Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating recurrent oral ulceration

Abstract

The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 10 to 20 parts of radix pseudostellariae, 8 to 12 parts of roasted rhizoma atractylodis macrocephalae, 10 to 20 parts of poria cocos, 10 to 15 parts of herba agrimoniae, 8 to 12 parts of herb tea, 5 to 10 parts of cortex cinnamomi, 8 to 12 parts of radix paeoniae alba, 5 to 10 parts of pericarpium citri reticulatae, 8 to 12 parts of radix angelicae, 5 to 10 parts of honey-fried licorice root and 5 to 10 parts of radix linderae. The traditional She medicinal herb tea is used as a monarch drug for clearing away heat and toxic materials and promoting mucosa healing; radix pseudostellariae, bighead atractylodes rhizome, poria cocos and honey-fried licorice root are used as ministerial drugs for invigorating spleen and replenishing qi; hairyvein agrimony, cinnamon, radix paeoniae alba, pericarpium citri reticulatae, radix angelicae and lindera aggregata have the effects of warming yang, ascending clearness and promoting The traditional Chinese medicine composition has the effects of tonifying spleen, removing dampness, warming the middle warmer and relieving pain, is suitable for the recurrent oral ulceration caused by spleen deficiency, weakness and unclear heat toxin, can improve clinical symptoms of the recurrent oral ulceration, and can avoid recurrence of the oral ulceration.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating recurrent oral ulcer. BACKGROUND

[0002] Recurrent oral ulcer (RAU) is a common oral mucosal ulcerative disease, which is characterized by the repeated occurrence of circular or elliptical ulcers in the oral mucosa, obvious burning pain, periodic onset and self-limiting. The pathogenesis of the disease is complex and has not been fully understood. It is generally believed that the disease is related to immune dysfunction, genetic factors, mental stress, nutritional deficiency, endocrine disorders and other factors. According to statistics, the prevalence rate of the disease in the population is as high as 10% to 25%, and it is more common in young adults, which seriously affects the eating, speaking and quality of life of patients. Long-term recurrent ulcers not only cause patients to have negative emotions such as anxiety and irritability, but also can cause secondary infection, and even a few cases have the risk of malignant change. Therefore, the effective treatment of recurrent oral ulcer has always been an important topic in clinical research.

[0003] At present, the drugs used for treating recurrent oral ulcer in clinical mainly include two types of local drugs and systemic drugs. Local drugs such as gargling agent, lozenge, ulcer film, etc. are mainly aimed at anti-inflammatory, analgesic and promoting healing, but the action time is short, frequent medication is required, and the effect of reducing recurrence is limited. Systemic drugs such as immunomodulators, vitamin drugs, etc. can regulate the body state to a certain extent, but have obvious side effects and large individual differences.

[0004] It can be seen that the existing treatment scheme for recurrent oral ulcer is difficult to fundamentally improve the immune imbalance state and mucosal repair ability of patients, and cannot effectively reduce the recurrence frequency, and the clinical needs have not been fully met.

[0005] In the field of national medicine, Shes medicine has formed a unique theoretical system and diagnosis and treatment experience through thousands of years of clinical practice. Shes medicine classifies oral ulcer as "kousheng" and "kouchang", and the core of its etiology is "saxi causing ulcer" - it is believed that the disease is caused by internal attack of "saxi" or "hot and toxic stagnation" caused by improper diet, and then "saxi" is formed, which blocks the ascending and descending of qi, attacks the mouth and tongue, and corrodes the mucosa to cause ulcer. Based on this theory, Shes medicine emphasizes "clearing heat and resolving toxin, regulating qi and invigorating spleen, expelling saxi and removing toxin" in treatment, and Shilengcha is praised as the "first taste of Shes medicine" as the core drug for removing "saxi". It has the effects of clearing heat and resolving toxin, regulating qi and invigorating spleen, and is commonly used in Shes folk for treating oral mucosal diseases caused by heat and toxin, and has accumulated rich clinical experience.

