1956 results about "Cyclohexanes" patented technology

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a di-hydrochloride salt or a dihydrochloride, dihydrate.

The invention provides a method for synthesizing adiponitrile through selective ammoxidation of cyclohexene oxide. The invention aims to simulate and optimize the process of synthesizing adiponitrile from cyclohexene oxide by a one-step direct ammoxidation method to develop a novel multiphase composite metal vanadium-based oxide catalyst, the composition of the catalyst is CoaVbPcModMNOx / TiO2, the active elements of the catalyst comprise vanadium element V, cobalt element Co, phosphorus element P and molybdenum element Mo, M is an auxiliary metal element (Mn, Cr, Fe or Ni), and N is an alkali metal (Na, K or Cs); the value range of a is 0.2 to 1.2; the value range of b is 0.8 to 1.5; the value range of c is 0.1 to 0.23; the value range of d is 0.07 to 0.35; x is the oxygen atom proportion required by the metal oxidation valence state. The catalyst has the advantages of simple preparation, good cycling stability, high yield and the like. The yield and the product purity of the adiponitrile are improved, the energy consumption in the production process of the adiponitrile is reduced, and the breakthrough of the production technology of the adiponitrile is realized.

The invention provides a process for preparing cyclohexane-1, 2-dioctyl phthalate, which adopts a loop reaction process to perform hydrogenation reaction of dioctyl phthalate, and comprises the following steps: under the condition of excessive hydrogen atmosphere, firstly putting a catalyst, a solvent and a target product into a reaction tank to form a circulating material; when reaction liquid passes through the Venturi ejector, hydrogenation reaction can be carried out, the Venturi reactor can provide a high gas-liquid mixing ratio, the reaction rate is high, and the production efficiency is high. The catalyst and the reaction mixed liquid are separated by combining a membrane separation process, so that the catalyst is recycled, and the cost is reduced. The target product is added into the system to maintain material balance in the system, so that stable production is ensured. Compared with the traditional technical process, the method has the advantages that the reaction time is shortened, the energy consumption of the device and the investment cost are reduced, the high conversion rate of reactants and the high selectivity of target products can be kept, the operation period of the device is long, and continuous and stable production is realized.

The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.

The invention discloses a method for synthesizing deuterated olefin under catalysis of a palladium membrane by taking D2O as a deuterium source, and belongs to the technical field of synthesis of deuterated olefin building blocks. According to the method, a three-chamber electrolytic tank separated by a palladium membrane and an ion exchange membrane is used as a reactor, the palladium membrane is used as a working electrode, an electrolyte deuterium aqueous solution is used as an electrolyte, deuterium water is electrolyzed through a constant-potential electrolysis method, and formed active deuterium is transmitted to one side of an organic reaction taking absolute ethyl alcohol or cyclohexane as an organic solvent; and catalyzing an alkyne compound by using a palladium membrane modified by sodium thiophenol to perform reduction deuterization so as to synthesize a deuterated olefin compound with high selectivity, and further synthesizing a corresponding deuterated drug. The invention provides a green, efficient, high-universality and low-cost amplification synthesis method for synthesizing a deuterated olefin building block containing a functional group easy to reduce and hydrolyze, and the method has a wide application prospect.

The invention discloses high-temperature-resistant and corrosion-resistant unsaturated polyester resin for a grid and a preparation method thereof, and belongs to the technical field of unsaturated polyester resin. The raw materials comprise the following components in parts by weight: 330 to 400 parts of isophthalic acid, 55 to 80 parts of 1, 4-cyclohexanedimethanol, 150 to 200 parts of ethylene glycol, 125 to 220 parts of first reaction stage propylene glycol, 0.2 to 0.6 part of a catalyst, 0.1 to 0.3 part of a first reaction stage antioxidant, 90 to 120 parts of second reaction stage propylene glycol, 30 to 50 parts of phthalic anhydride, 300 to 380 parts of maleic anhydride, 0.1 to 0.3 part of a second reaction stage antioxidant, 0.1 to 0.5 part of a polymerization inhibitor and 600 to 630 parts of a cross-linking agent. The high-temperature-resistant and corrosion-resistant unsaturated polyester resin for the grating has the characteristics of high corrosion resistance, high temperature resistance and high mechanical property, is low in cost and is suitable for being used as a raw material for manufacturing the grating.

