18 results about "Mucosal healing" patented technology

The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting5 with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, 5 an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 20 24 28 71 87 23 D ec 2 02 4 2 0 2 4 2 8 7 1 8 7 2 3 D e c 2 0 2 4 A b s t r a c t 5 1 0

The invention discloses a composite solution for treating reflux esophagitis and a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations, the composite solution is formed by physically mixing drug-loaded microspheres and a gastric buoyant raft matrix solution; wherein the drug-loaded microspheres are solid particles which take thiolated pectin as a carrier, are crosslinked and cured through divalent metal ions and are coated with a periplaneta americana extract; the gastric buoyant raft matrix solution comprises a hydrophilic colloid, a component capable of generating gas when encountering acid and a stabilizer. The magnesium mercapto pectin microspheres provide excellent mucous membrane adhesion, and the acting time of the medicine on the esophageal focus is prolonged; the gastric buoyant raft substrate forms a physical barrier in a gastric acid environment to inhibit regurgitation of gastric contents. Through cooperation of the two, a dual treatment mechanism of local repair and source control is realized. The preparation can remarkably prolong the in-vivo residence time and effectively promote esophageal mucosa healing, and the curative effect is better than that of a pure periplaneta americana extract preparation.

The invention relates to application of a composition taking taurine as a main active ingredient in preparation of a medicine for promoting mucous membrane healing. Water is used as a solvent, the taurine oral liquid contains 0.1 wt%-40wt% of taurine, 0.01 wt%-1wt% of amino acid, 0.01 wt%-0.5 wt% of vitamin, a protective agent, a bacteriostatic agent, a preservative, a swelling and pain relieving agent and the like. Through verification, the composition disclosed by the invention is prepared into oral spray, fine mist particles of 10-70 microns generated by a spray instrument show a good treatment effect on radiation-induced oral mucositis, and also have a good healing promoting effect on normal oral mucosa tissues after an alveolar surgery.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine intestinal administration preparation for treating UC and a preparation method. The traditional Chinese medicine intestinal administration preparation for treating UC comprises the following raw material medicines in parts by weight: 20-50 parts of rhizoma coptidis, 20-50 parts of cortex phellodendri, 20-50 parts of radix sanguisorbae, 20-50 parts of radix paeoniae alba, 20-50 parts of rhizoma bletillae, 10-40 parts of radix sophorae flavescentis and 10-40 parts of liquorice root. The composition is prepared by combining various medicines, has the effects of eliminating dampness and heat, cooling blood, stopping bleeding, astringing sores and promoting tissue regeneration, and the seven medicines are used together, so that the treatment effect is improved, a synergistic effect is achieved, and the composition is good in effect and free of toxic and side effects when being used for clinical treatment of UC for a long time; the preparation has strong heat-clearing and bleeding-stopping effects, can quickly relieve symptoms such as stomachache, tenesmus and hematochezia caused by UC, and effectively promotes intestinal mucosa healing.

The invention discloses a mucous membrane healing evaluation method based on energy spectrum CT iodine quantification, and belongs to the field of medical image processing and clinical diagnose.The mucous membrane healing evaluation method comprises the following steps that an energy spectrum CT intestinal stage scanning image of a patient suffering from Crohn's disease is obtained, and a three-dimensional volume area of a diseased intestinal segment is delineated on an energy spectrum CT iodine substance decomposition graph; selecting a reference blood vessel area, and measuring an iodine concentration value; calculating a normalized iodine concentration value, wherein the normalized iodine concentration value is equal to a result obtained by dividing the iodine concentration value of the lesion intestinal segment by the iodine concentration value of the reference blood vessel region; and comparing the normalized iodine concentration value with a preset threshold value 0.44, if the normalized iodine concentration value is less than 0.44, determining that the mucous membrane is healed, otherwise, determining that the active inflammation is caused. According to the scheme, traditional invasive enteroscopy is replaced with energy spectrum CT image analysis, contraindications of endoscope operation, patient pain and examination blind areas are avoided, the acceptability and examination feasibility of patients are remarkably improved, and the method is particularly suitable for patients who cannot tolerate an endoscope or need frequent follow-up visit.

The application discloses an oral care composition and a preparation method thereof, relates to the technical field of oral care compositions, and the oral care composition comprises medium-chain triglycerides, a herbal active compound and fat-soluble vitamins; the herbal active compound comprises frankincense oil extract, drynaria fat-soluble extract and magnolia bark extract. The pure oil phase oral care composition provided by the application can effectively inhibit the breeding of microorganisms, the use of medium-chain triglycerides instead of long-chain fatty acid coconut oil commonly used in traditional oil drawing can greatly reduce the overall viscosity of the oral care composition, and the problem of "greasy and difficult to swallow" of the pure oil phase product is solved, so that the sense of taste is improved. Further, by introducing the herbal active compound and the fat-soluble vitamins, the oral care composition is endowed with the functions of bacteriostasis, caries prevention, anti-allergy repair and mucosal healing, and the above components can be stably dissolved and dispersed in the whole oil system, which is beneficial to improving the product stability and ensuring the stable exertion of the functions.

