Banana starch Janus particle oral ulcer patch and preparation method thereof

Abstract

The invention belongs to the field of oral patches, and particularly relates to a banana starch Janus particle oral ulcer patch and a preparation method thereof. Natural starch extracted from bananas is used as a main raw material, the Pickering emulsion can be prepared by modifying and adjusting the hydrophobicity of the natural starch, then the extract prepared from dandelion, pericarpium citri reticulatae and litchi pericarp and the lotus leaf extract are added, and finally the banana starch Janus granules are prepared, can remarkably inhibit growth of candida albicans and escherichia coli causing oral ulcer, and have the advantages that the oral ulcer can be inhibited, the oral ulcer can be inhibited, and the oral ulcer can be inhibited. The traditional Chinese medicine composition has a remarkable treatment effect on oral ulcer. In the invention, the banana starch has the advantages of reproducibility, biocompatibility and degradability, is suitable for green application, is low in cost, has no side effect, does not cause anaphylactic reaction, is remarkably improved in safety when being used for treating the oral ulcer, and can be used as a standing medicine when the oral ulcer repeatedly attacks.

Description

Technical Field

[0001] This invention belongs to the field of oral patches, specifically relating to an oral ulcer patch made of banana starch Janus granules and its preparation method. Background Technology

[0002] Oral ulcers are a common oral mucosal disease, manifesting as round or oval painful ulcers on the lips, palate, tongue, and cheeks. The causes of oral ulcers are complex, and the burning pain during an attack is very pronounced, severely affecting daily eating and speaking. Furthermore, oral ulcers are highly prone to recurrence, making the development of medications for treating oral ulcers crucial for people's daily lives. Oral patches are effective in treating oral ulcers due to their simple application and sustained efficacy. However, existing oral patches often use single-component formulations, which can easily lead to side effects with long-term use, significantly limiting their effectiveness in treating oral ulcers, especially recurrent ones. Therefore, developing green, safe, highly effective, low-toxicity oral ulcer patches suitable for long-term use is imperative. Summary of the Invention

[0003] This invention provides an oral ulcer patch containing banana starch Janus granules and its preparation method. By adding banana starch to the oral ulcer patch, the prepared Janus granules can not only significantly improve the treatment effect on oral ulcers, but also significantly inhibit the recurrence of oral ulcers, making it suitable for long-term use.

[0004] The technical solution of this invention is implemented as follows: An oral ulcer composition of banana starch Janus granules, comprising the following components in parts by weight: 10-20 parts banana starch, 5-10 parts lotus leaf extract, 15-25 parts dandelion, 10-15 parts dried tangerine peel, 13-17 parts litchi peel, 1-4 parts octenyl succinic anhydride, and 30-100 parts long-chain fatty acids.

[0005] Furthermore, it includes the following components in parts by weight: 15 parts banana starch, 7 parts lotus leaf extract, 20 parts dandelion, 12 parts dried tangerine peel, 15 parts lychee peel, 3 parts octenyl succinic anhydride, and 50 parts long-chain fatty acids.

[0006] Furthermore, the long-chain fatty acid is lauric acid or myristic acid; Furthermore, the method for preparing the banana starch includes the following steps: Take green bananas (6-7 ripe, with a completely green peel, firm flesh, and not yet softened), wash and slice them, then soak them in a 0.3-0.5% citric acid solution for 3-5 minutes. After soaking, blend them together with the citric acid solution into a pulp. Add pectinase and cellulase to the pulp and enzymatically hydrolyze it at 35-40℃ for 1-2 hours. Filter to remove the precipitate, adjust the pH to 4-6, centrifuge, collect the lower layer, add water and centrifuge again, collect the lower layer, and freeze-dry under vacuum to obtain banana starch. Furthermore, the method for preparing the lotus leaf extract includes the following steps: Take fresh lotus leaves, wash them, add water equal to the weight of the lotus leaves and pulp them, filter and collect the filtrate. Add water equal to the weight of the lotus leaves to the residue and filter again. Combine the filtrates, add an equal volume of anhydrous ethanol to the filtrate and stir thoroughly. Let stand at 4°C for 24 hours, take the supernatant and freeze-dry to obtain lotus leaf extract.