The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2′,2″-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

The invention discloses a pure silicon Beta molecular sieve packaging metal catalyst and a preparation method and application thereof, and the preparation method comprises the following steps: dissolving a silicon source, a template agent, a ligand, a metal salt and a mineralizer in water, carrying out a crystallization reaction at 120-200 DEG C, and carrying out calcination treatment and reduction treatment on the crystallized solid to obtain the pure silicon Beta molecular sieve packaging metal catalyst. The pure silicon Beta molecular sieve packaged metal catalyst is obtained. The pure silicon twelve-membered ring macroporous Beta molecular sieve encapsulated metal catalyst is prepared through a ligand protection in-situ hydrothermal synthesis strategy, so that the size of a metal nanocluster can be reduced, the high-temperature thermal stability of the metal nanocluster is improved, the adsorption and diffusion processes of guest molecules can be regulated and controlled, and the stability of the metal nanocluster is improved. Furthermore, the catalyst shows excellent catalytic performance when being used for catalyzing a propane dehydrogenation reaction and a methyl cyclohexane dehydrogenation reaction, and efficient and stable propane and methyl cyclohexane dehydrogenation performance is achieved.

The invention provides a method for catalytically converting waste PET (Polyethylene Terephthalate) plastic into 1, 4-cyclohexanedimethanol by a two-step method, which comprises the following steps of: 1, hydrogenating the waste PET plastic dispersed in methanol under the action of a nickel-based catalyst to obtain dimethyl 1, 4-cyclohexane dicarboxylate; and 2, centrifugally separating the catalyst and the reaction liquid in the step 1, and hydrogenating the reaction liquid under the action of a CuMgAl catalyst to obtain the target product 1, 4-cyclohexanedimethanol. The 1, 4-cyclohexanedimethanol is a key raw material for producing high-end polyester, and has very high market requirements. Under the optimal reaction condition, the molar yield of the 1, 4-cyclohexanedimethanol can reach 83.8%, and the separation purity reaches up to 99.5%. According to the method, upgrading and recycling of the PET waste are achieved so as to cope with the threat of white pollution to the ecological environment and human health.

The invention relates to the technical field of nano materials, and particularly discloses a preparation method of surface modified nano calcium carbonate for a battery diaphragm coating. According to the method, the technical paths of microemulsion confinement crystal form regulation and control, gradient surface modification and boehmite compounding and porosity regulation and control are fused, and the functional nano calcium carbonate adaptive to the battery diaphragm coating is prepared. According to the technical scheme, limestone is used as a raw material, after calcination and digestion, the particle size of nano calcium carbonate is controlled through microemulsion carbonization (a cyclohexane-span 80-n-butyl alcohol system); a silane coupling agent KH560-KH570 is adopted for gradient modification to introduce an electrophilic functional group, boehmite is compounded to form a composite coating, and the porosity is regulated and controlled by adjusting the solid content in coating slurry and the coating speed. The method is stable in process and high in compatibility, and meets the requirements of diaphragm coatings of lithium ion batteries and solid-state batteries.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention discloses an application of a zirconium sulfate solid superacid and a nickel-carbon catalyst in concerted catalysis of hydrodeoxygenation of a lignite model compound. Under the mild conditions of 140-180 DEG C, 1 MPa H2 and 2-4 h, SO4 < 2-> / ZrO2 and 10% Ni / AC are used as catalysts, and 100% conversion rate of lignite model compounds such as diphenyl ether and the like and 100% high selectivity of cyclohexane are achieved. The solid superacid catalyst and the metal catalyst are physically mixed to synergistically catalyze hydrodeoxygenation of the lignite model compound, and a new thought is provided for clean and efficient utilization of coal.

The invention relates to the technical field of cell culture media, in particular to a marine invertebrate cell culture medium. Comprising the following components in parts by weight: 0.5 to 1 part of a compound supplement, 1 to 4 parts of glucose, 0.3 to 0.5 part of L-glutamine, 0.01 to 0.05 part of vitamin, 10 to 15 parts of fetal calf serum, 0.02 to 0.04 part of penicillin, 0.01 to 0.03 part of trehalose, 0.3 to 0.7 part of a sodium chloride osmotic pressure regulator, 0.5 to 1 part of inorganic salt and 10 to 25 parts of a sodium bicarbonate buffer agent, wherein the compound supplement is prepared by mixing meson, diatom and disodium cyclohexane diamine tetraacetate according to the mass ratio of 1: (0.2-0.6): (0.1-0.5), the application range of the culture medium is widened by adopting the compound supplement, the meson and the diatom are added into the cell culture medium after enzymolysis, and compared with a chemically synthesized culture medium, the culture medium better meets the requirements of marine invertebrate cells; therefore, cell growth is effectively promoted, and the purposes of rapid growth and stable passage are achieved.