The invention relates to the field of medical image analysis, in particular to an intestinal ultrasonic prediction system based on a machine learning model, which comprises a data acquisition module, a feature processing module, a feature screening module, a prediction model module, a result evaluation module and a clinical decision support module. Extracting visual interpretation features and radiomics features from the ultrasonic image, and integrating clinical information to form multi-dimensional feature data; after feature screening, a full-connection deep neural network based on an attention mechanism is constructed based on key features and is used for predicting the mucous membrane healing condition of a patient after the patient is treated by using the Usterinum monoclonal antibody. According to the method, early transmural response and transmural healing are introduced as prediction indexes, and accurate prediction of the treatment effect of the patient suffering from the Crohn disease is achieved; through multi-dimensional feature fusion and an attention mechanism, the prediction accuracy is remarkably improved; the treatment effect of the patient suffering from the Crohn disease is non-invasively evaluated, and the medical cost is reduced.

The application provides a laryngology blowing sore powder and a preparation method and application thereof. The blowing sore powder is a three-stage slow-release microsphere with a core-shell structure. The preparation method comprises the following steps: S1. loading Fritillaria cirrhosa Hance, pollen typhae and radix angelicae dahuricae on modified hydroxyapatite-calcined borax composite micro-nuclei to form an inner long-acting slow-release core; S2. coating the inner micro-nuclei with an enzyme-responsive methacrylated gelatin / poly-epsilon-caprolactone double-network composite gel, and loading salt cortex phellodendri, rhizoma coptidis, rhizoma anemarrhenae, artificial bovine bezoar and natural borneol to form a middle medium-release drug layer; and S3. constructing an outer micro-needle anchoring layer on the surface of the microsphere by freeze-etching chitosan quaternary ammonium salt embedded with menthol. The microsphere realizes physical anchoring and electrostatic adsorption through the outer micro-needle, prolongs the retention time, the middle gel is degraded in response to the ulcer inflammation microenvironment, and releases anti-inflammatory and antibacterial components; and the inner micro-nuclei slowly release repair components to promote mucosal healing, so that targeted retention and graded release of drugs are realized, and the drug efficacy utilization rate is improved.

The invention provides application of indigo in preparation of a medicine for treating Crohn's disease, and relates to medical application of bisindole compounds. Specifically, the invention relates to a medicine / composition prepared from indigo blue for treating the Crohn's disease, and the medicine / composition can inhibit intestinal inflammatory response of the Crohn's disease and promote mucous membrane healing. Mechanism research finds that the therapeutic mechanism of the invention is to inhibit polarization of M1 type macrophages. Indigo can regulate differentiation of macrophages and reduce the number of spleen M1 type macrophages in Crohn's disease, so that the purpose of treating Crohn's disease is achieved.

The present disclosure introduces a sprayable formulation for the enhanced treatment of inflammatory bowel disease (IBD). A lyophilized formulation (102) comprises probiotic- derived extracellular vesicles (EVs) (104) sourced from the VSL#3 probiotic blend, encapsulated within a thermo-responsive polymer matrix (106) made from poly(N-isopropyl acrylamide) (PNIPAM) and hyaluronic acid. Available as an off-the-shelf lyophilized powder, the formulation (102) is easy to store and rehydrate for use. Upon application, the lyophilized formulation (102) undergoes a phase transition at physiological temperature, forming a gel-like coating over the inflamed areas of the gut. This matrix (106) ensures localized delivery of the encapsulated EVs (104) directly to the disease site. The combination of hyaluronic acid and probiotic-derived EVs (104) reduces inflammation and promotes mucosal healing, addressing critical aspects of gut health in IBD management.

The invention discloses a treatment evaluation method for a Crohn disease patient, which belongs to the crossing field of medical imaging technology and artificial intelligence, and comprises the following steps: step A, patient image data acquisition and preprocessing: acquiring CTE image data of the Crohn disease patient at a specified time point after treatment, and transmitting the CTE image data to a medical image analysis platform for preprocessing, the preprocessing comprises image denoising and alignment; step B, automatic segmentation and feature extraction of a lesion area: a lesion intestinal wall area VOI is sketched through medical image analysis software, an adjacent mesenteric fat area VOI is automatically constructed, image omics features in the VOI are extracted, a feature matrix is formed, and the image omics features comprise texture features, shape features, intensity features and iodine quantitative features; according to the method, mucous membrane healing evaluation is achieved through CTE examination, invasive operation is not needed, pains and risks of enteroscopy are avoided, a patient can accept the method more easily, and the method is especially suitable for multiple dynamic monitoring after treatment.

