7 results about "Hyperforin" patented technology

The application discloses application of an active ingredient hypericin in Hypericum perforatum in preparation of anti-migraine drugs, relates to the technical field of medicines, and identifies the active ingredient hypericin that can enter the brain from Hypericum perforatum extract, further combines BV2 cell in-vitro anti-inflammatory experiments, and analyzes blood rheology indexes of cerebral blood vessels and blood stasis changes after drug administration of rats, and confirms that the hypericin has good anti-migraine effect. The application provides definite experimental basis for the application of the active ingredient in anti-migraine drugs.

The invention belongs to the technical field of natural anti-corrosion materials, and provides a natural anti-corrosion composition containing cinnamon bark extract and a preparation method and application of the natural anti-corrosion composition. The natural preservative composition provided by the invention comprises a cinnamon bark extract and a synergistic compound, the synergistic compound comprises a mangnolia officinalis bark extract, a perilla leaf extract, a rhizoma atractylodis root extract, a folium artemisiae argyi extract, a wrinkled gianthyssop herb extract, a radix ophiopogonis root extract, a pomegranate seed extract, a pomelo extract, a thyme leaf extract, a calendula extract, a hyperforin perforatum extract, a melaleuca alternifolia leaf extract, a ginger root extract and an eucalyptus globulus leaf extract; the mass content of cinnamyl aldehyde in the cinnamon bark extract is less than or equal to 20wt%, and the antibacterial composition has the advantages of broad-spectrum bacteriostasis, high stability, difficulty in discoloration and precipitation, acid and alkali resistance, high temperature resistance, safety and small irritation. The antibacterial composition is prepared from at least one of a ginseng root extract, a rosemary leaf extract, a papaya fruit extract, a chamomile flower extract, a soybean seed extract and a wheat bran extract, and the mass content of cinnamyl aldehyde in the cinnamon bark extract is less than or equal to 20wt%.

The invention belongs to the field of daily chemicals, and discloses an oil-control soothing composition which comprises the following components in parts by weight: 0.5-5 parts of a yeast / zinc fermentation product; 0.5-5 parts by weight of a lactobacillus fermentation lysate; 0.5 to 5 parts by weight of dipeptide-15; 0.1-10 parts by weight of a flower / leaf / stem extract of hyperforin perforatum; and 0.5-5 parts by weight of an olive leaf extract. The composition adopts a yeast / zinc fermentation product, a lactobacillus fermentation lysate, dipeptide-15, a hyperforin perforatum flower / leaf / stem extract and an olive leaf extract to control oil from multiple angles, a good oil control effect is achieved, and meanwhile, the formula of the composition also has a relatively good soothing performance. Meanwhile, the invention further discloses application of the composition and cosmetics.

The invention relates to the technical field of traditional Chinese medicine composition preparation and application, and particularly discloses a traditional Chinese medicine composition for treating ulcerative colitis and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials: hyperforin perforatum, myristica fragrans, codonopsis pilosula nnannf, herba patriniae, semen cuscutae, vinegar schisandra chinensis, roasted rhizoma atractylodis macrocephalae, carbonized sanguisorba root, fructus evodiae, radix curcumae, radix paeoniae alba, rhizoma zingiberis, smoked plum, radix aucklandiae, coptis chinensis and liquorice. The traditional Chinese medicine raw material composition and dosage compatibility of the traditional Chinese medicine composition conform to the traditional Chinese medicine differentiation theory, the levels of IL-1beta, IL-6 and TNF-alpha in DAI and serum of chronic ulcerative colitis rats can be effectively reduced, Claudin-1, ZO-1 and Occludin protein expression is remarkably improved, the effect of relieving intestinal inflammation is achieved, and the traditional Chinese medicine composition can be used for preparing medicine for treating ulcerative colitis.

The invention provides a novel preparation method and application of hyperforin. According to the invention, all metabolism genes in the biosynthesis process of hypericin are analyzed for the first time in the field. The analysis process is pioneering work and comprises discovery of the gene and the enzyme coded by the gene, functional demonstration and analysis of the hyperforin produced by using yeast and tobacco as biological chassis. The invention lays a foundation for industrial production of the hypericin and the intermediate thereof.

The application belongs to the technical field of medicines, and particularly relates to application of hyperforin in preparation of medicines for treating inflammatory bowel disease, and proves that hyperforin treatment can increase the colon length of a DSS-induced mouse colitis model, improve the pathological structure and clinical symptoms of the colon tissue of the model mouse, and significantly up-regulate ZO-1 protein and improve the levels of related inflammatory factors such as TNF-alpha, IL-6 and IL-1beta, and has significant anti-ulcerative colitis activity, and the hyperforin can provide a new approach for preparing medicines for treating ulcerative colitis in the future.

The invention belongs to the technical field of medicines, and discloses hypericum perforatum isopentenyl transferase and application thereof. In particular to novel isopentenyl transferase, a nucleic acid sequence for coding the transferase, an expression vector and a recombinant cell for producing the transferase, and further relates to application of the isopentenyl transferase in preparation of a hypericin biosynthesis precursor.