Multi-effect mild facial cleanser and preparation method thereof

Abstract

The invention discloses a multi-effect mild facial cleanser and a preparation method thereof, and belongs to the technical field of nursing products. The facial cleanser is prepared from the following components: EDTA-2Na (Ethylene Diamine Tetraacetic Acid), an amino acid surfactant, a glucoside surfactant, a betaine surfactant, glycolipid, glycerol, EGDS (Ethylene Diamine Tetraacetic Acid), propylene glycol laurate, water and the like. Based on the matching use of sodium lauroyl methyl aminopropionate, palmitoyl glycine and other amino acid surfactants, the facial cleanser can effectively overcome the technical problems of difficult thickening, poor foam stability and the like of a traditional amino acid facial cleansing product, and also can relieve chronic skin inflammation, restore skin balance and promote microangiogenesis, so that the facial cleanser has the effects of nourishing skin and improving skin quality. The skin is recovered to a young and compact state, and the full components are ensured to have a biodegradable characteristic.

Description

Technical Field

[0001] The invention relates to a facial cleanser, in particular to a multi-effect mild facial cleanser and a preparation method thereof, belonging to the technical field of nursing products. Background Art

[0002] As consumers' demand for mild cleansing products continues to rise, amino acid surfactants have become the mainstream of the market due to their pH value close to that of the skin and low irritation. Among them, sodium lauroyl methylaminopropionate, as a special amino acid surfactant, not only has the characteristics of mildness and low irritation of conventional amino acid surfactants, but also has rich foam, easy to rinse, and a refreshing wash feeling, which is suitable for most skin types. At the same time, it has low residue, which can avoid skin sensitivity, itching, acne and other problems caused by some surfactant residues, and is suitable for products for pregnant women and children. However, sodium lauroyl methylaminopropionate and other amino acid surfactant ingredients usually have obvious defects in formulation applications, such as: (1) Thickening problem: anionic amino acid surfactants such as sodium lauroyl methylaminopropionate have a short carbon chain and high hydrophilicity in their molecular structure, resulting in weak micelle aggregation ability. To achieve the target viscosity, traditional thickeners, such as carbomer and xanthan gum, usually need to be added in an amount of 0.5% to 1.5%. However, high addition levels may undermine the mildness of the product. For example, carbomer needs to be neutralized before use. If there are residual unreacted monomers, it may cause allergic problems. Conventional thickeners, such as PEG-150 distearate, PEG-120 methyl glucose dioleate, and acrylic acid (ester) copolymers, are often not effective in thickening when used in the formulation system. Moreover, the addition of these components is often accompanied by obvious defoaming, which is not conducive to the formation of a cleansing product system with rich foam and moderate viscosity, thereby further limiting the application of amino acid surfactants in facial cleansing products. (2) Insufficient foam stabilization: Amino acid cleansing products generally have the problem of sparse foam and fast dissipation. The foam retention rate within 5 minutes is usually less than 75%. To improve this situation, additional foam stabilizers are often needed, but such ingredients may introduce irritation. (3) Single function: Traditional thickeners can only provide physical thickening and cannot contribute to the cleaning or skin care effects of the product. For example, Chinese patent (CN114795989B) discloses a method for preparing an amino acid shampoo containing sodium lauroylmethylaminopropionate. This method combines a specific dosage ratio of multiple amino acid surfactants with conventional thickeners such as ceteareth-60 myristyl glycol, PEG-150 distearate, and cocamidomethyl MEA to effectively thicken and improve the foaming properties of the shampoo combination. However, these ingredients also pose significant skin irritation risks and can introduce hazardous substances. High concentrations or prolonged contact can cause skin dryness, itching, and other discomforts. Careful dosage control is crucial during formulation to avoid adverse reactions. Furthermore, shampoo products typically require relatively low viscosity, typically between 4,000 and 8,000 mPa.s. For facial cleansers with higher viscosity requirements, these thickening solutions cannot meet the consistency requirements of cleansing creams.Chinese patent (CN117815087A) discloses a facial cleanser containing sodium lauroylmethylaminopropionate and its preparation method. It uses one or more of cocamide methyl MEA, PEG-150 pentaerythritol tetrastearate, PEG-150 distearate, PEG-120 methyl glucose trioleate, and cocamide MIPA as thickeners to increase the viscosity of the facial cleanser. However, these traditional thickeners present significant skin irritation, allergenicity, and the introduction of hazardous substances. For example, cocamide methyl MEA and cocamide MIPA may contain secondary alkylamines and nitrosamines, which are cosmetic hazardous substances. PEG-150 pentaerythritol tetrastearate, PEG-150 distearate, and PEG-120 methyl glucose trioleate may introduce dioxane and diethylene glycol, which are cosmetic hazardous substances. Furthermore, these ingredients are not biodegradable and are prone to significant environmental pollution during the industrial production of raw materials, which is inconsistent with the principles of environmental protection and sustainable development.

