22 results about "Propionic acid ester" patented technology

The invention discloses a synthesis method of a glutaric acid ester compound, which comprises the following steps: reacting a propionate compound as shown in a formula 1 with a diazo compound as shown in a formula 2 in a solvent in a nitrogen atmosphere in the presence of a reducing agent under the illumination condition of visible light, and after the reaction is completed, separating out the glutaric acid ester compound, thereby obtaining the glutaric acid ester compound. And separating and purifying the reaction mixture to obtain the glutaric acid ester compound as shown in the formula 3. The propionate compound and the diazo compound are used as reaction substrates, the compound can be generated through reaction under mild conditions, the yield of the target product is improved, operation is easy and convenient, the reaction conditions are mild, the price of raw materials and solvents used in the whole process is low, and cost control is facilitated.

The application belongs to the field of organic synthesis and particularly relates to a synthesis method of polysubstituted indole propionate derivatives. Aryl acetate compounds and sulfonyl indole compounds are used as raw materials, and the reaction is carried out through an isothiourea organic small molecule catalyst. The reaction raw materials are simple and easy to obtain, the reaction conditions are mild, the operation is simple, the reaction time is short, the reaction has good diastereoselectivity and high yield, the synthesis method of the polysubstituted indole propionate derivatives overcomes the defects and deficiencies of the existing synthesis method, and has the characteristics of high efficiency, simplicity and wide universality.

The invention discloses a method for preparing optically active 2-fluoropropionate. The method comprises the following steps: step 1, preparing nitrobenzenesulfonyl fluoride; step 2, synthesizing 2-fluoropropionate with optical activity; the raw material nitrobenzenesulfonyl chloride can be conveniently prepared through a sulfonation reaction of substituted aromatic hydrocarbon, potassium fluoride, (S)-(-)-lactate and the like are commercialized bulk chemicals, the purchase channel is wide, the price is low, and the industrial production cost is remarkably reduced. According to the method, the use of a dangerous fluorinating reagent HF is avoided, and the reaction solvent can be recycled and reused; the water phase generated in the reaction in the first step can be recycled after potassium fluoride is supplemented, and the nitrobenzene sulfonate byproduct generated in the reaction in the second step can be recycled for preparing nitrobenzene sulfonyl chloride, so that the resource circulation is realized, and the emission of three wastes is greatly reduced.

The application discloses a method for synthesizing N-alkyl-beta-amino propionic acid sodium from alkyl amine and 3-halogenated propionic acid ester, and belongs to the technical field of organic synthesis. Long-chain fatty amine and an alkali catalyst are dissolved in a solvent to form a uniform solution, then 3-halogenated propionic acid ester is slowly added dropwise in the solution to perform a substitution reaction, after the completion of the substitution reaction, a sodium hydroxide solution is added to perform a hydrolysis reaction, and thus N-alkyl-beta-amino propionic acid sodium is obtained. The method has the characteristics of simple operation, mild conditions, easy separation of the product, high yield and the like.

A substantially neutral base multi-surface cleaning formulation. The formulation comprises an alkyl amine oxide surfactant, a levulinate solvent, a chelator and / or salt, and water. In some disclosed embodiments, the formulation further includes a buffer. The formulation has a substantially neutral pH from about 5 to about 8, from about 6 to about 8, or from about 6.5 to about 7.5. The formulation may be used as a spray, dosed on cleaning wipes, as a concentrate, in a soaps, or a wide variety of other forms.

The invention belongs to the technical field of adhesive preparation, and particularly relates to a recyclable aziridine propionate adhesive as well as a preparation method and application thereof. The recyclable aziridine propionate adhesive is prepared from the following raw materials in parts by weight: 40 to 50 parts of aziridine propionate monomers; 20-25 parts by weight of an olefine acid monomer and 20-25 parts by weight of an acetylenic acid monomer. According to the recyclable adhesive provided by the invention, aziridine propionate monomers are taken as a matrix, olefine acid monomers and acetylenic acid monomers are added to generate dynamic bonds, the network density of a polymer is improved, hydroxyl is introduced into the matrix, so that the content of hydrogen bonds is increased, and the deformation resistance of the adhesive is improved; the problem of low bonding strength of aziridine propionate adhesives in the prior art is solved.

