31 results about "Sodium propionate" patented technology

The present invention relates to a method for treating a bacterial infection by using Paracoccus wg1 T The invention relates to a method for treating wastewater containing high concentration of inorganic nitrogen, which belongs to the technical field of waste resource utilization and water environment treatment. T The seed liquid after culture is used to treat nitrogen-containing wastewater, and the Paracoccus wg1 of the present invention T , has a very high tolerance to high concentrations of inorganic nitrogen, and has excellent denitrification capabilities under conditions of high concentrations of inorganic nitrogen. Specifically, sodium nitrate is used as the nitrogen source, sodium propionate is used as the carbon source, NO3 ‑ When the ‑N concentration is 6258.85 mg / L‑N, 97.68 mg / L‑N of NO3 can be degraded in 48 hours ‑ -N; ammonium sulfate as nitrogen source, sodium propionate as carbon source, NH4 + When the ‑N concentration is 9326.28 mg / L‑N, 92.28 mg / L‑N of NH4 can be degraded in 48 hours + ‑N. paracoccus wg1 T Biological denitrification treatment of high-concentration inorganic nitrogen wastewater has great application prospects.

The invention provides a method for reversibly regulating and controlling the water solubility of long-chain alkyl trimethyl ammonium bromide, which comprises the following steps of: mixing sodium benzyl selenopropionate serving as an auxiliary agent with long-chain alkyl trimethyl ammonium bromide, adding water for dissolving, reducing the Krafft temperature of the long-chain alkyl trimethyl ammonium bromide to 10 DEG C or below, and then adding sodium benzyl selenopropionate, according to the method, benzyl selenium sodium propionate is oxidized into benzyl selenium oxygen sodium propionate by adding an oxidizing agent, so that the KT of long-chain alkyl trimethyl ammonium bromide is increased, and the water solubility of the long-chain alkyl trimethyl ammonium bromide is reduced, so that the long-chain alkyl trimethyl ammonium bromide is crystallized and separated out from an aqueous solution, and the separation, recovery and reutilization of the long-chain alkyl trimethyl ammonium bromide are realized; the residual water phase solution after the long-chain alkyl trimethyl ammonium bromide is recovered can be used as the plant leaf selenium fertilizer.

The invention relates to a sodium propionate-containing hydrate inhibitor for guaranteeing flow of a carbon dioxide conveying pipeline, which comprises sodium propionate, glycine, polyvinyl pyrrolidone and methanol, and the sodium propionate, the glycine, the polyvinyl pyrrolidone and the methanol are mixed with a sodium chloride solution serving as a solvent, so that the sodium propionate, the glycine, the polyvinyl pyrrolidone and the methanol are mixed according to the molar percentage as follows: 1-15 mol% of the sodium propionate, 1-15 mol% of the glycine, 0.1-1 mol% of the polyvinyl pyrrolidone and 5-60 mol% of the methanol. The sodium propionate, the glycine, the polyvinyl pyrrolidone and the methanol are compounded for use, so that the effect of a single inhibitor is enhanced, the application range is wider, a better inhibition effect is achieved at a lower concentration, and the generation of carbon dioxide hydrate can be better inhibited. The mixed use reduces the cost of the inhibitor, reduces the use amount of the mixture, and weakens the toxicity and pollution of the inhibitor.

The invention discloses a synthesis, separation and purification method of N-alkyl-beta-aminopropionate, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: sequentially carrying out addition reaction and saponification reaction on long-chain fatty amine and an acrylate compound to obtain saponification reaction liquid; adjusting the temperature of the saponification reaction solution to 55-70 DEG C, adding water, adjusting the pH value to 3.0-5.0 by using an acid solution, fully stirring, standing for layering, separating out an upper organic layer while the solution is hot, continuously adjusting the pH value of the organic layer to 0.5-1.5 by using the acid solution, cooling to realize layering, separating out an upper product, and neutralizing by using an alkali solution to obtain the N-alkyl-beta-aminopropionate. The method has the advantages of simple operation, short flow, high product separation recovery rate and high purity, can reduce the production cost of the N-alkyl-beta-amino sodium propionate, and meets the industrial production.