The invention relates to the technical field of flow battery energy storage, and discloses a nanofiber / graphite felt composite electrode material for a flow battery and a preparation method of the nanofiber / graphite felt composite electrode material. The preparation method of the electrode material comprises the following steps: by taking a carbon fiber graphite felt as a carrier, silicon powder and silicon dioxide powder as silicon sources, growing silicon carbide nanowires in situ on the fiber surface by adopting a vacuum thermal evaporation method, or by taking ferrocene as a catalyst precursor, cyclohexane as a solvent and a reaction carbon source and thiophene as an additive, preparing the carbon fiber graphite felt / silicon carbide nanowire composite electrode material. And growing a carbon nanotube on the surface of the fiber by adopting a floating catalyst chemical vapor deposition method, and performing water vapor activation on the prepared silicon carbide nanowire / graphite felt composite electrode material or the carbon nanotube / graphite felt composite electrode material in an activation furnace to prepare the modified nanofiber / graphite felt composite electrode material for the flow battery. The specific surface area, the hydrophilicity and the electric conduction and heat conduction performance of the carbon fiber graphite felt are greatly improved, and the application of the nanofiber / graphite felt composite electrode material in the field of flow battery energy storage is realized.

The utility model discloses a cyclohexane dehydrogenation device, which is characterized in that raw materials cyclohexane and hydrogen are jointly sent to a raw material preheater for preheating, then are heated in a raw material heater and then enter a dehydrogenation reactor, a dehydrogenation product is cooled by an outlet cooler, and the cooled product is subjected to gas-liquid separation by a first gas-liquid separation tank; the gas enters the hydrogen compressor to be pressurized, then is cooled and then enters the second gas-liquid separation tank to be separated again, one part of the gas separated by the second gas-liquid separation tank returns to the hydrogen raw material inlet, and the other part of the gas enters the hydrogen impurity removal and purification device to be purified and then is subjected to hydrogen energy recycling; liquid separated by the second gas-liquid separation tank returns to the first gas-liquid separation tank, and a liquid phase outlet is connected with a benzene storage tank through a pump and a pipeline. The by-product cyclohexane in the cyclohexanol production process is completely converted into benzene, the benzene is combined with an existing device and directly enters an existing system, and the advantage that benzene refining separation is not needed is embodied.

The invention relates to the technical field of multi-layer copolyester films, and discloses a high-temperature-resistant antistatic multi-layer copolyester film and a preparation method and application thereof, and the multi-layer copolyester film comprises an ABA three-layer structure obtained through melt co-extrusion; the layer A is prepared from the following raw materials in percentage by mass: 5 to 30 percent of anti-blocking agent master batch and the balance of modified copolyester; the raw material of the layer B is modified copolyester; the modified copolyester is prepared from a binary acid mixture, a dihydric alcohol mixture and a catalyst through an esterification reaction and a condensation polymerization reaction; the binary acid mixture comprises furandicarboxylic acid and 2, 2 '-bifuran-5, 5'-dicarboxylic acid, and the dihydric alcohol mixture comprises ethylene glycol, 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol and 1, 4-cyclohexanedimethanol. According to the invention, the modified copolyester is used as a main raw material, and the film is endowed with good temperature resistance in a copolymerization modification manner, and has stable and lasting antistatic performance.

The invention relates to the technical field of polyester preparation, and provides isosorbide modified polyethylene glycol terephthalate-1, 4-cyclohexanedimethanol ester and a preparation method of the isosorbide modified polyethylene glycol terephthalate-1, 4-cyclohexanedimethanol ester. The preparation method comprises the following steps: mixing terephthalic acid, ethylene glycol, 1, 4-cyclohexanedimethanol, isosorbide and a compound catalyst, and sequentially carrying out an esterification reaction and a condensation polymerization reaction to obtain the isosorbide modified polyethylene terephthalate-1, 4-cyclohexanedimethanol. By introducing the isosorbide, the heat resistance and oxygen barrier property of the copolyester are greatly improved, the problems of poor heat resistance and poor oxygen barrier property of the existing PETG material are solved, and the obtained copolyester inherits good mechanical properties, transparency and processability of the PETG material and has a wide application prospect. In addition, the preparation method provided by the invention is simple, mild in condition, stable in product performance and suitable for large-scale production.