The present application relates to a kind of synthesis method of organic compound, specifically to a kind of synthesis method of 3-trifluoromethyl pyridine or 3-difluoromethyl pyridine compound. By the pyridine compound shown in formula I, methyl propionic acid ester, dimethyl acetylene dicarboxylate is reacted to prepare the oxazolone-pyridine complex of formula II; With fluoroalkylating agent in the presence of base and solvent, under the condition of photosensitizer, visible light irradiation, at 15~35oC reaction preparation obtains formula III compound, after reaction with acid, preparation obtains the 3-fluoroalkyl substituted pyridine compound shown in formula IV, wherein, R is hydrogen, methyl, methoxy, methylthio, fluorine, chlorine, bromine, iodine, trifluoromethyl, trifluoromethoxy, methoxycarbonyl, nitrile group one or more, or or

The application discloses a continuous closed-loop cyclic production process for preparing propionic acid ester by taking methanol or dimethyl ether as raw material, and belongs to the technical field of organic synthesis chemical industry. The process comprises the following steps: S1, methyl acetate is hydrogenated to generate mixed alcohol of methanol and ethanol; S2, mixed alcohol is etherified with methanol to generate mixed ether comprising dimethyl ether, diethyl ether and methyl ethyl ether; S3, mixed ether is carbonylated with dimethyl ether and carbon monoxide to generate mixed ester comprising methyl acetate, ethyl acetate, methyl propionate and ethyl propionate; S4, ethyl acetate, methyl propionate and ethyl propionate products are obtained through rectification separation in a plurality of towers in series connection, and methyl acetate is recovered; and S5, the recovered methyl acetate is recycled back to the step S1. By constructing a methyl acetate directional closed-loop cyclic system, the application realizes efficient co-production of propionic acid ester and ethyl acetate, uses solid catalysts in the whole process, avoids strong acid corrosion, has high raw material utilization rate, has mild reaction conditions, can be continuously produced in industry, and effectively solves the problems of high cost, single product and non-recyclable utilization in the prior art.

The application provides a high polymer material modified organic lipophilic hydrophobic bentonite and a preparation method thereof, belongs to the technical field of coating materials, and is a product of sodium-based bentonite modified by intercalation modification of a high polymer modifier and hydrophobic propylene glycol methyl ether acetate. The high polymer modifier is prepared by the reaction of methacryloyloxyethyl trimethyl ammonium chloride, caprolactone acrylate, gamma-methacryloyloxypropyl trimethoxysilane, bis(dodecyl)-3,3'-thiobispropionic acid ester, ammonium mercaptoacetate and ammonium persulfate initiator. The bentonite preparation method comprises pre-synthesis of the high polymer modifier, preparation and purification of bentonite slurry, intercalation modification of the high polymer, post-treatment and hydrophobic modification of the modified product. The application solves the problems of strong hydrophilicity and poor dispersion of natural bentonite and weak interface combination and insufficient thixotropy of early organic bentonite from the molecular level, and realizes the performance upgrading of lipophilic hydrophobic, stable dispersion and long-acting protection.

The present application provides a method for preparing a propionic acid ester thiofuran ester compound from a levulinic acid ester compound, comprising the following steps: reacting a compound 1 and a sulfur reagent in the presence of a catalyst to obtain a compound 2; wherein, R 2 and R 3 are each independently hydrogen, alkyl, ROC(=O)‑(CH2)2‑ or aryl; R 1 is hydrogen, alkyl or aryl; R is each independently alkyl or aryl; and m is independently 1 or 2. The present application provides a method for preparing a thiofuran ester compound from a levulinic acid ester compound, which uses a biomass-based levulinic acid ester compound as a starting material, is prepared through a condensation thio reaction, and is separated and purified through column chromatography to obtain the thiofuran ester compound. The preparation method provided by the present application has the advantages of low cost, high efficiency, green environmental protection, sustainability, mild preparation process conditions, simple separation and purification, and high application potential of the obtained product in the fields of medicine, essence, plasticizer, battery and the like.

The present application relates to the field of molecular sieve, and particularly to a preparation method of levulinic acid ester.The present application provides a preparation method of levulinic acid ester, comprising the following steps: subjecting composite molecular sieve, cellulose, acid liquor and alcohol solvent to alcoholysis reaction to obtain levulinic acid ester; the composite molecular sieve is composed of transition metal and molecular sieve, and the transition metal exists in the molecular sieve framework in monodispersed tetrahedral coordination form.The method provided by the present application uses the composite molecular sieve with transition metal compounded in the framework and the pore channel as a catalyst to prepare levulinic acid ester by alcoholysis, and has high yield.Experiments show that in the whole reaction, the cellulose alcoholysis mainly generates the corresponding solvent levulinic acid ester, and the side reaction is less; under suitable conditions, the conversion rate of cellulose can reach 100%, and the molar yield of corresponding levulinic acid ester is greater than 60%.