A process for producing a nitrogen-doped peony-shaped molybdenum oxide, comprising the following steps: (1) adding a regulator to a molybdenum-containing solution for reacting, concentrating and thermally treating to obtain a peony-shaped molybdenum oxide; and (2) dissolving the peony-shaped molybdenum oxide in a conditioning agent and adding an amine source for standing, centrifuging, washing, and heat-treating, thereby obtaining the nitrogen-doped peony-shaped molybdenum oxide; wherein the regulator is at least one of the following: nitric acid, ammonium nitrate, sodium persulfate, ammonium persulfate, concentrated sulfuric acid, H2O2, ozone, sodium hypochlorite, wherein in step (2), the conditioning agent is at least one of the following: sodium acetate, ammonium acetate, sodium formate, diaminoethane, sodium oxalate, ammonium benzoate, sodium phenylacetate, sodium propionate, sodium tartrate, sodium citrate, ammonium citrate; and wherein in step (2) the amine source is at least one of the following: aniline, dimethylamine, trimethylamine, benzylamine, phenethylamine, ethylamine, diethylamine, propylamine, phenylenediamine, xylylenediamine, amphetamine.

The application discloses a method for synthesizing N-alkyl-beta-amino propionic acid sodium from alkyl amine and 3-halogenated propionic acid ester, and belongs to the technical field of organic synthesis. Long-chain fatty amine and an alkali catalyst are dissolved in a solvent to form a uniform solution, then 3-halogenated propionic acid ester is slowly added dropwise in the solution to perform a substitution reaction, after the completion of the substitution reaction, a sodium hydroxide solution is added to perform a hydrolysis reaction, and thus N-alkyl-beta-amino propionic acid sodium is obtained. The method has the characteristics of simple operation, mild conditions, easy separation of the product, high yield and the like.

The application provides a synergistic promoter suitable for SNCR denitration and application thereof, the synergistic promoter comprises the following components in parts by weight: 2-80 parts of an activator, the activator is selected from at least one of sodium glycinate, sodium glutamate, sodium iminodiacetate, sodium aspartate, sodium aminopropionate, sodium aspartate and potassium aspartate; 3-12 parts of a catalyst, the catalyst is selected from a soluble heteropoly acid; 1-10 parts of a catalytic aid; the catalytic aid is selected from at least one of a soluble tungstate and a molybdate. A trace amount of the synergistic promoter is added in a commonly used SNCR denitration solution, the reaction speed of NO x with a reducing agent such as ammonia or urea can be accelerated, the temperature window of SNCR reaction is moved downwards, the application range of traditional SNCR technology is expanded, the removal efficiency of NO x is improved, and a low-cost and high-efficiency method is provided for nitrogen oxide pollution treatment in waste gas.

The application relates to a sodium propionate hydrate inhibitor containing sodium propionate for carbon dioxide conveying pipeline flow guarantee, which comprises sodium propionate, glycine, polyvinyl pyrrolidone and methanol, and the molar percentage of the four after being mixed with a sodium chloride solution as a solvent is as follows: 1-15mol% of sodium propionate, 1-15mol% of glycine, 0.1-1mol% of polyvinyl pyrrolidone and 5-60mol% of methanol. In the application, the composite use of sodium propionate, glycine, polyvinyl pyrrolidone and methanol enhances the effect of a single inhibitor, the use range is more extensive, better inhibiting effect can be achieved at a lower concentration, and the generation of carbon dioxide hydrate can be better inhibited. The mixed use reduces the cost of the inhibitor, reduces the use amount of the mixture and weakens the toxicity and pollution of the inhibitor.

The present invention relates to a fermentationally produced propionate powder comprising: 25 wt.% to 60 wt.% of propionic acid equivalents; 3 wt.% to 16 wt.% of an acetic acid equivalent; 2 wt.% to 12 wt.% of a succinic acid equivalent; 0.1 mol to 0.8 mol of a Ca < 2 + > / mol propionate; 0 mol to 1.0 mol of a Na < + > / mol propionate; 0 mol to 1.0 mol of a K < + > / mol propionate; wherein 0.4 < = ([Na +] + [K +]) / [propionate] < = 1.4; 1.1 < = (2 [Ca < 2 + >] + [Na +] + [K +]) / [propionate] < = 2.8; [Ca < 2 + >] represents the concentration of Ca < 2 + > and takes mmol / g powder as a unit; [Na < + >] represents the concentration of Na < + >, and mmol / g powder is taken as a unit; [K < + >] represents the concentration of K < + >, and mmol / g powder is taken as a unit; [propionate] represents the concentration of propionate in mmol / g powder. These fermentationally produced propionate powders are superior to fermentationally produced propionate powders in which the majority of the propionate is composed of calcium, sodium or potassium propionate, in particular in terms of taste, odor and / or flow properties.