[0003] In addition, consumers' expectations for cleansing products are no longer limited to simple cleansing functions. They hope that they can also have skin care effects, such as moisturizing, anti-sensitivity, soothing, firming, brightening, etc. However, most products on the market currently need to rely on subsequent skin care products to achieve their additional skin care functions. Summary of the Invention

[0004] In response to the defects of the existing technology, the first purpose of the present invention is to provide a multi-effect mild facial cleanser. The facial cleanser is based on the compound use of Palmitoyl Glycine and Sodium Lauroyl Methylaminopropionate. By utilizing the synergistic effect of the two ingredients, it can effectively overcome the technical difficulties of traditional amino acid cleansing products such as the difficulty in thickening and poor foam stability. While achieving cleansing of the skin, it can also reduce chronic skin inflammation, restore skin balance, promote microangiogenesis, and restore the skin to a youthful and firm state, while ensuring that all ingredients are biodegradable.

[0005] The multi-effect mild facial cleanser of the present invention avoids the use of difficult-to-degrade thickeners such as acrylic acid polymers, polyethylene glycol synthetic esters, fatty alcohol polyether polymers, and fatty acid amide M / DEA, thereby avoiding pollution to the environment and reducing environmental risks, enabling it to meet the requirements for cosmetic ingredients in the EU Cosmetics Regulation (EC No. 1223 / 2009) and China's Cosmetics Supervision and Administration Regulations.

[0006] The second object of the present invention is to provide a method for preparing a multi-effect mild cleanser, which has a wide source of raw materials, simple operation, mild conditions, low cost, and meets the requirements of industrial production.

[0007] In order to achieve the above technical objectives, the present invention provides a multi-effect mild facial cleanser, which comprises the following components in percentage by weight: 0.10-0.15% EDTA-2Na; 8-23% amino acid surfactant; 1-3% glucoside surfactant; 1-4% betaine surfactant; 3-5% glycolipid; 5-10% glycerol;

[0008] EGDS 1~2%; Propylene glycol laurate 1~2%; Citric acid 0.5~2%; Preservative 0.5~1%; Flavor 0.1~0.8%; Water, balance;

[0009] The amino acid surfactant is composed of sodium lauroylmethylaminopropionate, palmitoylglycine and an auxiliary amino acid surfactant;

[0010] The auxiliary amino acid surfactant includes at least one of cocoyl glycinate, cocoyl glutamate, lauroyl glutamate, lauroyl sarcosinate, cocoyl amino propionate, and cocoyl methyl taurate.

[0011] The key to the multi-effect mild facial cleanser of the present invention lies in the combined use of two amino acid surfactants, palmitoyl glycine and sodium lauroyl methylaminopropionate. Palmitoyl glycine is amphiphilic, with its palmitoyl chain providing hydrophobicity and the glycine head group providing hydrophilicity. This unique structure enables it to form complex micelles with sodium lauroyl methylaminopropionate through hydrophobic interactions and hydrogen bonds, thereby enhancing the viscoelasticity of the system. Simultaneously, the resulting complex micelle network encapsulates bubbles, significantly improving foam retention. In summary, by fully leveraging the synergistic effect between palmitoyl glycine and sodium lauroyl methylaminopropionate, the present invention effectively overcomes the technical difficulties of traditional amino acid surfactant-based cleansing products, such as the difficulty in thickening and poor foam stability.