[0007] An oral ulcer composition for use with banana starch Janus granules, the preparation method of which includes the following steps: (1) Dandelion and dried tangerine peel are boiled in water for 20-30 minutes, filtered to obtain filtrate, and dried to obtain extract one; litchi peel is crushed and soaked in 95% ethanol, and the ethanol is removed from the filtrate at 40-50℃ to obtain extract two. (2) Banana starch and deionized water were mixed to obtain starch emulsion. Octenyl succinic anhydride was added to starch emulsion, and sodium hydroxide was added to adjust pH to 7-9. The mixture was stirred for 3-5 hours. After the reaction was completed, the mixture was filtered, the precipitate was washed and dried, and the dried product was pulverized to obtain hydrophobically modified starch granules. (3) Add hydrophobic modified starch granules and long-chain fatty acids to water, mix the three together evenly, and then homogenize them into an emulsion. After homogenization, the emulsion is first refrigerated and then taken out and placed at room temperature to stabilize it to obtain Pickering emulsion. (4) Dissolve extract one, extract two and lotus leaf extract in acetic acid aqueous solution to form a mixed solution with a mass concentration of 1 mg / mL. Adjust the pH value to 4.5-5 and stir continuously for 3-5 h. After removing the residue of insoluble particles with a filter membrane with a pore size of 0.45µm, preheat at 50℃ for 15 min. Add 0.5 mg / mL sodium tripolyphosphate (TPP) aqueous solution under stirring at 700 rpm and react for 20-30 min to obtain a mixed dispersion. (5) Add the mixed dispersion to the Pickering emulsion obtained in step (4) at a volume ratio of 1:1 and react for 20 minutes to obtain a mixed system of the two. Remove the excess chitosan nanoparticle dispersion, add deionized water and perform ultrasonic and centrifugation treatment in sequence, remove the supernatant, and repeat centrifugation 2-3 times to obtain the composition.

[0008] Furthermore, in step (1), dandelion and dried tangerine peel are decocted in 5-8 times their total weight of water for 20-30 minutes; 95% ethanol is added in an amount of 5-6 times the weight of lychee peel and soaked for 30-60 minutes.

[0009] Furthermore, in step (2), banana starch is added to deionized water to obtain a starch emulsion with a mass concentration of 20%, and 0.3% by weight of banana starch octenyl succinic anhydride is added to the starch emulsion; the stirring reaction conditions are: stirring for 0.5-1 hours, reacting at 30-45℃ for 2.5-3 hours; the precipitate is repeatedly washed with deionized water 3-4 times and then dried at 40-50℃.

[0010] Furthermore, in step (3), the homogenization conditions are: homogenize at 12000 rpm for 2-4 min; refrigerate at 1-4℃ for 30-50 min; and control the room temperature at 20-30℃.

[0011] Furthermore, in step (4), the volume ratio of sodium tripolyphosphate (TPP) aqueous solution to the mixed solution is 1:5-7.

[0012] Furthermore, in step (5), the ultrasound is performed at 40°C for 30 minutes and centrifuged at 4000 rpm for 5 minutes.

[0013] The above-described composition is used in the preparation of formulations for treating oral ulcers.

[0014] The above-described compositions are used in the preparation of preparations that inhibit Candida albicans and / or Escherichia coli.

[0015] Furthermore, the preparation is a topical preparation.

[0016] Furthermore, the topical preparations are patches, ointments, creams, gels, pastes, and / or liniments.

[0017] A patch for treating oral ulcers, comprising the composition described above.

[0018] The beneficial effects of this invention are:

[0019] This invention uses natural starch extracted from bananas as the main raw material. Pickering emulsion is prepared by modifying its hydrophobicity. Extracts from dandelion, dried tangerine peel, and lychee peel, as well as lotus leaf extract, are then added to produce banana starch Janus granules. These granules significantly inhibit the growth of Candida albicans and Escherichia coli, which cause oral ulcers, and have a significant therapeutic effect on oral ulcers. In this invention, banana starch has the advantages of being renewable, biocompatible, and biodegradable, making it suitable for green applications and cost-effective. Janus granules prepared from banana starch have no side effects and do not cause allergic reactions. Their safety is significantly improved when used to treat oral ulcers, and they can be used as a readily available medication for recurrent oral ulcers. Detailed Implementation

