Lamiophlomis rotata aqueous extract gel preparation capable of improving oral mucosa adhesion performance and preparation method and application of lamiophlomis rotata aqueous extract gel preparation

By optimizing the ratio of Duyiwei water extract, carbomer 940 and triethanolamine and using a low-temperature unidirectional grinding process, an ordered gel structure was constructed, which solved the problem of insufficient adhesion of traditional Chinese medicine gel in the oral environment. This achieved long-term drug retention and improved ulcer treatment effect, making it suitable for industrial production while ensuring safety.

CN122097244APending Publication Date: 2026-05-29CHINA PHARM UNIV
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Patent Information

Application Number
CN202610304731.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-13
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing Chinese herbal gel formulations have insufficient adhesion in the oral environment and cannot be effectively retained, resulting in insufficient time for the drug to exert its effects. Furthermore, the compatibility and adhesion mechanism between the active ingredients of Chinese herbal medicine and the carbomer matrix are unclear, and there is a lack of directional design methods.

Method used

By optimizing the ratio of Duyiwei water extract, carbomer 940 and triethanolamine, and using a low-temperature unidirectional grinding process, an ordered gel network structure was constructed, the gel adhesion force and adhesion strength were adjusted, and a stable Duyiwei water extract gel formulation was prepared by combining pH adjustment and vacuum degassing treatment.

Benefits of technology

It significantly improves the retention time of oral mucosa, enhances drug utilization, strengthens the treatment effect of oral ulcers, reduces the frequency of administration, ensures the stability and safety of the formulation, is suitable for industrial production, and has readily available and controllable raw materials.

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Abstract

The invention discloses a lamiophlomis rotata aqueous extract gel preparation for improving oral mucosa adhesion performance and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine gel preparations. The gel preparation is prepared from the following components in percentage by mass: 0.2 percent to 0.6 percent of lamiophlomis rotata aqueous extract, 0.5 percent to 1.5 percent of carbomer 940, 0.5 percent to 3 percent of triethanolamine, 5 percent to 15 percent of glycerol, 0.3 percent to 0.5 percent of sodium benzoate and the balance of purified water. And preparing by adopting a 15 DEG C low-temperature one-way grinding process to obtain a gel finished product. An ordered gel net structure is constructed through a low-temperature one-way grinding process, and the ratio of the lamiophlomis rotata aqueous extract to the gel matrix is optimized, so that the oral cavity residence time of the preparation under the condition of simulating the saliva flow rate exceeds 4 hours, and the oral cavity residence time is remarkably superior to that of an existing product. In an SD (Sprague Dawley) rat oral ulcer model, the ulcer area of the gel preparation is reduced by about 70% within 48 hours, and the treatment effect is superior to that of a positive control drug mirabilitum praeparatum spray.
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