[0012] The multi-effect mild cleanser of this invention not only cleanses the skin but also restores the skin's youthful and firm state by alleviating chronic inflammation, restoring skin balance, and promoting microangiogenesis. All ingredients are biodegradable. In vitro experimental results demonstrate that: 1) Palmitoyl glycine can inhibit the activity of collagenase (MMP-1) with a half-inhibitory concentration (IC50) of 35 μM, effectively reducing UV-induced collagen degradation. This core benefit significantly differs from traditional thickeners. 2) Palmitoyl glycine can reduce IL-6 content by 39%, equivalent to restoring a 60% youthful phenotype. Through this function, palmitoyl glycine can reduce aging caused by chronic inflammation, restore skin balance, promote microangiogenesis, restore skin radiance, and assist in the synthesis and arrangement of collagen fiber networks, restoring skin firmness.

[0013] In the multi-effect mild cleanser of the present invention, sodium lauroylmethylaminopropionate serves as the main surfactant, forming a synergistic system with other auxiliary amino acid surfactants to improve the skin feel and after-washing feel of the cleanser, and enhance the product user experience by optimizing the balance between cleaning and moisturizing. Palmitoyl glycine, as a modified amino acid surfactant, plays a role in thickening and improving foam stability. The introduction of betaine surfactants helps to improve the cleaning effect of the product. Glucoside surfactants and glycolipid surfactants improve irritation while providing a cleaning effect, while providing a moisturizing and nourishing feeling after washing, which does not dry out the skin and optimizes the product experience. EDTA-2Na is used as a chelating agent to improve the product's resistance to hard water. EGDS can provide a pearlescent effect to the product and enhance its appearance. Glycerin has a moisturizing effect. Propylene glycol laurate can provide a thickening effect.

[0014] As a preferred solution, the sodium lauroyl methylaminopropionate accounts for 6-15% of the mass of the cleanser. As the main surfactant, sodium lauroyl methylaminopropionate fully exerts its surface activity, and its proportion should not be too low.

[0015] As a preferred embodiment, the palmitoyl glycine accounts for 1-3% of the cleanser's mass. The multi-effect mild cleanser of the present invention achieves optimal results when the palmitoyl glycine is added in an amount of 1-3%. Palmitoyl glycine's viscosity-enhancing efficiency is 3-5 times that of traditional thickeners, and it can increase foam retention to over 95%. If added in an amount greater than 3%, the system will become too viscous, causing the material to stick together and making it difficult to disperse in water and react with water to produce a cleansing effect. If added in an amount less than 1%, the thickening effect will fail, the material will be too thin, and the feel will be poor. Furthermore, the active ingredients in the product will precipitate, making the product unstable and potentially causing product failure and deterioration.

[0016] As a preferred solution, the auxiliary amino acid surfactant accounts for 1-5% of the cleanser's mass. This auxiliary amino acid surfactant component, combined with sodium lauroyl methylaminopropionate, forms a synergistic system that improves the cleanser's skin feel and after-wash sensation, enhancing the product's user experience by optimizing the cleansing and moisturizing balance.

[0017] As a preferred embodiment, the auxiliary amino acid surfactant includes at least one of cocoyl glycinate, cocoyl glutamate, lauroyl glutamate, lauroyl sarcosinate, cocoamido propionate, and cocoyl methyl taurate. Specific examples include sodium (potassium) cocoyl glycinate, disodium (potassium) cocoyl glutamate, sodium (potassium) lauroyl glutamate, sodium (potassium) lauroyl sarcosinate, sodium (potassium) cocoamido propionate, and sodium (potassium) cocoyl methyl taurate.

[0018] As a preferred solution, the glucoside surfactant includes at least one of Plantacare 2000, Plantacare 818 up, and Plantacare 1200 up.

[0019] As a preferred solution, the betaine surfactant includes at least one of cocamidopropyl betaine and cocamidohydroxysulfopropyl betaine.