[0020] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0021] In the following embodiments, the method for preparing banana starch includes the following steps: Take green bananas (6-7 ripe, with a completely green peel, firm flesh, and not yet softened), wash and slice them, then soak them in a 0.3-0.5% citric acid solution for 3-5 minutes. After soaking, blend them together with the citric acid solution into a pulp. Add pectinase and cellulase to the pulp and enzymatically hydrolyze it at 35-40℃ for 1-2 hours. Filter to remove the precipitate, adjust the pH to 4-6, centrifuge, collect the lower layer, add water and centrifuge again, collect the lower layer, and freeze-dry under vacuum to obtain banana starch. The method for preparing the lotus leaf extract includes the following steps: Take fresh lotus leaves, wash them, add water equal to the weight of the lotus leaves and pulp them, filter and collect the filtrate. Add water equal to the weight of the lotus leaves to the residue and filter again. Combine the filtrates, add an equal volume of anhydrous ethanol to the filtrate and stir thoroughly. Let stand at 4°C for 24 hours, take the supernatant and freeze-dry to obtain lotus leaf extract. Example 1

[0022] An oral ulcer composition of banana starch Janus granules comprises the following components in parts by weight: 10 parts banana starch, 5 parts lotus leaf extract, 15 parts dandelion, 10 parts dried tangerine peel, 13 parts litchi peel, 1 part octenyl succinic anhydride, and 30 parts long-chain fatty acids.

[0023] An oral ulcer composition for use with banana starch Janus granules, the preparation method of which includes the following steps: (1) Dandelion and dried tangerine peel were boiled in water for 20 minutes, filtered to obtain filtrate, and dried to obtain extract one; litchi peel was crushed and soaked in 95% ethanol, and the filtrate was removed at 40°C to obtain extract two; dandelion and dried tangerine peel were boiled in water at 5 times their total weight for 20 minutes; 95% ethanol was added at 5 times the weight of litchi peel and soaked for 30 minutes.

[0024] (2) After mixing banana starch with deionized water, a starch emulsion with a mass concentration of 20% was obtained. Octenyl succinic anhydride of 0.3% by weight of banana starch was added to the starch emulsion. Sodium hydroxide was added to adjust the pH to 7-9. The mixture was stirred for 0.5 hours and then kept at 30°C for 2.5 hours. After the reaction was completed, the mixture was filtered, and the precipitate was washed repeatedly with deionized water 3 times. The product was dried at 40°C and pulverized to obtain hydrophobically modified starch granules.

[0025] (3) Add hydrophobic modified starch granules and long-chain fatty acids to water, mix the three evenly, and then homogenize into an emulsion. After homogenization, the emulsion is first refrigerated and then taken out and placed at room temperature to stabilize to obtain Pickering emulsion. The long-chain fatty acid is lauric acid or myristic acid. The homogenization conditions are: homogenize at 12000 rpm for 2 min; refrigerate at 1℃ for 30 min; and control the room temperature at 20℃.

[0026] (4) Dissolve extract one, extract two and lotus leaf extract in acetic acid aqueous solution to form a mixed solution with a mass concentration of 1 mg / mL. Adjust the pH value to 4.5-5 and stir continuously for 3 h. After removing the residue of insoluble particles with a filter membrane with a pore size of 0.45 µm, preheat at 50 °C for 15 min. Add 0.5 mg / mL sodium tripolyphosphate (TPP) aqueous solution under stirring at 700 rpm and react for 20 min to obtain a mixed dispersion. The volume ratio of sodium tripolyphosphate (TPP) aqueous solution to mixed solution is 1:5.

[0027] (5) Add the mixed dispersion to the Pickering emulsion obtained in step (4) at a volume ratio of 1:1 and react for 20 min to obtain a mixed system of the two. Remove the excess chitosan nanoparticle dispersion, add deionized water and perform ultrasonic treatment at 40℃ for 30 min, centrifuge at 4000 rpm for 5 min, remove the supernatant, repeat centrifugation twice to obtain the composition. Example 2

[0028] An oral ulcer composition of banana starch Janus granules comprises the following components in parts by weight: 20 parts banana starch, 10 parts lotus leaf extract, 25 parts dandelion, 15 parts dried tangerine peel, 17 parts litchi peel, 4 parts octenyl succinic anhydride, and 100 parts long-chain fatty acids.

