Efficient anti-dandruff shampoo and preparation method thereof

Abstract

The invention relates to efficient anti-dandruff shampoo and a preparation method thereof, and belongs to the technical field of shampoo. The efficient anti-dandruff shampoo comprises the following raw materials: 0.7%-1% of a plant extract, 0.04% of asiatic acid, 30%-35% of a humectant, 7%-10% of a surfactant, 18% of sodium propionate, 2%-4% of a thickener, 0.2%-0.3% of an emulsifier, 0.8%-1% of an acidity regulator, 0.05% of tremella polysaccharide, 2%-3% of dextran enzyme, 0.3%-0.5% of a preservative, 2%-3% of a conditioner, 0.5% of isethionate and the balance of deionized water. Three effective components including lophatherum gracile ketone, cacumen biotae extract and cnidium monnieri extract are prepared into microcapsules to be added into the shampoo, the microcapsules are mixed with asiatic acid and an anti-dandruff component isethionate, and through the combined action of all the components, the purpose of effectively removing dandruff is achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of shampoo, and relates to a high - efficiency anti - dandruff shampoo and its preparation method. Background Art

[0002] Dandruff, also known as pityriasis capitis, is a common skin disease. Its characteristic manifestation is scalp peeling accompanied by itching, usually without obvious inflammation. Excessive dandruff can affect personal image and cause psychological pressure. If patients pay too much attention to the problem of dandruff, they may have inferiority complex, and even affect social activities.

[0003] The generation of dandruff is directly related to Malassezia. Malassezia globosa, Malassezia furfur and Malassezia pachydermatis can all encode and secrete a variety of esterases, enabling them to survive and reproduce on human skin by decomposing sebum produced by sebaceous glands. Through the action of esterases, individuals show dandruff - related symptoms on the scalp.

[0004] In order to relieve the problem of excessive dandruff or greasy hair, it is usually necessary to add anti - dandruff and / or oil - control components to shampoo. Therefore, it is particularly important to have a shampoo product that can regulate the scalp micro - ecosystem, balance oil, and the anti - dandruff agent is a plant - derived or natural - source derivative. Summary of the Invention

[0005] The purpose of the present invention is to provide a high - efficiency anti - dandruff shampoo and its preparation method. By making micro - capsules of three active ingredients, namely tenuifolione, Platycladus orientalis leaf extract and Cnidium monnieri extract, and adding them to the shampoo, and mixing them with asiatic acid and the anti - dandruff ingredient hydroxyethylsulfonate, through the combined action of each component, the effect of effectively removing dandruff is achieved.

[0006] The purpose of the present invention can be realized by the following technical solutions:

[0007] A high - efficiency anti - dandruff shampoo, calculated by mass percentage, the high - efficiency anti - dandruff shampoo comprises the following raw materials: 0.7 - 1% of plant extract, 0.04% of asiatic acid, 30 - 35% of humectant, 7 - 10% of surfactant, 18% of sodium propionate, 2 - 4% of thickener, 0.2 - 0.3% of emulsifier, 0.8 - 1% of acidity regulator, 0.05% of tremella polysaccharide, 2 - 3% of dextranase, 0.3 - 0.5% of preservative, 2 - 3% of conditioner, 0.5% of hydroxyethylsulfonate, and the rest is deionized water;

[0008] Wherein the plant extract exists in the shampoo in the form of micro - capsules, using tenuifolione, Platycladus orientalis leaf extract, Cnidium monnieri extract treated with mussel protein and sorbitol as the core material, and sodium alginate modified by phosphorylated Dendrobium officinale polysaccharide as the wall material.

[0009] As a preferred technical solution of the present invention, the moisturizer is taurine, betaine and propylene glycol with a mass ratio of 1:2:0.01.

[0010] As a preferred technical solution of the present invention, the thickener is one or more of Peg-80, Peg-150 and carbomer.

[0011] As a preferred technical solution of the present invention, the emulsifier is lecithin, the acidity regulator is citric acid, and the surfactant is sodium sarcosinate.

[0012] As a preferred technical solution of the present invention, the preservative is one or two of sodium benzoate and phenoxyethanol.

[0013] As a preferred technical solution of the present invention, the conditioner is Litsea cubeba oil, silicone oil and almond oil with a mass ratio of 1:2:0.01.