The invention discloses a method for detecting raw materials, impurities and products in a methylglycine trisodium diacetate reaction solution. The method comprises the following steps: respectively preparing a lactic acid, iminodiacetic acid, dimer and MGDA mixed standard substance solution, a sodium 2-chloropropionate standard substance solution and a sample solution, determining the solutions by utilizing high performance liquid chromatography, and calculating the contents of iminodiacetic acid, dimer, lactic acid MGDA and 2-chloropropionic acid in the sample solution according to a single-point external standard method; the calculation formula is as follows. The detection method is high in analysis accuracy, can be applied to central control analysis of the MGDA synthesis process, can be used for tracking the reaction process and material balance of the synthesis process for preparing MGDA from 2-chloropropionic acid, and is of great significance to quality control of MGDA.

The application discloses a method and application of sodium propionate for inhibiting Salmonella virulence factors, and comprises the following steps: inoculating Salmonella liquid into modified Martin culture medium for culture to obtain first bacterial liquid; inoculating the first bacterial liquid into new modified Martin culture medium for culture to obtain second bacterial liquid; centrifuging the second bacterial liquid, washing, and diluting by using modified Martin solution to obtain bacterial suspension; culturing the bacterial suspension and sodium propionate under certain conditions to obtain third bacterial liquid; and detecting the expression of virulence factors of Salmonella in the third bacterial liquid. It is found through detection that different concentrations of sodium propionate can significantly reduce the expression of Salmonella virulence factors. The method provided by the application can weaken the infection toxicity of Salmonella, so that the infection and incidence probability of poultry Salmonella can be reduced, and the infection symptoms can be alleviated.

The high-boiling-point low-conductivity ultralow-temperature secondary refrigerant comprises the following components in percentage by mass: 5%-10% of antifreeze protein, 8%-15% of weak conductive salt, 1%-3% of a low-temperature protective agent, 0.15%-2.1% of a pH regulator, 15%-25% of a high-boiling-point aid and the balance of water, the weak conductive salt is sodium acetate and sodium propionate; the low-temperature protective agent is a trehalose or protease inhibitor; the pH regulator is composed of citric acid and sodium hydroxide; the high-boiling-point auxiliary agent is ethylene glycol or propylene glycol. The finally prepared secondary refrigerant is not prone to layering and solidification at the ultralow temperature, higher in stability, capable of avoiding system pressure sudden rise caused by boiling of the secondary refrigerant at the high temperature, low in conductivity, capable of using electricity safely, capable of avoiding the risk of electric leakage, low in corrosion rate and capable of avoiding corrosion loss of a traditional acid / alkaline secondary refrigerant to equipment and prolonging the service life of a system.

The invention discloses a method for preparing sodium 2, 2, 3, 3-tetrafluoropropionate by electrochemical oxidation of 2, 2, 3, 3-tetrafluoropropanol based on a stacked bipolar plate electrolytic bath, the 2, 2, 3, 3-tetrafluoropropanol is electrically oxidized into 2, 2, 3, 3-tetrafluoropropionic acid through the stacked bipolar plate electrolytic bath, the 2, 2, 3, 3-tetrafluoropropionic acid reacts with NaOH in an electrolyte to generate the sodium 2, 2, 3, 3-tetrafluoropropionate, and the sodium 2, 2, 3, 3-tetrafluoropropionate is prepared from the sodium 2, 2, 3, 3-tetrafluoropropionate. In the process, a NiCo-OH / NF electrode and a NiFe-OH / NF electrode are adopted as a catalytic anode and a catalytic cathode, the yield of sodium tetrafluoropropionate can reach 85% or above, the Faraday efficiency exceeds 90%, the process route is simple, the reaction condition is mild, the method can completely replace a low-yield and high-consumption chemical synthesis method, and the potential of large-scale production and application is achieved.