[0029] (1) Dandelion and dried tangerine peel were boiled in water for 25 minutes, filtered to obtain filtrate, and dried to obtain extract one; litchi peel was crushed and soaked in 95% ethanol, and the ethanol was removed from the filtrate at 45°C to obtain extract two; dandelion and dried tangerine peel were boiled in water with a total weight of 6 times for 25 minutes; the amount of 95% ethanol added was 6 times the weight of litchi peel, and soaked for 50 minutes.

[0030] (2) After mixing banana starch with deionized water, a starch emulsion with a mass concentration of 20% is obtained. Octenyl succinic anhydride of 0.3% by weight of banana starch is added to the starch emulsion. Sodium hydroxide is added to adjust the pH to 7-9. The mixture is stirred for 1 hour and then kept at 40℃ for 3 hours. After the reaction is completed, the mixture is filtered, and the precipitate is washed repeatedly with deionized water 3-4 times. The product is dried at 40-50℃ and then pulverized to obtain hydrophobically modified starch granules.

[0031] (3) Add hydrophobic modified starch granules and long-chain fatty acids to water, mix them evenly, and then homogenize them into an emulsion. After homogenization, the emulsion is first refrigerated and then taken out and placed at room temperature to stabilize it to obtain Pickering emulsion. The long-chain fatty acid is lauric acid or myristic acid. The homogenization conditions are: homogenize at 12000 rpm for 3 min; refrigerate at 3℃ for 40 min; and control the room temperature at 25℃.

[0032] (4) Dissolve extract one, extract two and lotus leaf extract in acetic acid aqueous solution to form a mixed solution with a mass concentration of 1 mg / mL. Adjust the pH value to 4.5-5 and stir continuously for 4 h. After removing the residue of insoluble particles with a filter membrane with a pore size of 0.45 µm, preheat at 50 °C for 15 min. Add 0.5 mg / mL sodium tripolyphosphate (TPP) aqueous solution under stirring at 700 rpm and react for 25 min to obtain a mixed dispersion. The volume ratio of sodium tripolyphosphate (TPP) aqueous solution to mixed solution is 1:6.

[0033] (5) Add the mixed dispersion to the Pickering emulsion obtained in step (4) at a volume ratio of 1:1 and react for 20 min to obtain a mixed system of the two. Remove the excess chitosan nanoparticle dispersion, add deionized water and perform ultrasonic treatment at 40℃ for 30 min, centrifuge at 4000 rpm for 5 min, remove the supernatant, repeat centrifugation 3 times to obtain the composition. Example 3

[0034] An oral ulcer composition of banana starch Janus granules comprises the following components in parts by weight: 15 parts banana starch, 7 parts lotus leaf extract, 20 parts dandelion, 12 parts dried tangerine peel, 15 parts litchi peel, 3 parts octenyl succinic anhydride, and 50 parts long-chain fatty acids.

[0035] (1) Dandelion and dried tangerine peel were boiled in water for 30 minutes, filtered to obtain filtrate, and dried to obtain extract one; litchi peel was crushed and soaked in 95% ethanol, and the filtrate was removed at 50°C to obtain extract two; dandelion and dried tangerine peel were boiled in water with a total weight of 8 times for 30 minutes; the amount of 95% ethanol added was 6 times the weight of litchi peel, and soaked for 60 minutes.

[0036] (2) After mixing banana starch with deionized water, a starch emulsion with a mass concentration of 20% was obtained. Octenyl succinic anhydride of 0.3% by weight of banana starch was added to the starch emulsion. Sodium hydroxide was added to adjust the pH to 7-9. The mixture was stirred for 1 hour and then kept at 45°C for 2.5 hours. After the reaction was completed, the mixture was filtered, and the precipitate was washed repeatedly with deionized water 4 times. The product was dried at 50°C and pulverized to obtain hydrophobically modified starch granules.

[0037] (3) Add hydrophobic modified starch granules and long-chain fatty acids to water, mix the three together evenly, and then homogenize into an emulsion. After homogenization, the emulsion is first refrigerated and then taken out and placed at room temperature to stabilize to obtain Pickering emulsion. The long-chain fatty acid is lauric acid or myristic acid. The homogenization conditions are: homogenize at 12000 rpm for 4 min; refrigerate at 4℃ for 50 min; and control the room temperature at 30℃.