[0006] However, traditional She medicine prescriptions are mostly used empirically, and lack of optimized combination and modern mechanism interpretation for the pathogenesis of recurrent oral ulcer (especially the recurrence root), which greatly limits the standardization and modernization of She medicine in the treatment of RAU. SUMMARY

[0007] The application aims to provide a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating recurrent oral ulcer, which can effectively improve the clinical symptoms of recurrent oral ulcer and effectively avoid the recurrence of oral ulcer.

[0008] To achieve the above application purposes, the technical solutions of the application are as follows: The application first provides a traditional Chinese medicine composition for treating recurrent oral ulcer, which is composed of the following raw medicinal materials in parts by mass: 10-20 parts of radix pseudostellariae, 8-12 parts of fried atractylodes, 10-20 parts of poria cocos, 10-15 parts of herba agrimoniae, 8-12 parts of herba rubi chinenis, 5-10 parts of cinnamomum cassia, 8-12 parts of radix paeoniae alba, 5-10 parts of pericarpium citri reticulatae, 8-12 parts of radix angelicae dahuricae, 5-10 parts of prepared licorice, and 5-10 parts of lindera.

[0009] The present prescription takes herba rubi chinenis as the monarch drug, which has the effects of clearing heat and detoxifying and promoting mucosal healing; the four gentlemen decoction composed of radix pseudostellariae, fried atractylodes, poria cocos and prepared licorice is used as the minister drug, which can invigorate the spleen and replenish qi; in combination with herba agrimoniae, cinnamomum cassia, radix paeoniae alba, pericarpium citri reticulatae, radix angelicae dahuricae and lindera, yang can be warmed and clear can be raised, which can promote mucosal repair together with the monarch drug. The whole prescription has the effects of invigorating the spleen, removing dampness, warming the middle and stopping pain, and is suitable for treating recurrent oral ulcer caused by spleen deficiency, weakness, and unremoved heat and toxin. The present prescription can not only effectively improve the clinical symptoms of recurrent oral ulcer, but also effectively avoid the recurrence of oral ulcer.

[0010] Preferably, the traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by mass: 15 parts of radix pseudostellariae, 10 parts of fried atractylodes, 15 parts of poria cocos, 12 parts of herba agrimoniae, 10 parts of herba rubi chinenis, 5 parts of cinnamomum cassia, 10 parts of radix paeoniae alba, 6 parts of pericarpium citri reticulatae, 10 parts of radix angelicae dahuricae, 6 parts of prepared licorice, and 6 parts of lindera.

[0011] The application further provides a traditional Chinese medicine preparation for treating recurrent oral ulcer, which is prepared from the above traditional Chinese medicine composition. The traditional Chinese medicine preparation of the application can be a decoction (obtained by water decocting) prepared by a conventional method, or can be further added with conventional medicinal adjuvants in the water decoction to prepare a powder, a plaster, a pill, a tablet, a capsule, a granule or an oral liquid.

[0012] Taking the decoction as an example, the preparation process of the traditional Chinese medicine preparation is as follows: all the raw medicinal materials are weighed according to the preset mass parts, washed and then added with 8-12 times of water, and decocted for at least 2 times, each time for 0.5-2 h; all the water decoctions are combined and filtered to obtain the traditional Chinese medicine preparation.

[0013] Compared with the prior art, the technical effects of the present application are embodied in: The present application is a traditional Chinese medicine composition for treating recurrent oral ulcer, which comprises: Radix Pseudostellariae 15 g, Poria cocos 15 g, Herba Monotropaei 12 g, Herba Rubi 10 g, Cinnamomum cassia 5 g, Radix Paeoniae Alba 10 g, Pericarpium Citri Reticulatae 6 g, Radix Angelicae Dahuricae 10 g, Radix Angelicae Sinensis 6 g, and Glycyrrhizae 6 g. DETAILED DESCRIPTION

[0014] The technical solutions of the present application are further described below by way of examples. Example 1

[0015] The present application is a traditional Chinese medicine composition for treating recurrent oral ulcer, which comprises: Radix Pseudostellariae 15 g, Poria cocos 15 g, Herba Monotropaei 12 g, Herba Rubi 10 g, Cinnamomum cassia 5 g, Radix Paeoniae Alba 10 g, Pericarpium Citri Reticulatae 6 g, Radix Angelicae Dahuricae 10 g, Radix Angelicae Sinensis 6 g, and Glycyrrhizae 6 g.