[0014] As a preferred technical solution of the present invention, the preparation process of the plant extract is as follows:

[0015] S1. By weight, 5-10 parts of lophatherum ketone, 20-40 parts of Platycladus orientalis leaf extract, and 5-10 parts of Cnidium monnieri extract are ball-milled at a speed of 300 r / min for 40-60 min by a ball mill to obtain a uniformly mixed mixture A;

[0016] S2. 3-5 parts of mussel protein solution with a concentration of 5-10 mg / mL and 1-2 parts of sorbitol are mixed with mixture A, stirred at a speed of 400 r / min for 50 min, and then obtained mixture B after freeze-drying;

[0017] S3. Phosphorylated Dendrobium officinale polysaccharide, sodium alginate and deionized water are stirred at a mass ratio of 1:(6-8):10 at a speed of 400 r / min for 40-60 min to obtain a uniformly mixed modified sodium alginate solution. The modified sodium alginate solution is used as the wall material aqueous solution, mixture B is added as the core material, and then an emulsifier is added, and stirring is continued for 35 min. The wall material and core material mixture is slowly dropped into a calcium chloride solution with a mass fraction of 2-5% through a syringe, cured for 30 min to form microcapsules, and dried in a blast drying oven at 60 °C for 12 h to obtain the plant extract. The mass ratio of the core material, the modified sodium alginate solution to the emulsifier is (1-1.5):(1-3):0.3.

[0018] As a preferred technical solution of the present invention, in step S3, the preparation process of the phosphorylated Dendrobium officinale polysaccharide is as follows:

[0019] Under the condition of 40 - 60 °C, dissolve polysaccharide from Dendrobium officinale in deionized water to prepare solution A with a concentration of 50 mg / mL. Add solution B according to a volume ratio of 4:1, where solution B is a mixture of chloroform and n-butanol with a volume ratio of 4:1. Centrifuge at a speed of 1000 r / min for 30 - 50 min, dialyze for 48 h, and freeze-dry at -40 °C for 48 h to obtain purified polysaccharide from Dendrobium officinale.

[0020] Dissolve sodium tripolyphosphate in deionized water, adjust the pH to 8.5 with 6 mol / L NaOH, and add the purified polysaccharide from Dendrobium officinale at 60 °C. The mass ratio of sodium tripolyphosphate, purified polysaccharide from Dendrobium officinale, and deionized water is 5:2:100. Stir at a rotation speed of 400 r / min for 5 - 7 h at pH 8.5. After stirring, neutralize to pH 7.0 with 0.1 mol / L HCl, dialyze for 72 h, and then freeze-dry at -40 °C for 48 h to obtain phosphorylated polysaccharide from Dendrobium officinale.

[0021] As a preferred technical solution of the present invention, in step S3, the emulsifier is one of Tween 80 or pectin.

[0022] A preparation method of an efficient anti-dandruff shampoo, comprising the following steps: [[ID=...]] [[ID=...]]

[0023] By mass percentage, mix the surfactant and deionized water, heat up to 75 - 85 °C and stir at a speed of 600 - 800 r / min for 30 - 40 min, then cool down to 40 - 45 °C. Continue to add asiatic acid and the humectant, and keep stirring at the same speed for 15 - 20 min. Then add sodium propionate, thickener, emulsifier, acidity regulator, tremella polysaccharide, preservative, and conditioner, and continue to stir for 20 - 30 min. Finally, add dextranase, isethionate, and plant extract, increase the rotation speed to 800 - 1000 r / min, and stir for 30 - 45 min. After filtration, the efficient anti-dandruff shampoo can be obtained.

[0024] The flavonoid glycosides in lophatherum ketone have various biological activities, such as antioxidant, anti-aging, antibacterial and anti-inflammatory, and enhancing immune function. There are mainly flavonoid glycosides and flavonoid C-glycosides. Among them, the antioxidant substances can scavenge various common free radicals and inhibit lipid peroxidation, etc. The antibacterial substances can relieve swelling, inhibit hyaluronidase, significantly reduce the gene expression of TRPV1, and have the effect of inhibiting 5α-reductase, which can regulate the excessive secretion of sebum by sebaceous glands to achieve oil control, and thus can achieve the effect of anti-dandruff.

