A packing bag for sucralfate suspension gel

Abstract

The utility model provides a kind of aluminium sucrose suspension gel packing bag, the aluminium sucrose suspension gel packing bag includes bag body, the bag body adopts packing bag composite film;The packing bag composite film sequentially includes: low-density polyethylene heat-seal layer, first adhesive layer, aluminium barrier layer, second adhesive layer and polyester protective layer;The bag body has hollow cavity formed by the two ends of rectangular packing bag composite film sealing, and the two ends of the bag body along hollow cavity axial form sealing portion.The aluminium sucrose suspension gel packing bag provided by the present application has good barrier properties, stability and mechanical properties such as tear resistance, and provides effective packaging, storage protection for aluminium sucrose suspension gel preparation.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical packaging technology, specifically relating to a packaging bag for sucralfate suspension gel. Background Technology

[0002] Sucralfate suspension gel is an effective gastric mucosal protectant, widely used clinically to treat gastric ulcers, duodenal ulcers, and acute gastric mucosal bleeding. Its active ingredient, sucralfate, forms a viscous gel in an acidic environment, selectively adhering to the ulcer surface and forming a protective barrier. This unique pharmacological action places extremely stringent requirements on its packaging. First, the packaging must have excellent barrier properties, especially moisture resistance, to prevent moisture loss from the gel, which could lead to drug clumping, deformation, or changes in concentration. Second, the packaging material must have good biocompatibility to ensure that no substances leached from the inner liner migrate into the drug, affecting efficacy or introducing safety risks. Finally, the packaging also needs to possess certain mechanical properties, such as flexibility and tear resistance, to facilitate transportation and storage.

[0003] However, existing packaging bags generally use a film layer structure of polyvinyl chloride or polypropylene, which makes the packaging bags less stable, and their flexibility and tear resistance are also slightly insufficient, which is not conducive to the long-term use and preservation of sucralfate suspension gel. Utility Model Content

[0004] The purpose of this invention is to provide a packaging bag for sucralfate suspension gel, which has good barrier properties, stability and tear resistance, and other mechanical properties, providing effective packaging and storage protection for sucralfate suspension gel formulations.

[0005] To achieve the objective of this utility model, the following technical solution is adopted:

[0006] This utility model provides a packaging bag for sucralfate suspension gel. The packaging bag for sucralfate suspension gel includes a bag body, which is made of a composite film for packaging bags. The composite film for packaging bags includes, in sequence: a low-density polyethylene heat-sealing layer, a first adhesive layer, an aluminum barrier layer, a second adhesive layer, and a polyester protective layer. The bag body has a hollow cavity formed by sealing both ends of a rectangular composite film for packaging bags, and sealing portions are formed at both ends of the bag body along the axial direction of the hollow cavity.

[0007] The packaging bag for sucralfate suspension gel provided by this invention has good barrier properties, stability and tear resistance, and provides effective packaging and storage protection for sucralfate suspension gel formulations.

[0008] Preferably, an ink layer is further provided between the polyester protective layer and the first adhesive layer.

[0009] Preferably, the low-density polyethylene heat-sealable layer comprises a polyethylene layer with a melt index of 7.9-8.1 g / 10 min. The melt index of the polyethylene layer can be 7.9 g / 10 min, 7.95 g / 10 min, 8.0 g / 10 min, 8.05 g / 10 min, or 8.1 g / 10 min, but is not limited to the listed values; other unlisted values ​​within the range are also applicable.

[0010] Preferably, the low-density polyethylene heat-sealing layer comprises a DOW LDPE 722 polyethylene layer.

[0011] Preferably, the thickness of the low-density polyethylene heat-sealing layer is 50-80 μm, for example, it can be 50 μm, 55 μm, 60 μm, 65 μm, 70 μm, 75 μm or 80 μm, but is not limited to the listed values, and other unlisted values ​​within the range are also applicable.

[0012] Preferably, one side of the adjacent first adhesive layer of the low-density polyethylene heat-sealing layer is configured as a corona-electrode surface.

[0013] Preferably, the first adhesive layer comprises a polyurethane adhesive layer.

[0014] Preferably, the thickness of the first adhesive layer is 3-8 μm, for example, it can be 3 μm, 4 μm, 5 μm, 6 μm, 7 μm or 8 μm, but is not limited to the listed values, and other unlisted values ​​within the range are also applicable.

[0015] Preferably, the polyester protective layer and the aluminum barrier layer are formed by a first adhesive layer to form a dry composite.

[0016] Preferably, the aluminum barrier layer comprises an aluminum foil layer and / or an aluminum-plated film layer.