[0020] As a preferred embodiment, the glycolipid includes at least one of rhamnolipid, sophorolipid, trehalolipid, and mannose-erythroid glycolipid.

[0021] As a preferred solution, the multi-effect mild cleanser further comprises citric acid, a preservative and a fragrance. Citric acid serves as a pH regulator.

[0022] As a preferred embodiment, the preservative is a combination of phenoxyethanol and ethylhexylglycerin, wherein the mass ratio of the phenoxyethanol to the ethylhexylglycerin is 5 to 15:1.

[0023] The present invention also provides a method for preparing a multi-effect mild cleanser, which comprises the following steps:

[0024] S1: Add EDTA-2Na to water, heat to 75-80°C, and stir to dissolve evenly.

[0025] S2: Add auxiliary amino acid surfactant, sodium lauroylmethylaminopropionate, glucoside surfactant, betaine surfactant and glycolipid to water, maintain the temperature, and continue stirring to dissolve evenly;

[0026] S3: Add palmitoyl glycine pre-dispersed with glycerol to water, cool to 65-75°C, and continue stirring to dissolve evenly.

[0027] S4: Add EGDS and propylene glycol laurate to water, maintain the temperature, and stir to dissolve evenly;

[0028] S5: Add the additives to the water, cool it down to 45-55°C, adjust the pH to 6-7, continue stirring to dissolve evenly, and then cool it down to below 40°C before discharging.

[0029] The multi-effect mild facial cleanser of the present invention is prepared by a staged mixing method, wherein palmitoyl glycine needs to be mixed with glycerin at room temperature for pre-dispersion. Before adding citric acid to adjust the pH, the system is cooled to below 70°C and added to a pot and stirred evenly to avoid direct contact between palmitoyl glycine powder and surfactant, which would cause adhesion and agglomeration, resulting in difficulty in dispersion, uneven material body, or degradation of the product under long-term high temperature conditions due to excessive stirring and dispersion time.

[0030] Compared with the existing technology, the technical solution of the present invention brings the following beneficial technical effects:

[0031] 1) This invention discovers for the first time that palmitoyl glycine has a synergistic effect on sodium lauroyl methylaminopropionate in directional thickening, foam stabilization, and pearlescence. Combining the two in a facial cleanser successfully solves the technical difficulties of existing amino acid surfactant-based facial cleansers, such as difficulty in thickening and poor foam stability.

[0032] 2) The present invention introduces palmitoyl glycine into the cleanser, thereby giving the cleanser the triple functions of cleansing, thickening and anti-inflammatory, effectively reducing the complexity of the formula.

[0033] 3) The cleanser of the present invention uses biodegradable palmitoyl glycine to completely replace traditional synthetic thickeners, complying with the requirements of the EU Green Deal. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 These are the test results of the chicken embryo chorioallantoic membrane test of Examples 1 to 6 and Comparative Examples 1 and 3. DETAILED DESCRIPTION

[0035] The following specific examples are intended to further illustrate the present invention in detail, rather than to limit the scope of protection of the present claims.

[0036] In the following specific examples, the formula and ingredient ratios of the multi-effect mild cleanser are:

[0037]

[0038] in,

[0039] The auxiliary amino acid surfactant includes but is not limited to at least one of sodium (potassium) cocoyl glycinate, disodium (potassium) cocoyl glutamate, sodium (potassium) lauroyl glutamate, sodium (potassium) lauroyl sarcosinate, sodium (potassium) cocoylaminopropionate, and sodium (potassium) cocoyl methyl taurate.

[0040] The glucoside surfactant includes but is not limited to at least one of Plantacare 2000 (decyl glucoside), Plantacare 818 up (cocoyl glucoside), and Plantacare 1200 up (lauryl glucoside).

[0041] The betaine surfactant includes but is not limited to at least one of cocamidopropyl betaine and cocamidohydroxysulfopropyl betaine.

[0042] The glycolipids include but are not limited to at least one of rhamnolipids, sophorolipids, trehalolipids, and mannose-erythrolipids.

[0043] The preservative is a mixture of phenoxyethanol and ethylhexylglycerin, and the ratio of phenoxyethanol to ethylhexylglycerin is 9:1.

