43 results about "Topical Gel" patented technology

The invention discloses a fructus psoraleae total flavone extract as well as a preparation method and application thereof in promoting hair growth. According to the preparation method of the fructus psoraleae total flavone extract, the specific eutectic solvent is adopted, the ultrasonic technology is combined for extraction, the content of total flavone in the fructus psoraleae extract can be remarkably increased, and the fructus psoraleae total flavone can be efficiently extracted; and the adopted extraction solvent has the advantages of greenness, environmental protection, efficient process, low cost, high safety and the like, and can solve the problems of the existing extraction process. The malaytea scurfpea fruit total flavone extract obtained by the method has the effect of promoting hair growth and can remarkably promote hair follicle cell proliferation and prolong the hair growth period, the prepared external gel product has the hair growth effect, the preparation method is simple, and external use is convenient. The malaytea scurfpea fruit total flavone extract provided by the invention can be used for developing more cosmetics and medical products for preventing alopecia and promoting hair growth, and a new scheme is provided for green extraction of natural active ingredients and treatment of alopecia.

The invention belongs to the technical field of pharmaceutical preparations, and relates to an external gel emplastrum containing local anesthetics as well as a preparation method and application of the external gel emplastrum. The gel emplastrum comprises a backing layer, an emplastrum body layer and an anti-sticking film from bottom to top, wherein the pasty fluid layer adopts organic water-retaining resin as a framework structure, and contains local anesthetics accounting for 1-20% of the weight of the pasty fluid layer. The external gel emplastrum containing the local anesthetic can have a higher transdermal release rate, and can improve the stability of a supply chain of the added part of neutralized polyacrylic acid.

The invention belongs to the technical field of medical materials, and discloses an external gel material for treating oral mucositis and a preparation method of the external gel material. The gel is temperature-sensitive slow-release antibacterial gel, adopts safe components, has a temperature-sensitive characteristic, is in a sol state in a low-temperature state, is convenient to smear, can be converted into a gel state when the temperature is close to the body temperature of a human body, can be tightly attached to an oral mucosa, is good in adhesiveness to the oral mucosa, can also slowly release drugs, and has relatively strong antibacterial performance; the repair and regeneration of oral mucosa epithelial tissues can be promoted. The gel can effectively act on the treatment process of oral diseases, is also suitable for daily oral care, and provides guarantee for oral health.

The invention discloses a traditional Chinese medicine composition for treating acute gout, an external gel and a preparation method thereof, and the traditional Chinese medicine composition comprises the following raw material components in parts by mass: 5-20 parts of radix clematidis, 5-20 parts of polygonum cuspidatum, 5-20 parts of honeysuckle stem, 5-15 parts of radix aconiti preparata, 5-15 parts of pine nodular branch, 1-5 parts of corydalis tuber and 1-3 parts of asarum. The gel disclosed by the invention is an external gel prepared by researching through a traditional Chinese medicine composition intermediate extraction process and a preparation forming process, has the effective effects of directly reaching an affected part, taking effect quickly, being good in patient compliance and the like, and can realize industrial production through pilot scale-up experiment verification. Animal experiment research results show that the radix clematidis pain-relieving gel has remarkable anti-inflammatory and pain-relieving effects.

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine composition for reducing uric acid and application thereof, and the traditional Chinese medicine composition comprises the following components in parts by mass: 15-20 parts of ash bark, 20-25 parts of clerodendranthus spicatus, 18-22 parts of astragalus membranaceus, 12-15 parts of prepared polygonum multiflorum, 15-18 parts of rhizoma smilacis glabrae, 8-10 parts of ligusticum wallichii, 10-12 parts of roasted rhizoma atractylodis macrocephalae and 10-15 parts of salt-fried semen plantaginis. The preparation method comprises the three steps of segmented extraction, sustained-release pellet forming and preparation forming. The traditional Chinese medicine composition disclosed by the invention has the high-efficiency performance of reducing uric acid, protecting healthy qi and achieving long-term effect, and can regulate and control a uric acid metabolic pathway in a multi-target manner; the product can be widely applied to the fields of products for treating primary hyperuricemia and gout in a sustained-release period, products for improving hyperuricemia metabolic syndrome, health-care tea for hyperuricemia and high-risk people, gel products for relieving red, swollen and heat pain of joints in an acute attack period of gout and the like, and the preparation process is controllable and easy to industrialize.