[0016] All the raw medicinal materials are recorded in the Chinese Pharmacopoeia 2025 Edition Volume I and purchased from Zhejiang Kangning Pharmaceutical Co., Ltd. Example 2

[0017] The present application is a traditional Chinese medicine composition for treating recurrent oral ulcer, which comprises: Radix Pseudostellariae 15 g, Poria cocos 15 g, Herba Monotropaei 12 g, Herba Rubi 10 g, Cinnamomum cassia 5 g, Radix Paeoniae Alba 10 g, Pericarpium Citri Reticulatae 6 g, Radix Angelicae Dahuricae 10 g, Radix Angelicae Sinensis 6 g, and Glycyrrhizae 6 g. (1) Take 40 parts of the prescription amount of the traditional Chinese medicine raw materials according to the prescription of Example 1, wash and reserve; (2) Add the traditional Chinese medicine raw materials in step (1) into 8 times the mass of water, decoct for 2 times, 1 hour each time, stand, filter, combine the filtrates, and fill into bottles to obtain the traditional Chinese medicine decoction (hereinafter referred to as the Kouyangqing mixture) of the present application.

[0018] The Kouyangqing mixture of Example 2 was used by the patient, and the patient's pre-medication symptoms, medical advice medication scheme and efficacy are shown in Table 1.

[0019] Table 1 Efficacy evaluation of the Kouyangqing mixture

[0020] As can be seen from Table 1, after taking the Kouyangqing mixture of the present application for one course of treatment, the oral ulcer can be basically cured, and will not recur after continuing to take one course of treatment to consolidate the drug effect.

Claims

1. A traditional Chinese medicine composition for treating recurrent oral ulcers, characterized in that, By weight, it is composed of the following raw materials: 10-20 parts of Codonopsis pilosula, 8-12 parts of stir-fried Atractylodes macrocephala, 10-20 parts of Poria cocos, 10-15 parts of Agrimonia pilosa, 8-12 parts of herbal tea, 5-10 parts of cinnamon, 8-12 parts of Paeonia lactiflora, 5-10 parts of Citrus reticulata peel, 8-12 parts of Angelica dahurica, 5-10 parts of prepared Glycyrrhiza uralensis, and 5-10 parts of Lindera strychnifolia.

2. The traditional Chinese medicine composition as described in claim 1, characterized in that, By weight, it is composed of the following raw materials: 15 parts of Codonopsis pilosula, 10 parts of stir-fried Atractylodes macrocephala, 15 parts of Poria cocos, 12 parts of Agrimonia pilosa, 10 parts of herbal tea, 5 parts of cinnamon, 10 parts of Paeonia lactiflora, 6 parts of Citrus reticulata peel, 10 parts of Angelica dahurica, 6 parts of prepared Glycyrrhiza uralensis, and 6 parts of Lindera strychnifolia.

3. A traditional Chinese medicine preparation for treating recurrent oral ulcers, characterized in that, It is made using the traditional Chinese medicine composition described in claim 1 or 2.

4. The traditional Chinese medicine preparation as described in claim 3, characterized in that, It can be in the form of decoction, powder, paste, pill, tablet, capsule, granule or oral liquid.

5. The traditional Chinese medicine preparation as described in claim 4, characterized in that, It is made using the following method: Weigh all raw materials according to the preset mass proportions, wash them, add 8-12 times the amount of water, and decoct at least twice, each time for 0.5-2 hours; combine all the decoctions and filter to obtain the Chinese medicine preparation.

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