[0025] The extract of Platycladus orientalis mainly achieves the anti-dandruff effect through antibacterial, regulating scalp oil secretion, and promoting scalp blood circulation. The extract of Cnidium monnieri mainly reduces the generation of dandruff by antibacterial, relieving itching, promoting hair growth, and regulating the balance of scalp oil. The three components cooperate with each other and play a role together.

[0026] Mix the above three components with mussel protein and sorbitol as the core material. When these extracts are used as the core material alone, phenomena such as aggregation and stratification may occur during processes such as mixing and drying. Mussel protein can act as a natural stabilizer. Through interactions with the core material components, such as hydrogen bonding and electrostatic interactions, the core material can be evenly dispersed in the system. At the same time, during the freeze-drying process, mussel protein can also prevent physical damage to the core material components caused by ice crystal formation and maintain the physical stability of the core material. Meanwhile, mussel protein has certain viscosity and gel properties. During the preparation of microcapsules, it can act as a binder, helping the core material and the wall material to better combine and improving the forming rate and integrity of the microcapsules.

[0027] At the same time, adding sorbitol can improve the aggregation and precipitation that may occur to mussel protein due to intermolecular interactions in the solution, avoiding affecting its uniform distribution in the core material and the subsequent preparation effect of microcapsules. And sorbitol has good hydrophilicity and can form hydrogen bonds with water molecules, increasing the polarity and hydration layer thickness of the solution. When sorbitol is present, it will preferentially bind to water molecules, forming a hydration protection film around the mussel protein molecules, reducing the direct contact and interaction between mussel protein molecules, thereby reducing the possibility of mussel protein aggregation, enabling mussel protein to be more stably dispersed in the solution. At the same time, sorbitol can improve the fluidity of the core material.

[0028] Therefore, after mixing mixture A, mussel protein solution and sorbitol, various functions can be exerted and they can cooperate with each other to better control the release of the core material.

[0029] Phosphorylated Dendrobium officinale polysaccharide carries phosphate groups, making its molecules negatively charged. Sodium alginate molecules also contain acidic groups such as carboxyl groups, which are also negatively charged after partial dissociation in the solution environment. However, the charge distribution between them is not uniform, and the electrostatic interaction can be used to adjust the microcapsule network structure. Phosphorylated Dendrobium officinale polysaccharide has good stability. After mixing with sodium alginate, it can enhance the overall stability of the microcapsule wall material. In a complex system such as shampoo, containing components such as surfactants, the mixed wall material can better resist the damage of these components to the microcapsule structure. Dendrobium officinale polysaccharide itself has certain biocompatibility. After phosphorylation modification, this property may be further enhanced. When used as the microcapsule wall material for shampoo, after contacting the scalp and hair, it can reduce the irritation to the skin and hair. Compared with the pure sodium alginate wall material, this mixed wall material is more conducive to use in the sensitive environment of the human scalp, reducing the occurrence probability of adverse reactions such as allergies.

[0030] Phosphorylated Dendrobium officinale polysaccharide can enhance the mechanical strength of the microcapsule wall material. After adding phosphorylated Dendrobium officinale polysaccharide, it can interact with sodium alginate, such as through hydrogen bonding or electrostatic interaction, etc., to enhance the toughness and elasticity of the wall material, enabling the microcapsule to withstand greater external forces without breaking.

[0031] During the use of the prepared microcapsules in shampoo, through scalp friction, the active components can adhere to the damaged cutin scales on the hair surface, enabling some capsules to adsorb and remain on the hair and scalp of consumers after washing, thereby achieving the long-acting anti-dandruff function.

[0032] Advantages of the present invention:

[0033] By making microcapsules from three active ingredients, namely lophatherum ketone, Platycladus orientalis leaf extract, and cnidium fruit extract, adding them to shampoo, and mixing them with asiatic acid and the anti-dandruff ingredient hydroxyethyl sulfonate, and through their combined action, the effective removal of dandruff is achieved. Description of the Drawings

[0034] For the convenience of those skilled in the art to understand, the present invention will be further described below in conjunction with the drawings.