The invention relates to the technical field of medicine, and discloses an artemisinin external gel composition as well as a preparation method and application thereof, the gel composition comprises 0.1-5 parts of artemisinin, 1-20 parts of a solubilizer, 0.5-15 parts of a gel matrix, 5-30 parts of a penetration enhancer, 0.01-1 part of a stabilizer, 0.01-2 parts of a pH regulator, 0.05-1.5 parts of a preservative, 1-15 parts of a humectant and purified water. According to the technical scheme, a peroxide bridge structure of artemisinin is used for removing active oxygen, the multiple effects of resisting inflammation, resisting oxidation, resisting bacteria, promoting repair and resisting scars are achieved by regulating and controlling channels such as NF-kappa B and TGF-beta, and meanwhile, a gel matrix maintains a moist environment of a wound surface and promotes transdermal absorption of drugs. Experiments prove that the composition can reduce MDA content of wound surfaces, increase SOD activity, inhibit IL-6, TNF-alpha and other inflammatory factors, reduce collagen deposition and inhibit bacterial growth, can effectively improve the pathological process of scalds and burns, and provides a novel multi-mechanism synergistic external composition for clinical treatment.

The application provides a kind of drug composition, preparation and its preparation method and application for assisting treatment chronic soft tissue injury disease, the drug composition of the application is developed into Lifa paste by using Lijia such as descending true incense, centipede, etc., its preparation method is to process each raw material respectively, the composition can be made into external use gel ointment, the drug composition is stirred under pulsed electric field and is added to the matrix solvent containing olive oil, propylene glycol and various components.Treatment of chronic soft tissue injury, evaluation of clinical efficacy, evaluation of safety and side effects. Formulate Lifa paste standard preparation process. The technical problems to be solved include formula optimization, preparation process standardization, efficacy evaluation method, aiming at inheriting and developing Lizu medicine culture, improving the application value of Liju in modern medicine. To explore the mechanism of Lifa paste in treating chronic soft tissue injury and provide clinical data support for the next step, promote the development of Liju.

This invention discloses a composition and its preparation method for treating human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), belonging to the field of traditional Chinese medicine technology. The formula consists of 6-15 parts of American cockroach, 5-11 parts of hawthorn, 5-11 parts of chicory, 3-9 parts of *Scutellaria baicalensis*, 8-20 parts of *Sophora flavescens*, and 6-15 parts of *Cnidium monnieri*, and also contains 0.01-1 parts by weight of toad venom. The dosage form is one or more of the following: external gel, rinse, foam, suppository, and film preparation. It has high safety and is suitable for HPV infection and CIN changes, solving the problem of poor efficacy in existing treatments.

The invention belongs to the technical field of gel preparations, and particularly relates to an external gel preparation based on a pepper fragrance formula as well as a preparation method and application of the external gel preparation. The external gel preparation based on the pepper fragrance formula is prepared from rhizoma atractylodis, white pepper, fructus evodiae, clove, cinnamon, radix paeoniae alba and pericarpium arecae according to the weight ratio of (4-7): (2-4): (0.4-0.6): (2-4): (0.8-1.2): (0.5-1.5): (2-4). The externally-used gel preparation can be used for treating diarrhea, the effect is stable, the externally-used characteristic is suitable for treating infantile diarrhea, and the technical problems that traditional Chinese medicine volatile oil components are poor in water solubility and insufficient in stability are solved.

The invention provides a traditional Chinese medicine compound preparation for treating primary menstrual dysmenorrhea of women and a use method thereof. The traditional Chinese medicine compound preparation comprises a traditional Chinese medicine composition A and an external gel B adopting an extract of the traditional Chinese medicine composition A as an active ingredient, the traditional Chinese medicine composition A is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-30 parts of vinegar-processed rhizoma corydalis, 10-15 parts of angelica sinensis, 12-18 parts of salted eucommia ulmoides, 9-12 parts of roses, 6-9 parts of wine-processed radix paeoniae alba and 3-6 parts of ginger charcoal; the traditional Chinese medicine composition has the advantages of taking qi stagnation, blood stasis and kidney-yang deficiency composite pathogenesis synergistic treatment into consideration, avoiding the potential safety hazard of toxic medicinal materials, and realizing the dual effects of quickly relieving pain and periodically conditioning.