[0017] Preferably, the thickness of the aluminum barrier layer is 6-12 μm, for example, it can be 6 μm, 7 μm, 8 μm, 9 μm, 10 μm, 11 μm or 12 μm, but is not limited to the listed values, and other unlisted values ​​within the range are also applicable.

[0018] Preferably, the second adhesive layer comprises a polyurethane adhesive layer.

[0019] Preferably, the thickness of the second adhesive layer is 3-8 μm, for example, it can be 3 μm, 4 μm, 5 μm, 6 μm, 7 μm or 8 μm, but is not limited to the listed values, and other unlisted values ​​within the range are also applicable.

[0020] Preferably, the aluminum barrier layer and the low-density polyethylene heat-sealing layer are formed by a second adhesive layer to form a dry composite.

[0021] Preferably, the polyester protective layer comprises a biaxially oriented PET film layer.

[0022] Preferably, the thickness of the polyester protective layer is 12-25 μm, for example, it can be 12 μm, 15 μm, 18 μm, 20 μm, 22 μm or 25 μm, but is not limited to the listed values, and other unlisted values ​​within the range are also applicable.

[0023] Preferably, the polyester protective layer has a corona discharge surface on one side adjacent to the second adhesive layer.

[0024] Preferably, the sealing part is formed by hot-pressing the packaging bags on both sides of the opening of the hollow cavity with a composite film, and the sealing part is provided with an easy-tear opening.

[0025] Preferably, the tear-off opening includes a V-shaped notch, a semi-circular notch, or a laser-etched mark.

[0026] This utility model also provides a method for preparing the composite film for packaging bags, the method comprising the following steps:

[0027] (1) Use a gravure rotary high-speed printing machine, add benzene-free and ketone-free ink to print on the side of the polyester film with corona discharge. The ink should have good leveling properties, high adhesion, bright color, and be environmentally friendly and pollution-free. Print important information such as drug name and production date on the film.

[0028] (2) Apply polyurethane resin two-component adhesive to one side of the corona side of the polyester film with a wire roller, and then dry the solvent in three ovens at 50-60℃, 60-70℃ and 70-80℃ in sequence. Then, it is combined with aluminum film into a composite roller and rolled up after being combined with a hot roller.

[0029] (3) The polyester film-aluminum film composite layer prepared in step (2) is coated with polyurethane resin two-component adhesive by a wire roller, and the solvent is dried in three ovens at 50-60℃, 60-70℃ and 70-80℃ in sequence. Then it is laminated with the corona side of the polyethylene film to form a composite film semi-finished product.

[0030] (4) Place the composite film semi-finished product into a curing chamber at 50-60℃ and cure for 45-50 hours to allow the two-component adhesive between the composite layers to fully cross-link and cure, so that the linear structure is cured into a three-dimensional network structure, thereby increasing the bonding force between the composite layers and enhancing the heat resistance between the composite adhesive layers.

[0031] (5) The composite packaging film is slit into rolls using a slitting machine to produce the required size and shape. Mechanical cutting or blade cutting can be used to ensure the accuracy and efficiency of slitting.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] The packaging bag for sucralfate suspension gel provided by this invention has good barrier properties, stability and tear resistance, and provides effective packaging and storage protection for sucralfate suspension gel formulations. Attached Figure Description

[0034] Figure 1 This is a schematic diagram of the structure of the composite film for packaging bags provided in Example 1;

[0035] Among them, 1 is a low-density polyethylene heat-sealing layer; 2 is a first adhesive layer; 3 is an aluminum barrier layer; 4 is a second adhesive layer; 5 is a polyester protective layer; and 6 is an ink layer.

[0036] Figure 2 A top view of the packaging bag for the sucralfate suspension gel provided in Example 1;

[0037] 10 is the bag body; 11 is the sealing part. Detailed Implementation

[0038] It should be understood that in the description of this utility model, the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0039] It should be noted that, in the description of this utility model, unless otherwise explicitly specified and limited, the terms "set," "connected," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0040] The technical solution of this utility model will be further described below with reference to the accompanying drawings and specific embodiments.

[0041] Example 1

[0042] This embodiment provides a method such as Figure 1 The composite film for packaging bags of the sucralfate suspension gel shown herein comprises, in sequence: a low-density polyethylene heat-sealing layer 1, a first adhesive layer 2, an aluminum barrier layer 3, a second adhesive layer 4, and a polyester protective layer 5.

[0043] The low-density polyethylene heat-sealing layer 1 is made of Dow LDPE 722 polyethylene, purchased from Dow Chemical Company, USA. The melt index of the Dow LDPE 722 polyethylene is 8.0 g / 10 min. The thickness of the low-density polyethylene heat-sealing layer 1 is 60 μm. One side of the low-density polyethylene heat-sealing layer 1 adjacent to the first adhesive layer 2 is set as a corona-electrode surface.