The invention belongs to the field of functional materials and surface engineering, and particularly relates to ant-cave-shaped photo-thermal super-hydrophobic sponge and a preparation method and application thereof.The preparation method comprises the steps that melamine sponge is soaked in an absolute ethyl alcohol solution to be repeatedly soaked and then dried; adding dopamine hydrochloride into the tris buffer solution, stirring to obtain a mixed solution, immersing the surface of the dried melamine sponge into the mixed solution, and drying to obtain PDA (at) MS; the preparation method comprises the following steps: firstly adding PDMS and a curing agent thereof into a cyclohexane solution, stirring, then adding MWCNTs, MnO2 and CuO, stirring to form a mixed solution, then spraying the mixed solution on the surface of PDA (at) MS, and drying to obtain a PMOS (P-channel Metal Oxide Semiconductor); and immersing the PMOS surface into a mixed solution of ethanol containing PFOTES and deionized water, and then taking out and drying. Through the fine cross-scale multi-layer gap structure design, high mechanical durability and excellent light absorption capacity are achieved, and efficient anti-icing, deicing, interface evaporation and fresh water production in an extreme environment are achieved.

The invention relates to a preparation method of 3-[(1S, 2S)-1-[5-[(4S)-2, 2-dimethyl oxacyclohexane-4-yl]-2-[(4S)-2-(4-fluoro-3, 5-dimethyl phenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6, 7-dihydro-4H-pyrazolo [4, 3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1, 2, 3-triazolo [4, 3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-1, 2, 4-triazolo [4, 3-c] pyridine-5- The invention relates to synthesis of 1, 2, 4-oxadiazole-5-one or a salt thereof, and related synthesis intermediate compounds.

The invention discloses an SERS (Surface Enhanced Raman Scattering) detection method for paclitaxel drug concentration in blood of a breast cancer patient, and belongs to the technical field of detection. The method comprises the following steps: performing acetonitrile two-step precipitation centrifugal treatment on a blood sample to obtain a detection sample; the method comprises the following steps: constructing a high-sensitivity SERS substrate (the volume ratio of gold nanoparticles to ethanol is 1: (90-100), and a film is formed on a water-cyclohexane interface) through self-assembly of gold nanoparticles on a liquid-liquid interface; the method comprises the following steps: dropwise adding a sample into a substrate, and detecting characteristic peaks of 1024cm <-1 > and 1053cm <-1 > by using a portable Raman spectrometer (785nm, 30mW, 0.5 s); and calculating the paclitaxel concentration in combination with a pre-established quantitative curve. The method is easy and convenient to operate and suitable for clinical bedside rapid monitoring.

This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4 -yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

The invention relates to a lignin-based polymer pervaporation membrane, a preparation method thereof and a method for separating and purifying cyclohexane-KA oil. The invention aims to provide a pervaporation membrane which is high in permselectivity, high in stability and good in mechanical property. The pervaporation membrane is used for cyclohexane-KA oil separation and has the advantages of high separation efficiency, low energy consumption and simple process. The preparation method comprises the following steps: adding the surfactant, the polymer and the solvent into a reactor, and stirring at 50-70 DEG C for 4-6 hours to obtain a mixed solution; the method comprises the following steps: adding lignin and a solvent into a reactor, and stirring at room temperature for 4-6 hours to obtain a lignin solution; dropwise adding the lignin solution into the mixed solution, and continuously stirring at constant temperature for 12-24 hours to obtain a membrane casting solution; transferring the membrane casting solution to a centrifugal tube, performing centrifugal separation, and uniformly coating the membrane casting solution on an ultrafiltration membrane material with the membrane thickness of 100-200mm to form a uniform liquid membrane; and drying the liquid membrane to obtain the lignin-based polymer pervaporation membrane. Belongs to the technical field of membrane separation.

The present invention discloses a Pt-based catalyst and its preparation method and application, belonging to the technical field of dehydrogenation catalysts. The preparation method of the Pt-based catalyst comprises the following steps: mixing an aqueous solution I containing magnesium ions, aluminum ions and platinum ions with an aqueous solution II containing a hydroxide-containing alkaline compound and a carbonate, and reacting to obtain a Pt-based catalyst. The preparation method of the present invention utilizes PtCl6 2‑ The strong electrostatic interaction with the magnesium-aluminum hydrotalcite layer (positively charged) and the change of Pt loading amount realize the microstructural regulation of Pt in the Pt-based catalyst. The Pt-based catalyst prepared by this method has a small Pt particle size, a highly dispersed state, and a high atomic utilization rate. When it is used for the dehydrogenation reaction of methylcyclohexane, compared with the catalyst prepared by the traditional impregnation method, under the same reaction conditions, the methylcyclohexane conversion rate is increased by 3.3 times, and it also has good stability.