[0044] Preparation process of multi-effect mild cleanser:

[0045] S1: Add water and EDTA-2Na into a stirring container, stir until dissolved evenly, heat to 75-80°C, and stir at a speed of 100-300 r / min;

[0046] S2: Maintaining the above heating temperature, accurately weigh the auxiliary amino acid surfactant, sodium lauroylmethylaminopropionate (30%), glucoside surfactant, betaine surfactant, and glycolipid, add them to the stirring container, stir at a speed of 100-300 r / min, and stir for 20-25 minutes until uniformly dissolved;

[0047] S3: Cool down to 65-75°C, accurately weigh palmitoyl glycine and glycerol, moisten the palmitoyl glycine with glycerol, add the mixture to a stirring container, stir at a speed of 100-300 r / min, and stir for 20-25 minutes to uniformly dissolve the palmitoyl glycine in the material;

[0048] S4: Add EGDS and propylene glycol laurate, stir and dissolve evenly, stirring speed 100-300 r / min, stirring time 10-20 min;

[0049] S5: Cool down to 45~55℃, add preservatives, flavors, citric acid, adjust pH to 6.0~7.0, continue stirring at low speed (stirring speed 50~120r / min) for 10min, and discharge the material after cooling down to below 40℃.

[0050] Examples 1 to 6

[0051]

[0052] Preparation method of the facial cleanser of Examples 1 to 6:

[0053] S1: Add water and EDTA-2Na into a stirring container, stir and dissolve evenly, heat to 80°C, and stir at 200 r / min;

[0054] S2: Maintaining the above heating temperature, accurately weigh the auxiliary amino acid surfactant, sodium lauroyl methylaminopropionate (30%), glucoside surfactant, betaine surfactant, and glycolipid, add them to the stirring container, stir at a speed of 200 r / min, and stir for 25 min until uniformly dissolved;

[0055] S3: Cool to 70°C, accurately weigh palmitoyl glycine and glycerol, moisten palmitoyl glycine with glycerol, add to a stirring container, stir at 200 r / min, and stir for 25 minutes to uniformly dissolve the palmitoyl glycine in the material;

[0056] S4: Add EGDS and propylene glycol laurate, stir and dissolve evenly, stirring speed 200r / min, stirring time 15min;

[0057] S5: Cool down to 50°C, add preservatives, flavors, and citric acid, adjust the pH to about 6.5 (10% aqueous solution), continue stirring at low speed (stirring speed 100r / min) for 10 minutes, and then discharge the material after cooling down to below 40°C.

[0058] Comparative Examples 1-3

[0059]

[0060] Preparation method of the facial cleanser of Comparative Examples 1 to 3:

[0061] Comparative Example 1: Same as Example 1.

[0062] Comparative Example 2: Different from Example 1, in step S1, an amount of citric acid equal to that of Example 1 was added in advance and mixed with water. In step S3, palmitoylglycine was directly added to the formula in powder form.

[0063] Comparative Example 3: Different from the example, in step S5, SF-1 was pre-mixed with 2 times the amount of water, then added to a stirring container and stirred for 10 minutes until uniformly dissolved, at a stirring speed of 150 r / min.

[0064] Performance test of facial cleanser:

[0065] (1) Appearance, stability and viscosity test: Instrument: Brookfield viscometer NDJ-5S;

[0066] Test results:

[0067]

[0068] Test conclusion:

[0069] Examples 1 to 6 all produced white, pearlescent, viscous emulsions with a uniform appearance, good high and low temperature stability, and a material viscosity ranging from 10,000 to 40,000 mPa.s. The higher the amount of palmitoyl glycine used, the higher the viscosity. Commercial facial cleansers typically have a viscosity above 10,000 mPa.s. Examples 1 to 6, as facial cleansers, have a moderate viscosity and are easily extrudable, making them suitable for pump or hose packaging.

[0070] Compared with Example 1, the amount of palmitoyl glycine used in Comparative Example 1 was increased, and the material was a white paste with a pearlescent luster. As a facial cleanser product, the viscosity was relatively high and it was not suitable for pump packaging, but was suitable for hose packaging.