[0044] The first adhesive layer 2 includes a polyurethane adhesive layer, which is a two-component polyurethane resin adhesive, and the thickness of the first adhesive layer 2 is 5 μm.

[0045] The aluminum barrier layer 3 is an aluminum foil layer, and the thickness of the aluminum barrier layer 3 is 9μm.

[0046] The aluminum barrier layer 3 and the low-density polyethylene heat-sealing layer 1 are formed by a dry composite through the first adhesive layer 2.

[0047] The second adhesive layer 4 includes a polyurethane adhesive layer, which is a two-component polyurethane resin adhesive, and the thickness of the second adhesive layer 4 is 5 μm.

[0048] The polyester protective layer 5 includes a biaxially oriented PET film layer, the thickness of the polyester protective layer 5 is 15μm, and a corona discharge surface is provided on one side of the polyester protective layer 5 adjacent to the second adhesive layer 4.

[0049] The polyester protective layer 5 and the aluminum barrier layer 3 are dry-composite through the second adhesive layer 4.

[0050] An ink layer 6 is disposed between the polyester protective layer 5 and the second adhesive layer 4.

[0051] This embodiment provides a method such as Figure 2 The packaging bag for sucralfate suspension gel shown includes a bag body 10, which is made of the composite film for packaging bags. The bag body has a hollow cavity formed by sealing both ends of the rectangular composite film for packaging bags, and sealing portions 11 are formed at both ends of the bag body along the axial direction of the hollow cavity.

[0052] The sealing part is formed by hot-pressing the packaging bags on both sides of the opening of the hollow cavity with a composite film, thereby forming a sealed hollow cavity inside the bag. The hollow cavity is used to contain sucralfate suspension gel, and easy-tear openings are provided at the sealing parts at both ends of the bag.

[0053] Example 2

[0054] This embodiment provides a composite film for packaging bags of sucralfate suspension gel. The composite film for packaging bags includes, in sequence: a low-density polyethylene heat-sealing layer 1, a first adhesive layer 2, an aluminum barrier layer 3, a second adhesive layer 4, and a polyester protective layer 5.

[0055] The low-density polyethylene heat-sealing layer 1 is made of Dow LDPE 722 polyethylene, purchased from Dow Chemical Company, USA. The melt index of the Dow LDPE 722 polyethylene is 8.0 g / 10 min. The thickness of the low-density polyethylene heat-sealing layer 1 is 50 μm. One side of the low-density polyethylene heat-sealing layer 1 adjacent to the first adhesive layer 2 is set as a corona-electrode surface.

[0056] The first adhesive layer 2 includes a polyurethane adhesive layer, which is a two-component polyurethane resin adhesive, and the thickness of the first adhesive layer 2 is 8 μm.

[0057] The aluminum barrier layer 3 is an aluminum foil layer, and the thickness of the aluminum barrier layer 3 is 6μm.

[0058] The aluminum barrier layer 3 and the low-density polyethylene heat-sealing layer 1 are formed by a dry composite through the first adhesive layer 2.

[0059] The second adhesive layer 4 includes a polyurethane adhesive layer, which is a two-component polyurethane resin adhesive, and the thickness of the second adhesive layer 4 is 3μm.

[0060] The polyester protective layer 5 includes a biaxially oriented PET film layer, the thickness of the polyester protective layer 5 is 12μm, and a corona discharge surface is provided on one side of the polyester protective layer 5 adjacent to the second adhesive layer 4.

[0061] The polyester protective layer 5 and the aluminum barrier layer 3 are dry-composite through the second adhesive layer 4.

[0062] An ink layer 6 is also provided between the polyester protective layer 5 and the second adhesive layer 4.

[0063] This embodiment provides a packaging bag for sucralfate suspension gel. The packaging bag for sucralfate suspension gel includes a bag body 10. The bag body is made of the composite film for packaging bags. The bag body has a hollow cavity formed by sealing both ends of the rectangular composite film for packaging bags. Sealing portions 11 are formed at both ends of the bag body along the axial direction of the hollow cavity.

[0064] The sealing part 11 is formed by hot-pressing the packaging bags on both sides of the opening of the hollow cavity with a composite film, thereby forming a sealed hollow cavity inside the bag. The hollow cavity is used to contain sucralfate suspension gel, and easy-tear openings are provided at the sealing parts at both ends of the bag.