The invention discloses a refining method for preparing high-purity natural benzaldehyde from bitter apricot kernel essential oil, and relates to the technical field of benzaldehyde refining, the bitter apricot kernel essential oil and a sodium propionate-acetic acid buffer solution with the pH value of 5.5 + / -0.2 are hydrolyzed for 30-35 min through an immobilized beta-glucosidase reactor at the flow rate of 0.8-1.2 mL / min and at the temperature of 40 + / -2 DEG C; directly introducing a reactor outlet product into a PDMS membrane permeation unit, and continuously separating benzaldehyde; cooling and condensing the permeation steam through a two-stage condenser, filtering the obtained liquid concentrate through a 0.2 mu m micropore, feeding the filtered liquid concentrate into a solid-phase adsorption column filled with molecular MIP, and eluting with ethanol and water; removing ethanol from the MIP eluent, introducing the MIP eluent into an SMB chromatographic system, and realizing continuous extraction of benzaldehyde with the purity of more than or equal to 99.5% and the yield of more than or equal to 85% by using a water-ethanol mobile phase. According to the method, the immobilized beta-glucosidase is combined with online degassing, so that online efficient hydrolysis of cyanoglycoside and safe degradation of cyanide are realized, the problems that thermal degradation is serious in traditional distillation and cyanide is difficult to remove in conventional extraction are solved, cyanide residues are effectively eliminated, and the product is safe and environment-friendly.

The invention belongs to the technical field of food, and discloses a compound biological preservative antioxidant softener capable of prolonging the shelf life of cakes and application of the compound biological preservative antioxidant softener. The compound biological preservative antioxidant softener comprises the following components in percentage by mass: a part A: 14.58% of sodium propionate, 5.83% of potassium sorbate, 34,99% of mono-and diglycerides of fatty acids, 1.75% of nisin and 0.87% of epsilon-polylysine, and a part B: 14.58% of sodium propionate, 5.83% of potassium sorbate, 34,99% of mono-and diglycerides of fatty acids, 1.75% of nisin and 0.87% of epsilon-polylysine; a part B: propylene glycol (34.99%); and a part C: tea polyphenol (4.66%) and tert-butylhydroquinone (2.33%). When the prepared compound biological preservative antioxidant softener is added into a cake product, the shelf life can be remarkably prolonged, and meanwhile the quality of the cake is remarkably improved.

A particulate composition is disclosed, comprising, calculated by weight of dry matter: (a) 25-85 wt. % of organic acid salt selected from sodium acetate, potassium acetate, sodium lactate, potassium lactate, calcium lactate, sodium propionate, potassium propionate and combinations thereof; (b) 6-40 wt. % of diacetate component selected from sodium diacetate, potassium diacetate and combinations thereof; and (c) 5-30 wt. % of disodium diphosphate; wherein components (a), (b), and (c) together constitute at least 80 wt. % of the dry matter that is contained in the particulate composition. The particulate composition may suitably be applied as a food preservative, e.g. in meat products.

The invention relates to the technical field of chemical industry, and particularly discloses an organic additive for preparing cyclohexene by partial hydrogenation of benzene, the organic additive contains alcohol, alcohol amine, a surfactant and organic alkali; the mass ratio of the active ingredients is (0.01-10): (0.01-10): (0.01-10) Wherein the surfactant is selected from one or more of polyvinylpyrrolidone, a polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer, a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer and alkyl oxyethylene phenol ether; the organic base is one or more of sodium citrate, sodium oxalate, sodium oleate, sodium benzoate and sodium propionate. The organic additive can increase the surface hydrophilicity of the catalyst, is beneficial to desorption of cyclohexene, can prevent the desorbed cyclohexene from being subjected to adsorption hydrogenation again to generate cyclohexane, and improves the yield of cyclohexene.

The invention discloses a nemadectin high-yield fermentation method and a fermentation medium, and belongs to the technical field of microbial fermentation. The fermentation culture medium is characterized in that soybean cake powder hydrolysate is used for replacing yeast extract to serve as a nitrogen source, and 0.05-0.2 g / L choline chloride and 0.01-0.05 g / L sodium molybdate are added into a composite culture medium; according to the fermentation method, two-stage dissolved oxygen control (30% is maintained in 0-48 h and increased to 50% after 48 h) is adopted, and 0.1% of sodium propionate is supplemented in a pulse mode in 72 h of fermentation. The method is mainly used for improving the fermentation titer and purity of nemadectin and reducing the production cost. Compared with a traditional method, the yield is increased by 48.3%, the impurity component A is reduced by 30%, and the nitrogen source cost is reduced by 58%.

The invention provides a preparation method of olivine-type sodium ferric phosphate, olivine-type sodium ferric phosphate and a sodium ion battery, and particularly relates to the technical field of sodium ion secondary batteries. The preparation method comprises the following steps: dissolving sodium propionate and sodium salt, adding olivine type iron phosphate, and grinding to obtain precursor slurry; and carrying out spray drying on the precursor slurry, and sintering at 200-400 DEG C to obtain the olivine type sodium ferric phosphate. In the preparation method provided by the invention, sodium propionate not only serves as a sodium source, but also can promote a kinetic process of a solid-phase reaction, so that purer olivine sodium ferric phosphate is prepared, and the capacity is further improved. And in order to reduce high content of ineffective carbon caused by difficult decomposition of propionate at low temperature, a proper metal oxide precursor needs to be additionally introduced to facilitate effective decomposition of carbonaceous species in the pyrolysis process, and a feasible path is provided for low-cost and large-scale preparation of the high-performance NaFePO4 material.