[0071] Comparative Example 2, compared with Example 1, changed the method of adding palmitoylglycine. Citric acid was pre-dispersed in the aqueous phase, and palmitoylglycine was directly added to the material in the form of a powder for dispersion. The material obtained in Comparative Example 2 was a white pearly liquid with low viscosity, which was not suitable for use as a facial cleanser. The material was also uneven, with a large number of white agglomerated particles inside. This was because in step S3, when palmitoylglycine was added to the material, the material was weakly acidic to neutral. Palmitoylglycine is an acidic substance that is insoluble in water and is only soluble under alkaline conditions. Moreover, since palmitoylglycine was not wetted and directly added to the material, the difficulty of palmitoylglycine contacting with water was increased, resulting in difficulty in dispersing and dissolving palmitoylglycine.

[0072] In Comparative Example 3, compared with Example 1, 4 parts of the traditional acrylic copolymer thickener SF-1 were used instead of palmitoyl glycine. The material was a white pearlescent emulsion with slightly low viscosity, which was not suitable for use as a facial cleanser. In addition, the material became coarse after being stored under low temperature conditions for a long time, and the stability was average. This shows that palmitoyl glycine has a better viscosity-gaining effect and stability-enhancing effect on the facial cleanser system than 4 parts of the traditional acrylic copolymer thickener.

[0073] (2) Foam performance test:

[0074] Test method: Use Roche foam tester to test the foam performance of 1% hard water solution of sample at 40℃ water temperature, and record the relevant data after 5 minutes.

[0075] Test results:

[0076]

[0077] Test conclusion:

[0078] Examples 1-6 achieved high foam yields and excellent foam stability, with foam retention rates exceeding 95% after 5 minutes. This is due to the unique advantages afforded by palmitoyl glycine's amphiphilic molecular structure. When combined with structurally similar amino acid surfactants, such as sodium lauroyl methylaminopropionate, they form a unique synergistic effect, significantly reducing the surface tension of water. When a cleanser is used and rubbed to generate bubbles, its molecules rapidly migrate to the air-liquid interface, with the hydrophobic tails extending toward the air and the hydrophilic head groups remaining in the water. This arrangement forms a strong, elastic, and charged film around the bubbles, significantly increasing the foam yield of this cleansing formula. Furthermore, palmitoyl glycine typically exists as an anionic form in ion-rich cleansing system formulations. The negative charge it carries creates electrostatic repulsion between adjacent bubble membranes. This repulsion effectively prevents bubble merging (coalescing) and bursting, allowing the foam to persist longer, resulting in a richer, more stable foam. Consequently, the cleansing formula incorporating palmitoyl glycine exhibits a high foam retention rate.

[0079] In Comparative Example 1, due to the addition of excessive palmitoylglycine, the foam volume was also improved, and the foam retention rate was still at a high level.

[0080] In Comparative Example 3, palmitoyl glycine was replaced with the traditional thickener acrylic copolymer SF-1. The foam volume was low, and the foam was unstable, easily coalescing and breaking, and the foam retention rate was low. This is because SF-1 does not have surface activity and has no synergistic effect with the surfactant in the formula. It only plays a role of suspension thickening. Therefore, the foam performance is poor.

[0081] (3) Consumers’ evaluation of the effects of use:

[0082] Testing Method: Ten subjects (five women and five men) applied the product to their hands and evaluated its effectiveness during use. Five indicators were measured: foam volume, foam smoothness, rinseability, slipperiness, and post-wash skin feel. The results of all ten subjects were tallied and the average of each indicator was calculated (scoring scale: 1-5, with 1 being very poor and 5 being the best).

[0083] Test results:

[0084]

[0085] Test conclusion:

[0086] The consumer evaluation scores of Examples 1 to 6 for the five indicators of the use effect were all above 4 points, with a high comprehensive score. The products had rich and fine foam, were easy to rinse, and did not feel slippery or dry after washing.