[0035] Figure 1 Picture of the antibacterial zone test of the anti-dandruff shampoo prepared in Example 1;

[0036] Figure 2 Picture of the antibacterial zone test of the anti-dandruff shampoo prepared in Comparative Example 6;

[0037] Figure 3 Picture of the antibacterial zone test of the blank control group. Detailed Embodiments

[0038] To further elaborate on the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following will, in conjunction with the embodiments, describe in detail the specific embodiments, structures, features, and their effects of the present invention.

[0039] The emulsifier used in the present invention is lecithin, the acidity regulator is citric acid, the surfactant is sodium sarcosinate, the conditioner is essence litsea cubeba oil, silicone oil, and almond oil with a mass ratio of 1:2:0.01, and the moisturizer is taurine, betaine, and propylene glycol with a mass ratio of 1:2:0.01.

[0040] Taurine: purchased from Shanghai Yuanye Biotechnology Co., Ltd., product number: S20155-25g; sodium propionate, sodium sarcosinate, PEG-150: purchased from Shanghai Yuanye Biotechnology Co., Ltd.; PEG-80: purchased from Beijing Lingbao Technology Co., Ltd.; betaine: purchased from Zhengzhou Rongyuan Chemical Products Co., Ltd.; propylene glycol: purchased from Shanghai Fandi Oil Technology Co., Ltd.; lecithin: purchased from Shanghai MacLean Biochemical Technology Co., Ltd., product number: L829397; extracts of bamboo leaves, arborvitae leaves, and cnidium monnieri: all purchased from Chengdu Pusi Biotechnology Co., Ltd.; asiatic acid: purchased from Shanghai Yien Chemical Technology Co., Ltd., product number: R02500 1; citric acid: purchased from Shanghai Haohong Biotechnology Co., Ltd., product number: 1043422; Tremella fuciformis polysaccharide: purchased from Shanghai Maclean Biochemical Technology Co., Ltd., product number: T861210; dextranase: purchased from Shanghai Yuanye Biotechnology Co., Ltd.; sodium benzoate: purchased from Shanghai Maclean Biochemical Technology Co., Ltd., product number: S817523; phenoxyethanol: purchased from Nantong Runfeng Petrochemical Co., Ltd.; Litsea cubeba oil, silicone oil, almond oil, and isethionate: purchased from Shanghai Yuanye Biotechnology Co., Ltd.; Dendrobium officinale polysaccharide: purchased from Fufeng Snot Biotechnology Co., Ltd.; mussel protein: purchased from Xi'an Zebang Biotechnology Co., Ltd.

[0041] Example 1

[0042] The preparation process of phosphorylated Dendrobium officinale polysaccharide is as follows:

[0043] At 40°C, Dendrobium officinale polysaccharide was dissolved in deionized water to prepare a solution A with a concentration of 50 mg / mL, and solution B was added at a volume ratio of 4:1, wherein solution B was chloroform and n-butanol at a volume ratio of 4:1. The solution was centrifuged at 1000 r / min for 30 minutes, dialyzed for 48 hours, and freeze-dried at -40°C for 48 hours to obtain purified Dendrobium officinale polysaccharide.

[0044] Sodium tripolyphosphate was dissolved in deionized water, and the pH was adjusted to 8.5 with 6 mol / L NaOH. Purified Dendrobium officinale polysaccharide was added at 60°C, wherein the mass ratio of sodium tripolyphosphate, purified Dendrobium officinale polysaccharide and deionized water was 5:2:100. The mixture was stirred at a speed of 400 r / min for 5 hours, and the pH was 8.5. After stirring, the mixture was neutralized with 0.1 mol / L HCl to pH 7.0. After dialyzing for 72 hours, the mixture was freeze-dried at -40°C for 48 hours to obtain phosphorylated Dendrobium officinale polysaccharide.

[0045] The preparation process of plant extracts is as follows:

[0046] S1. Mill 5 parts of hyssop ketone, 20 parts of Platycladus orientalis leaf extract, and 5 parts of cnidium monnieri extract by ball mill at 300 r / min for 40 min and mix them uniformly to obtain a mixture A.