[0065] Example 3

[0066] This embodiment provides a composite film for packaging bags of sucralfate suspension gel. The composite film for packaging bags includes, in sequence: a low-density polyethylene heat-sealing layer 1, a first adhesive layer 2, an aluminum barrier layer 3, a second adhesive layer 4, and a polyester protective layer 5.

[0067] The low-density polyethylene heat-sealing layer 1 is made of Dow LDPE 722 polyethylene, purchased from Dow Chemical Company, USA. The melt index of the Dow LDPE 722 polyethylene is 8.0 g / 10 min. The thickness of the low-density polyethylene heat-sealing layer 1 is 80 μm. One side of the low-density polyethylene heat-sealing layer 1 adjacent to the first adhesive layer 2 is set as a corona-electrode surface.

[0068] The first adhesive layer 2 includes a polyurethane adhesive layer, which is a two-component polyurethane resin adhesive, and the thickness of the first adhesive layer 2 is 3μm.

[0069] The aluminum barrier layer 3 is an aluminum-plated layer, and the thickness of the aluminum barrier layer 3 is 12μm.

[0070] The aluminum barrier layer 3 and the low-density polyethylene heat-sealing layer 1 are formed by a dry composite through the first adhesive layer 2.

[0071] The second adhesive layer 4 includes a polyurethane adhesive layer, wherein the polyurethane adhesive is a two-component polyurethane resin adhesive, and the thickness of the second adhesive layer 4 is 8 μm.

[0072] The polyester protective layer 5 includes a biaxially oriented PET film layer, the thickness of the polyester protective layer 5 is 25μm, and a corona discharge surface is provided on one side of the polyester protective layer 5 adjacent to the second adhesive layer 4.

[0073] The polyester protective layer 5 and the aluminum barrier layer 3 are dry-composite through the second adhesive layer 4.

[0074] An ink layer 6 is also provided between the polyester protective layer 5 and the second adhesive layer 4.

[0075] This embodiment provides a packaging bag for sucralfate suspension gel. The packaging bag for sucralfate suspension gel includes a bag body 10. The bag body is made of the composite film for packaging bags. The bag body has a hollow cavity formed by sealing both ends of the rectangular composite film for packaging bags. Sealing portions 11 are formed at both ends of the bag body along the axial direction of the hollow cavity.

[0076] The sealing part is formed by hot-pressing the packaging bags on both sides of the opening of the hollow cavity with a composite film, thereby forming a sealed hollow cavity inside the bag. The hollow cavity is used to contain sucralfate suspension gel, and easy-tear openings are provided at the sealing parts at both ends of the bag.

[0077] In summary, the packaging bag for sucralfate suspension gel provided by the present invention has good barrier properties, stability and tear resistance, and provides effective packaging and storage protection for sucralfate suspension gel formulations.

[0078] The above description is only a specific embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Those skilled in the art should understand that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present utility model fall within the protection and disclosure scope of the present utility model.

Claims

1. A packaging bag for sucralfate suspension gel, characterized in that, The packaging bag for the sucralfate suspension gel includes a bag body, which is made of a composite film for packaging bags. The composite film for packaging bags includes, in sequence: a low-density polyethylene heat-sealing layer, a first adhesive layer, an aluminum barrier layer, a second adhesive layer, and a polyester protective layer. The bag body has a hollow cavity formed by sealing both ends of a rectangular composite film for packaging bags, and the two ends of the bag body along the axial direction of the hollow cavity form sealing portions.

2. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, An ink layer is also provided between the polyester protective layer and the second adhesive layer.

3. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The low-density polyethylene heat-sealing layer comprises a polyethylene layer with a melt index of 7.9-8.1 g / 10 min.

4. The packaging bag for sucralfate suspension gel according to claim 3, characterized in that, The low-density polyethylene heat-sealable layer includes a DOW LDPE 722 polyethylene layer.

5. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The thickness of the low-density polyethylene heat-sealing layer is 50-80 μm.

6. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The first adhesive layer includes a polyurethane adhesive layer; The thickness of the first adhesive layer is 3-8 μm.

7. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The aluminum barrier layer includes an aluminum foil layer and / or an aluminum-plated film layer; The thickness of the aluminum barrier layer is 6-12 μm.

8. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The second adhesive layer includes a polyurethane adhesive layer; The thickness of the second adhesive layer is 3-8 μm.

9. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The polyester protective layer includes a biaxially oriented PET film layer; The thickness of the polyester protective layer is 12-25 μm.

10. The packaging bag for sucralfate suspension gel according to claim 1, characterized in that, The sealing part is formed by hot-pressing the packaging bags on both sides of the opening of the hollow cavity with a composite film, and the sealing part is provided with an easy-tear opening.

Images