[0087] The overall score of Comparative Example 1 was relatively low. The test subjects reported that the product was difficult to rub apart when rubbed, the amount of foam was very small, the foam was not dense, and it was difficult to rinse off, resulting in a poor overall use experience. This is because an excessive amount of palmitoyl glycine was added to Comparative Example 1, which increased the viscosity of the material while significantly enhancing the stickiness of the material. The molecules were too tightly connected, resulting in the need to rub vigorously for a long time to fully contact and moisten it with water molecules when rubbing it with water. In daily use scenarios for cleansing, the rubbing time is usually short. Therefore, during the evaluation process, a large amount of the material in Comparative Example 1 adhered to the skin and could not be rubbed apart, resulting in only a portion of the material being moistened and producing a small amount of foam. At the same time, during the rinsing process, since a large amount of the material adhered to the skin, it was difficult to rinse it clean, resulting in a poor rinsing experience.

[0088] The overall score of Comparative Example 3 is slightly lower than that of the embodiment. The evaluation scores of foam volume and foam fineness among the five indicators are slightly low. This result is consistent with the test results of foam volume in Effect Example 2. The foam volume is low and easy to break. Therefore, consumers gave poor evaluations on the foam and fineness of this product in the use effect evaluation test.

[0089] (4) Irritation test:

[0090] Test Method: Prepare the sample with normal saline to a 1% concentration in a 2ml volume. Use normal saline as a blank control and 0.4% sodium hydroxide as a positive control. Test the sample for irritation using the chick embryo chorioallantoic membrane (HET-CAM) test, with a rating scale of 0 (no irritation) to 3 (severe irritation).

[0091] Test results see Figure 1 and Table 7.

[0092]

[0093] Test conclusion:

[0094] Example 1 is non-irritating, while Comparative Example 3 is mildly irritating. This is because Comparative Example 3 uses a traditional thickener, acrylate copolymer SF-1, instead of palmitoyl glycine as a thickener. SF-1 is an anionic polyelectrolyte, which may damage the lipid barrier of the stratum corneum at high concentrations and enhance the penetration of other irritants. At the same time, the production process of acrylate polymers also carries the risk of residual unreacted acrylic acid monomers (known skin irritants). The amino acid structure in palmitoyl glycine has unique skin-friendly properties. The raw materials are derived from natural products and are safe and non-irritating. While it has excellent biocompatibility, it also helps resist chronic inflammation inside the skin, reduces damage to the skin caused by external stimuli, and reduces irritation that may occur during and after use of the product.

[0095] (5) Human efficacy test:

[0096] Test method: 10 subjects aged 20 to 50 years with mild to moderate chronic skin inflammation (questionnaire + doctor evaluation) were selected. They used the target cleansing product (Example 1) twice a day, morning and evening, for a total of 4 weeks. On the 0th day, the 14th day, and the 28th day, the facial data of the subjects were collected using a multifunctional skin analyzer, and the subjects completed the test questionnaire.

[0097] Test results:

[0098]

[0099] Note: To unify the test data, facial score = single test result - reference value of the subject's age group

[0100]

[0101] Test conclusion:

[0102] Long-term use of the cleansing product in Example 1 improved skin hydration, excessive oiliness, redness, and elasticity. The results were particularly significant in improving sensitive skin redness and increasing skin moisture and elasticity, demonstrating that the test product improves chronic skin inflammation and repairs the skin barrier. This is because all ingredients in the formula of Example 1 are selected from safe, non-irritating, or low-irritating cosmetic ingredients. The production process and raw material sources are environmentally friendly, free of potentially irritating substances, and have high biocompatibility, ensuring the safety and effectiveness of the ingredients. At the same time, the alkyl glucoside surfactants in the formula help increase skin hydration and improve dryness and dehydration caused by chronic inflammation following barrier damage. Glycolipid surfactants, with their unique structure mimicking skin lipids, actively inhibit the TLR pathway while leaving the barrier intact after washing, reducing neurotoxicity and achieving an anti-inflammatory and repairing effect. Palmitoyl glycine is a multi-targeted anti-inflammatory and anti-aging ingredient that can reduce IL-6 levels in the skin and inhibit collagenase MMP-1 activity, regulating procollagen 1 production and promoting microvascular network formation, thereby enhancing skin activity, balancing inflammation, and reducing redness. These multifunctional ingredients, combined with amino acid surfactants, are precisely formulated and meticulously controlled to achieve a multi-functional cleansing, anti-inflammatory, and repairing solution, addressing skin concerns through multiple pathways. This formula is particularly suitable as a daily stabilizing cleansing and care product for sensitive skin.