The application discloses a synthesis method of 3-methylamino propionic acid and belongs to the technical field of organic synthesis. 3-amino propionic acid ester is dissolved in hexafluoroisopropanol to form a uniform solution, in the solution, trimethyl phosphate is added dropwise to perform N-alkylation reaction, after the N-alkylation reaction is completed, lye is added to perform saponification, and the saponification product is subjected to acidification, so that 3-methylamino propionic acid is obtained. The method can obtain 3-methylamino propionic acid at a high yield, is simple in operation, mild in condition, easy in product separation, and favorable for industrialized production.

The invention relates to a method for reducing the viscosity of urethane acrylate, which comprises the following steps: dissolving urethane acrylate in a solvent capable of dissolving urethane acrylate and paraformaldehyde, then reacting with paraformaldehyde for 5-12 hours under the conditions that the pH is 9-10 and the temperature is 60-90 DEG C, and purifying the mixture obtained by the reaction to obtain a finished product, the mass ratio of the solvent capable of dissolving the polyurethane acrylate and the paraformaldehyde to the polyurethane propionate is (2-3): 1, and the molar ratio of the paraformaldehyde to the polyurethane acrylate is (1.05-1.2): 1. According to the invention, the viscosity of the urethane acrylate is effectively reduced by destroying the hydrogen bond of the urethane acrylate.

The invention discloses a process method and device for synthesizing methyl propionate through ethylene hydrogen esterification. The process comprises the steps of reaction, separation and rectification, and the device mainly comprises a synthesis reactor, a separation tank and a rectification tower which are connected in sequence. In a synthesis reactor, ethylene, carbon monoxide and methanol are subjected to a hydrogen esterification reaction under the action of a catalyst; after the reaction, separating out unreacted ethylene, carbon monoxide and a catalyst-containing material through a separation tank and an evaporation tank, and respectively returning to the reactor through a circulating pipeline for reuse; and feeding a gas-phase product into a rectifying tower, returning the separated methanol to the reaction system, and outputting methyl propionate as a product. The method is high in atom economy, sufficient in raw material utilization rate, low in three-waste emission, green and efficient in process, high in product purity and low in production cost.

The invention provides a spraying polyurea composition, and relates to the technical field of polyurea. The spraying polyurea composition is composed of a component A and a component B, the component A and the component B do not contain unsaturated carbon-carbon bonds, and the viscosity of the component A at 25 DEG C is 100-300 cps; the component A comprises the following raw material components in percentage by weight: 60-75% of bifunctional N-propionate secondary amino resin, 10-20% of aspartate resin and 15-20% of polyether secondary amino resin; the polyether secondary amino resin contains hydroxyl; and the component B is an isocyanate curing agent. The spraying polyurea composition disclosed by the invention is short in gelation time, and a polyurea coating is high in tensile strength, good in adhesive force, good in weather resistance and high in glossiness.

The invention relates to the technical field of synthesis of fluorine-containing heterocyclic compounds, and discloses a preparation method of 3-phthalimido-2, 2-difluoropropionic acid, which comprises the following steps: reacting phthalimide potassium salt, 3-halo-2, 2-difluoropropionate, polyamine organic alkali serving as a synergistic activator and N, N-dimethylformamide serving as a structural stable factor in a solvent to prepare 3-phthalimido-2, 2-difluoropropionic acid, thereby obtaining the 3-phthalimido-2, 2-difluoropropionic acid. The method comprises the following steps: putting N, N '-dimethylurea into an aprotic polar solvent containing cyclic organic carbonate to construct a heterogeneous reaction system; a reaction system is controlled to be subjected to a nucleophilic substitution reaction, an intermolecular hydrogen bond association body is formed by using a structure stable factor and two symmetrical carbonyl oxygen atoms of a phthalimide anion, a nucleophilic attack path of the anion to a self heterocyclic skeleton is blocked, and a target product is obtained through acidic hydrolysis after an intermediate is generated. Through an intermolecular precise charge shielding mechanism, the contradiction between activity and stability in the nucleophilic substitution process is solved, the ring-opening side reaction is inhibited, and the product purity is improved.

The invention discloses a preparation method of a phenylpropionate derivative, which comprises the following steps: dissolving a compound 1 in a first organic solvent, dropwise adding a catalyst while stirring, carrying out heating reflux reaction completely, and carrying out post-treatment to obtain a compound 2; dissolving the compound 2 in a second organic solvent, adding an alkylating reagent and alkali, carrying out room temperature or heating reflux until the reaction is complete, and carrying out post-treatment to obtain a compound 3; compared with the prior art, the synthetic raw materials are easy to obtain, the preparation route is novel, the reaction operation and post-treatment are simple, the reaction conditions are mild, the reaction time is short, and energy conservation is facilitated. The synthesis steps are convenient, the product quality is good, the yield is high, and the industrial production value is remarkable.