[0047] S2. Mix 3 parts of mussel protein solution with a concentration of 5 mg / mL, 1 part of sorbitol and mixture A, stir at a speed of 400 r / min for 50 min, and obtain mixture B after freeze-drying;

[0048] S3. Stir phosphorylated Dendrobium officinale polysaccharide, sodium alginate and deionized water at a mass ratio of 1:6:10 at a speed of 400 r / min for 40 min. After mixing evenly, obtain a modified sodium alginate solution. Take the modified sodium alginate solution as the wall material aqueous solution, add mixture B as the core material, then add Tween 80, continue to stir for 35 min, and slowly drip the wall material and core material mixture into a calcium chloride solution with a mass fraction of 2% through a syringe, and cure for 30 min to form microcapsules. Dry in a blast drying oven at 60 °C for 12 h to obtain the plant extract. The mass ratio of the core material, the modified sodium alginate solution to the emulsifier is 1:1:0.3.

[0049] Preparation of high-efficiency anti-dandruff shampoo:

[0050] By mass percentage, mix 7% of surfactant and 36.41% of deionized water, heat up to 75 °C and stir at a speed of 600 r / min for 30 min, cool down to 40 °C, then continue to add 0.04% of asiatic acid and 30% of moisturizer, keep stirring at the same speed for 15 min, then add 18% of sodium propionate, 2% of Peg-80, 0.2% of emulsifier, 0.8% of acidity regulator, 0.05% of Tremella polysaccharide, 0.3% of sodium benzoate and 2% of conditioner, continue to stir for 20 min, and finally add 2% of dextranase, 0.5% of isethionate and 0.7% of plant extract, increase the speed to 800 r / min, stir for 30 min, and obtain the high-efficiency anti-dandruff shampoo after filtration.

[0051] Example 2

[0052] The preparation process of phosphorylated Dendrobium officinale polysaccharide is as follows:

[0053] Under the condition of 50 °C, dissolve Dendrobium officinale polysaccharide in deionized water to make solution A with a concentration of 50 mg / mL, add solution B according to a volume ratio of 4:1, where solution B is a mixture of chloroform and n-butanol with a volume ratio of 4:1, centrifuge at a speed of 1000 r / min for 40 min, dialyze for 48 h, and freeze-dry at -40 °C for 48 h to obtain purified Dendrobium officinale polysaccharide;

[0054] Dissolve sodium tripolyphosphate in deionized water, adjust the pH to 8.5 with 6 mol / L NaOH, add purified Dendrobium officinale polysaccharide at 60 °C. The mass ratio of sodium tripolyphosphate, purified Dendrobium officinale polysaccharide and deionized water is 5:2:100. Stir at a speed of 400 r / min for 6 h, pH 8.5. After stirring, neutralize to pH 7.0 with 0.1 mol / L HCl, dialyze for 72 h and then freeze-dry at -40 °C for 48 h to obtain phosphorylated Dendrobium officinale polysaccharide.

[0055] The preparation process of the plant extract is as follows:

[0056] S1. By weight, ball-mill 8 parts of lophatherum ketone, 30 parts of Platycladus orientalis leaf extract, and 6 parts of Cnidium monnieri extract at a speed of 300 r / min for 50 min, and mix evenly to obtain mixture A;

[0057] S2. Mix 4 parts of mussel protein solution with a concentration of 7 mg / mL, 1.5 parts of sorbitol with mixture A, stir at a speed of 400 r / min for 50 min, and obtain mixture B after freeze-drying;

[0058] S3. Stir the phosphorylated Dendrobium officinale polysaccharide, sodium alginate, and deionized water at a mass ratio of 1:7:10 at a speed of 400 r / min for 50 min. After mixing evenly, obtain a modified sodium alginate solution. Use the modified sodium alginate solution as the wall material aqueous solution, add mixture B as the core material, then add Tween 80, continue to stir for 35 min, and slowly drip the wall material and core material mixture into a calcium chloride solution with a mass fraction of 2-5% through a syringe, and solidify for 30 min to form microcapsules. Dry in a blast drying oven at 60 °C for 12 h to obtain the plant extract. The mass ratio of the core material, the modified sodium alginate solution and the emulsifier is 1.3:2:0.3.

[0059] Preparation of the high-efficiency anti-dandruff shampoo:

[0060] By mass percentage, mix 8% of surfactant with 29.96% of deionized water, heat up to 80 °C and stir at a speed of 700 r / min for 35 min, cool down to 43 °C, continue to add 0.04% of asiatic acid and 33% of moisturizer, keep stirring at the same speed for 17 min, then add 18% of sodium propionate, 3% of Peg-150, 0.25% of emulsifier, 0.9% of acidity regulator, 0.05% of Tremella fuciformis polysaccharide, 0.4% of sodium benzoate and 2.5% of conditioner, continue to stir for 25 min, and finally add 2.5% of dextranase, 0.5% of hydroxyethyl sulfonate and 0.9% of plant extract, increase the stirring speed to 900 r / min, stir for 38 min, and obtain the high-efficiency anti-dandruff shampoo after filtration.