[0038] (4) Dissolve extract one, extract two and lotus leaf extract in acetic acid aqueous solution to form a mixed solution with a mass concentration of 1 mg / mL. Adjust the pH value to 4.5-5 and stir continuously for 5 h. After removing the residue of insoluble particles with a filter membrane with a pore size of 0.45 µm, preheat at 50 °C for 15 min. Add 0.5 mg / mL sodium tripolyphosphate (TPP) aqueous solution under stirring at 700 rpm and react for 30 min to obtain a mixed dispersion. The volume ratio of sodium tripolyphosphate (TPP) aqueous solution to mixed solution is 1:7.

[0039] (5) Add the mixed dispersion to the Pickering emulsion obtained in step (4) at a volume ratio of 1:1 and react for 20 min to obtain a mixed system of the two. Remove the excess chitosan nanoparticle dispersion, add deionized water and perform ultrasonic treatment at 40℃ for 30 min, centrifuge at 4000 rpm for 5 min, remove the supernatant, repeat centrifugation 3 times to obtain the composition.

[0040] The above-described composition can be used to prepare formulations for treating oral ulcers. These formulations can be various topical preparations such as patches, ointments, creams, gels, pastes, and liniments. This invention does not impose any specific limitations. Example 4

[0041] A patch for treating oral ulcers, comprising the preparation of any one of Examples 1-3. During patch preparation, the composition described in this invention can be directly applied to the drug-carrying layer of the patch. In use, the drug-carrying layer is simply placed firmly against the oral ulcer. The drug-carrying layer can be made of pharmaceutically common materials, such as non-woven fabric, absorbent cotton, polyester fiber, etc.

[0042] The composition of this invention exhibits inhibitory activity against oral ulcer pathogens. Using Candida albicans and Escherichia coli as test strains, the differences in inhibitory activity against oral ulcer pathogens were compared between compositions prepared by different methods.

[0043] Experimental methods for Escherichia coli: Escherichia coli ( Escherichia coli (ATCC 11229) was inoculated onto broth medium and incubated at 37°C for 8-12 hours, then diluted with sterile broth to a concentration of 10. -3 The concentration was determined, and then 0.1 mL of the diluted bacterial solution was transferred to a broth agar plate and spread evenly. Sterile filter paper discs (5 mm in diameter) were placed on the center of the culture medium surface, and 0.03 mL of each sample was added to the filter paper disc. The plates were then covered and incubated at 37°C for 24 hours. The results were observed, and the diameter of the inhibition zone was recorded. An equal volume of distilled water was added as a control. Five replicates were set up for each group.

[0044] Candida albicans experimental method: Candida albicans ( Candida albicans The slant culture of ATCC MYA-2876 was washed off with sterile PBS, and the concentration of the bacterial suspension was adjusted to approximately 3.8 × 10⁻⁶. 8 CFU / mL, then diluted to approximately 3.8 × 10⁻⁶. 5 CFU / mL. Pour Sabouraud dextrose agar (SDA) cooled to 60°C into a petri dish and allow it to solidify horizontally. Inoculate 0.1 mL of the diluted bacterial suspension onto the surface of the medium and spread evenly. Place sterile filter paper discs (5 mm in diameter) at the center of the medium surface, and then add 0.03 mL of each sample onto the filter paper disc. Cover the petri dish and incubate at 28±2°C for 48 hours. Measure the diameter of the inhibition zone. Use an equal volume of distilled water as a control. Perform triplicate for each sample.

[0045] Inhibition rate (%) = (Diameter of inhibition zone of test sample - Diameter of inhibition zone of control) / Diameter of inhibition zone of test sample × 100 Table 1 Composition and preparation method of each test sample Serial Number Composition and preparation method of the composition Example 1 The composition prepared in Example 1 Example 2 The composition obtained in Example 2 Example 3 The composition obtained in Example 3 Comparative Example 1 Remove dandelion from the components; the remaining operations are the same as in Example 3. Comparative Example 2 Remove the dried tangerine peel from the ingredients; the remaining operations are the same as in Example 3. Comparative Example 3 Remove lotus leaf extract from the components; the remaining operations are the same as in Example 3. Comparative Example 4 The composition ratio is the same as in Example 3, except that lychee peel, dandelion, and dried tangerine peel are added simultaneously and decocted to obtain the extract. Comparative Example 5 The composition ratio is the same as in Example 3, except that the weight of lotus leaves required for preparing lotus leaf extract is added simultaneously with dandelion and dried tangerine peel for decoction to obtain the extract. Table 2 Comparison of antibacterial activities of each test sample Serial Number Escherichia coli inhibition rate (%) Candida albicans inhibition rate (%) Example 1 88.35 93.87 Example 2 89.56 92.69 Example 3 89.71 93.70 Comparative Example 1 64.29 56.73 Comparative Example 2 55.33 62.25 Comparative Example 3 57.64 63.07 Comparative Example 4 60.32 59.18 Comparative Example 5 46.02 62.37 As can be seen from Table 2, the combinations prepared in the three embodiments of the present invention significantly improved the antibacterial activity against Escherichia coli and Candida albicans, which was significantly higher than that of the five comparative examples.