In screening cooling agents for their actions in the oral cavity, the molecule FEMA 4557, registered for use in chewing gum and hard candy, produced a long-lasting, stinging, and painful cold, like ice chips on the throat. To further study its properties, FEMA 4557 was formulated as a topical gel and shown to relieve skin discomfort without causing any skin injury or irritation. FEMA 4557 relieved inflammation from flea bites and a bumble bee sting and relieved the inflammation of dermatological disorders such as skin allergy, urticaria, and thermal injury. The duration of the anti-inflammatory action was for several hours after a single application. The pharmacological potency of FEMA 4557 did not correlate to the EC50 potency at the TRPM8 receptor. Surprisingly, when FEMA 4557 was delivered to the inflamed nasal mucosa with a compressor-nebulizer, it relieved nasal stuffiness and inhibited phlegm secretion in subjects with rhinitis, as measured by patient-outcome responses and an objective gravimetric method, respectively. FEMA 4557 was also effective for treating rhinitis when administered in nose drops or in a rinse. The effective therapeutic amount of FEMA 4557 was about 1 to 5 mg per retained dose. The conclusion is that FEMA 4557 is a potent non-irritating suppressor of acute inflammation in the nasal cavity and sinuses, a property not previously described for other topical cooling agents. Thus, FEMA 4557 and related analogs may have therapeutic utility for treating nasal inflammation and mucus hypersecretion.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The present invention pertains to a formulation designed for the treatment of acne, possessing potent antibacterial activity The invention additionally outlines a method for preparing this formulation tailored for acne treatment. The formulation, presented as a topical gel, incorporates a synergistic blend of doxycycline and riboflavin, along with key components such as carbopol, emollient, penetration enhancer, parabens, distilled water, and triethanolamine. Utilizing a 32 factorial design approach, the formulation is statistically optimized to achieve optimal characteristics. Notably, the formulation demonstrates a harmonious interaction between doxycycline and riboflavin, resulting in enhanced antibacterial efficacy. Furthermore, the formulation exhibits proven nonirritant properties and maintains stability during storage.

The present invention relates to a gel or cream formulation for topical use, the formulation comprising beta-D-mannuronic acid or alpha-L-guluronic acid or a mixture of beta-D-mannuronic acid and alpha-L-guluronic acid, their oligomers or their pharmaceutically acceptable salts, where, based on 100 g of the gel or cream formulation, the content of the beta-D-mannuronic acid or alpha-L-guluronic acid or the mixture of beta-D-mannuronic acid and alpha-L-guluronic acid or alpha-L-guluronic acid or alpha-L-guluronic acid or alpha-L-guluronic acid or alpha- the total amount of beta-D-mannuronic acid or alpha-L-guluronic acid or a mixture of beta-D-mannuronic acid and alpha-L-guluronic acid, their oligomers or their pharmaceutically acceptable salts is from 0.5 g to 40 g, said formulation further comprising caffeic acid. Furthermore, the present invention relates to a gel or cream formulation for topical use in a method of treating inflammation and / or any inflammatory response and / or pain, as well as a method of preparing the gel or cream formulation.

This invention discloses a combined system formulation for mobile phone health protection and its preparation method, belonging to the field of daily health care. The formulation consists of an oral compound herbal solid beverage and an external acupoint gel. The solid beverage uses medicinal and edible ingredients such as blueberries, achieving a combination of food and medicine, and employs a self-regulating structure of "natural blending," resulting in mild medicinal properties, optimized taste, and suitability for long-term consumption. The external gel is formulated specifically for five core syndrome types, based on an innovative "pathogenesis-acupoint-acupoint combination method," integrating three acupoint combination methods—Yu-Mu, distant and near, and upper and lower—to target corresponding acupoints. The two work synergistically to achieve rapid relief of local symptoms and long-term regulation of organ function, comprehensively preventing and treating complex discomforts such as eye fatigue and neck and shoulder pain caused by mobile phone use, combining immediate relief, long-term maintenance, and proactive prevention—a "prevention before disease" effect. The preparation process of this invention is stable, effectively retains active ingredients, and is suitable for industrial production.

The invention relates to application of bornyl acetate and an external gel preparation thereof in preparation of a medicine for relieving or treating chronic pruritus. Compared with the prior art, the bornyl acetate separated from volatile components of the folium artemisiae argyi supercritical extract has remarkable effects of inhibiting mast cell degranulation and inhibiting expression of pruritus-related factors at a cellular level and an animal level, and can be used for remarkably relieving mouse skin injury caused by DNCB; the polypeptide has the advantages of good safety, high selection index and the like, can be used for developing drugs for relieving and / or treating chronic itching and expanding treatment schemes of chronic itching, and has wide application prospects and important clinical significance.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an external gel preparation and a preparation method thereof. The invention provides an external gel preparation containing substitutable carbomer as a gel matrix and a preparation method of the external gel preparation, specifically, a concentrated dispersion of an acrylamide / sodium dimethyl taurate acrylate copolymer in isohexadecane, such as Sepino P 600, is used for replacing carbomer, so that the problems that in an existing brimonidine gel preparation, due to the fact that carbomer is inconvenient to swell, the gel matrix can not be used as a gel matrix, and the gel matrix can not be used as a gel matrix are solved. The swelling time is long; the production efficiency is low; and the cost is increased. The product obtained by the preparation method is good in performance, and the preparation process is simple and quick to operate and suitable for industrial large-scale production.