[0061] Example 3

[0062] The preparation process of phosphorylated Dendrobium officinale polysaccharide is as follows:

[0063] At 60 °C, dissolve Dendrobium officinale polysaccharide in deionized water to prepare solution A with a concentration of 50 mg / mL. Add solution B in a volume ratio of 4:1, where solution B is a mixture of chloroform and n-butanol with a volume ratio of 4:1. Centrifuge at a speed of 1000 r / min for 50 min, dialyze for 48 h, and freeze-dry at -40 °C for 48 h to obtain purified Dendrobium officinale polysaccharide;

[0064] Dissolve sodium tripolyphosphate in deionized water, adjust the pH to 8.5 with 6 mol / L NaOH, and add purified Dendrobium officinale polysaccharide at 60 °C. The mass ratio of sodium tripolyphosphate, purified Dendrobium officinale polysaccharide, and deionized water is 5:2:100. Stir at a speed of 400 r / min for 7 h at pH 8.5. After stirring, neutralize to pH 7.0 with 0.1 mol / L HCl, dialyze for 72 h, and then freeze-dry at -40 °C for 48 h to obtain phosphorylated Dendrobium officinale polysaccharide.

[0065] The preparation process of the plant extract is as follows:

[0066] S1. By weight, ball-mill 10 parts of lophatherum ketone, 40 parts of Platycladus orientalis leaf extract, and 10 parts of Cnidium monnieri extract at a speed of 300 r / min for 60 min in a ball mill, and mix evenly to obtain mixture A;

[0067] S2. Mix 5 parts of mussel protein solution with a concentration of 10 mg / mL, 2 parts of sorbitol with mixture A, stir at a speed of 400 r / min for 50 min, and obtain mixture B after freeze-drying;

[0068] S3. Stir phosphorylated Dendrobium officinale polysaccharide, sodium alginate, and deionized water in a mass ratio of 1:8:10 at a speed of 400 r / min for 60 min to obtain a modified sodium alginate solution after mixing evenly. Use the modified sodium alginate solution as the wall material aqueous solution, add mixture B as the core material, then add Tween 80, continue to stir for 35 min, and slowly drip the wall material and core material mixture into a 5% calcium chloride solution through a syringe, and solidify for 30 min to form microcapsules. Dry in a blast drying oven at 60 °C for 12 h to obtain the plant extract. The mass ratio of the core material, modified sodium alginate solution, and emulsifier is 1.5:3:0.3.

[0069] Preparation of high-efficiency anti-dandruff shampoo:

[0070] Mix 10% surfactant and 23.61% deionized water by mass percentage, heat up to 85°C, stir at 800 r / min for 40 min, cool down to 45°C, then continue to add 0.04% asiatic acid and 35% humectant, keep stirring at the same rotation speed for 20 min, add 18% sodium propionate, 4% Peg-80, 0.3% emulsifier, 1% acidity regulator, 0.05% tremella polysaccharide, 0.5% sodium benzoate and 3% conditioner, continue to stir for 30 min, finally add 3% dextranase, 0.5% isethionate and 1% plant extract, increase the rotation speed to 1000 r / min, stir for 45 min, and after filtration, the high-efficiency anti-dandruff shampoo can be obtained.

[0071] Comparative Example 1

[0072] The difference between Comparative Example 1 and Example 1 is that in the preparation process of the plant extract in Comparative Example 1, phosphorylated dendrobium officinale polysaccharide is not added, and the rest of the operations are the same.

[0073] Comparative Example 2

[0074] The difference between Comparative Example 2 and Example 1 is that in step S2 of the preparation process of the plant extract in Comparative Example 2, mussel protein is not added, and the rest of the operations are the same.

[0075] Comparative Example 3

[0076] The difference between Comparative Example 3 and Example 1 is that in the preparation process of the plant extract in Comparative Example 3, mixture A is used as the core material, and the rest of the operations are the same.