[0046] Patients with oral ulcers aged 20-40 years were randomly selected as experimental subjects and divided into groups of 10. Sterile non-woven fabric sheets with a side length of 5 mm were immersed in the compositions prepared in Examples 1-3 and Comparative Examples 1-5 for 10 minutes, then applied to the affected area. A commercially available oral ulcer patch (dexamethasone acetate oral patch) served as the control group. The condition of the oral ulcer wounds was observed daily, and the healing time was recorded (average value). Recording continued for 3 months after healing. If oral ulcers recurred, the corresponding patch was used again. The number of patients and the frequency of recurrence in each group within 3 months were counted, and the average number of recurrences in each group was calculated. The results are shown in Table 3.

[0047] Average number of relapses (per person) = Total number of relapses per group / Number of people experiencing relapses Table 3 Comparison of the therapeutic effects of different patches on oral ulcers Serial Number Number of participants (persons) Recovery time (days) Number of relapses (people) Average number of relapses per person Example 1 10 4.1 3 1.0 Example 2 10 3.9 2 1.0 Example 3 10 4.2 2 1.0 Comparative Example 1 10 5.5 4 2.0 Comparative Example 2 10 5.8 5 2.4 Comparative Example 3 10 5.8 3 2.3 Comparative Example 4 10 5.9 4 2.2 Comparative Example 5 10 6.4 6 2.5 control group 10 4.5 4 1.75 As can be seen from the statistical data in Table 3, the healing time of the patches prepared in the three embodiments of the present invention is 3.9-4.2 days, slightly longer than the 4.5 days of the control group, indicating that the oral ulcer patch of the present invention has a significant therapeutic effect on oral ulcers, and the therapeutic effect is relatively stable. The healing time in Comparative Examples 1-5 is prolonged to varying degrees, indicating that the components and preparation methods of the patches prepared in the three embodiments of the present invention can produce a synergistic effect, significantly improving the therapeutic effect. Comparative Examples 1-5 changed the composition of the materials or the preparation method, and the therapeutic effect on oral ulcers in these examples did not reach the level of the three embodiments.

[0048] The number of recurrences was statistically analyzed. The number of recurrences in the three examples was not only lower than the control group to varying degrees, but also lower than comparative examples 1-5. Comparative example 5 had the highest number of recurrences, followed by comparative example 2, which was significantly higher than the three examples. The other comparative examples were slightly higher than the three examples. However, the average number of recurrences was significantly higher in all five comparative examples, not only significantly higher than the three examples but also higher than the control group. This indicates that the present invention, which can reduce the recurrence of oral ulcers, has varying degrees of effectiveness compared to the control group and the five comparative examples.

[0049] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for oral ulcers made from banana starch Janus granules, characterized in that, It includes the following components in parts by weight: 10-20 parts banana starch, 5-10 parts lotus leaf extract, 15-25 parts dandelion, 10-15 parts dried tangerine peel, 13-17 parts lychee peel, 1-4 parts octenyl succinic anhydride, and 30-100 parts long-chain fatty acids.

2. The oral ulcer composition of banana starch Janus granules as described in claim 1, characterized in that, The product contains the following components in parts by weight: 15 parts banana starch, 7 parts lotus leaf extract, 20 parts dandelion, 12 parts dried tangerine peel, 15 parts lychee peel, 3 parts octenyl succinic anhydride, and 50 parts long-chain fatty acids.

3. The oral ulcer composition of banana starch Janus granules as described in claim 1, characterized in that, The long-chain fatty acid mentioned is lauric acid or myristic acid.