The invention relates to the field of polyester, and discloses a method for continuously producing 1, 4-cyclohexanedimethanol by taking waste polyester as a raw material. Comprising the following steps: 1) mixing waste polyester with ethylene glycol, and performing alcoholysis under the action of an alcoholysis catalyst to obtain alcoholysis liquid containing diethylene glycol terephthalate; 2) performing primary hydrogenation on the alcoholysis solution under the catalysis of a hydrogenation catalyst A to obtain a reaction solution containing 1, 4-cyclohexane dioctyl phthalate diglycol ester; 3) performing secondary hydrogenation on the reaction liquid under the catalysis of a hydrogenation catalyst B to obtain a reaction liquid containing 1, 4-cyclohexanedimethanol; and 4) carrying out gas-liquid separation and rectification on the reaction liquid to obtain ethylene glycol and 1, 4-cyclohexanedimethanol. According to the method, the CHDM is produced by taking the waste polyester as the raw material, the method is simple in production process flow, and continuous production can be realized; through optimization of the catalyst and the process, high PET conversion rate, high CHDM selectivity, high CHDM yield and low production cost can be realized under relatively mild reaction conditions.

The invention discloses a wood-based composite phase-change material and a preparation method thereof, and belongs to the technical field of phase-change materials.The preparation method of the wood-based composite phase-change material comprises the following steps that wood is cut and then added into delignification liquid to be heated, the wood is taken out and washed with water, and delignified wood is obtained; the delignification wood is added into the modification liquid to be heated, and after being taken out, the delignification wood is washed and dried to obtain pretreated wood; mixing polyethylene glycol, citric acid and boric acid, heating and stirring to obtain a phase change material; dipping the pretreated wood into the phase change material for vacuum dipping, taking out and drying to obtain the phase change material. The modified liquid is prepared from an ethanol water solution, a modified filler, 2-(3, 4-cyclohexene oxide) ethyltrimethoxysilane and triethylamine. The delignification liquid and the modification liquid are adopted for pretreating the wood, so that the wood can be better firmly combined with the phase change material, leakage is prevented, and the finally prepared wood-based composite phase change material has excellent heat management capacity and stability.

The invention relates to a catalyst for preparing 1, 4-cyclohexanedimethanol through hydrogenation of dimethyl 1, 4-cyclohexanedicarboxylate as well as a preparation method and application of the catalyst. The surface of the carrier CeO2 is modified by Zn-Zr alloy, so that the carrier has richer oxygen vacancies, the dispersity of active metal on the surface of the carrier can be improved, and the active metal shows higher performance. The prepared catalyst is applied to a 1, 4-dimethyl cyclohexanedicarboxylate hydrogenation reaction, and 1, 4-cyclohexanedimethanol with higher conversion rate, higher selectivity and higher trans-cis ratio can be obtained.

The invention relates to the technical field of adhesives, in particular to a bio-based adhesive and a preparation method thereof. The bio-based adhesive is prepared from the following raw material components: bio-based polyol, bio-based isocyanate and cyclohexane diisocyanate, a tin catalyst, a chain extender and an organic solvent are not contained; the invention also provides a preparation method of the bio-based adhesive, the bio-based adhesive prepared by the invention has good biodegradability, thermoplasticity and biocompatibility, can realize biodegradation under various environmental conditions, reduces pollution to the environment, and is more environment-friendly in treatment after being discarded compared with traditional petroleum-based polyurethane.

The invention relates to the technical field of water treatment, in particular to a nanofiltration membrane and a preparation method thereof. The preparation method comprises the following steps: soaking a base membrane in a water phase solution, taking out the base membrane, performing surface drying, coating the base membrane with an oil phase solution, performing interfacial polymerization reaction, and curing to obtain the nanofiltration membrane, the water-phase solution comprises a polyamine monomer, a surfactant, an acid-binding agent and water; the acid binding agent is bicarbonate; the oil phase solution comprises an acyl chloride monomer, an organic solvent a and an organic solvent b; the organic solvent a is ethyl cyclohexane; the organic solvent b comprises at least one of methane chloride, monochloroethane, diethyl ether, methyl ethyl ether, dimethyl ether and methyl formate. The membrane flux is improved while the acid chemical cleaning resistance of the membrane is improved.