This disclosure provides compositions and methods for using stool-derived eukaryotic nucleic acid biomarkers to diagnose disease, assess disease activity, monitor mucosal healing, and predict treatment response. The biomarkers of the present invention can be used by physicians to better diagnose, manage, and treat inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD).

The invention discloses a remote nursing method and system for patients in the digestive system department, and relates to the technical field of medical nursing. Based on mucous membrane healing quantitative evaluation of artificial intelligence and three-dimensional space registration, subjective experience is converted into objective data flow, and through a deep learning segmentation model, an objective data flow is obtained; a focus area in an endoscope image is automatically identified and segmented, endoscope sequences of previous examinations of a patient are reconstructed and registered to the same three-dimensional intestinal coordinate system, and on the unified space reference, the change of a first quantitative index, a second quantitative index and a third quantitative index along with time is dynamically presented in the form of a curve graph, so that quantitative tracking of remote monitoring precision is realized; according to the quantitative data based on the specific focus identity, adjustment of the treatment strategy can be established on the basis of tiny and measurable changes, the diagnosis and treatment accuracy is greatly improved, and doctors can visually judge the healing rate and fluctuation and recognize the risk of poor treatment response in advance.

The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 10 to 20 parts of radix pseudostellariae, 8 to 12 parts of roasted rhizoma atractylodis macrocephalae, 10 to 20 parts of poria cocos, 10 to 15 parts of herba agrimoniae, 8 to 12 parts of herb tea, 5 to 10 parts of cortex cinnamomi, 8 to 12 parts of radix paeoniae alba, 5 to 10 parts of pericarpium citri reticulatae, 8 to 12 parts of radix angelicae, 5 to 10 parts of honey-fried licorice root and 5 to 10 parts of radix linderae. The traditional She medicinal herb tea is used as a monarch drug for clearing away heat and toxic materials and promoting mucosa healing; radix pseudostellariae, bighead atractylodes rhizome, poria cocos and honey-fried licorice root are used as ministerial drugs for invigorating spleen and replenishing qi; hairyvein agrimony, cinnamon, radix paeoniae alba, pericarpium citri reticulatae, radix angelicae and lindera aggregata have the effects of warming yang, ascending clearness and promoting The traditional Chinese medicine composition has the effects of tonifying spleen, removing dampness, warming the middle warmer and relieving pain, is suitable for the recurrent oral ulceration caused by spleen deficiency, weakness and unclear heat toxin, can improve clinical symptoms of the recurrent oral ulceration, and can avoid recurrence of the oral ulceration.

The utility model relates to a self-adhesive sponge for nasal septum perforation repair, which is used for fixing cartilage at a nasal septum perforation position and comprises a sponge support body, the sponge support body comprises a sponge support layer, an adhesive layer and an anti-sticking layer which are sequentially attached, the adhesive layer is arranged on one side of the sponge support layer attached to a wound surface, and the anti-sticking layer is arranged on the other side of the sponge support layer attached to the wound surface. And the surface of the adhesion layer is covered with an anti-adhesion layer. Compared with the prior art, the self-adhesive sponge disclosed by the utility model has good mechanical property, good adhesive capacity between the sponge bracket main body and a wound surface, can be firmly attached to a cartilage of a perforated nasal septum and promote mucous membrane healing, and also has good biological safety, degradability and intraoperative operability; the nasal septum perforation repair effect is improved, the nasal septum perforation rate is reduced, and the life quality of a patient is improved.

This application discloses an information-based planning and evaluation system for the treatment of active ulcerative colitis, belonging to the field of planning and evaluation technology. By analyzing the state data of food and drugs after they pass through the digestive tract, and calculating sharpness and residue load, it quantifies the potential mechanical stimulation or burden that different foods and drugs may cause to the fragile and damaged colonic mucosa. It provides a more sensitive and accurate quantitative tool by automatically extracting microscopic feature data from endoscopic images. In addition to predicting drug efficacy, it also predicts mucosal healing trends under specific food patterns. Regarding drug recommendations, it obtains a drug recommendation list through weighted integration using machine learning models and the aforementioned prediction results. For dietary advice, it combines association rule mining and Bayesian networks to obtain specific food pattern suggestions, improving the targeting and patient suitability of dietary management, and enhancing the transparency and safety of clinical decision-making.

This invention discloses a magnetically guided probiotic-nanovesicle complex, its preparation method, and its applications, relating to the fields of biotechnology and medicine. The complex consists of turmeric-derived nanovesicles (Tur) and magnetically engineered probiotics (EcN@Fe3O4), which are directed to inflamed intestinal regions via an external magnetic field. This system exhibits significant anti-inflammatory and antioxidant effects, accelerates mucosal healing, restores intestinal microbiota balance, and possesses high biocompatibility and low toxicity. This invention provides a novel solution for the treatment of intestinal dysfunction and shows promising therapeutic effects on a range of inflammatory intestinal diseases.