The invention relates to a method for synthesizing propionate by catalyzing hydrogen esterification of ethylene. Specifically, the method provided by the invention comprises the following steps: a) in a reaction kettle, dissolving a platinum catalyst, a phosphine ligand and acid in alcohol and an optional solvent; b) introducing ethylene into the kettle, and then introducing carbon monoxide for reaction; c) finishing the reaction, and separating to obtain a product propionate; wherein the phosphine ligand is a phosphine ligand as shown in a formula I or a phosphine ligand as shown in a formula II. The method has the characteristics of high catalytic efficiency, high product yield, high selectivity, simplicity and convenience in operation and the like.

The application discloses a method for synthesizing 2,6-dimethoxyphenol and relates to the technical field of organic compound synthesis, and comprises the following steps: S1, a methylation reaction: 2,6-dihydroxybenzoic acid is used as a starting raw material, concentrated sulfuric acid is used as a catalyst, and methyl alcohol is used as a methylation reagent to obtain 2,6-dimethoxybenzoic acid methyl ester; S2, a Grignard reaction: ethyl magnesium chloride is used as a Grignard reagent to obtain 1-(2,6-dimethoxyphenyl)-1-propanone; S3, a Baeyer-Villiger oxidation reaction: 2,6-dimethoxyphenyl propionic acid ester is obtained; and S4, a hydrolysis reaction: 2,6-dimethoxyphenol is obtained under alkaline conditions. The method is very simple in each reaction step, the reaction condition is simple, post-treatment is convenient, industrial production is easy, and the reaction conversion rate is high.

The invention discloses a quaternary phosphonium salt antibacterial agent with a stable structure. The preparation method comprises the following steps: dissolving borneol and halogenated propionic acid in a water-carrying agent, discharging water completely through reflux, and carrying out alkali washing, water washing and drying to obtain halogenated propionic acid borneol ester; the preparation method comprises the following steps: dissolving halogenated borneol propionate and tertiary phosphine in an anhydrous solvent, reacting for 0.5-24 hours at 20-100 DEG C under the protection of a nitrogen atmosphere, concentrating, precipitating in diethyl ether, and drying to obtain the halogenated borneol propionate quaternary phosphonium salt. The obtained product has an efficient inhibition effect on various bacteria (such as escherichia coli and staphylococcus aureus), two carbon atoms are spaced between a phosphine group and an ester bond of the product, so that the environmental stability is improved, two simple synthesis paths are provided, and the method is suitable for industrial production. The antibacterial agent can be widely applied to the field of antibacterial treatment of disinfectants, medical instruments, daily necessities and packaging materials.

The invention relates to a water-based industrial anti-corrosion stoving varnish coating and a preparation method thereof, and belongs to the technical field of coatings. The coating comprises the following components: modified water-soluble hydroxyl resin, compound modified methylated amino resin, propylene glycol methyl ether propionate, a wetting agent, a flatting agent, a defoaming agent, phenolic ether phosphate, a pH regulator, a modified urea solution, titanium dioxide, modified graphene oxide and deionized water. The modified water-soluble hydroxyl resin is prepared by preparing a pre-emulsion from hydroxyethyl acrylate, methyl methacrylate, styrene, epoxy phosphate, polyester resin and deionized water, and adding ammonium persulfate and methyl glucosamine to react. The compound modified methylated amino resin is prepared by mixing hexamethoxy methyl melamine formaldehyde resin and methyl etherified high imino melamine resin, and adding p-toluenesulfonic acid and polyglycerol-2 diisostearate to react. The modified graphene oxide is prepared by carrying out surface modification on graphene oxide through a silane coupling agent.

The invention discloses a method for synthesizing 2, 6-dimethoxyphenol, and relates to the technical field of organic compound synthesis, the method comprises the following steps: S1, methylation reaction: 2, 6-dihydroxybenzoic acid is used as a starting material, concentrated sulfuric acid is used as a catalyst, methanol is used as a methylation reagent, and methyl 2, 6-dimethoxybenzoate is obtained; s2, Grignard reaction: taking ethyl magnesium chloride as a Grignard reagent to obtain 1-(2, 6-dimethoxyphenyl)-1-acetone; s3, a Baeyer-Villiger oxidation reaction is carried out, and 2, 6-dimethoxy phenyl propionate is obtained; and S4, hydrolysis reaction: reacting under an alkaline condition to obtain the 2, 6-dimethoxyphenol. Each reaction step is very simple, reaction conditions are simple, post-treatment is convenient, industrial production is easy, and the reaction conversion rate is high.