The humidity-controlling material of the present disclosure has a first humidity-controlling component that absorbs or releases moisture and a water-absorbing body that contains a water-absorbing material, the first humidity-controlling component being sodium propionate. Alternatively, the first humidity-controlling component contains at least one selected from the group consisting of sodium propionate, sodium formate, potassium formate, and potassium acetate.

The invention provides a positive electrode, an electrolyte, a low-temperature adaptive sodium-ion battery and a preparation method of the low-temperature adaptive sodium-ion battery. Sodium salts (sodium saka propionate, sodium cromoglycate, biotin sodium, 1, 2-benzenediol sodium salt and the like) are added to the positive electrode, so that a firm CEI membrane rich in anion components is constructed, and ion transport kinetics on the surface of the positive electrode is optimized; a low-temperature cosolvent is added into the electrolyte, and the weak coordination capability of the low-temperature cosolvent promotes more anions to occupy an internal Na < + > solvent sheath, so that the ion-dipole interaction is reduced, and extremely high ionic conductivity and rapid sodium ion migration can be maintained; a film-forming additive is added into the electrolyte to optimize an electrode interface, improve the stability of a solvent and enhance the overall electrochemical performance of the electrolyte; through the improvement in the three aspects, the internal resistance of the battery in a low-temperature environment is systematically reduced, so that rapid migration of sodium ions in the charging and discharging process is promoted, and the sodium ion battery has excellent low-temperature adaptability.

The invention belongs to the technical field of biological medicine, and particularly relates to application of sodium propionate or pharmaceutically acceptable salt thereof to preparation of a medicine for adjusting a microorganism-intestine-brain axis to treat colon cancer related depression. Sodium propionate regulates a microorganism-intestine-brain axis through three synergistic pathways: GPR41 / FFAR3 is activated to promote GLP-1 and PYY to release and regulate the central emotion function through vagus nerves; hDAC activity is inhibited, histone acetylation is enhanced, BDNF expression is promoted, and proinflammatory factors are inhibited; gPR43 / FFAR2 is activated to promote Treg differentiation and repair intestinal barriers, and experiments show that sodium propionate can improve depression-like behaviors of colon cancer tumor-bearing combined CUMS mice and inhibit tumor growth.

The application provides a positive electrode, an electrolyte and a low-temperature adaptive sodium ion battery and a preparation method thereof. The application adds sodium salt (sodium saccharin, sodium cromoglicate, sodium biotin, 1,2-benzene diol sodium salt, etc.) to the positive electrode, thereby constructing a solid CEI film rich in anion components, optimizing the ion transmission kinetics on the surface of the positive electrode; a low-temperature cosolvent is added to the electrolyte, the weak coordination ability of which promotes more anions to occupy the internal Na + solvent sheath, thereby reducing the ion-dipole interaction and maintaining high ionic conductivity and fast sodium ion migration; a film-forming additive is added to the electrolyte to optimize the electrode interface, improve the stability of the solvent and enhance the overall electrochemical performance of the electrolyte; the three improvements realize systematic reduction of the internal resistance of the battery in a low-temperature environment, so as to promote the fast migration of sodium ions in the charging and discharging process, thereby enabling the sodium ion battery to have excellent low-temperature adaptability.

An antimicrobial solution from white fingerroot-derived silver nanoparticles for medical and general use comprises deionized water, silver nanoparticles extracted from white fingerroot rhizomes, polyvinylpyrrolidone K-30, polyethylene glycol 200, sodium benzoate, glycerin, sodium propionate, HCO40 (Cremophor rh-40), 30% Sodium hydroxide and sodium hyaluronate. The invention applies Thai herbal innovation by chemically synthesizing silver nanoparticles from white fingerroot, producing particles with a size of 20–40 nanometers. These nanoparticles are incorporated into a formulation by mixing them into a solution containing the aforementioned ingredients, resulting in a clear liquid. The concentration is adjusted appropriately for use in cleaning medical instruments and general surfaces. The composition exhibits broad-spectrum antimicrobial activity, capable of eliminating a wide range of microorganisms, including viruses, fungi, common skin bacteria, multidrug-resistant hospital bacteria, anaerobic bacteria, and bacteria found in livestock environments.