[0077] Comparative Example 4

[0078] The difference between Comparative Example 4 and Example 1 is that in step S1 of the preparation process of the plant extract in Comparative Example 4, lophatherum ketone is not added, and the rest of the operations are the same.

[0079] Comparative Example 5

[0080] The difference between Comparative Example 5 and Example 1 is that in step S1 of the preparation process of the plant extract in Comparative Example 4, only lophatherum ketone is added, and the rest of the operations are the same.

[0081] Comparative Example 6

[0082] The difference between Comparative Example 6 and Example 1 is that in Comparative Example 6, the mixture A homogenized in step S1 is used as the plant extract, and steps S2 and S3 are not passed through, and the rest of the operations are the same.

[0083] Performance test:

[0084] 1. Bacteriostatic test:

[0085] Test samples: Shampoos prepared in Examples 1 to 3 and Comparative Examples 1 to 6. Positive control: Phosphate buffer solution (PBS) with a test concentration of 0.03 mol / L. The test procedure is as follows:

[0086] Take a 24-hour fresh slant culture of the test fungus Malassezia, wash it down with PBS, and dilute it with PBS to a bacterial suspension with a concentration of 1.0×10 3 CFU / mL for standby. At the same time, use PBS instead of the sample for parallel testing as the positive control. Observe the final result after culturing for 48 hours. Repeat the test 3 times and calculate the antibacterial rate;

[0087] Antibacterial rate (%) = (A 对照 - A 样品 ) / A 对照 ×100;

[0088] The obtained test results are shown in Table 1 below:

[0089] Table 1

[0090]

[0091]

[0092] 2. Refer to the standard "GB / T 39101-2020 Polypeptide Antibacterial Property Test - Inhibition Zone Method", test Examples 1-3 and Comparative Example 6. Wash Malassezia from the slant medium with sterile normal saline to make a bacterial suspension with a concentration of 2.3×10 6 cfu / mL. Add the prepared bacterial suspension to the sterile medium at an addition amount of 1%, mix well again, and wait for it to solidify for standby; Use a disposable pipette to aspirate the sample and add it to the round hole of the detection plate under aseptic operation. Place it in a constant temperature incubator at 37°C for 24 hours to observe the results. Use water as the blank control group, and measure the diameter of the inhibition zone with a vernier caliper. The obtained results are shown in Table 2 below:

[0093] Table 2

[0094] Group Inhibitory diameter (mm) Example 1 10.3 Example 2 10.5 Example 3 10.1 Comparative Example 6 9.6

[0095] According to the above data, it can be seen that the inhibition zone diameter and antibacterial rate of the examples are greater than those of Comparative Example 6, indicating that the present invention can effectively protect the active ingredients therein by preparing the plant extract into microcapsules and achieve a more efficient anti-dandruff effect. It can Figures 1-3 also be seen that the antibacterial effect of Example 1 is better.

[0096] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Although the present invention has been disclosed above with the preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to equivalent embodiments with equivalent changes within the scope of the technical solution of the present invention. However, as long as it does not depart from the content of the technical solution of the present invention, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. An efficient anti-dandruff shampoo, characterized in that, By mass percentage, it includes the following raw materials: 0.7 - 1% of plant extract, 0.04% of asiatic acid, 30 - 35% of humectant, 7 - 10% of surfactant, 18% of sodium propionate, 2 - 4% of thickener, 0.2 - 0.3% of emulsifier, 0.8 - 1% of acidity regulator, 0.05% of tremella polysaccharide, 2 - 3% of dextranase, 0.3 - 0.5% of preservative, 2 - 3% of conditioner, 0.5% of hydroxyethyl sulfonate, and the balance is deionized water; Among them, the plant extract exists in the shampoo in the form of microcapsules, with tenuifolin, Platycladus orientalis leaf extract, Cnidium monnieri extract treated with mussel protein and sorbitol as the core material, and sodium alginate modified by phosphorylated Dendrobium officinale polysaccharide as the wall material.

2. The high-efficiency anti-dandruff shampoo according to claim 1, characterized in that, The humectant is taurine, betaine and propylene glycol with a mass ratio of 1:2:0.

01.

3. The high-efficiency anti-dandruff shampoo according to claim 1, characterized in that The thickener is one or more of Peg - 80, Peg - 150 and carbomer.

