From both upstream immune regulation and downstream fibrosis inhibition levels, it dually blocks the pathological scar formation pathway, ultimately achieving high-quality, scar-free regenerative repair of infected wounds.

The utility model provides a scalpel which comprises a scalpel body, the scalpel body is used for penetrating into eye soft tissue, and the scalpel is characterized in that the scalpel body comprises a first thickness part and a second thickness part, and the thickness of the first thickness part is different from that of the second thickness part. By the adoption of the structure, at least two thicknesses are formed, so that the strength of the scalpel body can be improved through the thick part, fracture or deformation during an operation is avoided, the size of a surgical incision is reduced through the thin part, small puncture resistance is kept in the puncture process of the surgical scalpel, and a cut wound with high self-closing performance is formed; wound healing is facilitated, and postoperative complications of patients are reduced. Therefore, by the adoption of the structure of the implementation mode, the risks of fracture and deformation of the scalpel can be reduced, and postoperative complications of a patient can be reduced.

The invention belongs to the technical field of medical instruments, and particularly relates to a thoracic surgery postoperative rehabilitation nursing device which comprises a binding plate made of rubber, the left side and the right side of the binding plate are connected with the same binding band, and the lower side wall of the binding plate is connected with a plurality of compression boxes through connecting assemblies. The side wall of the compression box located on the rightmost side is connected with a controller, a first gauze pad and a second gauze pad are arranged below the compression box, the first gauze pad is located below the second gauze pad, and the compression box makes contact with the second gauze pad through a pressure assembly. When the nursing device is used for stopping bleeding in the later period of wound healing of the patient in the thoracic surgery department, targeted local compression hemostasis can be conducted on the wound according to the healing condition of the wound of the patient, and while compression hemostasis is conducted on the bleeding point of the wound, the problem that due to the fact that the wound healing position is continuously and excessively pressed, secondary damage of new tissue is caused is solved.