154 results about "Topical Gel" patented technology

The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. The present invention also provides a novel topical gel for the transdermal delivery of steroids using the fatty alcohol esters as permeation enhancers.

The invention relates to an alginate-based hydrogel dressing and a preparation method thereof, and belongs to the technical field of medical supplies. Raw materials of the invention are a compound of sodium alginate or other alginates and a thickener, a moisturizer and other functional matters, are subjected to swelling dosing, pre-crosslinking, film coating, spray crosslinking, constant-temperature crosslinking plasticizing and film-covering shear forming, and are then prepared into a three-dimensional water-containing grid structure through covalent cross-linking and ion cross-linking. The medical hydrogel dressing is a topical gel dressing, has good moisturizing performance, toughness and adhesion, is mainly suitable for superficial skin damage, such as cut wound, lacerated wound, scratch, burns, suture wounds and the like, protects skin wound healing of a patient, has effects of easing pain, inhibiting bacteria, resisting inflammation, keeping the wound moist, promoting wound healing, and improving the wound repairing quality, is more suitable for treating bedsore wounds, ulcer wounds and other sites hard to be bound after a surgery, can also be used for non-wound sites, and plays a role of moisturizing.

The invention discloses an externally used gel preparation containing human umbilical cord mesenchymal stem cell extract as well as a preparation method and an application of the externally used gel preparation. The externally used gel preparation contains the human umbilical cord mesenchymal stem cell extract and a gel solution, wherein the human umbilical cord mesenchymal stem cell extract is the extract obtained after starvation culture; the gel solution contains sodium alginate, a compound electrolyte injection, a humectant and a penetration enhancer, and a stable and homogeneous gelatinous substance is formed. The externally used gel preparation can be used for preparing drugs for treating skin ulcer, burns, scalds, eczema, trauma and other diseases.

A composition comprising: a benefit agent; at least one polymer including a polycaprolactone polymer; at least one lower alcohol; and at least one co-solvent; and a method for enhancing topical delivery of a benefit agent is disclosed.

Compositions containing a protease inhibitor and methods of use and production are described. The compositions contain an effective amount of a protease inhibitor in a carrier or diluent and are used for the treatment of inflammatory or hyperproliferic mucocutaneous disorders. The carrier or diluent is preferably a gelling agent, and the composition is a topical gel formulation containing alpha 1-antitrypsin in an aqueous liquid or viscous gel formulation.

A composition comprising: a benefit agent; at least one polymer including a poly(monostearoyl glycerol-co-succinate) polymer; at least one lower alcohol; and at least one co-solvent; and a method for enhancing topical delivery of a benefit agent are disclosed.

The invention discloses non-yellowing polyurethane resin for mirror synthetic leather and a preparation method of polyurethane resin. The non-yellowing polyurethane resin is prepared from following raw materials: polyol, a chain extender, diisocyanate, a solvent and an antioxidant, wherein polyol is a mixture of polytetramethylene ether glycol having a number average molecular weight of 2000, polytetramethylene ether glycol having a number average molecular weight of 3000, polydiol adipate having a number average molecular weight of 1000-3000; the chain extender is a mixture of C2-C6 aliphatic diol, piperazine and alicyclic diprimary amine; diisocyanate is aliphatic diisocyanate; the solvent comprises a solvent A, a solvent B and a solvent C, the solvent A is at least one selected from dimethylformamide and dimethylacetamide, the solvent B is at least one selected from toluene, butanone and ethyl acetate and the solvent C is at least one selected from isopropanol or isobutanol. By virtue of the non-yellowing polyurethane resin, the risk of generation of insoluble particulates and topical gel in the system is reduced and meanwhile, the non-yellowing polyurethane resin for synthetic leather has the characteristics of excellent low-temperature folding resistance and good anti-sticking performance.

The invention relates to a triptolide nano lipsome gelling agent of external use and its preparation method, which comprises externally used gelling agent composed of 10-70% of triptolide alcohol nano liposome turbid liquor and 90-30% of blank gel, wherein the weight ratio content of the triptolide alcohol in the total gelling agent is 0.1-2.0%, and the triptolide alcohol alcohol nano liposome turbid liquor comprises 0.7-4.2% of triptolide alcohol, 14-64% of phosphatides, 3.5-16% of cholesterin, 0.7-3.2% of anti-oxidant, 0.7-3.2% of surface active agent, and hydration medium. Its preparing process is also disclosed in the invention.

A topical gel composition comprising between about 0.005 and 1.0% ivermectin, between about 30 and 40% of a pharmaceutically acceptable alcohol, between about 30 and 40% of a pharmaceutically acceptable glycol, and a pharmaceutically acceptable carrier, useful for treating Pediculosis capitis infestation in a human patient.

Urea compositions useful for treatment of dermatological conditions. The compositions, which are free from perceptible solids, may include at least about 50 wt-% urea, zinc pyrithione, and lactic acid, and may be formulated as a topical gel.