4. The high-efficiency anti-dandruff shampoo according to claim 1, wherein The emulsifier is lecithin, the acidity regulator is citric acid, and the surfactant is sodium sarcosinate.

5. The high-efficiency anti-dandruff shampoo according to claim 1, characterized in that The preservative is one or two of sodium benzoate and phenoxyethanol.

6. The high-efficiency anti-dandruff shampoo according to claim 1, wherein The conditioner is Litsea cubeba oil, silicone oil and almond oil with a mass ratio of 1:2:0.

01.

7. The high-efficiency anti-dandruff shampoo according to claim 1, characterized in that, The preparation process of the plant extract is as follows: S1. By weight parts, 5 - 10 parts of tenuifolin, 20 - 40 parts of Platycladus orientalis leaf extract, and 5 - 10 parts of Cnidium monnieri extract are ball - milled at a speed of 300 r / min for 40 - 60 min by a ball mill, and mixed evenly to obtain mixture A; S2. 3 - 5 parts of mussel protein solution with a concentration of 5 - 10 mg / mL, 1 - 2 parts of sorbitol are mixed with mixture A, stirred at a speed of 400 r / min for 50 min, and after freeze - drying, mixture B is obtained; S3. Phosphorylated Dendrobium officinale polysaccharide, sodium alginate, and deionized water are stirred at a speed of 400 r / min for 40 - 60 min according to a mass ratio of 1:(6 - 8):10, and after mixing evenly, a modified sodium alginate solution is obtained. The modified sodium alginate solution is used as the wall - material aqueous solution, mixture B is added as the core material, and then an emulsifier is added, and stirring continues for 35 min. The wall - material and core - material mixture is slowly dropped into a calcium chloride solution with a mass fraction of 2 - 5% through a syringe, cured for 30 min to form microcapsules, and dried in a blast drying oven at 60 °C for 12 h to obtain the plant extract. The mass ratio of the core material, the modified sodium alginate solution to the emulsifier is (1 - 1.5):(1 - 3):0.

3.

8. The high-efficiency anti-dandruff shampoo according to claim 1, characterized in that In step S3, the preparation process of the phosphorylated Dendrobium officinale polysaccharide is as follows: Under the condition of 40 - 60 °C, Dendrobium officinale polysaccharide is dissolved in deionized water to form solution A with a concentration of 50 mg / mL, and solution B is added according to a volume ratio of 4:1, where solution B is a mixture of chloroform and n - butanol with a volume ratio of 4:

1. Centrifuge at a speed of 1000 r / min for 30 - 50 min, dialyze for 48 h, and freeze - dry at - 40 °C for 48 h to obtain purified Dendrobium officinale polysaccharide; Dissolve sodium tripolyphosphate in deionized water, adjust the pH to 8.5 with 6 mol / L NaOH, add purified Dendrobium officinale polysaccharide at 60 °C, where the mass ratio of sodium tripolyphosphate, purified Dendrobium officinale polysaccharide and deionized water is 5:2:100, stir at a speed of 400 r / min for 5 - 7 h, pH 8.

5. After stirring, neutralize to pH 7.0 with 0.1 mol / L HCl, dialyze for 72 h and then freeze-dry at -40 °C for 48 h to obtain phosphorylated Dendrobium officinale polysaccharide.

9. The high-efficiency anti-dandruff shampoo according to claim 1, characterized in that In step S3, the emulsifier is one of Tween 80 or pectin.

10. A preparation method of an efficient anti-dandruff shampoo according to any one of claims 1-9, characterized in that, It includes the following steps: By mass percentage, mix the surfactant with deionized water, heat up to 75 - 85 °C and stir at a speed of 600 - 800 r / min for 30 - 40 min, cool down to 40 - 45 °C, continue to add asiatic acid and the humectant, keep stirring at the same speed for 15 - 20 min, then add sodium propionate, thickener, emulsifier, acidity regulator, Tremella fuciformis polysaccharide, preservative and conditioner, continue to stir for 20 - 30 min, finally add dextranase, hydroxyethyl sulfonate and plant extract, increase the speed to 800 - 1000 r / min, stir for 30 - 45 min, and after filtration, the high-efficiency anti-dandruff shampoo can be obtained.

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