The invention discloses a preparation method of homo-2-methyl-4-chloropropionic acid. The preparation method comprises the following steps: S1, reacting to prepare sodium 2-chloropropionate; s2, reacting to prepare sodium p-chloro-o-cresol; s3, dehydrating the sodium chloro-o-cresol; s4, carrying out reaction on sodium 2-chloropropionate and sodium p-chloro-o-cresol; s5, carrying out acidification reaction; s6, cooling and crystallizing; and S7, dissolving with dichloroethane, carrying out water washing separation, and carrying out desolventizing treatment on the solution, thereby obtaining the high-2-methyl-4-chloropropionic acid. The method has the advantages of simple process, mild reaction conditions, less optical loss (less than 1.5%) in the preparation process and high yield, and the prepared product has high purity (the purity is greater than or equal to 96%).

The present invention provides a composition for improving intestinal microbial flora, the composition including: a ginseng extract or a fraction thereof; and sodium propionate. The composition for improving intestinal microbial flora of the present invention can increase the proportion of beneficial bacteria in intestinal microbial flora by promoting the growth of beneficial bacteria while inhibiting the growth of harmful bacteria, and thus, can improve the composition of intestinal microbial flora and maintain the balance thereof, ultimately contributing to improving physical health, for example, by enhancing immunity and improving skin texture.

The invention relates to the field of oilfield chemistry, in particular to a low-loss oilfield blocking remover and a using method thereof. Comprising the following raw materials in parts by weight: 5-30 parts of a modified flaky ferric hydroxide material, 1-10 parts of 3-hydroxy-2-[(phosphono formyl) amino] sodium propionate, 0.5-5 parts of a surface regulating agent, 0.5-3 parts of a slow release regulator, 0.2-2 parts of a pH buffer agent, 0.5-3 parts of a biodegradable stabilizer and 47-92.3 parts of deionized water, and through interface regulation and control and structural stability design, the blockage removal treatment on the reservoir blockage is effectively realized. The system can reduce secondary damage to strata while maintaining a good permeability improvement effect, has excellent viscosity retentivity and mineralized water stability, and is outstanding in emulsification and dispersion performance, and the overall performance shows higher applicability and persistence under complex stratum conditions.

The utility model provides a kind of polyacrylate preparation device with condensation reflux structure, it includes bearing assembly component, raw material containing component, atmosphere adjusting component, raw material stirring component, condensation reflux component, finished product curing component and tilting drive component, the condensation reflux component configured by the preparation equipment is through condensing tube shell and helical conduit structure, realize the efficient condensation and reflux of volatile gas in raw material containing component, not only reduce the emission of harmful gas, also ensure the proportion stability of each component in polyacrylate raw material, avoid the component fluctuation caused by volatilization, to improve the utilization of raw material and the purity and quality of product, atmosphere adjusting component can introduce inert gas, optimize reaction environment, raw material stirring component ensures uniform stirring of raw material, improves reaction efficiency, finished product curing component provides stable curing environment for polyacrylate product, further improves the performance of product.

Disclosed are a sodium phenylamino propionic acid derivative, a preparation method and application thereof. Specifically, disclosed is sodium 3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)-2-((2-(4-(4-(2-sodium carboxylate-2-((2-(4-fluorobenzoyl)phenyl)amino)ethyl)phenoxy)benzoyl)phenyl)amino)propanoate as shown in formula (I), a preparation method thereof and a use thereof for quality control of a raw material or preparation of siglitinide or a derivative thereof. In particular, the compound of formula (I) can be used as a control or standard for impurity / related substance inspection in siglitinide or a sodium salt drug.

The invention discloses a preparation method of 2-methyl-4-chlorobutyric acid. The preparation method comprises the following steps: S1, reacting to prepare sodium 2-chloropropionate; s2, reacting to prepare sodium p-chloro-o-cresol, and dehydrating; s3, carrying out reaction on sodium 2-chloropropionate and sodium p-chloro-o-cresol; s4, carrying out acidification reaction and cooling crystallization; and S5, dissolving dichloroethane, carrying out water washing separation, and carrying out desolventizing treatment on the solution to obtain the 2-methyl-4-chlorobutyric acid. The method has the advantages of simple process, mild reaction conditions, high yield, high product purity (the purity is greater than or equal to 96%), high product quality and low production cost.