The invention focuses on the fields of biotechnology and sanitary disinfection, and relates to a small molecule peptide combination, namely small molecule peptides A, B, C, D and E, for resisting HPV (human papillomavirus) extracted from agilawood. The high-purity small molecule peptide is obtained through the steps of supercritical carbon dioxide extraction, enzymolysis, ultrafiltration, ion exchange chromatography, gel filtration chromatography and the like. The compound can play a role in inducing apoptosis of infected cells by interfering virus adsorption, inhibiting gene expression and inducing apoptosis of the infected cells, and has a remarkable inhibiting effect on various HPV subtypes. The small molecule peptide has the advantages of high safety, strong specificity and difficult drug resistance, and can be prepared into vaginal suppositories, external gels, injections and the like for treating HPV infection related diseases.

Provided is a preparation that solves the problems of sagging, long-term stability, and texture in an externally applied gel containing a non-steroidal anti-inflammatory agent. 【Solution means】The following components (a) to (g): (a) Non-steroidal anti-inflammatory agent: 1% by mass or more (b) Isopropanol: 7.5 to 12.5% by mass (c) Pyrrolidone compound: 0.5 to 1% by mass (d) Gelator: 0.1 to 2% by mass (e) Nonionic surfactant: 0.1 to 2% by mass (f) Oil component: 1 to 10% by mass (g) Water containing, Component (e) is a combination of one or more nonionic surfactants selected from nonionic surfactants having an HLB of 10 or more and 20 or less and one or more nonionic surfactants selected from nonionic surfactants having an HLB of more than 2 and less than 10, and the total HLB value represented as the sum of the products of the HLB values and weight ratios of the constituent nonionic surfactants is 9.7 to 9.9. An externally applied gel composition that is a nonionic surfactant.

To provide a gel composition for external use which forms a gel having excellent salt resistance, acid resistance and alkali resistance and forms a film having no stickiness and excellent rubbing resistance even under high humidity, and to provide a cosmetic containing the same.SOLUTION: The gel composition for external use contains a copolymer (A) containing a constitutional unit represented by formula (a), a constitutional unit represented by formula (b) and a constitutional unit represented by formula (c), and a copolymer (B) containing a constitutional unit represented by formula (a) and a constitutional unit represented by formula (c) or a constitutional unit represented by formula (d). (a) - (CH2-C (R1) - C (= O) - OCH2CH2O - P (= O) (O -) - O (CH2) 2-N + (CH3) 3) - (b) - (CH2-C (R2) - C (= O) - O-X) - (c) - (CH2-C (R3) - C (= O) - O-X) - (d) - (- C () - C (= O) - - CH (OH) - - N + () 3) - CH3 R4 CH2 CH2 OCH2 R5 SELECTED DRAWING: None

The invention relates to traditional Chinese medicine external gel for preventing or treating HPV (human papillomavirus) infection as well as a preparation method and application of the traditional Chinese medicine external gel. The traditional Chinese medicine external gel comprises an active composition and a gel matrix, the active composition comprises a traditional Chinese medicine extract and menthol, and the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 9-15 parts of radix sophorae flavescentis, 9-15 parts of cortex phellodendri, 12-20 parts of rhizoma smilacis glabrae, 9-12 parts of honeysuckle, 9-12 parts of fructus forsythiae, 6-12 parts of safflower, 12-20 parts of fructus cnidii, 6-12 parts of rhizoma bletillae, 6-12 parts of radix aucklandiae and 12-20 parts of cockscomb; 5 to 10 parts by weight of menthol; the weight part of the gel matrix is 260 to 800 parts. The traditional Chinese medicine external gel provided by the invention can effectively inhibit HPV virus replication, treat cervical precancerous lesions caused by HPV infection and prevent cancers caused by HPV infection, and the traditional Chinese medicine external gel is convenient to use, stable in action effect and high in safety, and has important clinical significance.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The present invention relates to a topical formulation comprising cidofovir. Particularly, the invention relates to topical lipid based gel formulation comprising cidofovir.