4. The oral ulcer composition of banana starch Janus granules as described in claim 1, characterized in that, The method for preparing banana starch includes the following steps: After washing and slicing green bananas, soak them in a 0.3-0.5% citric acid solution for 3-5 minutes. Then blend them together with the citric acid solution into a slurry. Add pectinase and cellulase to the slurry and enzymatically hydrolyze it at 35-40℃ for 1-2 hours. Filter to remove the precipitate, adjust the pH to 4-6, centrifuge, take the lower layer, add water and centrifuge again, take the lower layer, and freeze-dry it under vacuum to obtain banana starch. The method for preparing the lotus leaf extract includes the following steps: Take fresh lotus leaves, wash them, add water equal to the weight of the lotus leaves and pulp them, filter and collect the filtrate. Add water equal to the weight of the lotus leaves to the residue and filter again. Combine the filtrates, add an equal volume of anhydrous ethanol to the filtrate and stir thoroughly. Let it stand at 4°C for 24 hours, and freeze-dry the supernatant to obtain lotus leaf extract.

5. A method for preparing an oral ulcer composition of banana starch Janus granules as described in claim 1 or 2, characterized in that, Includes the following steps: (1) Dandelion and dried tangerine peel are boiled in water for 20-30 minutes, filtered to obtain filtrate, and dried to obtain extract one; litchi peel is crushed and soaked in 95% ethanol, and the ethanol is removed from the filtrate at 40-50℃ to obtain extract two. (2) Banana starch and deionized water were mixed to obtain a starch emulsion. Octenyl succinic anhydride was added to the starch emulsion, and sodium hydroxide was added to adjust the pH to 7-9. The reaction was stirred and filtered after the reaction was completed. The precipitate was washed and dried. The dried product was pulverized to obtain hydrophobically modified starch granules. (3) Add hydrophobic modified starch granules and long-chain fatty acids to water, mix the three together evenly, and then homogenize them into an emulsion. After homogenization, the emulsion is first refrigerated and then taken out and placed at room temperature to stabilize it to obtain Pickering emulsion. (4) Dissolve extract one, extract two and lotus leaf extract in acetic acid aqueous solution to form a mixed solution with a mass concentration of 1 mg / mL. Adjust the pH value to 4.5-5 and stir continuously for 3-5 h. After removing the residue of insoluble particles with a filter membrane with a pore size of 0.45µm, preheat at 50℃ for 15 min. Add 0.5 mg / mL sodium tripolyphosphate (TPP) aqueous solution under stirring at 700 rpm and react for 20-30 min to obtain a mixed dispersion. (5) Add the mixed dispersion to the Pickering emulsion obtained in step (4) at a volume ratio of 1:1 and react for 20 minutes to obtain a mixed system of the two. Remove the excess chitosan nanoparticle dispersion, add deionized water and perform ultrasonic and centrifugation treatment in sequence, remove the supernatant, and repeat centrifugation 2-3 times to obtain the composition.

6. The preparation method according to claim 5, characterized in that, In step (1), dandelion and dried tangerine peel are decocted in 5-8 times their total weight of water for 20-30 minutes; 95% ethanol is added in an amount of 5-6 times the weight of lychee peel and soaked for 30-60 minutes. In step (2), banana starch is added to deionized water to obtain a starch emulsion with a mass concentration of 20%. Octenyl succinic anhydride of 0.3% by weight of banana starch is added to the starch emulsion. The stirring reaction conditions are: stirring for 0.5-1 hour, reacting in a water bath at 30-45℃ for 2.5-3 hours; the precipitate is washed repeatedly with deionized water 3-4 times and then dried at 40-50℃. In step (3), the homogenization conditions are: homogenize at 12000 rpm for 2-4 min; refrigerate at 1-4℃ for 30-50 min; and control the room temperature at 20-30℃. In step (4), the volume ratio of sodium tripolyphosphate (TPP) aqueous solution to the mixed solution is 1:5-7; In step (5), the ultrasound is performed at 40°C for 30 minutes and centrifuged at 4000 rpm for 5 minutes.

7. Use of the composition according to any one of claims 1-4 in the preparation of formulations for treating oral ulcers, inhibiting Candida albicans and / or inhibiting Escherichia coli.

8. The application as described in claim 7, characterized in that, The preparation described is for external use.

9. The application as described in claim 8, characterized in that, The aforementioned topical preparations are patches, ointments, creams, gels, pastes, and / or liniments.

10. A patch for treating oral ulcers, characterized in that, Includes the compositions described above.