[0103] In summary, the technical solution of the present invention exhibits the following core advantages:

[0104] Thickening efficiency: Only 1% palmitoyl glycine is needed to achieve the same thickening effect as 4% of traditional acrylic copolymer aqueous solution.

[0105] Foam persistence: The 5-minute foam retention rate and foam volume are significantly improved compared to traditional formulas.

[0106] Mildness: Chicken embryo is significantly less irritating than amino acid cleansing products using traditional thickeners.

[0107] Multi-functional empowerment: It has anti-inflammatory and soothing effects while cleansing the skin, meeting the market demand for multi-functional complex products.

[0108] Green and environmentally friendly: The raw materials used in the formula are biodegradable, meeting environmental protection needs.

Claims

1. A multi-effect mild cleanser, characterized by: Contains the following components by mass percentage: EDTA-2Na 0.10~0.15%; Amino acid surfactants 8~23%; Glucoside surfactants 1~3%; Betaine surfactant 1~4%; Glycolipids 3-5%; Glycerol 5-10%; EGDS 1~2%; Propylene glycol laurate 1~2%; Citric acid 0.5~2%; Preservatives 0.5~1%; Fragrance 0.1~0.8%; water, balance; The amino acid surfactant is composed of sodium lauroylmethylaminopropionate, palmitoylglycine and an auxiliary amino acid surfactant; The auxiliary amino acid surfactant includes at least one of cocoyl glycinate, cocoyl glutamate, lauroyl glutamate, lauroyl sarcosinate, cocoyl amino propionate, and cocoyl methyl taurate.

2. The multi-effect mild cleanser according to claim 1, characterized in that: The sodium lauroyl methylaminopropionate accounts for 6-15% of the mass of the cleanser.

3. The multi-effect mild facial cleanser according to claim 1, characterized in that: The palmitoyl glycine accounts for 1-3% of the mass of the cleanser.

4. The multi-effect mild cleanser according to claim 1, characterized in that: The auxiliary amino acid surfactant accounts for 1-5% of the mass of the cleanser.

5. The multi-effect mild facial cleanser according to any one of claims 1 to 4, characterized in that: The glucoside surfactant includes at least one of Plantacare 2000, Plantacare 818 up, and Plantacare 1200 up.

6. The multi-effect mild facial cleanser according to any one of claims 1 to 4, characterized in that: The betaine surfactant includes at least one of cocamidopropyl betaine and cocamidohydroxysulfopropyl betaine.

7. The multi-effect mild facial cleanser according to any one of claims 1 to 4, characterized in that: The glycolipid includes at least one of rhamnolipid, sophorolipid, trehalolipid and mannose-erythritol lipid.

8. The multi-effect mild facial cleanser according to any one of claims 1 to 4, characterized in that: The preservative is a composition of phenoxyethanol and ethylhexylglycerin; the mass ratio of the phenoxyethanol to the ethylhexylglycerin is 5-15:

1.

9. The method for preparing the multi-effect mild facial cleanser according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1: Add EDTA-2Na to water, heat to 75-80°C, and stir to dissolve evenly. S2: Add auxiliary amino acid surfactant, sodium lauroylmethylaminopropionate, glucoside surfactant, betaine surfactant and glycolipid to water, maintain the temperature, and continue stirring to dissolve evenly; S3: Add palmitoyl glycine pre-dispersed with glycerol to water, cool to 65-75°C, and continue stirring to dissolve evenly. S4: Add EGDS and propylene glycol laurate to water, maintain the temperature, and stir to dissolve evenly; S5: Add preservatives, flavors, and citric acid to the water, cool it down to 45-55°C, adjust the pH to 6-7, continue stirring to dissolve evenly, and then cool it down to below 40°C before discharging.

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