An object of the present invention is to provide a topical gel composition having high adaptability to human skins irrespective of the mode of use and having high strength. The present invention provides a topical gel composition formed of water soluble polymer having self-shape retainability, 30 to 95% by weight of water content, and 65 to 99% of a compressive deformation rate expressed by the maximum deformation rate till a partial fracture of the gel structure when the gel composition is compressed at a predetermined speed by using a plunger capable of pressing the gel composition at a constant speed.

The present invention provides a topical gel cream composition containing oil soluble UV filters.

The invention discloses a nux vomica total alkali micro-emulsion, a preparation method thereof, a preparation containing the nux vomica total alkali micro-emulsion and a preparation method of the preparation, and belongs to the field of medicinal preparations. The nux vomica total alkali micro-emulsion is prepared from nux vomica total alkali, oil phase, emulsifying agent, co-emulsifier and water phase. The nux vomica total alkali is preferably prepared to be external gel. The nux vomica total alkali transdermal drug delivery external preparation has special advantage to the medicine; a novel micro-emulsion medicine-delivery system is applied, so that the transdermal absorption of the medicine is increased, the clinical effect is enhanced, the toxic and side effect when the medicine is take orally and injected is avoided. The external preparation can be used for preparation of anti-inflammatory and analgesic medicine.

The Gatifloxacin gel preparation for external use and eye use has Gatifloxacin as main component and its supplementary material includes chitosan as gel substrate, iso-osmotic regulator, pH regulator, preservative, injection water, etc. The preparation has Gatifloxacin content of 0.1-3 wt% and chitosan content of 0.3-3 wt%. It has obvious anti-infection function and functions of speeding heal of wound, promoting epidermal growth, inhibiting formation of scar tissue, maintaining local medicine density for long term, etc. It is used in treating burns, scalds, skin infection, folliculitis, bacterial conjunctivitis, keratitis, etc.

The invention discloses an external gelata for treating cervical erosion, which consists of natural medicaments of nano silver antibacterial colloid (or other antibacterial agent), phellodendron amurense, catechu, and the like, and hydrogel matrix and transdermal absorbent. The invention provides a formulation composition of the medicament and a preparation process. The external gelata is applied through skin or mucous membrane, is used for treating female cervical erosion, cervicitis and various vaginitis, has remarkable curative effect, and has the popularization meaning for industrial production.

The invention discloses an endometrial stem cell exocrine concentrated solution gel preparation for treating endometrial injury, a preparation method and a drug administration method of the preparation. A method of starving endometrial stem cells is adopted to obtain a human endometrial stem cell exocrine extract in a short time, and the extract is concentrated through an ultracentrifugation method to obtain a human endometrial stem cell exosome with high concentration, wherein the gel for the human endometrial stem cell exosome contains sodium alginate and a compound electrolyte injection solution as stabilizers, a humectant and a transdermal absorption promoter to form stable and uniform gel-like substances which are beneficial to absorption. The preparation can be used for treating endometrial injury.

The invention relates to a topical gel composition for use in the treatment of actinic keratosis comprising (a) an active agent for treatment of actinic keratosis, (b) a keratolytically active agent, (c) a gel former, and (d) an organic solvent.

A topical pharmaceutical formulation made up of nimesulide or a pharmaceutically acceptable derivative of nimesulide, together with thiocolchicoside or a pharmaceutically acceptable derivative of thiocolchicoside. The present invention more particularly relates to pharmaceutical combinations of nimesulide and thiocolchicoside, in the form of topical gels, ointments, cream, sprays, or lotions with anti-inflammatory, analgesic, and myorelaxant activities.

The present invention is directed to an enhanced wound healing composition, including a gel containing vancomycin, useful for the prevention of the spread of resistant-type bacteria. Preferably, the drug is one or more antibiotic agents in therapeutically effective concentrations to reduce or eliminate MRSA. The composition is based on a gel composition containing one or more gel forming compounds, such as one or more polymers, preservatives, and/or pH stabilizers and buffers, which not only maintains a moist wound environment to enhance wound healing, but also provides an antibiotic agent which has sustained potency and stability. The composition, when placed in contact with a treatment site, delivers the drug to the site. By incorporating the drug into the gel composition that is formulated to enhance wound healing, the treatment of such disease is possible in a manner which promotes wound healing while reducing or eliminating the MRSA microbe.

A topical gel formulation of oxybutynin is provided that exhibits enhanced bioavailability, minimized adverse side effects and skin irritations, and improved patient compliance compared to the existing oral and transdermal formulations of oxybutynin.

The invention aims at disclosing a preparation method for an alanyl-glutamine biological adhesive preparation as well as a product and an application of the preparation. The alanyl-glutamine biological adhesive preparation is a topical gel preparation taking alanyl-glutamine as a main medicine ingredient for dental ulcer; the preparation has the characteristics of being capable of rapidly alleviating the pain of the affected parts, definite in curative effect, capable of being adhered to the surface of ulcer for a long time to protect the surface of a wound and slowly releasing medicines, less in irritation, good in biocompatibility, capable of integrating dental ulcer treatment, immune adjustment and recurrence prevention, convenient for patients to use, easy to carry and store, and low in price.

The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present topical formulations encompass a non-flammable solvent for malathion effective in killing head lice. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.