The invention discloses gel for external use, which is prepared from 2-{3-[3-amino-4-(7H-pyrrolo [2, 3-d] pyrimidine-4-yl)-1H-pyrazol-1-yl-1-(isopropylsulfonyl) azetidin-3-yl} acetonitrile or a crystal form of the 2-{3-[3-amino-4-(7H-pyrrolo [2, 3-d] pyrimidine-4-yl)-1H-pyrazol-1-yl-1-(isopropylsulfonyl) azetidin-3-yl} acetonitrile, a gel matrix and other medicinal auxiliary materials.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating acne and an external gel thereof. The traditional Chinese medicine composition is prepared from rheum officinale, cortex phellodendri and radix angelicae according to a specific ratio, specifically, 4 parts of rheum officinale, 1 part of cortex phellodendri and 1 part of radix angelicae (F1) are used for staphylococcus aureus, and 3 parts of rheum officinale, 12 parts of cortex phellodendri and 8 parts of radix angelicae (F2) are used for propionibacterium acnes; the external gel is prepared by taking carbomer 940 as a matrix, adding glycerol, propylene glycol, triethanolamine, Tween-80, potassium sorbate and the like as auxiliary materials and adding the traditional Chinese medicine extract. The composition can be used for treating acne and improving skin inflammation and hyperpigmentation, the gel is convenient to use and stable in property, skin irritation can be reduced, medication safety and patient compliance can be improved, and meanwhile the anti-inflammatory and antibacterial effects are enhanced.

The invention discloses an external gel for treating prostatitis and a preparation method thereof. The external gel is prepared from white pepper, asarum, poria cocos, borneol and menthol. And the auxiliary materials comprise 0.5% of potassium sorbate, carbomer 940, Tween 80 and propylene glycol. The traditional Chinese medicine composition has the effects of eliminating dampness and relieving pain, inducing diuresis to reduce edema and killing parasites to relieve itching, and is used for treating pelvic region pain or discomfort caused by prostatitis with symptoms such as frequent micturition, urgent urination, micturition pain, incomplete urination, white urethral orifice drop and scrotum pruritus. The gel disclosed by the invention is good in plasticity and can be fully filled in deep tissues; volatilization is not easy, and action time is long; the texture is fine and uniform, no greasy feeling exists, the irritation is small, and coating is easy; water solubility is good, and cleaning is easy. The safety is high and the side effect is small.

The present application relates to the technical field of medical dressings, in particular to an external use gel for preventing oral mucositis caused by chemotherapy, and a preparation method, which adopts a combination of catechol group modified polymers and an acidic anti-crosslinking system, and through the dual inhibition of catechol group oxidation by acidic pH and antioxidants in a brown bottle, the gel is stored as a flowable liquid for a long time, after being sprayed to the oral cavity, the catechol group is triggered to rapidly oxidize and crosslink, forming a solid gel film, which physically protects the oral ulcer site, and cooperates with a heat conduction functional system to greatly improve the heat conduction performance of the gel, enabling the cold quantity of cryotherapy to be uniformly transmitted to the superficial tissue of the oral mucosa, without the need for the tongue to push the ice block to move, thereby reducing the pain of the patient, and solving the problem of uneven cooling of existing cryotherapy.

The invention provides sulfated mulberry silkworm chrysalis cordyceps polysaccharide. In the sulfated mulberry silkworm chrysalis cordyceps polysaccharide, the total sugar content is 50.52 + / -2.62%, the uronic acid content is 1.77 + / -0.10%, the sulfate group content is 13.45 + / -0.36%, and the substitution degree is 1.193. The sulfated mulberry and silkworm chrysalis cordyceps polysaccharide provided by the invention has a remarkable bacteriostatic effect, and the minimum inhibitory concentration (MIC) of the sulfated mulberry and silkworm chrysalis cordyceps polysaccharide to escherichia coli (ATCC 25922) and bacillus subtilis (ATCC 6633) is 2.0 mg / mL; and when the concentration is 2.0 mg / mL, the inhibition rate on alpha-glucosidase reaches 92.5 + / -2.08%, which is higher than that of acarbose with the same concentration. The compound can be used for preparing related products such as spray, external gel and oral liquid.

The invention discloses a composition for improving erectile dysfunction. The composition is an external preparation mainly prepared from ethanol, carbomer, polyol and water, the external preparation does not contain glycols and active pharmaceutical ingredients. On the basis of the Eroxon external gel, the novel gel is formed by improving the prescription composition, the erectile dysfunction improving effect of the novel gel is remarkably improved, and the novel gel has a better erectile response effect, is suitable for ED patients of different degrees, especially moderate and severe ED patients, and has an excellent application prospect.